Detailed information for compound 1588058

Basic information

Technical information
  • TDR Targets ID: 1588058
  • Name: 1-(1,3-benzodioxol-5-ylmethyl)-3-ethylthioure a
  • MW: 238.306 | Formula: C11H14N2O2S
  • H donors: 1 H acceptors: 0 LogP: 1.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN=C(NCc1ccc2c(c1)OCO2)S
  • InChi: 1S/C11H14N2O2S/c1-2-12-11(16)13-6-8-3-4-9-10(5-8)15-7-14-9/h3-5H,2,6-7H2,1H3,(H2,12,13,16)
  • InChiKey: QEBSTUAPXDTNMM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1,3-benzodioxol-5-ylmethyl)-3-ethyl-thiourea
  • MLS000552972
  • SMR000177851
  • Oprea1_331639
  • ST5269410
  • 1-Benzo[1,3]dioxol-5-ylmethyl-3-ethyl-thiourea
  • BAS 03058307
  • ZINC00257726

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major asparaginyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0281 0.1156 0.2546
Leishmania major importin beta-1 subunit, putative 0.0025 0.0042 0.0135
Loa Loa (eye worm) beta-lactamase 0.004 0.0109 0.0226
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0109 0.0894
Loa Loa (eye worm) 63kd antigen 0.0052 0.0159 0.0338
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0042 0.0115 0.2989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2315 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0109 0.2833
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0051
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0043 0.0079
Schistosoma mansoni protein phosphatase-1 0.0025 0.0043 0.0071
Plasmodium falciparum aspartate--tRNA ligase 0.0052 0.0159 0.0674
Giardia lamblia Methionyl-tRNA synthetase 0.0042 0.0115 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0032 0.0032
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0088 0.0179
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0109 0.0894
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0187 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0727
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0109 0.045
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0156 0.0284
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0016 0.002
Schistosoma mansoni methionine-tRNA synthetase 0.0042 0.0115 0.0207
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.004 0.0109 0.0436
Echinococcus granulosus dna polymerase kappa 0.0019 0.0016 0.0016
Echinococcus multilocularis geminin 0.0332 0.1379 0.1372
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0016 0.002
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0109
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0338
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0042 0.0078
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0015
Echinococcus granulosus importin subunit beta 1 0.0031 0.0068 0.0068
Leishmania major GTP-binding protein, putative 0.0023 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0052 0.0159 0.0333
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0159 0.029
Mycobacterium tuberculosis Conserved protein 0.004 0.0109 0.0894
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0344 0.1548
Giardia lamblia Asparaginyl-tRNA synthetase 0.0052 0.0159 0.2552
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0017 0.0017
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0156 0.0156
Schistosoma mansoni protein phosphatase type 1 0.0025 0.0043 0.0071
Echinococcus multilocularis snurportin 1 0.033 0.1367 0.136
Treponema pallidum aspartyl-tRNA synthetase 0.0052 0.0159 0.1348
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0134
Schistosoma mansoni ran 0.0023 0.0032 0.0051
Echinococcus multilocularis methionine tRNA synthetase 0.0042 0.0115 0.0108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0088 0.0088
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0016 0.001
Leishmania major hypothetical protein, conserved 0.0027 0.0051 0.0176
Brugia malayi putative serine/threonine phosphatase 0.0025 0.0043 0.0074
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0014 0.0016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.0087
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0203 0.0818 0.1799
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0281 0.1156 0.2549
Echinococcus granulosus cpg binding protein 0.0121 0.0462 0.0462
Toxoplasma gondii methionyl-tRNA synthetase 0.0042 0.0115 0.0477
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.004 0.0109 0.0436
Schistosoma mansoni hypothetical protein 0.0332 0.1379 0.2587
Treponema pallidum leucyl-tRNA synthetase 0.0042 0.0115 0.0926
Brugia malayi beta-lactamase family protein 0.004 0.0109 0.0221
Plasmodium vivax replication protein A1, large subunit, putative 0.0505 0.2129 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0016 0.001
Leishmania major methionyl-tRNA synthetase, putative 0.0042 0.0115 0.0477
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0017 0.0022
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0187 0.018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1156 0.2168
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.004 0.0109 0.1711
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0262 0.1072 0.1072
Toxoplasma gondii hypothetical protein 0.0033 0.0075 0.0289
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0043 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0109 0.0196
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0109 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0044 0.0081
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0014 0.0035
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0042 0.0135
Echinococcus multilocularis leucyl tRNA synthetase 0.0042 0.0115 0.0108
Giardia lamblia Lysyl-tRNA synthetase 0.0052 0.0159 0.2552
Toxoplasma gondii hypothetical protein 0.0111 0.0415 0.1894
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.001
Echinococcus granulosus geminin 0.0332 0.1379 0.1379
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0262 0.1072 0.5618
Schistosoma mansoni kinase 0.0047 0.0137 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1156 0.2168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0344 1
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Plasmodium falciparum nucleic acid binding protein, putative 0.0052 0.0159 0.0674
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0159 0.029
Trypanosoma brucei protein phosphatase 1 0.0025 0.0043 0.0136
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0017 0.0007 0.0007
Plasmodium vivax methionine--tRNA ligase, putative 0.0042 0.0115 0.0463
Echinococcus multilocularis cpg binding protein 0.0121 0.0462 0.0455
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0052 0.0159 0.3136
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0052 0.0159 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.0109 0.0222
Plasmodium vivax aspartate--tRNA ligase, putative 0.0052 0.0159 0.0674
Schistosoma mansoni apoptosis regulator bax 0.0413 0.1728 0.3245
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.004 0.0109 0.0226
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0335 0.0727
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0187 0.0187
Plasmodium vivax importin-beta 2, putative 0.0031 0.0068 0.024
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0068 0.0061
Brugia malayi methionyl-tRNA synthetase 0.0262 0.1072 0.236
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0051 0.0161
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0335 0.1727
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0079
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0052 0.0159 0.0152
Plasmodium vivax methionine--tRNA ligase, putative 0.0042 0.0115 0.0463
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0051 0.0176
Leishmania major lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Giardia lamblia GTOR 0.0018 0.0014 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0058 0.0099
Chlamydia trachomatis lysine--tRNA ligase 0.0052 0.0159 0.0465
Echinococcus granulosus lysyl tRNA synthetase 0.0052 0.0159 0.0159
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0203 0.1795
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0109 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0109 0.045
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0022
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0025 0.0043 0.0136
Brugia malayi replication factor A 73 kDa subunit 0.1053 0.4514 1
Plasmodium falciparum asparagine--tRNA ligase 0.0052 0.0159 0.0674
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0052 0.0159 0.1379
Brugia malayi methionyl-tRNA synthetase 0.0042 0.0115 0.0234
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0052 0.0159 0.1379
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Toxoplasma gondii aspartate-tRNA ligase 0.0052 0.0159 0.0688
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0009
Mycobacterium leprae conserved hypothetical protein 0.004 0.0109 0.1266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1156 0.115
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0413 0.1728 0.1728
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0042 0.0115 0.0477
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.001
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0051 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0102 0.0377 0.0822
Onchocerca volvulus 0.0115 0.0433 0.0826
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Mycobacterium ulcerans beta-lactamase 0.004 0.0109 0.2833
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0413 0.1728 0.3815
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0262 0.1072 0.1066
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.1055 1
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.004 0.0109 0.0102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0058 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0088 0.0081
Plasmodium falciparum replication protein A1, large subunit 0.0505 0.2129 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0052 0.0159 0.0338
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0335 0.0722
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0015
Echinococcus multilocularis dna polymerase eta 0.0019 0.0016 0.0009
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.1053 0.4514 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0109 0.0109
Trypanosoma brucei unspecified product 0.0019 0.0016 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0032 0.0087
Schistosoma mansoni ran 0.0023 0.0032 0.0051
Schistosoma mansoni hypothetical protein 0.033 0.1367 0.2565
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0032 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0017 0.0015
Brugia malayi beta-lactamase 0.004 0.0109 0.0221
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0075 0.0548
Entamoeba histolytica replication factor A, putative 0.0102 0.0377 0.1953
Entamoeba histolytica replication factor A protein 1, putative 0.0453 0.1903 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1001 0.4288 0.9499
Trypanosoma brucei protein phosphatase 1, putative 0.004 0.0109 0.0451
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0014 0.0007
Plasmodium vivax asparagine--tRNA ligase, putative 0.0052 0.0159 0.0674
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.004 0.0109 0.0102
Loa Loa (eye worm) hypothetical protein 0.0413 0.1728 0.3818
Echinococcus granulosus dnaJ subfamily B 0.1237 0.5314 0.5314
Trichomonas vaginalis ran, putative 0.0023 0.0032 0.0056
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0109 0.0894
Leishmania major DNA polymerase eta, putative 0.0019 0.0016 0.001
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.0088
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0109
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0075 0.0274
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0016 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0014 0.0015
Echinococcus multilocularis glycyl tRNA synthetase 0.0203 0.0818 0.0811
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0043 0.0079
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.1053 0.4514 0.4514
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0042 0.0115 0.301
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0102
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0185
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0058 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.002
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0943 0.4033 1
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0203 0.0203
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.001
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0052 0.0159 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0335 0.0621
Leishmania major replication Factor A 28 kDa subunit, putative 0.0052 0.0159 0.0688
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0017 0.0052
Toxoplasma gondii histone lysine methyltransferase SET1 0.0218 0.088 0.4096
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0109 0.0894
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0042 0.0115 0.0239
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0052 0.0159 0.4368
Schistosoma mansoni leucyl-tRNA synthetase 0.0042 0.0115 0.0207
Mycobacterium ulcerans lipase LipD 0.004 0.0109 0.2833
Schistosoma mansoni hypothetical protein 0.0413 0.1728 0.3245
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0109 0.0196
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0203 0.0818 0.1795
Schistosoma mansoni hypothetical protein 0.0413 0.1728 0.3245
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0032 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0505 0.2129 1
Leishmania major lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Leishmania major aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0226
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0056
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0344 0.0337
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1053 0.4514 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0052 0.0159 0.0674
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Brugia malayi Importin beta-1 subunit 0.0031 0.0068 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0044 0.0073
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0255
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0109 0.0894
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0017 0.001
Mycobacterium tuberculosis Conserved protein 0.004 0.0109 0.0894
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0344 0.1548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0727
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0505 0.2129 0.4708
Trichomonas vaginalis esterase, putative 0.004 0.0109 0.0226
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.0088
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.0827 0.0827
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.1367 0.3016
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0203 0.0818 0.1799
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.1053 0.4514 1
Chlamydia trachomatis methionine--tRNA ligase 0.0262 0.1072 1
Loa Loa (eye worm) hypothetical protein 0.0262 0.1072 0.2363
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0156 0.0284
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.0087
Schistosoma mansoni protein phosphatase type 1 0.004 0.0109 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0109 0.0226
Leishmania major aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0016 0.0021
Leishmania major hypothetical protein, conserved 0.004 0.0109 0.045
Schistosoma mansoni cpg binding protein 0.0115 0.0433 0.0806
Loa Loa (eye worm) hypothetical protein 0.0051 0.0156 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Giardia lamblia Leucyl-tRNA synthetase 0.0042 0.0115 0.1805
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0015
Brugia malayi beta-lactamase family protein 0.004 0.0109 0.0221
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0344 0.0638
Brugia malayi glycyl-tRNA synthetase 0.0203 0.0818 0.1795
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.004 0.0109 0.0109
Brugia malayi CXXC zinc finger family protein 0.0115 0.0433 0.0941
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.042
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0109 0.0226
Schistosoma mansoni hypothetical protein 0.0332 0.1379 0.2587
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0042 0.0115 0.301
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0014 0.0035
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.004 0.0109 0.0222
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0043 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.0088
Schistosoma mansoni cpg binding protein 0.0121 0.0462 0.086
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0042 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0047 0.0088
Trypanosoma brucei polo-like protein kinase 0.0092 0.0335 0.1517
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0052 0.0159 0.0159
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0203 0.4744
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0159 0.4368
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0159 0.0688
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0017 0.0165
Trichomonas vaginalis protein phosphatase-1, putative 0.004 0.0109 0.0226
Schistosoma mansoni replication factor A 1 rfa1 0.1053 0.4514 0.8493
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0115 0.0463
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0109 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0044 0.0142
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0052 0.0159 0.0159
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0344 1
Leishmania major leucyl-tRNA synthetase, putative 0.0042 0.0115 0.0477
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1156 0.1156
Plasmodium falciparum methionine--tRNA ligase, putative 0.0042 0.0115 0.0463
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0016 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0115 0.0239
Treponema pallidum asparaginyl-tRNA synthetase 0.0052 0.0159 0.1348
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Brugia malayi Aspartyl-tRNA synthetase 0.0052 0.0159 0.0333
Schistosoma mansoni protein phosphatase-1 0.004 0.0109 0.0196
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0014 0.0007
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0159 0.4368
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0044 0.0037
Plasmodium vivax lysine--tRNA ligase, putative 0.0052 0.0159 0.0674
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0255
Brugia malayi hypothetical protein 0.0027 0.0051 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Echinococcus granulosus glycyl tRNA synthetase 0.0203 0.0818 0.0818
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0014 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1156 0.2168
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0017 0.0015
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0187 0.0394
Schistosoma mansoni hypothetical protein 0.1237 0.5314 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0051 0.0161
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0335 0.1517
Brugia malayi mbt repeat family protein 0.0051 0.0156 0.0325
Treponema pallidum methionyl-tRNA synthetase 0.0262 0.1072 1
Entamoeba histolytica hypothetical protein 0.0052 0.0159 0.0802
Echinococcus multilocularis dnaJ subfamily B 0.1237 0.5314 0.5311
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0052 0.0159 0.0152
Entamoeba histolytica Ran family GTPase 0.0023 0.0032 0.0132
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0156 0.0149
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0156 0.0149
Brugia malayi protein ZK524.3 0.0042 0.0115 0.0234
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.0109 0.0226
Mycobacterium leprae Probable lipase LipE 0.004 0.0109 0.1266
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0203 0.1795
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0043 0.0079
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0344 0.1561
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0344 0.2394
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0344 0.1561
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0433 0.0945
Brugia malayi lysyl-tRNA synthetase 0.0052 0.0159 0.0333
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0052 0.0159 0.0465
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0014 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0109 0.0226
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0226
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0344 1
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0042 0.0115 0.2989
Echinococcus granulosus methionine tRNA synthetase 0.0042 0.0115 0.0115
Trichomonas vaginalis protein phosphatase, caeel, putative 0.004 0.0109 0.0226
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0025 0.0043 0.0187
Plasmodium vivax asparagine--tRNA ligase, putative 0.0052 0.0159 0.0674
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0072
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.0088
Schistosoma mansoni protein phosphatase-1 0.004 0.0109 0.0196
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0226
Echinococcus multilocularis lysyl tRNA synthetase 0.0052 0.0159 0.0152
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0043 0.0079
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0335 0.0328
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0109 0.0226
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0042 0.0115 0.0239
Schistosoma mansoni hypothetical protein 0.0315 0.1303 0.2444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0044 0.0077
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0044 0.0044
Brugia malayi Probable ClpP-like protease 0.0094 0.0344 0.0743
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0187 0.018
Toxoplasma gondii tRNA ligases class I (M) protein 0.0042 0.0115 0.0477
Mycobacterium ulcerans hypothetical protein 0.004 0.0109 0.2833
Brugia malayi BRCA2 repeat family protein 0.0213 0.0859 0.1885
Trypanosoma brucei Replication factor A protein 1 0.0505 0.2129 1
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0043 0.0079
Plasmodium falciparum asparagine--tRNA ligase 0.0052 0.0159 0.0674
Leishmania major DNA polymerase kappa, putative 0.0019 0.0016 0.001
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0244 0.0994 0.1862
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0025 0.0043 0.0079
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0017 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0058 0.0058
Schistosoma mansoni protein phosphatase-1 0.0025 0.0043 0.0071
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0014 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0043 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1156 0.1156
Loa Loa (eye worm) MBCTL1 0.0058 0.0187 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0109 0.0226
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.0398
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0017 0.003
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0156 0.012
Schistosoma mansoni glycyl-tRNA synthetase 0.0203 0.0818 0.1531
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0058 0.0058
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0265 0.1084 0.5061
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0109 0.045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1156 0.115
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.022 0.0891 0.1961
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0413 0.1728 0.3245
Entamoeba histolytica hypothetical protein 0.0025 0.0044 0.0193
Loa Loa (eye worm) hypothetical protein 0.0042 0.0115 0.0239
Toxoplasma gondii ABC1 family protein 0.004 0.0109 0.045
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.0109 0.0451
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0335 0.1517
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0028 0.0069
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0043 0.0074
Toxoplasma gondii serine/threonine phosophatase PP1 0.004 0.0109 0.0451
Plasmodium falciparum lysine--tRNA ligase 0.0052 0.0159 0.0674
Giardia lamblia DINP protein human, muc B family 0.0019 0.0016 0.0148
Schistosoma mansoni DNA polymerase eta 0.0019 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0226
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0156 0.0284
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0344 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0014 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0014 0.001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0047 0.0088
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.0087
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0413 0.1728 0.1722
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0132 0.0277
Schistosoma mansoni protein phosphatase type 1 0.004 0.0109 0.0196
Trichomonas vaginalis protein phosphatase-5, putative 0.0025 0.0043 0.0079
Loa Loa (eye worm) hypothetical protein 0.004 0.0109 0.0226
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.004 0.0109 0.0109
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0109 0.0894
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0042 0.0115 0.095
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0016 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0086 0.017
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0052 0.0159 0.0802
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0043 0.0136
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0016 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0132 0.0277
Schistosoma mansoni hypothetical protein 0.0413 0.1728 0.3245
Schistosoma mansoni methionine-tRNA synthetase 0.0262 0.1072 0.201
Schistosoma mansoni cpg binding protein 0.0121 0.0462 0.086
Mycobacterium tuberculosis Conserved protein 0.004 0.0109 0.0894
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0051 0.0161
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0052 0.0159 0.3136
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0042 0.0115 0.0477
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0109 0.2833
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0097
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0052 0.0159 0.0152
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0335 0.1517
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0344 0.2394
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0102 0.0377 0.0684
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1694 0.7299 0.7297
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0025 0.0043 0.0079
Giardia lamblia Hypothetical protein 0.0154 0.0603 1
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0043 0.0074
Loa Loa (eye worm) BRCA2 repeat family protein 0.0213 0.0859 0.1889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0109 0.0102
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0335 0.0575
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0344 0.3099
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0042 0.0115 0.1482
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0014 0.0014
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.004 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0047 0.0088
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0044 0.0142
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0025 0.0043 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0051 0.0176
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0187 0.0187
Trypanosoma cruzi Replication factor A protein 1 0.0505 0.2129 1
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.004 0.0109 0.0102
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0109 0.0226
Trypanosoma brucei protein phosphatase 1 0.0025 0.0043 0.0136
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0043 0.0079
Loa Loa (eye worm) hypothetical protein 0.0094 0.0344 0.0747
Giardia lamblia Kinase, PLK 0.0092 0.0335 0.5493
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.0109 0.0226
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0044 0.0142
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0335 0.0335
Schistosoma mansoni hypothetical protein 0.0052 0.0159 0.029
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0043 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0727
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0727
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0047 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0335 0.0727
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0016 0.001
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0052 0.0159 0.0338
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0109 0.0226
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Trichomonas vaginalis helicase, putative 0.0026 0.0047 0.0088
Toxoplasma gondii lysine-tRNA ligase 0.0052 0.0159 0.0688
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0156 0.0156
Brugia malayi RNA, U transporter 1 0.0088 0.0315 0.0679
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.0109 0.0102
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0203 0.0196
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0042 0.0078
Plasmodium vivax hypothetical protein, conserved 0.004 0.0109 0.0435
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0052 0.0159 0.0152
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0344 0.0344
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0014 0.0016
Plasmodium falciparum methionine--tRNA ligase 0.0042 0.0115 0.0463
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0014 0.0014
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.0109 0.0451
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0051 0.0176
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0052 0.0159 0.0688
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.1053 0.4514 0.451
Echinococcus granulosus dna polymerase eta 0.0019 0.0016 0.0016
Toxoplasma gondii exonuclease III APE 0.0019 0.0017 0.0015
Leishmania major replication factor A, 51kDa subunit, putative 0.0505 0.2129 1
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0052 0.0159 0.4351
Entamoeba histolytica hypothetical protein 0.0052 0.0159 0.0802
Echinococcus granulosus snurportin 1 0.033 0.1367 0.1367
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0068 0.0255
Schistosoma mansoni aspartyl-tRNA synthetase 0.0052 0.0159 0.029
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0156 0.033
Schistosoma mansoni importin beta-1 0.0031 0.0068 0.0118
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.0827 0.082
Brugia malayi mbt repeat family protein 0.0051 0.0156 0.0325
Giardia lamblia Aspartyl-tRNA synthetase 0.0052 0.0159 0.2552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0014 0.0015
Plasmodium falciparum importin beta, putative 0.0031 0.0068 0.024
Loa Loa (eye worm) apoptosis regulator protein 0.0413 0.1728 0.3818
Onchocerca volvulus 0.0051 0.0156 0.012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0075 0.0274
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0043 0.0079

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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