TDR Targets

Basic information

Technical information

TDR Targets ID: 1588062
Name: 2-methylsulfanyl-N'-(2-morpholin-4-yl1,3-thia zole-4-carbonyl)pyridine-3-carbohydrazide
MW: 379.457 | Formula: C15H17N5O3S2
H donors: 2 H acceptors: 4 LogP: 1.59 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ncccc1C(=O)NNC(=O)c1csc(n1)N1CCOCC1
InChi: 1S/C15H17N5O3S2/c1-24-14-10(3-2-4-16-14)12(21)18-19-13(22)11-9-25-15(17-11)20-5-7-23-8-6-20/h2-4,9H,5-8H2,1H3,(H,18,21)(H,19,22)
InChiKey: NQAVAPWSYWKEAW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methylsulfanyl-N'-(2-morpholinothiazole-4-carbonyl)pyridine-3-carbohydrazide
2-(methylthio)-N'-[(2-morpholino-4-thiazolyl)-oxomethyl]-3-pyridinecarbohydrazide
2-(methylthio)-N'-(2-morpholinothiazole-4-carbonyl)nicotinohydrazide
2-methylsulfanyl-N'-[(2-morpholin-4-yl-1,3-thiazol-4-yl)carbonyl]pyridine-3-carbohydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Importin beta-1 subunit	0.0028	0.0102	0.0102
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Trypanosoma brucei	Replication factor A protein 1	0.0431	0.4678	1
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Onchocerca volvulus		0.0047	0.0312	0.013
Mycobacterium leprae	PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE)	0.0044	0.0283	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Echinococcus granulosus	aspartyl tRNA synthetase cytoplasmic	0.0044	0.0283	0.0283
Loa Loa (eye worm)	replication factor A 73 kDa subunit	0.0899	1	1
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0312	0.0312
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0805	0.8927	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0044	0.0283	0.2223
Schistosoma mansoni	ran	0.0021	0.0017	0.0017
Echinococcus granulosus	glycyl tRNA synthetase	0.005	0.0342	0.0342
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	0.0899	1	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0044	0.0283	1
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0312	0.0312
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0036
Echinococcus granulosus	replication protein A 70 kDa DNA binding	0.0899	1	1
Loa Loa (eye worm)	multisynthetase complex auxiliary component p43	0.0054	0.0388	0.0388
Treponema pallidum	methionyl-tRNA synthetase	0.0064	0.0504	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0302	0.0302
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0199	0.0199
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0302	0.0302
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0102	0.0102
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0199	0.0425
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase)	0.0044	0.0283	0.0372
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0199	0.0425
Loa Loa (eye worm)	63kd antigen	0.0044	0.0283	0.0283
Plasmodium falciparum	aspartate--tRNA ligase	0.0044	0.0283	0.0605
Echinococcus granulosus	lysyl tRNA synthetase	0.0044	0.0283	0.0283
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0199	0.0199
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0017	0.0017
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0061	0.013
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0044	0.0283	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0087	0.077	0.077
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0199	0.0199
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0899	1	1
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Brugia malayi	beta-lactamase family protein	0.0037	0.0199	0.0199
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Schistosoma mansoni	hypothetical protein	0.0285	0.3019	0.3019
Leishmania major	replication factor A, 51kDa subunit, putative	0.0431	0.4678	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.005	0.0342	0.0342
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0302	0.0302
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0087	0.077	0.0654
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0061	0.013
Leishmania major	hypothetical protein, conserved	0.0037	0.0199	0.0425
Loa Loa (eye worm)	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0386	0.0386
Chlamydia trachomatis	methionine--tRNA ligase	0.0064	0.0504	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0504	0.0504
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0786	0.8709	0.8709
Brugia malayi	BRCA2 repeat family protein	0.0182	0.1843	0.1843
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0199	0.0425
Leishmania major	GTP-binding protein, putative	0.0021	0.0017	0.0036
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.3226	0.3226
Trichomonas vaginalis	esterase, putative	0.0037	0.0199	0.0199
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0044	0.0283	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0061	0.013
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0199	0.0425
Brugia malayi	glycyl-tRNA synthetase	0.005	0.0342	0.0342
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0312	0.0312
Leishmania major	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	0.0431	0.4678	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0044	0.0283	1
Mycobacterium tuberculosis	Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase)	0.0044	0.0283	0.0372
Trichomonas vaginalis	ran, putative	0.0021	0.0017	0.0017
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0302	0.0302
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0199	0.0199
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Plasmodium vivax	aspartate--tRNA ligase, putative	0.0044	0.0283	0.0605
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.1879	0.1879
Entamoeba histolytica	hypothetical protein	0.0044	0.0283	0.0641
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0102	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0302	0.0302
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0386	0.0386
Toxoplasma gondii	hypothetical protein	0.0094	0.0853	0.1822
Schistosoma mansoni	lysyl-tRNA synthetase	0.0044	0.0283	0.0283
Loa Loa (eye worm)	BRCA2 repeat family protein	0.0182	0.1843	0.1843
Leishmania major	replication Factor A 28 kDa subunit, putative	0.0044	0.0283	0.0605
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0312	0.013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0302	0.0302
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0899	1	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0102	0.0218
Echinococcus multilocularis	asparaginyl tRNA synthetase	0.0044	0.0283	0.0283
Leishmania major	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0061	0.0061
Plasmodium vivax	lysine--tRNA ligase, putative	0.0044	0.0283	0.0605
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0386	0.0386
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0312	0.0312
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0199	0.0199
Brugia malayi	methionyl-tRNA synthetase	0.0064	0.0504	0.0504
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0036
Loa Loa (eye worm)	MBCTL1	0.0053	0.0386	0.0386
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0855	0.9496	0.9496
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0102	0.0102
Trichomonas vaginalis	aspartyl/lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0283
Trypanosoma brucei	asparaginyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Plasmodium falciparum	asparagine--tRNA ligase	0.0044	0.0283	0.0605
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0061	0.013
Brugia malayi	beta-lactamase family protein	0.0037	0.0199	0.0199
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0017
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0386	0.0386
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0199	0.0199
Trypanosoma cruzi	replication Factor A 28 kDa subunit, putative	0.0044	0.0283	0.0605
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0025	0.0061	0.0061
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Toxoplasma gondii	OB-fold nucleic acid binding domain-containing protein	0.0226	0.2347	0.5018
Echinococcus multilocularis	glycyl tRNA synthetase	0.005	0.0342	0.0342
Toxoplasma gondii	ABC1 family protein	0.0037	0.0199	0.0425
Leishmania major	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0036
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0312	0.0312
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0312	0.0312
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0017	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0044	0.0283	0.0605
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0102	0.0218
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0199	0.0199
Brugia malayi	mbt repeat family protein	0.0047	0.0312	0.0312
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0199	0.0199
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.1879	0.1879
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Schistosoma mansoni	hypothetical protein	0.0303	0.3226	0.3226
Brugia malayi	mbt repeat family protein	0.0047	0.0312	0.0312
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0064	0.0504	0.0504
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0102	0.0102
Wolbachia endosymbiont of Brugia malayi	aspartyl-tRNA synthetase	0.0044	0.0283	0.5
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0017	0.0017
Schistosoma mansoni	replication factor A 1 rfa1	0.0899	1	1
Brugia malayi	lysyl-tRNA synthetase	0.0044	0.0283	0.0283
Schistosoma mansoni	glycyl-tRNA synthetase	0.005	0.0342	0.0342
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0431	0.4678	0.4678
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0044	0.0283	0.0283
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0199	0.0199
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0036
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0302	0.0302
Plasmodium falciparum	replication protein A1, large subunit	0.0431	0.4678	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0199	0.0199
Mycobacterium ulcerans	aspartyl-tRNA synthetase	0.0044	0.0283	1
Plasmodium falciparum	importin beta, putative	0.0028	0.0102	0.0218
Echinococcus multilocularis	snurportin 1	0.0303	0.3226	0.3226
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0064	0.0504	0.1171
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0283	0.0605
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0199	0.0199
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0302	0.0302
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0064	0.0504	0.0504
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Leishmania major	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Brugia malayi	Asparaginyl-tRNA synthetase, cytoplasmic	0.0044	0.0283	0.0283
Plasmodium falciparum	asparagine--tRNA ligase	0.0044	0.0283	0.0605
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0386	0.0386
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0102	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0283	0.0283
Schistosoma mansoni	hypothetical protein	0.0044	0.0283	0.0283
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0061	0.013
Schistosoma mansoni	lysyl-tRNA synthetase	0.0044	0.0283	0.0283
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0017	0.0036
Toxoplasma gondii	aspartate-tRNA ligase	0.0044	0.0283	0.0605
Toxoplasma gondii	lysine-tRNA ligase	0.0044	0.0283	0.0605
Leishmania major	asparaginyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Entamoeba histolytica	replication factor A, putative	0.0087	0.077	0.1812
Entamoeba histolytica	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0641
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.005	0.0342	0.0342
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0199	0.0199
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0041	0.0041
Plasmodium vivax	replication protein A1, large subunit, putative	0.0431	0.4678	1
Brugia malayi	Aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Giardia lamblia	Asparaginyl-tRNA synthetase	0.0044	0.0283	0.2223
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0061	0.013
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0041	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0199	0.0199
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Schistosoma mansoni	importin beta-1	0.0028	0.0102	0.0102
Plasmodium falciparum	lysine--tRNA ligase	0.0044	0.0283	0.0605
Echinococcus multilocularis	lysyl tRNA synthetase	0.0044	0.0283	0.0283
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0044	0.0283	0.0605
Entamoeba histolytica	asparaginyl-tRNA synthetase, putative	0.0044	0.0283	0.0641
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Entamoeba histolytica	hypothetical protein	0.0044	0.0283	0.0641
Echinococcus granulosus	asparaginyl tRNA synthetase, cytoplasmic	0.0044	0.0283	0.0283
Echinococcus multilocularis	aspartyl tRNA synthetase, cytoplasmic	0.0044	0.0283	0.0283
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0061	0.013
Entamoeba histolytica	hypothetical protein	0.0023	0.0041	0.0058
Entamoeba histolytica	replication factor A protein 1, putative	0.0387	0.4174	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0061	0.013
Brugia malayi	beta-lactamase	0.0037	0.0199	0.0199
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0044	0.0283	0.0283
Giardia lamblia	Hypothetical protein	0.0132	0.1274	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0283
Plasmodium falciparum	nucleic acid binding protein, putative	0.0044	0.0283	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0312	0.0312
Giardia lamblia	Aspartyl-tRNA synthetase	0.0044	0.0283	0.2223
Echinococcus granulosus	asparaginyl tRNA synthetase cytoplasmic	0.0044	0.0283	0.0283
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.2461	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0041	0.0041
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0044	0.0283	0.0283
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0386	0.0386
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.005	0.0342	0.0342
Trypanosoma cruzi	asparaginyl-tRNA synthetase, putative	0.0044	0.0283	0.0605
Echinococcus granulosus	snurportin 1	0.0303	0.3226	0.3226
Schistosoma mansoni	methionine-tRNA synthetase	0.0064	0.0504	0.0504
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0302	0.0302
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0041	0.0087
Schistosoma mansoni	ran	0.0021	0.0017	0.0017
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0312	0.0312
Brugia malayi	RNA, U transporter 1	0.0081	0.0697	0.0697
Trypanosoma cruzi	Replication factor A protein 1	0.0431	0.4678	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1894651

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1588062