Detailed information for compound 1588237

Basic information

Technical information
  • TDR Targets ID: 1588237
  • Name: 2-chloro-N-(furan-2-ylmethyl)-5-pyrrolidin-1- ylsulfonylbenzamide
  • MW: 368.835 | Formula: C16H17ClN2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1Cl)S(=O)(=O)N1CCCC1)NCc1ccco1
  • InChi: 1S/C16H17ClN2O4S/c17-15-6-5-13(24(21,22)19-7-1-2-8-19)10-14(15)16(20)18-11-12-4-3-9-23-12/h3-6,9-10H,1-2,7-8,11H2,(H,18,20)
  • InChiKey: VWTICRVWLULTRB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(2-furylmethyl)-5-pyrrolidin-1-ylsulfonyl-benzamide
  • 2-chloro-N-(2-furylmethyl)-5-1-pyrrolidinylsulfonylbenzamide
  • 2-chloro-N-(furan-2-ylmethyl)-5-pyrrolidin-1-ylsulfonyl-benzamide
  • ZINC04869006

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0183 0.0646 0.1531
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.019 0.0671 0.1593
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0989 0.3793 0.91
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0139 0.1371
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0185 0.0423
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0104 0.3556
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0145 0.6458
Onchocerca volvulus 0.0075 0.0221 0.2276
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0176 0.0167
Brugia malayi jmjC domain containing protein 0.0206 0.0735 0.1746
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.027 0.129
Loa Loa (eye worm) MBCTL1 0.0057 0.0151 0.0343
Echinococcus multilocularis carboxylesterase 5A 0.1085 0.4167 0.4162
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Echinococcus granulosus replication factor c subunit 1 0.0022 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Mycobacterium ulcerans acetyl-CoA synthetase 0.0075 0.0221 0.2276
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0075 0.0221 0.1572
Entamoeba histolytica hypothetical protein 0.0153 0.0528 0.2596
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0631 0.6497
Loa Loa (eye worm) hypothetical protein 0.0254 0.0922 0.2197
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Brugia malayi CXXC zinc finger family protein 0.0088 0.0275 0.064
Loa Loa (eye worm) hypothetical protein 0.0163 0.0565 0.1338
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0064 0.278
Brugia malayi nuclear hormone receptor 0.0065 0.0185 0.0423
Brugia malayi protein C24B5.3 0.0032 0.0055 0.011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0787 0.1872
Schistosoma mansoni patched 1 0.0226 0.0814 0.1937
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0082 0.0824
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0315 0.0737
Schistosoma mansoni rotamase 0.0035 0.0067 0.014
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.027 0.129
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0185 0.0423
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0009 0.0292
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.001 0.0343
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0536 0.2024 0.4845
Schistosoma mansoni zinc finger protein 0.0031 0.005 0.0099
Brugia malayi ecdysteroid receptor 0.0065 0.0185 0.0423
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0124 0.0278
Onchocerca volvulus 0.0088 0.0275 0.2872
Echinococcus multilocularis protein dispatched 1 0.0258 0.094 0.0931
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0183 0.0646 0.1531
Brugia malayi hypothetical protein 0.0022 0.0014 0.0013
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0075 0.0221 0.991
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0059 0.0121
Loa Loa (eye worm) hypothetical protein 0.0082 0.0249 0.0577
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0185 0.0423
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0176 0.0401
Toxoplasma gondii patched family protein 0.0032 0.0055 0.0787
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0183 0.0646 0.1531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0185 0.0423
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0185 0.0423
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0022 0.0014 0.0095
Onchocerca volvulus 0.0032 0.0055 0.0442
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0075 0.0221 0.051
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0145 0.8102
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0082 0.3595
Mycobacterium ulcerans acyl-CoA synthetase 0.0254 0.0922 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0185 0.0423
Schistosoma mansoni hypothetical protein 0.0311 0.1147 0.2736
Toxoplasma gondii ATPase, AAA family protein 0.0022 0.0014 0.0095
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0075 0.0221 0.051
Loa Loa (eye worm) hypothetical protein 0.019 0.0671 0.1593
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.005 0.0041
Brugia malayi Pre-SET motif family protein 0.022 0.0787 0.1872
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0066
Trypanosoma cruzi importin beta-1 subunit, putative 0.0075 0.0223 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0206 0.0735 0.0727
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0203 0.0467
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0053 0.0106
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0075 0.0221 0.2276
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0014 0.054
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0249 0.3571
Schistosoma mansoni lamin 0.0059 0.016 0.0363
Loa Loa (eye worm) intermediate filament protein 0.0059 0.016 0.0363
Brugia malayi intermediate filament protein 0.0059 0.016 0.0363
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0076
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0249 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.009 0.0195
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.019 0.0671 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0221 0.1572
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.009 0.0195
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Trypanosoma brucei importin beta-1 subunit, putative 0.0093 0.0292 1
Schistosoma mansoni hypothetical protein 0.0218 0.0783 0.186
Loa Loa (eye worm) hypothetical protein 0.0163 0.0565 0.1338
Echinococcus granulosus Protein patched homolog 1 0.0226 0.0814 0.1937
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0185 0.0423
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.009 0.3978
Leishmania major 4-coumarate:coa ligase-like protein 0.0254 0.0922 1
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.0185 0.1879
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0075 0.0221 0.2276
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0151 0.0143
Echinococcus granulosus nibrin 0.0022 0.0014 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0013
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.019 0.0671 0.6984
Schistosoma mansoni nuclear hormone receptor 0.0031 0.005 0.0099
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0056 0.0114
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0145 0.0327
Schistosoma mansoni hypothetical protein 0.0153 0.0528 0.1248
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0145 0.6458
Echinococcus granulosus carboxylesterase 5A 0.1085 0.4167 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Schistosoma mansoni hypothetical protein 0.0021 0.001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0814 0.8994
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.005 0.0099
Entamoeba histolytica hypothetical protein 0.0153 0.0528 0.2596
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0104 0.4585
Schistosoma mansoni microtubule-associated protein tau 0.0747 0.2846 0.6823
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.009 0.1227
Schistosoma mansoni transcription factor LCR-F1 0.0153 0.0528 0.1248
Entamoeba histolytica acyl-coA synthetase, putative 0.0254 0.0922 0.4592
Schistosoma mansoni DNA ligase IV 0.0022 0.0014 0.0013
Brugia malayi Pax transcription activation domain interacting protein 0.0022 0.0014 0.0013
Schistosoma mansoni importin beta-1 0.0093 0.0292 0.0679
Trichomonas vaginalis set domain proteins, putative 0.025 0.0905 1
Schistosoma mansoni topbp1 0.0022 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.1085 0.4167 1
Echinococcus multilocularis cpg binding protein 0.0094 0.0295 0.0286
Brugia malayi Nuclear hormone receptor E75 0.0031 0.005 0.0099
Echinococcus multilocularis snurportin 1 0.0989 0.3793 0.3788
Plasmodium falciparum phd finger protein, putative 0.0063 0.0176 0.2514
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0082 0.0175
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.033 0.0771
Onchocerca volvulus 0.0075 0.0221 0.2276
Onchocerca volvulus 0.0105 0.0342 0.3604
Brugia malayi Carboxylesterase family protein 0.1085 0.4167 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0185 0.0423
Leishmania major GTP-binding protein, putative 0.0045 0.0104 0.1099
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0434 0.1023
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0104 0.0228
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0104 0.4585
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.019 0.0671 0.7236
Brugia malayi Bromodomain containing protein 0.0063 0.0176 0.0401
Loa Loa (eye worm) hypothetical protein 0.0032 0.0056 0.0114
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0114
Echinococcus multilocularis musashi 0.0059 0.016 0.0151
Brugia malayi Probable ClpP-like protease 0.0082 0.0249 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0067 0.066
Loa Loa (eye worm) hypothetical protein 0.0226 0.0814 0.1937
Echinococcus multilocularis sterol regulatory element binding protein 0.0226 0.0814 0.0806
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Leishmania major 4-coumarate:coa ligase-like protein 0.0254 0.0922 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0183 0.0646 0.0637
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.005 0.0099
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0145 0.0136
Onchocerca volvulus Protein patched homolog 0.0032 0.0055 0.0442
Schistosoma mansoni neuroligin 3 (S09 family) 0.0183 0.0646 0.1531
Onchocerca volvulus 0.025 0.0905 0.9806
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0185 0.0423
Brugia malayi steroid hormone receptor 0.0065 0.0185 0.0423
Trichomonas vaginalis spcc417.12 protein, putative 0.0183 0.0646 0.7111
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0056 0.0114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0075 0.0223 0.2399
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0535 0.2019 0.4833
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0185 0.0423
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0104 0.1632
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0104 0.1429
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0315 0.0737
Trichomonas vaginalis antibiotic synthetase, putative 0.0075 0.0221 0.2377
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0249 0.2584
Schistosoma mansoni survival motor neuron protein 0.0105 0.0342 0.08
Brugia malayi mbt repeat family protein 0.005 0.0124 0.0278
Echinococcus granulosus survival motor neuron protein 1 0.0517 0.195 0.4667
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.004 0.0463
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0183 0.0646 0.1531
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0065 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.005 0.0099
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0221 0.2276
Brugia malayi Carboxylesterase family protein 0.0183 0.0646 0.1531
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0075 0.0221 0.0212
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.004 0.0277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0315 0.0307
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0188 0.1175
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.002 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0188 0.0431
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Onchocerca volvulus Alhambra homolog 0.0063 0.0176 0.1774
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1085 0.4167 1
Brugia malayi hypothetical protein 0.0183 0.0646 0.1531
Trypanosoma brucei importin beta-1 subunit, putative 0.0093 0.0292 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0185 0.0423
Schistosoma mansoni acetyl-CoA synthetase 0.0075 0.0221 0.051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0134
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.051
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0151 0.0343
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0124 0.1211
Brugia malayi AF-10 protein 0.0021 0.001 0.0002
Brugia malayi Niemann-Pick C1 protein precursor 0.0528 0.1992 0.4768
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0014 0.054
Onchocerca volvulus 0.0183 0.0646 0.6952
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Brugia malayi Carboxylesterase family protein 0.0183 0.0646 0.1531
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0221 0.051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.001 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0056 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0059 0.0121
Mycobacterium ulcerans hypothetical protein 0.0254 0.0922 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0185 0.0423
Leishmania major 4-coumarate:coa ligase-like protein 0.0254 0.0922 1
Echinococcus multilocularis protein patched 0.0226 0.0814 0.0806
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Brugia malayi Patched related family protein 4 0.0032 0.0055 0.011
Echinococcus granulosus snurportin 1 0.0989 0.3793 0.91
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0185 0.0423
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.005 0.0099
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0151 0.0343
Loa Loa (eye worm) hypothetical protein 0.0059 0.016 0.0363
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0082 0.0862
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0176 0.2872
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0082 0.0824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0185 0.0423
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0139 0.013
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0104 0.0228
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0275 0.064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0206 0.0735 0.1746
Echinococcus granulosus acetylcholinesterase 0.1085 0.4167 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.001 0.0017
Echinococcus multilocularis importin subunit beta 1 0.0093 0.0292 0.0283
Plasmodium vivax replication factor C subunit 1, putative 0.0022 0.0014 0.0083
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0082 0.0073
Schistosoma mansoni acetylcholinesterase 0.0183 0.0646 0.1531
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.005 0.0099
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.005 0.0041
Echinococcus multilocularis Niemann Pick C1 protein 0.0754 0.2877 0.287
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0221 0.2376
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.016 0.0363
Mycobacterium ulcerans acyl-CoA synthetase 0.0254 0.0922 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0082 0.0073
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0064 0.278
Giardia lamblia PHD finger protein 15 0.0063 0.0176 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.004 0.0463
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0185 0.0176
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.005 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0065 0.0134
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.002 0.0026
Leishmania major hypothetical protein, conserved 0.002 0.0009 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0221 0.1572
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0063 0.0176 0.0401
Echinococcus granulosus GPCR family 2 0.0032 0.0056 0.0114
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0082 0.0175
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.005 0.0099
Brugia malayi jmjC domain containing protein 0.0081 0.0247 0.0572
Brugia malayi PHD-finger family protein 0.0063 0.0176 0.0401
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0022 0.0014 0.0000017462
Brugia malayi MAP kinase sur-1 0.0055 0.0145 0.0327
Schistosoma mansoni cpg binding protein 0.0088 0.0275 0.064
Loa Loa (eye worm) patched family protein 0.0032 0.0055 0.011
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0075 0.0221 0.1572
Echinococcus granulosus cpg binding protein 0.0094 0.0295 0.0688
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0075 0.0221 0.2276
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0145 0.1528
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0185 0.0423
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0022 0.0014 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0185 0.0176
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0254 0.0922 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0059 0.0121
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0134
Echinococcus granulosus acetylcholinesterase 0.1085 0.4167 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0022 0.0014 0.054
Schistosoma mansoni hypothetical protein 0.0063 0.0176 0.0401
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0022 0.0014 0.0073
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0145 0.0136
Toxoplasma gondii propionate-CoA ligase 0.0075 0.0221 0.3657
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.009 0.0918
Echinococcus granulosus sterol regulatory element binding protein 0.0226 0.0814 0.1937
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0082 0.3595
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0183 0.0646 0.6674
Schistosoma mansoni hypothetical protein 0.0105 0.0342 0.08
Loa Loa (eye worm) hypothetical protein 0.0254 0.0922 0.2197
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0249 0.2584
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Onchocerca volvulus 0.0033 0.0059 0.0491
Loa Loa (eye worm) hypothetical protein 0.019 0.0671 0.1593
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0249 0.4139
Onchocerca volvulus 0.0032 0.0055 0.0442
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0183 0.0646 0.1531
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0041 0.0032
Schistosoma mansoni hypothetical protein 0.0218 0.0783 0.186
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0075 0.0221 0.1572
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0151 0.0343
Echinococcus multilocularis para nitrobenzyl esterase 0.0183 0.0646 0.0637
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.005 0.0099
Brugia malayi hypothetical protein 0.0035 0.0065 0.0134
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0075 0.0223 0.2399
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.005 0.0099
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0075 0.0221 0.051
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0082 0.4182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0185 0.0423
Trichomonas vaginalis rotamase, putative 0.0034 0.0064 0.0624
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0185 0.0423
Entamoeba histolytica hypothetical protein 0.0075 0.0223 0.1055
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0075 0.0221 0.051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0176 0.0401
Schistosoma mansoni hypothetical protein 0.0218 0.0783 0.186
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0041 0.0077
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0221 0.1572
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0047 0.0092
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.005 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0185 0.0176
Brugia malayi MH2 domain containing protein 0.0129 0.0434 0.1023
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.005 0.0392
Schistosoma mansoni hypothetical protein 0.0989 0.3793 0.91
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus multilocularis geminin 0.036 0.1338 0.133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0059 0.0121
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0176 0.2872
Mycobacterium ulcerans acyl-CoA synthetase 0.0254 0.0922 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0075 0.0221 0.2276
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0565 0.0557
Echinococcus granulosus lamin 0.0059 0.016 0.0363
Brugia malayi hypothetical protein 0.0032 0.0055 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.0667 0.1583
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Schistosoma mansoni ap endonuclease 0.0041 0.009 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0145 0.1528
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0185 0.0176
Echinococcus granulosus jumonji domain containing protein 0.0088 0.0272 0.0632
Brugia malayi Carboxylesterase family protein 0.1085 0.4167 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0134
Echinococcus granulosus dnaJ subfamily B 0.0829 0.3169 0.7599
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0631 0.6497
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0145 0.1548
Brugia malayi Nuclear hormone receptor E75 0.0031 0.005 0.0099
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.004 0.1074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0631 0.6497
Mycobacterium tuberculosis Carboxylesterase LipT 0.0183 0.0646 0.6674
Plasmodium vivax importin-beta 2, putative 0.0093 0.0292 0.4265
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0082 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0254 0.0922 0.2197
Brugia malayi hypothetical protein 0.0035 0.0065 0.0134
Loa Loa (eye worm) patched family protein 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0087 0.027 0.0627
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0059 0.0121
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0022 0.0014 0.0013
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0139 0.0585
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0185 0.0423
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.009 0.3978
Schistosoma mansoni hypothetical protein 0.0218 0.0783 0.186
Brugia malayi AMP-binding enzyme family protein 0.0254 0.0922 0.2197
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0082 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0185 0.0423
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0185 0.0176
Onchocerca volvulus 0.0031 0.005 0.0392
Onchocerca volvulus 0.005 0.0124 0.1211
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0075 0.0221 0.1572
Brugia malayi hypothetical protein 0.0022 0.0014 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0185 0.0423
Brugia malayi nuclear receptor NHR-88 0.0065 0.0185 0.0423
Schistosoma mansoni BC026374 protein (S09 family) 0.0183 0.0646 0.1531
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0065 0.0134
Loa Loa (eye worm) DR-78 0.0031 0.005 0.0099
Echinococcus granulosus expressed conserved protein 0.0496 0.1867 0.4467
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.009 0.0195
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0185 0.0176
Loa Loa (eye worm) hypothetical protein 0.007 0.0203 0.0467
Schistosoma mansoni hypothetical protein 0.036 0.1338 0.3196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0315 0.0737
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0249 0.0577
Schistosoma mansoni topbp1 0.0022 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.009 0.3231
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0124 0.0278
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0188 0.2017
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0022 0.0014 0.0073
Plasmodium vivax patched family protein, putative 0.0032 0.0055 0.0689
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0022 0.0014 0.0496
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Onchocerca volvulus 0.0032 0.0055 0.0442
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0315 0.0307
Brugia malayi PHD-finger family protein 0.0026 0.003 0.005
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0185 0.0423
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0179 0.0631 0.6497
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.009 0.3097
Trichomonas vaginalis rotamase, putative 0.0035 0.0067 0.066
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.0437 0.103
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0185 0.0423
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0059 0.005
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.0185 0.0423
Echinococcus granulosus expressed protein 0.0035 0.0067 0.014
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0104 0.0228
Echinococcus granulosus Niemann Pick C1 protein 0.0754 0.2877 0.6896
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.009 0.1227
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0124 0.0116
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0064 0.0666
Trichomonas vaginalis ran, putative 0.0045 0.0104 0.1067
Loa Loa (eye worm) hypothetical protein 0.0254 0.0922 0.2197
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0185 0.0423
Entamoeba histolytica Ran family GTPase 0.0045 0.0104 0.0451
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0176 0.0401
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0221 0.051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0041 0.0077
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.005 0.0099
Echinococcus multilocularis acetylcholinesterase 0.1085 0.4167 0.4162
Brugia malayi nuclear receptor NHR-67 0.0031 0.005 0.0099
Onchocerca volvulus 0.0059 0.016 0.1603
Entamoeba histolytica acyl-CoA synthetase, putative 0.0254 0.0922 0.4592
Brugia malayi nuclear hormone receptor 0.0031 0.005 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0185 0.0423
Onchocerca volvulus 0.0075 0.0221 0.2276
Brugia malayi hypothetical protein 0.0153 0.0528 0.1248
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0082 0.2807
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0082 0.0341
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0185 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Brugia malayi AMP-binding enzyme family protein 0.0254 0.0922 0.2197
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0254 0.0922 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.005 0.0041
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0139 0.0313
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.005 0.0099
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0075 0.0221 0.1572
Echinococcus multilocularis Niemann Pick C1 protein 0.0528 0.1992 0.1984
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0185 0.0423
Toxoplasma gondii hypothetical protein 0.0028 0.004 0.0529
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0082 0.0175
Loa Loa (eye worm) patched family protein 0.0032 0.0055 0.011
Brugia malayi Patched protein homolog 1 0.0032 0.0055 0.011
Toxoplasma gondii patched family protein 0.0032 0.0055 0.0787
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.009 0.0954
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0185 0.0423
Loa Loa (eye worm) hypothetical protein 0.0039 0.0082 0.0175
Loa Loa (eye worm) hypothetical protein 0.1085 0.4167 1
Onchocerca volvulus 0.0031 0.005 0.0392
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus multilocularis survival motor neuron protein 1 0.0517 0.195 0.1943
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0185 0.0423
Echinococcus granulosus geminin 0.036 0.1338 0.3196
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Loa Loa (eye worm) hypothetical protein 0.0183 0.0646 0.1531
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0104 0.1429
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0075 0.0221 0.2276
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0151 0.0343
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.009 0.0918
Loa Loa (eye worm) hypothetical protein 0.019 0.0671 0.1593
Brugia malayi hypothetical protein 0.0032 0.0055 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0185 0.0423
Echinococcus multilocularis lamin 0.0059 0.016 0.0151
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.009 0.0081
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.005 0.0392
Echinococcus granulosus para nitrobenzyl esterase 0.0183 0.0646 0.1531
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.033 0.0771
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0342 0.08
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0124 0.0278
Brugia malayi hypothetical protein 0.0031 0.005 0.0099
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0145 0.0327
Loa Loa (eye worm) oxidoreductase 0.0075 0.0221 0.051
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0124 0.0278
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0153 0.0528 0.1248
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0185 0.0423
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0151 0.0343
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0075 0.0221 0.2276
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0145 0.0327
Onchocerca volvulus 0.0032 0.0055 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0185 0.0423
Brugia malayi DKFZp564C0469 protein 0.0022 0.0014 0.0013
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.073 0.1734
Echinococcus granulosus neuroligin 0.0183 0.0646 0.1531
Trichomonas vaginalis replication factor C large subunit, putative 0.0022 0.0014 0.0073
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0041 0.0032
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0221 0.991
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.0589 1
Toxoplasma gondii patched family protein 0.0032 0.0055 0.0787
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus granulosus Niemann Pick C1 protein 0.0528 0.1992 0.4768
Toxoplasma gondii HEAT repeat-containing protein 0.0093 0.0292 0.4872
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.005 0.0041
Echinococcus multilocularis peregrin 0.0063 0.0176 0.0167
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0013
Schistosoma mansoni intermediate filament proteins 0.0059 0.016 0.0363
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0249 0.0577
Brugia malayi Importin beta-1 subunit 0.0093 0.0292 0.0679
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0066
Brugia malayi Carboxylesterase family protein 0.0183 0.0646 0.1531
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0249 0.3624
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0176 0.2514
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0188 0.1912
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0188 0.0431
Onchocerca volvulus Protein patched homolog 0.0032 0.0055 0.0442
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.033 0.0771
Entamoeba histolytica hypothetical protein 0.0153 0.0528 0.2596
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0315 0.0737
Loa Loa (eye worm) carboxylesterase 0.0183 0.0646 0.1531
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0185 0.0423
Loa Loa (eye worm) hypothetical protein 0.0102 0.033 0.0771
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0254 0.0922 1
Brugia malayi hypothetical protein 0.0031 0.005 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0145 0.1528
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0145 0.1548
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0075 0.0221 0.1572
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0185 0.0423
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0226 0.0814 0.1937
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0075 0.0221 0.991
Onchocerca volvulus 0.0183 0.0646 0.6952
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0183 0.0646 0.6674
Brugia malayi hypothetical protein 0.0517 0.195 0.4667
Loa Loa (eye worm) hypothetical protein 0.0517 0.195 0.4667
Loa Loa (eye worm) patched family protein 0.0032 0.0055 0.011
Schistosoma mansoni gliotactin 0.0183 0.0646 0.1531
Plasmodium vivax SET domain protein, putative 0.0033 0.0059 0.0756
Loa Loa (eye worm) hypothetical protein 0.0183 0.0646 0.1531
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0221 0.051
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0528 0.1992 1
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0031 0.0333
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0075 0.0221 0.1572
Leishmania major importin beta-1 subunit, putative 0.0075 0.0223 0.2397
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0082 0.0175
Loa Loa (eye worm) hypothetical protein 0.0108 0.0351 0.0823
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0014 0.0073
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0145 0.6458
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0145 0.1528
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0221 0.051
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.005 0.0099
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.005
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0254 0.0922 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0075 0.0221 0.3657
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.005 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0082 0.0824
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.009 0.0835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0315 0.0737
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0145 0.4973
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.009 0.0383
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0188 0.3087
Echinococcus multilocularis replication factor c subunit 1 0.0022 0.0014 0.0005
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0145 0.2345
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0104 0.0095
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0139 0.0585
Loa Loa (eye worm) hypothetical protein 0.0183 0.0646 0.1531
Echinococcus multilocularis BC026374 protein (S09 family) 0.0183 0.0646 0.0637
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Brugia malayi nuclear receptor NHR-88 0.0031 0.005 0.0099
Echinococcus multilocularis dnaJ subfamily B 0.0829 0.3169 0.3163
Schistosoma mansoni coup transcription factor 0.0065 0.0185 0.0423
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0064 0.0946
Echinococcus multilocularis nibrin 0.0022 0.0014 0.0005
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0075 0.0221 0.2276
Brugia malayi topoisomerase 0.0022 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0829 0.3169 0.7599
Loa Loa (eye worm) hypothetical protein 0.0093 0.0292 0.0679
Brugia malayi Patched related family protein 10 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0124 0.0278
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0145 0.6458
Echinococcus granulosus lamin dm0 0.0059 0.016 0.0363
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0064 0.0181 0.1085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0056 0.0047
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0064 0.025
Brugia malayi Carboxylesterase family protein 0.0183 0.0646 0.1531
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.01 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.005 0.0099
Brugia malayi nuclear receptor RXR 0.0035 0.0065 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0014 0.0073
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0221 0.2276
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0249 0.3571
Brugia malayi ecdysone receptor 0.0031 0.005 0.0099
Schistosoma mansoni ran 0.0045 0.0104 0.0228
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.0272 0.0263
Mycobacterium ulcerans carboxylesterase, LipT 0.0183 0.0646 0.6952
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0134
Brugia malayi tailless protein 0.0031 0.005 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0315 0.0737
Echinococcus granulosus peregrin 0.0063 0.0176 0.0401
Leishmania major acetyl-CoA synthetase, putative 0.0075 0.0221 0.2376
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0029 0.002
Trichomonas vaginalis importin beta-1, putative 0.0075 0.0223 0.2399
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0029 0.0047
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0185 0.0176
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0124 0.0116
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0059 0.0864
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0249 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0254 0.0922 0.4592
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus granulosus intermediate filament protein 0.0059 0.016 0.0363
Loa Loa (eye worm) hypothetical protein 0.0183 0.0646 0.1531
Loa Loa (eye worm) acetylcholinesterase 1 0.1085 0.4167 1
Echinococcus granulosus BC026374 protein S09 family 0.0183 0.0646 0.1531
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0075 0.0221 0.2276
Loa Loa (eye worm) patched family protein 0.0032 0.0055 0.011
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0059 0.0121
Schistosoma mansoni ran 0.0045 0.0104 0.0228
Trypanosoma brucei protein kinase, putative 0.0055 0.0145 0.4973
Leishmania major acetyl-CoA synthetase, putative 0.0075 0.0221 0.2376
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0026 0.0031 0.0333
Onchocerca volvulus 0.0032 0.0055 0.0442
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.0185 0.0423
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Echinococcus multilocularis expressed conserved protein 0.0496 0.1867 0.1859
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0278
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.009 0.4706
Echinococcus granulosus microtubule associated protein 2 0.0747 0.2846 0.6823
Loa Loa (eye worm) jmjC domain-containing protein 0.0081 0.0247 0.0572
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0185 0.0423
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0185 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0014 0.0073
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0249 0.3624
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0185 0.1879
Loa Loa (eye worm) hypothetical protein 0.0075 0.0221 0.051
Echinococcus granulosus muscleblind protein 0.0163 0.0565 0.1338
Onchocerca volvulus 0.0075 0.0221 0.2276
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0124 0.0278
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0188 0.0179
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0013
Toxoplasma gondii exonuclease III APE 0.0041 0.009 0.1402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0185 0.0423
Echinococcus multilocularis muscleblind protein 0.0163 0.0565 0.0557
Brugia malayi Muscleblind-like protein 0.0163 0.0565 0.1338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0185 0.0423
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0065 0.0134
Loa Loa (eye worm) carboxylesterase 0.1085 0.4167 1
Brugia malayi hypothetical protein 0.0032 0.0055 0.011
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.073 0.0722
Loa Loa (eye worm) hypothetical protein 0.0183 0.0646 0.1531
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0022 0.0014 0.0073
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.002 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.016 0.0363
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0315 0.0737
Schistosoma mansoni hypothetical protein 0.007 0.0203 0.0467
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0247 0.0572
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0221 0.7584
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0185 0.0423
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0249 0.2584
Loa Loa (eye worm) hypothetical protein 0.0277 0.1014 0.2416
Brugia malayi CHE-14 protein 0.0226 0.0814 0.1937
Loa Loa (eye worm) hypothetical protein 0.019 0.0671 0.1593
Brugia malayi RNA, U transporter 1 0.0263 0.0959 0.2284
Toxoplasma gondii patched family protein 0.0032 0.0055 0.0787
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0221 0.1572
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Schistosoma mansoni nuclear hormone receptor 0.0031 0.005 0.0099
Schistosoma mansoni lamin 0.0059 0.016 0.0363
Onchocerca volvulus 0.0059 0.016 0.1603
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0254 0.0922 1
Schistosoma mansoni ap endonuclease 0.0041 0.009 0.0195
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.012 0.0267
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0009 0.0308
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0082 0.0175
Plasmodium vivax acyl-CoA synthetase, putative 0.019 0.0671 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0185 0.1879
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.001 0.0343
Loa Loa (eye worm) carboxylesterase 0.0183 0.0646 0.1531
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0185 0.0423
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0059 0.005
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0058 0.0156 0.0353
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0075 0.0221 0.2276
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0221 0.991
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0434 0.1023
Brugia malayi mbt repeat family protein 0.005 0.0124 0.0278
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.0185 0.0176
Loa Loa (eye worm) hypothetical protein 0.0528 0.1992 0.4768
Onchocerca volvulus 0.0032 0.0055 0.0442
Schistosoma mansoni cpg binding protein 0.0094 0.0295 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0014 0.0073
Brugia malayi Patched related family protein 12 0.0032 0.0055 0.011
Schistosoma mansoni cpg binding protein 0.0094 0.0295 0.0688
Echinococcus multilocularis expressed protein 0.0035 0.0067 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0185 0.0423
Onchocerca volvulus 0.0183 0.0646 0.6952
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0151 0.0143
Echinococcus granulosus importin subunit beta 1 0.0093 0.0292 0.0679
Echinococcus multilocularis microtubule associated protein 2 0.0747 0.2846 0.284
Onchocerca volvulus 0.0254 0.0922 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.005 0.0041
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0249 0.024
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0064 0.2191
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0067 0.014
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0423
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Schistosoma mansoni jumonji domain containing protein 0.0164 0.057 0.1348
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0075 0.0221 0.3202
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0065 0.0056
Plasmodium vivax acetyl-CoA synthetase, putative 0.0075 0.0221 0.3202
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0067 0.014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0033 0.0059 0.0121
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0041 0.0076
Schistosoma mansoni hypothetical protein 0.0032 0.0056 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0221 0.2276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0185 0.0423
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0254 0.0922 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Brugia malayi nuclear receptor RXR 0.0031 0.005 0.0099
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0249 0.4139
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0185 0.0423
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0065 0.0134
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0075 0.0221 0.3657
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.009 0.3231
Schistosoma mansoni hypothetical protein 0.036 0.1338 0.3196
Plasmodium falciparum importin beta, putative 0.0093 0.0292 0.4265
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0153 0.0528 0.0519
Brugia malayi Patched family protein 0.0032 0.0055 0.011
Echinococcus multilocularis acetylcholinesterase 0.1085 0.4167 0.4162
Echinococcus multilocularis neuroligin 0.0183 0.0646 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0014 0.0073
Onchocerca volvulus 0.0032 0.0055 0.0442
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0104 0.5537
Schistosoma mansoni nuclear receptor 0.0031 0.005 0.0099
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0075 0.0221 0.1045
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0254 0.0922 1
Brugia malayi protein C24B5.3 0.0032 0.0055 0.011
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0185 0.0423
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.0227 0.0218
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.0185 0.0423
Schistosoma mansoni chromosome transmission fidelity factor 0.0022 0.0014 0.0013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0188 0.0431
Plasmodium falciparum lipid/sterol:H+ symporter 0.0032 0.0055 0.0689
Brugia malayi hypothetical protein 0.0032 0.0055 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0145 0.0327
Loa Loa (eye worm) hypothetical protein 0.0183 0.0646 0.1531
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0183 0.0646 0.7111
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0075 0.0221 0.7584
Brugia malayi conserved hypotetical protein 0.0031 0.005 0.0099
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0075 0.0221 0.051
Plasmodium falciparum acyl-CoA synthetase 0.019 0.0671 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0188 0.1912
Onchocerca volvulus 0.0065 0.0185 0.1879
Onchocerca volvulus 0.0183 0.0646 0.6952
Echinococcus multilocularis lamin dm0 0.0059 0.016 0.0151
Echinococcus multilocularis GPCR, family 2 0.0032 0.0056 0.0047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0247 0.0572
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0254 0.0922 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0022 0.0014 0.054
Plasmodium falciparum replication factor C subunit 1, putative 0.0022 0.0014 0.0083
Echinococcus granulosus lysine specific demethylase 5A 0.0081 0.0247 0.0572
Onchocerca volvulus 0.0183 0.0646 0.6952
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0009 0.0292
Brugia malayi Myosin head containing protein 0.0032 0.0055 0.011
Schistosoma mansoni nuclear receptor 0.0031 0.005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.011
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0099
Entamoeba histolytica hypothetical protein 0.0153 0.0528 0.2596
Toxoplasma gondii hypothetical protein 0.0032 0.0055 0.0787
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0188 0.1912
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0065 0.0134
Trichomonas vaginalis antibiotic synthetase, putative 0.0075 0.0221 0.2377

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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