Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | para nitrobenzyl esterase | 0.0176 | 0.1557 | 0.1505 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0176 | 0.1557 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1043 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0062 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0062 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0176 | 0.1557 | 0.1505 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0062 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0176 | 0.1557 | 0.1505 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0176 | 0.1557 | 0.1505 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Echinococcus granulosus | acetylcholinesterase | 0.1043 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0176 | 0.1557 | 0.1505 |
Loa Loa (eye worm) | hypothetical protein | 0.1043 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0176 | 0.1557 | 0.1557 |
Brugia malayi | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0176 | 0.1557 | 0.1505 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0176 | 0.1557 | 0.1505 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0062 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0176 | 0.1557 | 0.1505 |
Onchocerca volvulus | 0.0176 | 0.1557 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1043 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0176 | 0.1557 | 0.1557 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Brugia malayi | Carboxylesterase family protein | 0.0176 | 0.1557 | 0.1557 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0176 | 0.1557 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0062 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Loa Loa (eye worm) | carboxylesterase | 0.0176 | 0.1557 | 0.1557 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0176 | 0.1557 | 0.1505 |
Echinococcus granulosus | acetylcholinesterase | 0.1043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Echinococcus multilocularis | acetylcholinesterase | 0.1043 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0062 | 0.5 |
Onchocerca volvulus | 0.0176 | 0.1557 | 0.5 | |
Onchocerca volvulus | 0.0176 | 0.1557 | 0.5 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0176 | 0.1557 | 0.1505 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0062 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1043 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0176 | 0.1557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1043 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0062 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0176 | 0.1557 | 1 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0535 | 0.5049 | 0.5018 |
Brugia malayi | Carboxylesterase family protein | 0.0176 | 0.1557 | 0.1557 |
Onchocerca volvulus | 0.0176 | 0.1557 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1043 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1043 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0062 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0176 | 0.1557 | 0.1505 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0062 | 0.0062 |
Onchocerca volvulus | 0.0176 | 0.1557 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0176 | 0.1557 | 1 |
Schistosoma mansoni | gliotactin | 0.0176 | 0.1557 | 0.1505 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1557 | 0.1557 |
Loa Loa (eye worm) | hypothetical protein | 0.1043 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1043 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0176 | 0.1557 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0176 | 0.1557 | 0.1557 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0176 | 0.1557 | 0.1505 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0176 | 0.1557 | 0.1505 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0062 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0062 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0176 | 0.1557 | 0.1505 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.9466 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.