Detailed information for compound 1588935

Basic information

Technical information
  • TDR Targets ID: 1588935
  • Name: 2-[(E)-2-nitroethenyl]-1H-indole
  • MW: 188.183 | Formula: C10H8N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)/C=C/c1cc2c([nH]1)cccc2
  • InChi: 1S/C10H8N2O2/c13-12(14)6-5-9-7-8-3-1-2-4-10(8)11-9/h1-7,11H/b6-5+
  • InChiKey: ZUQXVMIIRIIGTQ-AATRIKPKSA-N  


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Synonyms

  • (E)-N-hydroxy-2-(1H-indol-2-yl)ethenamine oxide
  • N-[(E)-2-(1H-indol-2-yl)ethenyl]-N-oxidohydroxylamine
  • 2-(2-nitroethenyl)-1H-indole
  • 2-(2-nitrovinyl)-1H-indole
  • 2-[(E)-2-nitrovinyl]-1H-indole
  • N-[(E)-2-(1H-indol-2-yl)vinyl]-N-oxido-hydroxylamine
  • N-[(E)-2-(1H-indol-2-yl)vinyl]-N-oxidohydroxylamine
  • N-[(E)-2-(1H-indol-2-yl)ethenyl]-N-oxido-hydroxylamine
  • 14255-18-6
  • NSC150982
  • NSC 150982
  • 1H-Indole, 2-[(E)-2-nitroethenyl]-
  • NCI60_001058
  • NCI150982
  • MLS000766159
  • SMR000528635
  • NCIStruc1_000132
  • NCIStruc2_000264
  • AIDS-063513
  • AIDS063513
  • 2-(2-(hydroxy(oxido)amino)vinyl)-1H-indole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus regulator of G protein signaling 3 0.0036 0.0285 0.027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0379 0.1031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0084 0.1398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0134 0.0263
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0379 0.6326
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0039
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0599 0.0584
Schistosoma mansoni hypothetical protein 0.0159 0.1781 0.1769
Loa Loa (eye worm) hypothetical protein 0.009 0.0948 0.1361
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0254 0.4251
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0423 0.0408
Brugia malayi regulator of G-protein signaling egl-10 0.0036 0.0285 0.041
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0379 0.1031
Echinococcus granulosus m phase inducer phosphatasecdc25 0.009 0.0948 0.0934
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0084 0.012
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0789 0.9465 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6651 0.6646
Plasmodium vivax SET domain protein, putative 0.0084 0.087 0.0874
Brugia malayi Bromodomain containing protein 0.0074 0.0752 0.1079
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.009 0.0948 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0379 0.0364
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.058 1
Echinococcus granulosus regulator of G protein signaling 7 0.0036 0.0285 0.027
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0379 0.0476
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0085 0.0431
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0371 0.0532
Schistosoma mansoni axis inhibition protein axin 0.0036 0.0285 0.027
Echinococcus multilocularis geminin 0.0159 0.1781 0.1769
Brugia malayi Regulator of G protein signaling domain containing protein 0.0036 0.0285 0.041
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0539 0.0525
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.012 0.0105
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0599 0.0753
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.2159 0.2147
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0183 0.0262
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni rab6-interacting 0.0019 0.0086 0.0071
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0379 0.0476
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0085 0.0107
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.009 0.0948 0.1193
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0078 0.1309
Mycobacterium ulcerans hypothetical protein 0.0023 0.0134 0.1394
Echinococcus granulosus lysosomal alpha glucosidase 0.015 0.1676 0.1663
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0036 0.0285 0.027
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0599 0.0584
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0036 0.0285 0.041
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0078 0.1309
Onchocerca volvulus 0.0318 0.372 0.468
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0134 0.1394
Echinococcus granulosus regulator of G protein signaling 3 0.0036 0.0285 0.027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0134 0.1694
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0503 0.0488
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0254 0.2683
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0568 0.0553
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0085 0.1412
Onchocerca volvulus 0.0043 0.0379 0.0476
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0281 0.0267
Schistosoma mansoni z-protein (S1r protein) 0.0036 0.0285 0.027
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0371 0.0532
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0085 0.0431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0371 0.0356
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0789 0.9465 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.0033 0.0553
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0036 0.0285 0.027
Trypanosoma brucei glucosidase, putative 0.0033 0.0254 0.4251
Giardia lamblia Dipeptidyl-peptidase I precursor 0.03 0.3498 0.3643
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0084 0.0414
Trypanosoma brucei polyadenylate-binding protein 1 0.0016 0.0047 0.078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0089
Echinococcus multilocularis Regulator of G protein signaling 20 0.0036 0.0285 0.027
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0054 0.0039
Onchocerca volvulus 0.0043 0.0379 0.0476
Trypanosoma cruzi polyadenylate-binding protein, putative 0.0016 0.0047 0.078
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0379 0.1031
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0102 0.0128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0193
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.012 0.0105
Echinococcus multilocularis regulator of G protein signaling 7 0.0036 0.0285 0.027
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0036 0.0285 0.027
Brugia malayi Cytochrome P450 family protein 0.0027 0.0183 0.0262
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0134 0.1394
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.058 0.1663
Loa Loa (eye worm) hypothetical protein 0.0083 0.0862 0.1238
Brugia malayi MAP kinase sur-1 0.0062 0.0599 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0084 0.087 0.0856
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.022 0.3672
Echinococcus multilocularis lysosomal alpha glucosidase 0.015 0.1676 0.1663
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3233 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0085 0.0107
Schistosoma mansoni ran 0.0019 0.0078 0.0063
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0379 0.0364
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0085 0.0431
Onchocerca volvulus 0.0023 0.0134 0.0169
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0102 0.0128
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0085 0.0431
Brugia malayi Rhodanese-like domain containing protein 0.009 0.0948 0.1361
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0039
Brugia malayi regulator of G-protein signaling rgs-7 0.0036 0.0285 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0285 0.0359
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0114 0.1237 0.1224
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0134 0.1694
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0084 0.0882
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0085 0.0107
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.009 0.0948 0.1193
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0085 0.0107
Brugia malayi Pre-SET motif family protein 0.0584 0.6965 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0285 0.0359
Brugia malayi PHD-finger family protein 0.0025 0.0149 0.0214
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0379 0.1031
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0379 0.0476
Trypanosoma cruzi polyadenylate-binding protein 1, putative 0.0016 0.0047 0.078
Leishmania major alpha glucosidase II subunit, putative 0.0033 0.0254 0.4251
Brugia malayi hypothetical protein 0.0019 0.0086 0.0124
Loa Loa (eye worm) cytochrome P450 0.0019 0.0085 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0292 0.0277
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0599 1
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6651 0.6646
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0036 0.0292 0.0419
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.015 0.1676 0.2407
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0089
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6651 0.6646
Leishmania major cytochrome p450-like protein 0.0019 0.0085 0.1412
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0599 0.0753
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.058 0.0565
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0134 0.1417
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0183 0.3054
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.022 0.0184
Echinococcus multilocularis regulator of G protein signaling 0.0036 0.0285 0.027
Brugia malayi polyadenylate-binding protein 1 0.0016 0.0047 0.0067
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0085 0.0431
Brugia malayi beta-lactamase family protein 0.0043 0.0379 0.0544
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0062 0.5
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6651 0.6646
Giardia lamblia Encystation-specific protease 0.03 0.3498 0.3643
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.009 0.0948 0.1193
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0281 0.0267
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0036 0.0285 0.027
Brugia malayi cytochrome P450 0.0019 0.0085 0.0121
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0085 0.0431
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0503 0.0488
Echinococcus granulosus polyadenylate binding protein 0.0016 0.0047 0.0031
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.03 0.3498 0.3664
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0285 0.0359
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0134 0.1417
Loa Loa (eye worm) raf kinase 0.0114 0.1237 0.1777
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0086 0.0071
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0084 0.0105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0371 0.0356
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0084 0.5
Leishmania major hypothetical protein, conserved 0.003 0.022 0.3672
Loa Loa (eye worm) MBCTL1 0.0054 0.0503 0.0722
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0318 0.0303
Onchocerca volvulus 0.0084 0.087 0.1094
Brugia malayi hypothetical protein 0.0019 0.0086 0.0124
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0078 0.0063
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0379 0.1031
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0423 0.0408
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0134 0.2245
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.058 0.0565
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0789 0.9465 1
Entamoeba histolytica Ran family GTPase 0.0019 0.0078 0.0826
Loa Loa (eye worm) hypothetical protein 0.0042 0.0362 0.052
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0789 0.9465 0.9464
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0085 0.004
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0085 0.0431
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0085 0.0107
Echinococcus multilocularis snurportin 1 0.0273 0.3176 0.3165
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0085 0.0107
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.022 0.0184
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0599 0.0584
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0134 0.1394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0101 0.1075 0.1061
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0086 0.0042
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0078 0.0112
Loa Loa (eye worm) hypothetical protein 0.0101 0.1075 0.1543
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0134 0.1394
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.012 0.0105
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0599 0.0584
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0254 0.032
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0599 1
Loa Loa (eye worm) hypothetical protein 0.0318 0.372 0.5341
Echinococcus multilocularis regulator of G protein signaling 3 0.0036 0.0285 0.027
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0085 0.0107
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.009 0.0948 0.0934
Mycobacterium ulcerans hypothetical protein 0.0043 0.0379 0.6113
Giardia lamblia Dipeptidyl-peptidase I precursor 0.03 0.3498 0.3643
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0134 0.1394
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0161 0.0121
Echinococcus multilocularis neutral alpha glucosidase AB 0.0033 0.0254 0.024
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0054 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0085 0.0107
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0078 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0134 0.2245
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0085 0.0431
Echinococcus granulosus regulator of G protein signaling 7 0.0036 0.0285 0.027
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0084 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0089
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0036 0.0285 0.0359
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0085 0.0107
Trichomonas vaginalis cdc25b, putative 0.009 0.0948 0.1193
Toxoplasma gondii cathepsin CPC1 0.0789 0.9465 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0062 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0584 0.6965 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0513 0.0499
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0084 0.0068
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0085 0.0107
Mycobacterium ulcerans lipase LipD 0.0043 0.0379 0.6113
Trypanosoma brucei polyadenylate-binding protein 2 0.0016 0.0047 0.078
Echinococcus granulosus histone lysine methyltransferase setb 0.0101 0.1075 0.1061
Loa Loa (eye worm) hypothetical protein 0.0054 0.0503 0.0722
Entamoeba histolytica rodhanase-like domain containing protein 0.009 0.0948 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0089
Echinococcus granulosus G protein signaling modulator 2 0.0032 0.0237 0.0222
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0423 0.0408
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0062 0.0016
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0102 0.1699
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0379 0.6113
Leishmania major poly(A)-binding protein 3 0.0016 0.0047 0.078
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0086 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0193
Onchocerca volvulus 0.009 0.0948 0.1193
Brugia malayi Importin beta-1 subunit 0.0026 0.0161 0.0231
Onchocerca volvulus 0.0665 0.7948 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0183 0.3054
Schistosoma mansoni regulator of G protein signaling 0.0036 0.0285 0.027
Onchocerca volvulus 0.0087 0.0906 0.114
Brugia malayi hypothetical protein 0.0318 0.372 0.5341
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0254 0.032
Trichomonas vaginalis cdc25c, putative 0.009 0.0948 0.1193
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0134 0.0193
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0379 0.6326
Echinococcus multilocularis G protein signaling modulator 2 0.0032 0.0237 0.0222
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.058 0.0566
Brugia malayi Pre-SET motif family protein 0.0084 0.087 0.1249
Brugia malayi Glycosyl hydrolases family 31 protein 0.015 0.1676 0.2407
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0085 0.0107
Mycobacterium tuberculosis Conserved protein 0.0043 0.0379 0.1031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0084 0.087 0.0856
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0503 0.0488
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0254 0.032
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.058 0.9688
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.041
Trichomonas vaginalis sucrase-isomaltase, putative 0.0033 0.0254 0.032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0544
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0379 0.0476
Loa Loa (eye worm) hypothetical protein 0.0047 0.0423 0.0607
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.041
Brugia malayi PXA domain containing protein 0.0036 0.0285 0.041
Brugia malayi Cytochrome P450 family protein 0.006 0.0579 0.0832
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0033 0.0254 0.0221
Schistosoma mansoni hypothetical protein 0.0032 0.0237 0.0222
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0599 1
Schistosoma mansoni polyadenylate binding protein 0.0016 0.0047 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0599 0.0753
Echinococcus granulosus axis inhibition protein axin 0.0036 0.0285 0.027
Mycobacterium ulcerans beta-lactamase 0.0043 0.0379 0.6113
Onchocerca volvulus 0.009 0.0948 0.1193
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0062 0.0037
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0379 0.6113
Schistosoma mansoni hypothetical protein 0.0015 0.0033 0.0018
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0085 0.1412
Echinococcus multilocularis beta adrenergic receptor kinase 0.0036 0.0292 0.0277
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0086 0.0071
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0086 0.0071
Schistosoma mansoni polycystin 1-related 0.0019 0.0086 0.0071
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.009 0.0948 0.1193
Schistosoma mansoni lipoxygenase 0.0055 0.0513 0.0499
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0085 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0285 0.0359
Brugia malayi RNA, U transporter 1 0.0073 0.0735 0.1056
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0379 0.0352
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0183 0.233
Entamoeba histolytica hypothetical protein 0.0036 0.0285 0.3008
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0285 0.0359
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0544
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0086 0.0042
Echinococcus multilocularis expressed protein 0.0463 0.5494 0.5487
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0085 0.1412
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0193
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0379 0.1031
Trypanosoma cruzi ISWI complex protein 0.0015 0.0033 0.0553
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0085 0.0431
Toxoplasma gondii exonuclease III APE 0.0019 0.0084 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0379 0.0476
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0599 0.0753
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0379 0.1031
Leishmania major importin beta-1 subunit, putative 0.0021 0.0102 0.1699
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0085 0.0431
Leishmania major hypothetical protein, conserved 0.0043 0.0379 0.6326
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0379 0.6326
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0316
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0134 0.1394
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0134 0.0193
Echinococcus granulosus expressed protein 0.0463 0.5494 0.5487
Schistosoma mansoni cytochrome P450 0.0019 0.0085 0.0069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0124
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0085 0.0107
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0423 0.0408
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0379 0.0544
Schistosoma mansoni alpha-glucosidase 0.0129 0.1422 0.1409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0371 0.0356
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0579 0.0832
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0084 0.0039
Leishmania major poly(A)-binding protein 2 0.0016 0.0047 0.078
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0568 0.0553
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0086 0.0071
Toxoplasma gondii ABC1 family protein 0.0043 0.0379 0.0352
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0084 0.0104
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0539 0.0525
Brugia malayi Regulator of G protein signaling domain containing protein 0.0036 0.0285 0.041
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0599 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0085 0.0431
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0539 0.0525
Loa Loa (eye worm) PXA domain-containing protein 0.0036 0.0285 0.041
Echinococcus multilocularis axis inhibition protein axin 0.0036 0.0285 0.027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0379 0.0364
Brugia malayi Cytochrome P450 family protein 0.0019 0.0085 0.0121
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0084 0.5
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0161 0.0146
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0544
Brugia malayi GoLoco motif family protein 0.0032 0.0237 0.034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.041
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0599 1
Leishmania major cytochrome p450-like protein 0.0027 0.0183 0.3054
Trypanosoma brucei ISWI complex protein 0.0015 0.0033 0.0553
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0084 0.087 0.0856
Schistosoma mansoni hypothetical protein 0.0159 0.1781 0.1769
Brugia malayi hypothetical protein 0.0036 0.0285 0.041
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0086 0.0071
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0539 0.0775
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0254 0.032
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0085 0.0431
Echinococcus granulosus zinc finger protein 0.0019 0.0085 0.0069
Schistosoma mansoni hypothetical protein 0.0019 0.0085 0.0069
Leishmania major cytochrome p450-like protein 0.0019 0.0085 0.1412
Echinococcus multilocularis polyadenylate binding protein 0.0016 0.0047 0.0031
Loa Loa (eye worm) hypothetical protein 0.007 0.07 0.1005
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0078 0.0034
Loa Loa (eye worm) hypothetical protein 0.0083 0.0862 0.1238
Brugia malayi Doublecortin family protein 0.0019 0.0086 0.0124
Loa Loa (eye worm) hypothetical protein 0.0032 0.0237 0.034
Plasmodium falciparum importin beta, putative 0.0026 0.0161 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0371 0.0356
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0254 0.4251
Loa Loa (eye worm) hypothetical protein 0.0038 0.0311 0.0446
Schistosoma mansoni alpha-glucosidase 0.0129 0.1422 0.1409
Echinococcus multilocularis regulator of G protein signaling 3 0.0036 0.0285 0.027
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0273 0.3176 0.456
Echinococcus multilocularis axis inhibition protein axin 0.0036 0.0285 0.027
Entamoeba histolytica rodhanase-like domain containing protein 0.009 0.0948 1
Echinococcus granulosus snurportin 1 0.0273 0.3176 0.3165
Toxoplasma gondii preprocathepsin c precursor, putative 0.0789 0.9465 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0379 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0292 0.0277
Schistosoma mansoni ap endonuclease 0.0019 0.0084 0.0068
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0503 0.0488
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0085 0.0431
Onchocerca volvulus 0.0019 0.0086 0.0109
Brugia malayi hypothetical protein 0.003 0.022 0.0316
Trichomonas vaginalis set domain proteins, putative 0.0665 0.7948 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0948 0.1361
Mycobacterium leprae Probable lipase LipE 0.0043 0.0379 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0611 0.0596
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0102 0.0128
Echinococcus granulosus RUN 0.0019 0.0086 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.022 0.0184
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0085 0.0431
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0085 0.1412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0124
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0084 0.1398
Onchocerca volvulus 0.009 0.0948 0.1193
Brugia malayi A-kinase anchor protein 10, precursor 0.0036 0.0285 0.041
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0085 0.0431
Brugia malayi beta-lactamase 0.0043 0.0379 0.0544
Trichomonas vaginalis esterase, putative 0.0043 0.0379 0.0476
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0085 0.0107
Leishmania major hypothetical protein, conserved 0.0015 0.0033 0.0553
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0081 0.0832 0.0818
Echinococcus granulosus beta-adrenergic receptor kinase 0.0036 0.0292 0.0277
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.022 0.0184
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0789 0.9465 1
Echinococcus granulosus importin subunit beta 1 0.0026 0.0161 0.0146
Brugia malayi PXA domain containing protein 0.0036 0.0285 0.041
Loa Loa (eye worm) beta-lactamase 0.0043 0.0379 0.0544
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0067
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0379 0.0544
Brugia malayi Raf kinase 0.0114 0.1237 0.1777
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0101 0.1075 0.1061
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0134 0.0193
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0599 1
Trypanosoma brucei protein kinase, putative 0.0062 0.0599 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0539 0.9013
Schistosoma mansoni loxhd1 0.0019 0.0086 0.0071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0254 0.2683
Schistosoma mansoni polyadenylate binding protein 0.0016 0.0047 0.0031
Echinococcus multilocularis zinc finger protein 0.0019 0.0085 0.0069
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0539 0.1536
Schistosoma mansoni lipoxygenase 0.0019 0.0086 0.0071
Entamoeba histolytica rodhanase-like domain containing protein 0.009 0.0948 1
Onchocerca volvulus 0.0047 0.0423 0.0532
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.009 0.0948 0.1193
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0285 0.0359
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0423 0.0607
Schistosoma mansoni rab6-interacting 0.0019 0.0086 0.0071
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.041
Schistosoma mansoni axis inhibition protein axin 0.0036 0.0285 0.027
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.03 0.3498 0.3664
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0085 0.0431
Onchocerca volvulus 0.009 0.0948 0.1193
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0084 0.0068
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0539 0.922
Schistosoma mansoni polyadenylate binding protein 0.0016 0.0047 0.0031
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0503 0.0722
Echinococcus multilocularis lysosomal alpha glucosidase 0.015 0.1676 0.1663
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0084 0.1398
Echinococcus granulosus neutral alpha glucosidase AB 0.0033 0.0254 0.024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0101 0.1075 0.1061
Schistosoma mansoni regulator of G protein signaling 0.0036 0.0285 0.027
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0493 0.0708
Schistosoma mansoni zinc finger protein 0.0019 0.0085 0.0069
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0085 0.1412
Echinococcus multilocularis regulator of G protein signaling 7 0.0036 0.0285 0.027
Mycobacterium tuberculosis Conserved protein 0.0043 0.0379 0.1031
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0134 0.0263
Brugia malayi Rhodanese-like domain containing protein 0.009 0.0948 0.1361
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0036 0.0292 0.0419
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0503 0.0488
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0085 0.0107
Schistosoma mansoni zinc finger protein 0.0015 0.0033 0.0018
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0085 0.0431
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0789 0.9465 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0183 0.0262
Loa Loa (eye worm) hypothetical protein 0.0026 0.0161 0.0231
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0539 0.922
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0085 0.0107
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0254 0.032
Loa Loa (eye worm) hypothetical protein 0.004 0.0339 0.0487
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0134 0.2245
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0161 0.2684
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0062 0.0016
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0078 0.0034
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0085 0.0431
Echinococcus granulosus Regulator of G protein signaling 20 0.0036 0.0285 0.027
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0423 0.0408
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.049 0.5816 0.7317
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0599 0.0859
Brugia malayi beta-lactamase family protein 0.0043 0.0379 0.0544
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0089
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0513 0.0499
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0078 0.1309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0371 0.0356
Entamoeba histolytica hypothetical protein 0.0036 0.0285 0.3008
Schistosoma mansoni importin beta-1 0.0026 0.0161 0.0146
Brugia malayi mbt repeat family protein 0.0047 0.0423 0.0607
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0544
Entamoeba histolytica hypothetical protein 0.0021 0.0102 0.1072
Schistosoma mansoni alpha glucosidase 0.0033 0.0254 0.024
Echinococcus granulosus geminin 0.0159 0.1781 0.1769
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.0161 0.2684
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0033 0.0254 0.0365
Schistosoma mansoni hypothetical protein 0.029 0.3386 0.3376
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0084 0.012
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0423 0.0408
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0423 0.0532
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0084 0.1398
Mycobacterium tuberculosis Conserved protein 0.0043 0.0379 0.1031
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.058 0.0565
Schistosoma mansoni ap endonuclease 0.0019 0.0084 0.0068
Schistosoma mansoni regulator of G protein signaling 0.0036 0.0285 0.027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0544
Brugia malayi Cytochrome P450 family protein 0.0027 0.0183 0.0262
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0183 0.0262
Onchocerca volvulus 0.0043 0.0379 0.0476
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0085 0.0107
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.022 0.3672
Loa Loa (eye worm) RGS-3 protein 0.0036 0.0285 0.041
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0254 0.0365
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0085 0.0431
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0134 0.1417
Brugia malayi GoLoco motif family protein 0.0032 0.0237 0.034
Brugia malayi hypothetical protein 0.002 0.0088 0.0127
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0097 0.014
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0085 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0599 0.0584
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0599 0.0554
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0379 0.0364
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0183 0.3054
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0084 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.058 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0085 0.0107
Brugia malayi mbt repeat family protein 0.0047 0.0423 0.0607
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0085 0.0107
Brugia malayi hypothetical protein 0.0036 0.0285 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0371 0.0356
Toxoplasma gondii cathepsin CPC2 0.03 0.3498 0.3664
Trichomonas vaginalis cdc25b, putative 0.009 0.0948 0.1193
Echinococcus granulosus raf serine:threonine protein kinase 0.0114 0.1237 0.1224
Schistosoma mansoni hypothetical protein 0.0273 0.3176 0.3165
Schistosoma mansoni ran 0.0019 0.0078 0.0063
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.058 0.0565
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0036 0.0292 0.0419
Trichomonas vaginalis ran, putative 0.0019 0.0078 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.058 1
Brugia malayi Bromodomain containing protein 0.0038 0.031 0.0445
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0599 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.2159 0.2147
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0599 0.0586
Schistosoma mansoni hypothetical protein 0.002 0.0097 0.0082
Echinococcus multilocularis 0.0019 0.0085 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0254 0.032
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0036 0.0285 0.027
Schistosoma mansoni regulator of G protein signaling 0.0036 0.0285 0.027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0084 0.087 0.0874
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0254 0.032
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0084 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.041
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1237 0.1224
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0078 0.0112
Loa Loa (eye worm) GoLoco domain-containing protein family protein 0.0032 0.0237 0.034
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0134 0.1394
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0254 0.032
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0085 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0292 0.0277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0371 0.0356
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0086 0.0124
Echinococcus multilocularis RUN 0.0019 0.0086 0.0071
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0423 0.0408
Echinococcus granulosus axis inhibition protein axin 0.0036 0.0285 0.027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0544
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.022 0.3672
Leishmania major GTP-binding protein, putative 0.0019 0.0078 0.1309
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0085 0.0431
Plasmodium vivax importin-beta 2, putative 0.0026 0.0161 0.0121
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0078 0.0034
Entamoeba histolytica hypothetical protein 0.0036 0.0285 0.3008
Onchocerca volvulus 0.0019 0.0086 0.0109

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.49 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.364 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.007 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.882 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.834 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.83 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.812 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.77 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.752 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.703 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.561 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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