Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0715 | 0.0804 | 0.0804 |
Brugia malayi | Carboxylesterase family protein | 0.4503 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.4503 | 1 | 1 |
Onchocerca volvulus | 0.0761 | 0.0914 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.0914 | 0.0914 |
Onchocerca volvulus | 0.0761 | 0.0914 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0761 | 0.0914 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4503 | 1 | 1 |
Onchocerca volvulus | 0.0761 | 0.0914 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.4503 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.4503 | 1 | 1 |
Onchocerca volvulus | 0.0761 | 0.0914 | 0.5 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.4228 | 0.9331 | 1 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0908 | 0.1271 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.4503 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.4228 | 0.9331 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.4503 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.4503 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.4503 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0761 | 0.0914 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0761 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | carboxylesterase | 0.4503 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.0914 | 0.0914 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.4503 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.0914 | 0.0914 |
Onchocerca volvulus | 0.0761 | 0.0914 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.0914 | 0.0914 |
Echinococcus granulosus | acetylcholinesterase | 0.4503 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0761 | 0.0914 | 0.0914 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.393 | 0.8608 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 46 % | Inhibition of human recombinant BACE1 at 2 uM by FRET assay | ChEMBL. | 22178553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.