Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0391 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0391 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0391 | 1 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0391 | 1 | 0.5 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0391 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.0435 | 0.0435 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.4236 | 0.4236 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0391 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0391 | 1 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0391 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.4236 | 0.4236 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.4236 | 0.4236 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0175 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0391 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0184 | 0.0435 | 0.0435 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.4236 | 0.4236 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0391 | 1 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0391 | 1 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0391 | 1 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0391 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0391 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.4236 | 0.4236 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0266 | 0.4236 | 0.4236 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0391 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0391 | 1 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0391 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0391 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log LC50 (ADMET) | = 1.815 | Toxicity determined using Golden Orfe Fish Test | ChEMBL. | 2033592 |
Log S | = 0.49 | Aqueous solubility | ChEMBL. | 10866370 |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
pTD50 (ADMET) | = 1.233 | Hepatotoxicity in mouse assessed as carcinogenic potency | ChEMBL. | 19272677 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.