TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 298.165 | Formula: C14H13Cl2NO2
H donors: 0 H acceptors: 2 LogP: 3.71 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc[n+](cc1)C1=C(Cl)C(=O)C(=C(C1=O)C)C.[Cl-]
InChi: 1S/C14H13ClNO2.ClH/c1-8-4-6-16(7-5-8)12-11(15)13(17)9(2)10(3)14(12)18;/h4-7H,1-3H3;1H/q+1;/p-1
InChiKey: GXGUULPKISAYBB-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Brugia malayi	phosphoglycerate mutase family protein	0.0022	0.0027	0.0028
Schistosoma mansoni	hypothetical protein	0.0022	0.0027	0.0027
Echinococcus multilocularis	lipoxygenase domain containing protein	0.4209	0.9866	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Mycobacterium leprae	probable isochorismate synthase EntC	0.0022	0.0027	0.0042
Onchocerca volvulus		0.0058	0.0112	0.0113
Echinococcus granulosus	cathepsin l1	0.0015	0.0012	0.0012
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0071	0.0062
Trypanosoma cruzi	major cysteine proteinase, putative	0.0046	0.0083	0.0246
Schistosoma mansoni	cpg binding protein	0.0058	0.0112	0.0112
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0106	0.0525
Echinococcus multilocularis	phosphoglycerate mutase	0.0022	0.0027	0.0018
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0025	0.0034	0.0593
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0022	0.0027	0.0059
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0022	0.0027	0.0151
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0022	0.0027	0.0154
Toxoplasma gondii	phosphoglycerate mutase	0.0022	0.0027	0.0788
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Schistosoma mansoni	jumonji domain containing protein	0.0014	0.001	0.001
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0107	0.0228	0.0231
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0022	0.0027	0.0059
Schistosoma mansoni	phosphatidylserine receptor	0.0014	0.001	0.001
Trichomonas vaginalis	glucosylceramidase, putative	0.0377	0.0861	0.6499
Echinococcus multilocularis	lipoxygenase domain containing protein	0.4209	0.9866	1
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0018	0.0018
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.1268	0.2955	0.9829
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0022	0.0027	0.0059
Echinococcus multilocularis	phosphoglycerate mutase	0.0022	0.0027	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0022	0.0027	0.0018
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0014	0.001	0.001
Leishmania major	phosphoglycerate mutase protein, putative	0.0022	0.0027	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0028
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.0761	0.1764	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Onchocerca volvulus		0.0015	0.0012	0.0012
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.0401
Schistosoma mansoni	cpg binding protein	0.0061	0.012	0.012
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.0233	1
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0012	0.0012
Brugia malayi	jmjC domain containing protein	0.0014	0.001	0.001
Brugia malayi	UBASH3A protein homolog	0.0022	0.0027	0.0028
Leishmania major	hypothetical protein, conserved	0.0022	0.0027	0.0059
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Trichomonas vaginalis	glucosylceramidase, putative	0.0377	0.0861	0.6499
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0027	0.0073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0894	0.2076	0.2097
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0007	0.0051
Echinococcus granulosus	microtubule associated protein 2	0.0761	0.1763	0.1787
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Schistosoma mansoni	aldehyde dehydrogenase	0.0055	0.0106	0.0106
Entamoeba histolytica	acyl-coA synthetase, putative	0.0022	0.0027	0.0151
Echinococcus granulosus	peptidase Clp S14 family	0.0047	0.0086	0.0087
Leishmania major	phosphoglycerate mutase, putative	0.0022	0.0027	0.0059
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0027	0.1635
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.001	0.001
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0022	0.0027	0.0205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0012	0.0012
Echinococcus multilocularis	cpg binding protein	0.0061	0.012	0.0112
Echinococcus granulosus	JmjC domain containing protein 4	0.0014	0.001	0.001
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0047	0.0086	0.7848
Trichomonas vaginalis	glucosylceramidase, putative	0.0377	0.0861	0.6499
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0027	0.0076
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0022	0.0027	0.0059
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0012	0.0012
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.0012	0.0012
Echinococcus granulosus	Polycystic kidney disease protein	0.4209	0.9866	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Toxoplasma gondii	hypothetical protein	0.0025	0.0034	0.1076
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0015	0.0012	0.0002
Schistosoma mansoni	polycystin 1-related	0.4209	0.9866	0.9866
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Mycobacterium ulcerans	hydrolase MutT1	0.0022	0.0027	0.0076
Trichomonas vaginalis	glucosylceramidase, putative	0.0574	0.1325	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0025	0.0034	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Echinococcus multilocularis	cysteine protease	0.0015	0.0012	0.0002
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Schistosoma mansoni	microtubule-associated protein tau	0.0761	0.1763	0.1763
Echinococcus granulosus	cpg binding protein	0.0061	0.012	0.0121
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0027	0.0027
Brugia malayi	phosphoglycerate mutase family protein	0.0022	0.0027	0.0028
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1268	0.2955	0.9829
Onchocerca volvulus		0.0022	0.0027	0.0028
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0022	0.0027	0.0059
Plasmodium falciparum	phosphoglucomutase-2	0.0022	0.0027	0.0018
Schistosoma mansoni	jumonji domain containing protein	0.0053	0.0102	0.0102
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0027	0.0076
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0022	0.0027	0.0205
Schistosoma mansoni	hypothetical protein	0.0022	0.0027	0.0027
Schistosoma mansoni	phosphoglycerate mutase	0.0022	0.0027	0.0027
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0022	0.0027	0.0059
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0071	0.0143	0.5973
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0015	0.0012	0.0012
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0055	0.0106	0.0107
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0007	0.0051
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0053	0.0102	0.0094
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0007	0.0051
Schistosoma mansoni	hypothetical protein	0.0022	0.0027	0.0027
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0022	0.0027	0.0042
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0028
Schistosoma mansoni	aldehyde dehydrogenase	0.0055	0.0106	0.0106
Schistosoma mansoni	cpg binding protein	0.0061	0.012	0.012
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0022	0.0027	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0739	0.1713	0.1737
Loa Loa (eye worm)	hypothetical protein	0.0014	0.001	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1268	0.2955	0.9829
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0071	0.0071
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0071	0.0143	0.0136
Onchocerca volvulus		0.0015	0.0012	0.0012
Trichomonas vaginalis	glucosylceramidase, putative	0.0574	0.1325	1
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0022	0.0027	0.0059
Leishmania major	hypothetical protein, conserved	0.0022	0.0027	0.0059
Leishmania major	4-coumarate:coa ligase-like protein	0.0022	0.0027	0.0057
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0055	0.0106	0.0098
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0027	0.0027
Plasmodium vivax	acyl-CoA synthetase, putative	0.0016	0.0014	0.0004
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0015	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Mycobacterium ulcerans	hypothetical protein	0.0761	0.1764	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0574	0.1325	1
Schistosoma mansoni	phosphoglycerate mutase	0.0022	0.0027	0.0027
Plasmodium vivax	phosphoglycerate mutase, putative	0.0022	0.0027	0.0018
Mycobacterium ulcerans	phosphoglycerate mutase	0.0022	0.0027	0.0076
Onchocerca volvulus	Huntingtin homolog	0.0135	0.0293	0.0297
Echinococcus multilocularis	microtubule associated protein 2	0.0761	0.1763	0.1779
Echinococcus granulosus	phd:f box containing protein	0.0014	0.001	0.001
Onchocerca volvulus	Protein UBASH3A homolog	0.0022	0.0027	0.0028
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1268	0.2955	0.9829
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0022	0.0027	0.0059
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.0017	0.0018
Loa Loa (eye worm)	hypothetical protein	0.4209	0.9866	1
Echinococcus multilocularis	cysteine protease	0.0015	0.0012	0.0002
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0071	0.0143	0.5
Schistosoma mansoni	hypothetical protein	0.0022	0.0027	0.0027
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0022	0.0027	0.0154
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0027	0.0073
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0071	0.0143	0.0136
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0053	0.0101	0.0304
Brugia malayi	jmjC domain containing protein	0.0057	0.0109	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0014	0.001	0.001
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0071	0.0143	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0071	0.0143	1
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0012	0.0012
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0574	0.1325	0.1343
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0112	0.0113
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.0401
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Onchocerca volvulus		0.0022	0.0027	0.0027
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.001	0.001
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0012	0.0012
Echinococcus multilocularis	phosphoglycerate mutase	0.0022	0.0027	0.0018
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.055	0.1269	0.4203
Onchocerca volvulus		0.1289	0.3006	0.3047
Leishmania major	4-coumarate:coa ligase-like protein	0.0022	0.0027	0.0057
Schistosoma mansoni	protein phosphatase 2C	0.0014	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0027	0.0073
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0109	0.0111
Plasmodium falciparum	LCCL domain-containing protein	0.4209	0.9866	1
Leishmania major	cathepsin L-like protease	0.0058	0.0112	0.0343
Trichomonas vaginalis	glucosylceramidase, putative	0.0397	0.0909	0.6859
Plasmodium vivax	vivapain-2	0.0015	0.0012	0.0002
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0761	0.1764	1
Schistosoma mansoni	hypothetical protein	0.004	0.0071	0.0071
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0018	0.0018
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0109	0.0109
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0022	0.0027	0.1583
Loa Loa (eye worm)	jmjC domain-containing protein	0.0014	0.001	0.001
Echinococcus granulosus	phosphoglycerate mutase	0.0022	0.0027	0.0028
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0055	0.0106	0.0321
Onchocerca volvulus	Cathepsin L homolog	0.0015	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Mycobacterium ulcerans	acid phosphatase	0.0022	0.0027	0.0076
Echinococcus granulosus	lysine specific demethylase 6a	0.0014	0.001	0.001
Leishmania major	cathepsin L-like protease	0.0015	0.0012	0.0008
Leishmania major	cysteine peptidase A (CPA)	0.0015	0.0012	0.0008
Schistosoma mansoni	hypothetical protein	0.0823	0.191	0.191
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0027	0.0205
Onchocerca volvulus	Protein UBASH3A homolog	0.0022	0.0027	0.0028
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0022	0.0027	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0293	0.0297
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0071	0.0072
Brugia malayi	jmjC domain containing protein	0.0014	0.001	0.001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0027	0.1583
Onchocerca volvulus	Protein UBASH3A homolog	0.0022	0.0027	0.0028
Mycobacterium leprae	conserved hypothetical protein	0.0022	0.0027	0.0042
Mycobacterium leprae	conserved hypothetical protein	0.0022	0.0027	0.0042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0106	0.0525
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0014
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0047	0.0086	0.0077
Plasmodium vivax	vivapain-2	0.0015	0.0012	0.0002
Echinococcus multilocularis	phosphoglycerate mutase	0.0022	0.0027	0.0018
Echinococcus multilocularis	phosphoglycerate mutase	0.0022	0.0027	0.0018
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0112	0.0343
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0022	0.0027	0.0059
Onchocerca volvulus	Cathepsin F homolog	0.0015	0.0012	0.0012
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.055	0.1269	0.4203
Trichomonas vaginalis	glucosylceramidase, putative	0.0574	0.1325	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.0012	0.0012
Leishmania major	cathepsin L-like protease	0.0015	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0012	0.0012
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.0401
Leishmania major	glycerolphosphate mutase, putative	0.0022	0.0027	0.0059
Schistosoma mansoni	lipoxygenase	0.0107	0.0228	0.0228
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0027	0.0205
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0022	0.0027	0.1635
Echinococcus granulosus	6 phosphofructo 2 kinase:fructose 2	0.1289	0.3006	0.3047
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0071	0.0143	0.0738
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0022	0.0027	0.0042
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Leishmania major	hypothetical protein, conserved	0.0022	0.0027	0.0059
Echinococcus granulosus	lipoxygenase domain containing protein	0.4209	0.9866	1
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1289	0.3006	1
Onchocerca volvulus		0.4209	0.9866	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0027	0.0073
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0022	0.0027	0.0151
Mycobacterium ulcerans	lipoprotein LpqD	0.0022	0.0027	0.0076
Trichomonas vaginalis	glucosylceramidase, putative	0.0574	0.1325	1
Leishmania major	cathepsin L-like protease	0.0058	0.0112	0.0343
Leishmania major	cathepsin L-like protease	0.0015	0.0012	0.0008
Trichomonas vaginalis	glucosylceramidase, putative	0.0377	0.0861	0.6499
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.0401
Onchocerca volvulus		0.0015	0.0012	0.0012
Giardia lamblia	Hypothetical protein	0.0761	0.1764	0.5
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0022	0.0027	0.0076
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.055	0.1269	0.4203
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Echinococcus multilocularis	RUN	0.4209	0.9866	1
Mycobacterium tuberculosis	Conserved protein	0.0022	0.0027	0.1635
Schistosoma mansoni	hypothetical protein	0.0022	0.0027	0.0027
Onchocerca volvulus	Protein UBASH3A homolog	0.0022	0.0027	0.0028
Mycobacterium ulcerans	phosphoglycerate mutase	0.0022	0.0027	0.0076
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0106	0.0525
Loa Loa (eye worm)	hypothetical protein	0.1289	0.3006	0.3047
Giardia lamblia	Hypothetical protein	0.0761	0.1764	0.5
Echinococcus granulosus	phosphoglycerate mutase	0.0022	0.0027	0.0028
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0022	0.0027	0.0073
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0071	0.0143	0.0738
Toxoplasma gondii	cathepsin CPL	0.0015	0.0012	0.0101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0022	0.0027	0.1635
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0022	0.0027	0.0042
Onchocerca volvulus		0.0022	0.0027	0.0028
Onchocerca volvulus		0.0015	0.0012	0.0012
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.1289	0.3006	0.304
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Trichomonas vaginalis	helicase, putative	0.0013	0.0007	0.0051
Leishmania major	cathepsin L-like protease	0.0058	0.0112	0.0343
Loa Loa (eye worm)	fibroinase	0.0015	0.0012	0.0012
Entamoeba histolytica	cysteine protease, putative	0.0015	0.0012	0.0067
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0007	0.0051
Schistosoma mansoni	rab6-interacting	0.4209	0.9866	0.9866
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0015	0.0012	0.0002
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0015	0.0012	0.0012
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0071	0.0143	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0143	0.0145
Onchocerca volvulus	Huntingtin homolog	0.0135	0.0293	0.0297
Brugia malayi	hypothetical protein	0.0135	0.0293	0.0297
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0012	0.0012
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0018	0.0018
Mycobacterium leprae	conserved hypothetical protein	0.0022	0.0027	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0022	0.0027	0.0154
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0047	0.0086	0.7848
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0022	0.0027	0.0028
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0071	0.0143	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0014
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.0109	0.0111
Brugia malayi	jmjC domain containing protein	0.0014	0.001	0.001
Plasmodium vivax	multidomain scavenger receptor, putative	0.4209	0.9866	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0028
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0112	0.0113
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0025	0.0034	0.0024
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0112	0.0343
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0022	0.0027	0.0788
Schistosoma mansoni	hypothetical protein	0.4209	0.9866	0.9866
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0022	0.0027	0.0788
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0007	0.0051
Echinococcus granulosus	jumonji domain containing 1A	0.0014	0.001	0.001
Trichomonas vaginalis	glucosylceramidase, putative	0.0377	0.0861	0.6499
Leishmania major	cathepsin L-like protease	0.0015	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0014
Brugia malayi	jmjC domain containing protein	0.0053	0.0102	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0022	0.0027	0.0018
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0015	0.0012	0.0012
Loa Loa (eye worm)	jmjC domain-containing protein	0.0014	0.001	0.001
Entamoeba histolytica	cysteine proteinase, putative	0.0015	0.0012	0.0067
Plasmodium vivax	phosphoglucomutase-2, putative	0.0022	0.0027	0.0018
Loa Loa (eye worm)	cysteine protease	0.0015	0.0012	0.0012
Loa Loa (eye worm)	ctsf protein	0.0015	0.0012	0.0012
Echinococcus multilocularis	cathepsin L cysteine protease	0.0015	0.0012	0.0002
Echinococcus granulosus	dnaJ subfamily B	0.0823	0.191	0.1936
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0007	0.0051
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0022	0.0027	0.0059
Leishmania major	4-coumarate:coa ligase-like protein	0.0022	0.0027	0.0057
Leishmania major	cathepsin L-like protease	0.0015	0.0012	0.0008
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0022	0.0027	0.0059
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0022	0.0027	0.0059
Schistosoma mansoni	loxhd1	0.4209	0.9866	0.9866
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0047	0.0086	0.5056
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0022	0.0027	0.0076
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1289	0.3006	1
Onchocerca volvulus		0.0015	0.0012	0.0012
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0025	0.0034	0.0024
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0007	0.0051
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0071	0.0143	1
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0022	0.0027	0.0059
Loa Loa (eye worm)	doublecortin family protein	0.4209	0.9866	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0574	0.1325	0.1343
Echinococcus multilocularis	Polycystic kidney disease protein	0.4209	0.9866	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0123	0.0264	0.0264
Plasmodium falciparum	acyl-CoA synthetase	0.0016	0.0014	0.0004
Schistosoma mansoni	6-phosphofructokinase	0.1289	0.3006	0.3006
Mycobacterium ulcerans	phosphoglyceromutase	0.0022	0.0027	0.0076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0015	0.0012	0.0089
Echinococcus granulosus	lipoxygenase domain containing protein	0.4209	0.9866	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0022	0.0027	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0015	0.0012	0.0089
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0022	0.0027	0.0205
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0015	0.0012	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Loa Loa (eye worm)	jmjC domain-containing protein	0.0014	0.001	0.001
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0053	0.0102	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Echinococcus granulosus	phosphoglycerate mutase	0.0022	0.0027	0.0028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0071	0.0143	0.0136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Echinococcus multilocularis	cathepsin L cysteine protease	0.0015	0.0012	0.0002
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0022	0.0027	0.0018
Echinococcus granulosus	phosphoglycerate mutase	0.0022	0.0027	0.0028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0022	0.0027	0.0073
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.0017	0.0008
Schistosoma mansoni	peptidase Clp (S14 family)	0.0071	0.0143	0.0143
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0022	0.0027	0.0788
Echinococcus multilocularis	lysine specific demethylase 5A	0.0053	0.0102	0.0094
Mycobacterium tuberculosis	Conserved protein	0.0022	0.0027	0.1635
Onchocerca volvulus		0.0015	0.0012	0.0012
Onchocerca volvulus		0.0022	0.0027	0.0028
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0018	0.0009
Loa Loa (eye worm)	hypothetical protein	0.4209	0.9866	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0055	0.0106	0.4303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Onchocerca volvulus	Cathepsin L homolog	0.0015	0.0012	0.0012
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0022	0.0027	0.0073
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0007	0.0051
Trypanosoma cruzi	cysteine peptidase, putative	0.0015	0.0012	0.0008
Trichomonas vaginalis	glucosylceramidase, putative	0.0397	0.0909	0.6859
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0007	0.0051
Trypanosoma cruzi	cruzipain precursor, putative	0.0058	0.0112	0.0343
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0022	0.0027	0.1635
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0022	0.0027	0.0042
Schistosoma mansoni	phd/f-box containing protein	0.0014	0.001	0.001
Onchocerca volvulus		0.4209	0.9866	1
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0022	0.0027	0.1635
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1289	0.3006	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0022	0.0027	0.0059
Onchocerca volvulus		0.0015	0.0012	0.0012
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0022	0.0027	0.0042
Brugia malayi	hypothetical protein	0.4209	0.9866	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0377	0.0861	0.6499
Brugia malayi	jmjC domain containing protein	0.0014	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0071	0.0143	0.5973
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0016	0.0014	0.022
Onchocerca volvulus	Glucosylceramidase homolog	0.0377	0.0861	0.0873
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0012	0.0089
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0022	0.0027	0.0073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Leishmania major	hypothetical protein, unknown function	0.0022	0.0027	0.0059
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0022	0.0027	0.1635
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Brugia malayi	hypothetical protein	0.004	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.055	0.1269	0.4203
Echinococcus multilocularis	phosphoglycerate mutase	0.0022	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.1268	0.2955	0.2995
Loa Loa (eye worm)	phosphoglycerate mutase	0.0022	0.0027	0.0028
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0015	0.0012	0.0002
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0022	0.0027	0.1028
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0022	0.0027	0.1635
Entamoeba histolytica	cysteine proteinase, putative	0.0015	0.0012	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0014	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0022	0.0027	0.0059
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0022	0.0027	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0107	0.0228	0.0222
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1289	0.3006	1
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0022	0.0027	0.0028
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0022	0.0027	0.0059
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0109	0.0109
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0027	0.0027
Brugia malayi	Doublecortin family protein	0.4209	0.9866	1
Echinococcus multilocularis	dnaJ subfamily B	0.0823	0.191	0.1928
Trichomonas vaginalis	glucosylceramidase, putative	0.0377	0.0861	0.6499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0012	0.0089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0112	0.0343
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0112	0.0343
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0015	0.0012	0.0002
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0022	0.0027	0.0059
Schistosoma mansoni	rab6-interacting	0.4209	0.9866	0.9866
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.0022	0.0027	0.0027
Trichomonas vaginalis	glucosylceramidase, putative	0.0574	0.1325	1
Brugia malayi	hypothetical protein	0.4209	0.9866	1
Echinococcus granulosus	RUN	0.4209	0.9866	1
Brugia malayi	Probable ClpP-like protease	0.0071	0.0143	0.0145
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0055	0.0106	1
Echinococcus granulosus	phosphoglycerate mutase	0.0022	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0293	0.0297
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0022	0.0027	0.0788

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 3.2 ug ml-1	Antifungal activity against Cryptococcus neoformans Berkout KCCM 50564 after 1 day by two fold broth dilution method	ChEMBL.	22115590
MIC (functional)	= 12.5 ug ml-1	Antifungal activity against Candida albicans Berkout KCCM 50235 after 1 day by standard two fold broth dilution method	ChEMBL.	22115590

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1935375

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1589519