Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0254 | 0.0019 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0783 | 0.1595 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1305 | 0.3147 | 0.9791 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0254 | 0.0019 | 0.5 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.1327 | 0.3214 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0254 | 0.0019 | 0.0058 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1305 | 0.3147 | 0.9792 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.3352 | 0.9244 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0254 | 0.0019 | 0.0058 |
Plasmodium vivax | hypothetical protein, conserved | 0.0254 | 0.0019 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0254 | 0.0019 | 0.0058 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1327 | 0.3214 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0783 | 0.1595 | 0.1579 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1327 | 0.3214 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0566 | 0.0949 | 0.2951 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0566 | 0.0949 | 0.2951 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0254 | 0.0019 | 0.5 |
Onchocerca volvulus | 0.1327 | 0.3214 | 1 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.1327 | 0.3214 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0783 | 0.1595 | 0.1579 |
Plasmodium vivax | hypothetical protein, conserved | 0.0254 | 0.0019 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3606 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1305 | 0.3147 | 0.9792 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0254 | 0.0019 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1305 | 0.3147 | 0.9792 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0254 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.1528 | 0.4723 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0254 | 0.0019 | 0.5 |
Brugia malayi | hypothetical protein | 0.0254 | 0.0019 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0566 | 0.0949 | 0.2951 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0783 | 0.1595 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0566 | 0.0949 | 0.2951 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0254 | 0.0019 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0254 | 0.0019 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0783 | 0.1595 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1327 | 0.3214 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0254 | 0.0019 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0254 | 0.0019 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0254 | 0.0019 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1305 | 0.3147 | 0.9792 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (ADMET) | = 22 % | Transactivation of glucocorticoid receptor in human HepG2 cells assessed as induction of TAT measuring degradation of tyrosine to p-hydroxy phenyl pyruvate at 1 uM relative to untreated control | ChEMBL. | 22197391 |
Efficacy (ADMET) | = 32 % | Transactivation of glucocorticoid receptor in rat H42E cells assessed as induction of TAT measuring degradation of tyrosine to p-hydroxy phenyl pyruvate at 1 uM relative to prednisolone | ChEMBL. | 22197391 |
Efficacy (binding) | = 98 % | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-8 production at 1 uM relative to prednisolone | ChEMBL. | 22197391 |
IC50 (binding) | = 13.5 nM | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-8 production | ChEMBL. | 22197391 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.