Detailed information for compound 1589689

Basic information

Technical information
  • TDR Targets ID: 1589689
  • Name: 6-(4-methoxyphenyl)-2-oxo-4-phenyl-1-[3,4,5-t rihydroxy-6-(hydroxymethyl)oxan-2-yl]pyridine -3-carbonitrile
  • MW: 464.467 | Formula: C25H24N2O7
  • H donors: 4 H acceptors: 6 LogP: 0.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C(C1O)O)O)n1c(cc(c(c1=O)C#N)c1ccccc1)c1ccc(cc1)OC
  • InChi: 1S/C25H24N2O7/c1-33-16-9-7-15(8-10-16)19-11-17(14-5-3-2-4-6-14)18(12-26)24(32)27(19)25-23(31)22(30)21(29)20(13-28)34-25/h2-11,20-23,25,28-31H,13H2,1H3
  • InChiKey: GXKMWJJALPVOEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-methoxyphenyl)-2-oxo-4-phenyl-1-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]pyridine-3-carbonitrile
  • 6-(4-methoxyphenyl)-2-oxo-4-phenyl-1-[3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]-3-pyridinecarbonitrile
  • 2-keto-6-(4-methoxyphenyl)-4-phenyl-1-(3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl)nicotinonitrile
  • NCI60_013401

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.164 0.1826
Plasmodium falciparum plasmepsin V 0.0137 0.8967 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0538 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0538 0.1561
Loa Loa (eye worm) cysteine protease 0.0026 0.0538 0.0603
Brugia malayi calpain 5 0.0028 0.0706 0.0792
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0538 0.1512
Loa Loa (eye worm) trypsin family protein 0.0019 0.0013 0.0015
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0538 0.0274
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0015
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0538 0.0538
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0064 0.3447 0.3863
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0015
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0048 0.2215 0.5764
Schistosoma mansoni cathepsin D (A01 family) 0.0151 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.1802
Echinococcus multilocularis calpain 5 0.004 0.1608 0.1789
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0538 0.0274
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Plasmodium falciparum plasmepsin II 0.0059 0.3032 0.3151
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.164 0.1838
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0013 0.0013
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0064 0.3447 0.3853
Entamoeba histolytica DNA repair and recombination protein, putative 0.0064 0.3447 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0538 0.0603
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.2215 0.6425
Loa Loa (eye worm) calpain 0.004 0.1608 0.1802
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0538 0.1561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Loa Loa (eye worm) ctsf protein 0.0026 0.0538 0.0603
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0538 0.0589
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.2215 0.2215
Echinococcus multilocularis calpain 0.004 0.1608 0.1789
Plasmodium falciparum plasmepsin VI 0.0059 0.3032 0.3151
Onchocerca volvulus 0.0019 0.0013 0.0037
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0538 0.0603
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.8923 0.8923
Echinococcus granulosus cathepsin b 0.0137 0.8923 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0026 0.0538 0.0603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0015
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0064 0.3447 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.164 0.1838
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0019 0.0013 0.0015
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0064 0.3447 0.3863
Brugia malayi Cathepsin L-like precursor 0.0026 0.0538 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Loa Loa (eye worm) aspartyl protease 6 0.0022 0.0301 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0538 0.0603
Brugia malayi hypothetical protein 0.0022 0.0301 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Trypanosoma cruzi calpain cysteine peptidase, putative 0.004 0.1608 0.1802
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0015
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0019 0.0013 0.0015
Brugia malayi hypothetical protein 0.0019 0.0013 0.0015
Leishmania major kinesin, putative 0.0028 0.0706 0.0579
Loa Loa (eye worm) hypothetical protein 0.0059 0.3032 0.3398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Trypanosoma brucei antigen, putative 0.004 0.1608 0.3677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Brugia malayi aspartic protease BmAsp-1, identical 0.0022 0.0301 0.0337
Toxoplasma gondii aspartyl protease ASP1 0.0059 0.3032 0.3915
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.3677
Onchocerca volvulus 0.0026 0.0538 0.1512
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0064 0.3447 1
Plasmodium falciparum plasmepsin I 0.0059 0.3032 0.3151
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.3032 0.3032
Echinococcus granulosus enteropeptidase 0.0019 0.0013 0.0015
Brugia malayi Cathepsin L-like precursor 0.0026 0.0538 0.0603
Brugia malayi Trypsin family protein 0.0019 0.0013 0.0015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.3447 1
Echinococcus multilocularis calpain A 0.0113 0.7173 0.8036
Entamoeba histolytica hypothetical protein, conserved 0.0064 0.3447 1
Echinococcus granulosus calpain 5 0.004 0.1608 0.1802
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0013
Onchocerca volvulus 0.0019 0.0013 0.0037
Brugia malayi Pepsin A precursor 0.0022 0.0301 0.0337
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0538 0.0589
Trypanosoma brucei calpain-like protein, putative 0.004 0.1608 0.3677
Schistosoma mansoni hypothetical protein 0.004 0.164 0.164
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0538 0.0603
Schistosoma mansoni calpain C (C02 family) 0.004 0.1608 0.1608
Trypanosoma brucei calpain-like protein, putative 0.004 0.1608 0.3677
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0538 0.1561
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0013 0.0013
Echinococcus multilocularis caspase 2 0.0057 0.2942 0.3287
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Onchocerca volvulus 0.0026 0.0538 0.1512
Plasmodium vivax aspartyl proteinase, putative 0.0059 0.3032 0.3151
Echinococcus multilocularis calpain 7 (C02 family) 0.004 0.1608 0.1789
Trypanosoma cruzi kinesin, putative 0.0028 0.0706 0.0792
Brugia malayi Cell death protein 3 precursor 0.0057 0.2942 0.3297
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0113 0.7156 0.8017
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0538 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Brugia malayi calpain family protein 1 0.0105 0.6556 0.7348
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0538 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0538 0.0603
Giardia lamblia Rrm3p helicase 0.0064 0.3447 1
Onchocerca volvulus 0.0026 0.0538 0.1512
Brugia malayi Cathepsin L-like precursor 0.0026 0.0538 0.0603
Onchocerca volvulus 0.0022 0.0301 0.0846
Echinococcus granulosus calpain 7 C02 family 0.004 0.1608 0.1802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Echinococcus granulosus glycoprotein Antigen 5 0.0019 0.0013 0.0015
Onchocerca volvulus 0.0019 0.0013 0.0037
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0064 0.3447 1
Onchocerca volvulus 0.0026 0.0538 0.1512
Onchocerca volvulus 0.0026 0.0538 0.1512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Brugia malayi Cathepsin L-like precursor 0.0026 0.0538 0.0603
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Brugia malayi hypothetical protein 0.004 0.164 0.1838
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0538 0.1561
Brugia malayi hypothetical protein 0.0022 0.0301 0.0337
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0059 0.3032 0.3388
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0059 0.3032 0.3398
Loa Loa (eye worm) hypothetical protein 0.0105 0.6556 0.7348
Echinococcus multilocularis hypothetical protein 0.004 0.1608 0.1789
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0538 0.0603
Schistosoma mansoni Mername-AA248 (C02 family) 0.004 0.1608 0.1608
Onchocerca volvulus 0.0026 0.0538 0.1512
Loa Loa (eye worm) hypothetical protein 0.0078 0.446 0.4998
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0137 0.8923 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0013 0.0013
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0538 0.0589
Brugia malayi calpain 7 0.004 0.1608 0.1802
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0113 0.7156 0.802
Plasmodium falciparum plasmepsin IV 0.0059 0.3032 0.3151
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0538 0.1512
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Echinococcus granulosus caspase 2 0.0057 0.2942 0.3297
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0048 0.2215 0.2482
Onchocerca volvulus 0.0026 0.0538 0.1512
Entamoeba histolytica calpain large subunit domain III containing protein 0.0028 0.0706 0.205
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0059 0.3032 0.3398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Brugia malayi Trypsin family protein 0.0019 0.0013 0.0015
Echinococcus granulosus cathepsin b 0.0137 0.8923 1
Brugia malayi Trypsin family protein 0.0019 0.0013 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.3677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0064 0.3447 0.3863
Loa Loa (eye worm) calpain family protein 1 0.0078 0.446 0.4998
Trypanosoma cruzi kinesin, putative 0.0028 0.0706 0.0792
Loa Loa (eye worm) hypothetical protein 0.0093 0.5655 0.6338
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0013 0.0013
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.1608 0.1608
Toxoplasma gondii cathepsin B 0.0048 0.2215 0.2743
Schistosoma mansoni calpain (C02 family) 0.004 0.1608 0.1608
Echinococcus granulosus calpain 0.004 0.1608 0.1802
Brugia malayi cathepsin B-like cysteine proteinase 0.0137 0.8923 1
Plasmodium vivax vivapain-2 0.0026 0.0538 0.0274
Echinococcus multilocularis cysteine protease 0.0026 0.0538 0.0589
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.1802
Brugia malayi Trypsin-like protease protein 5 0.0019 0.0013 0.0015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0026 0.0538 0.0603
Plasmodium vivax calpain, putative 0.004 0.1608 0.1508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Plasmodium vivax plasmepsin V, putative 0.0137 0.8967 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0538 0.0274
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.1608 0.1802
Trypanosoma brucei calpain-like protein, putative 0.004 0.1608 0.3677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Loa Loa (eye worm) hypothetical protein 0.0057 0.2942 0.3297
Mycobacterium ulcerans hypothetical protein 0.0019 0.0013 0.5
Echinococcus multilocularis cathepsin b 0.0137 0.8923 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0064 0.3447 1
Loa Loa (eye worm) fibroinase 0.0026 0.0538 0.0603
Onchocerca volvulus 0.0022 0.0301 0.0846
Loa Loa (eye worm) hypothetical protein 0.0066 0.3559 0.3988
Echinococcus multilocularis cathepsin b 0.0137 0.8923 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Brugia malayi calpain family protein 1 0.0105 0.6556 0.7348
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0013
Onchocerca volvulus 0.0066 0.3559 1
Plasmodium vivax plasmepsin IV, putative 0.0059 0.3032 0.3151
Loa Loa (eye worm) hypothetical protein 0.0137 0.8923 1
Onchocerca volvulus 0.004 0.164 0.4609
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.004 0.1608 0.3677
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0538 0.0603
Loa Loa (eye worm) hypothetical protein 0.0022 0.0301 0.0337
Echinococcus multilocularis cysteine protease 0.0026 0.0538 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0137 0.8923 0.8923
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.1802
Loa Loa (eye worm) hypothetical protein 0.0022 0.0301 0.0337
Entamoeba histolytica protein kinase, putative 0.0028 0.0706 0.205
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.3677
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.1608 0.1802
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.1608 0.1802
Echinococcus granulosus calpain A 0.004 0.1608 0.1802
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0019 0.0013 0.0013
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.3677
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0538 0.0538
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0022 0.0301 0.0337
Loa Loa (eye worm) hypothetical protein 0.0026 0.0538 0.0603
Brugia malayi Trypsin family protein 0.0019 0.0013 0.0015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.7156 0.7156
Brugia malayi Eukaryotic aspartyl protease family protein 0.0022 0.0301 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Echinococcus granulosus Mastin 0.0019 0.0013 0.0015
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.2942 0.2942
Brugia malayi aspartic protease BmAsp-2, identical 0.0022 0.0301 0.0337
Echinococcus granulosus calpain A 0.0113 0.7173 0.8039
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.1608 0.1802
Trypanosoma brucei cysteine peptidase C (CPC) 0.0048 0.2215 0.5764
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.1608 0.1802
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0105 0.6556 0.6556
Echinococcus multilocularis calpain family protein 1, d 0.0078 0.446 0.4991
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0538 0.0589
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0538 0.1561
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0019 0.0013 0.0015
Loa Loa (eye worm) cathepsin B 0.0048 0.2215 0.2482
Onchocerca volvulus 0.0019 0.0013 0.0037
Onchocerca volvulus 0.0019 0.0013 0.0037
Schistosoma mansoni hypothetical protein 0.0064 0.3447 0.3447
Plasmodium vivax vivapain-2 0.0026 0.0538 0.0274
Entamoeba histolytica cysteine protease, putative 0.0026 0.0538 0.1561
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0059 0.3032 0.3915
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0538 0.1512
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0013 0.0013
Echinococcus granulosus transmembrane protease serine 3 0.0019 0.0013 0.0015
Onchocerca volvulus 0.0019 0.0013 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.1608 0.1802
Loa Loa (eye worm) calpain family protein 1 0.0105 0.6556 0.7348
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0301 0.0301
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0064 0.3447 0.3863
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.2942 0.8265
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.7156 0.7156
Toxoplasma gondii cathepsin CPL 0.0026 0.0538 0.034
Echinococcus granulosus cathepsin l1 0.0026 0.0538 0.0603
Loa Loa (eye worm) calpain 5 0.0028 0.0706 0.0792
Trypanosoma brucei kinesin, putative 0.0028 0.0706 0.0579
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0059 0.3032 0.8797
Toxoplasma gondii aspartyl protease ASP5 0.0115 0.7276 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0022 0.0301 0.0301
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.8923 0.8923
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0013 0.0013
Trypanosoma brucei calpain-like protein, putative 0.004 0.1608 0.3677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0538 0.1561
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.1608 0.1608
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.8923 0.8923

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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