Detailed information for compound 1589795

Basic information

Technical information
  • TDR Targets ID: 1589795
  • Name: N-[(3-ethyl-5-methyl-4-oxo-1,3-thiazolidin-2- ylidene)amino]-2-(3-ethyl-4-oxoquinazolin-2-y l)sulfanylacetamide
  • MW: 419.521 | Formula: C18H21N5O3S2
  • H donors: 1 H acceptors: 3 LogP: 2.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1/C(=N/NC(=O)CSc2nc3ccccc3c(=O)n2CC)/SC(C1=O)C
  • InChi: 1S/C18H21N5O3S2/c1-4-22-15(25)11(3)28-18(22)21-20-14(24)10-27-17-19-13-9-7-6-8-12(13)16(26)23(17)5-2/h6-9,11H,4-5,10H2,1-3H3,(H,20,24)/b21-18-
  • InChiKey: AVRQOBSJGKPFJG-UZYVYHOESA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(3-ethyl-5-methyl-4-oxo-thiazolidin-2-ylidene)amino]-2-(3-ethyl-4-oxo-quinazolin-2-yl)sulfanyl-acetamide
  • N-[(3-ethyl-5-methyl-4-oxo-2-thiazolidinylidene)amino]-2-[(3-ethyl-4-oxo-2-quinazolinyl)thio]acetamide
  • N-[(3-ethyl-4-keto-5-methyl-thiazolidin-2-ylidene)amino]-2-[(3-ethyl-4-keto-quinazolin-2-yl)thio]acetamide
  • N-[(3-ethyl-5-methyl-4-oxo-1,3-thiazolidin-2-ylidene)amino]-2-(3-ethyl-4-oxo-quinazolin-2-yl)sulfanyl-ethanamide
  • AIDS-027065
  • AIDS027065
  • NSC691529
  • NCI60_032841
  • N'-[(2Z)-3,5-Dimethyl-4-oxo-1,3-thiazolidin-2-ylidene]-2-[(3-ethyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio]acetohydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0141 0.3932 0.7008
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0194 0.5581 1
Onchocerca volvulus Huntingtin homolog 0.0141 0.3932 0.6817
Onchocerca volvulus 0.0194 0.5581 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0186 0.0237
Echinococcus granulosus biogenic amine 5HT receptor 0.0194 0.5581 1
Echinococcus multilocularis fmrfamide receptor 0.0194 0.5581 1
Schistosoma mansoni histamine h1 receptor 0.0194 0.5581 1
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0107 0.2886 0.5171
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0194 0.5581 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.1655 0.2943
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.04 0.0552
Brugia malayi jmjC domain containing protein 0.0018 0.0113 0.008
Brugia malayi follicle stimulating hormone receptor 0.0194 0.5581 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0194 0.5581 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0194 0.5581 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.04 0.1035
Brugia malayi hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0194 0.5581 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.04 0.0552
Schistosoma mansoni neuropeptide F-like receptor 0.0194 0.5581 1
Schistosoma mansoni myosin xvIII 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Schistosoma mansoni amine GPCR 0.0194 0.5581 1
Echinococcus multilocularis musashi 0.0031 0.0516 0.0897
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.04 0.0479
Echinococcus multilocularis dro:myosuppressin receptor 0.0194 0.5581 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.04 0.0479
Schistosoma mansoni jumonji domain containing protein 0.0067 0.1655 0.282
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.04 0.0479
Echinococcus granulosus tm gpcr rhodopsin 0.0194 0.5581 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.5581 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0194 0.5581 1
Echinococcus granulosus neuropeptide receptor 0.0194 0.5581 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0194 0.5581 1
Echinococcus granulosus intermediate filament protein 0.0031 0.0516 0.0897
Brugia malayi jmjC domain containing protein 0.0018 0.0113 0.008
Onchocerca volvulus 0.0194 0.5581 1
Echinococcus multilocularis fmrfamide receptor 0.0194 0.5581 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.1655 0.2943
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.5581 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.04 0.0479
Loa Loa (eye worm) hypothetical protein 0.002 0.0186 0.0333
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0194 0.5581 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.1188 0.2128
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0194 0.5581 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1188 0.2103
Echinococcus multilocularis muscleblind protein 1 0.0171 0.4892 0.8762
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1188 0.1965
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.04 0.0479
Brugia malayi jmjC domain containing protein 0.0018 0.0113 0.008
Schistosoma mansoni amine GPCR 0.0194 0.5581 1
Brugia malayi AKH receptor 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Echinococcus multilocularis g protein coupled receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus neuropeptide s receptor 0.0194 0.5581 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0113 0.0172
Loa Loa (eye worm) G-protein coupled receptor 0.0194 0.5581 1
Brugia malayi Serotonin receptor 0.0194 0.5581 1
Echinococcus granulosus tm gpcr rhodopsin 0.0194 0.5581 1
Schistosoma mansoni lamin 0.0031 0.0516 0.0738
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.5581 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1188 0.2103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0194 0.5581 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0107 0.2886 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.007 0.1729 0.3453
Echinococcus multilocularis lamin dm0 0.0031 0.0516 0.0897
Mycobacterium ulcerans hypothetical protein 0.0027 0.04 0.0479
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0107 0.2886 0.5156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi Dopamine receptor protein 1 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0516 0.0925
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.007 0.1729 0.5266
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.1655 0.282
Loa Loa (eye worm) hypothetical protein 0.003 0.0499 0.0894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0113 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0027 0.04 0.0601
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0194 0.5581 1
Echinococcus granulosus serotonin receptor 0.0194 0.5581 1
Echinococcus granulosus muscleblind protein 0.0171 0.4892 0.8762
Schistosoma mansoni adenoreceptor 0.0194 0.5581 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0516 0.0738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.1655 0.282
Echinococcus granulosus g protein coupled receptor 0.0194 0.5581 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0113 0.0172
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni biogenic amine receptor 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0186 0.0333
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi jmjC domain containing protein 0.0067 0.1655 0.2877
Brugia malayi AMP-binding enzyme family protein 0.0027 0.04 0.0601
Echinococcus granulosus peptide allatostatin:somatostatin 0.0194 0.5581 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0186 0.0237
Echinococcus granulosus phd:f box containing protein 0.0018 0.0113 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0194 0.5581 1
Brugia malayi sulfakinin receptor protein 0.0194 0.5581 1
Brugia malayi larval opioid receptor 0.0194 0.5581 1
Echinococcus multilocularis g-protein coupled receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0194 0.5581 1
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0117 0.3183 1
Echinococcus granulosus somatostatin receptor 0.0194 0.5581 1
Echinococcus granulosus neuropeptide Y receptor 0.0194 0.5581 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Brugia malayi putative neuropeptide receptor 0.0194 0.5581 1
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0113 0.0172
Onchocerca volvulus 0.0194 0.5581 1
Echinococcus multilocularis allatostatin A receptor 0.0194 0.5581 1
Brugia malayi intermediate filament protein 0.0031 0.0516 0.0812
Brugia malayi Serotonin receptor 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Schistosoma mansoni biogenic amine receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.3932 0.7045
Echinococcus multilocularis sex peptide receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0186 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.04 0.1035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0194 0.5581 1
Echinococcus multilocularis somatostatin receptor 0.0194 0.5581 1
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0516 0.0925
Brugia malayi Tachykinin-like peptides receptor 99D 0.0194 0.5581 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1188 0.1965
Schistosoma mansoni hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1655 0.2965
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0107 0.2886 0.604
Echinococcus multilocularis g protein coupled receptor 0.0194 0.5581 1
Brugia malayi MH2 domain containing protein 0.0137 0.382 0.6805
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Echinococcus multilocularis neuropeptide receptor A26 0.0194 0.5581 1
Echinococcus granulosus neuropeptide Y receptor 0.0194 0.5581 1
Echinococcus granulosus neuropeptides capa receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0186 0.0333
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0186 0.0077
Echinococcus granulosus g protein coupled receptor 0.0194 0.5581 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0194 0.5581 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0113 0.0203
Loa Loa (eye worm) hypothetical protein 0.0171 0.4892 0.8766
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0164 0.4656 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0335 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0194 0.5581 1
Brugia malayi ORL1-like opioid receptor 0.0194 0.5581 1
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0107 0.2886 0.5156
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0194 0.5581 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0194 0.5581 1
Schistosoma mansoni neuropeptide receptor 0.0194 0.5581 1
Echinococcus multilocularis serotonin receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi G-protein coupled receptor 0.0194 0.5581 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0194 0.5581 1
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0113 0.0172
Echinococcus granulosus lamin 0.0031 0.0516 0.0897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) neuropeptide F receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0194 0.5581 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0194 0.5581 1
Echinococcus granulosus lamin dm0 0.0031 0.0516 0.0897
Onchocerca volvulus Neuropeptide F receptor homolog 0.0194 0.5581 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0164 0.4656 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.04 0.0601
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0194 0.5581 1
Onchocerca volvulus Huntingtin homolog 0.0141 0.3932 0.6817
Loa Loa (eye worm) hypothetical protein 0.0171 0.4892 0.8766
Echinococcus multilocularis neuropeptide FF receptor 2 0.0194 0.5581 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.5581 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.04 0.1035
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.1655 0.2943
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0194 0.5581 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Echinococcus multilocularis neuropeptides capa receptor 0.0194 0.5581 1
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0034 0.0625 0.1846
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0117 0.3183 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0194 0.5581 1
Echinococcus multilocularis neuropeptide receptor 0.0194 0.5581 1
Schistosoma mansoni neuropeptide receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni neuropeptide receptor 0.0194 0.5581 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.5581 1
Brugia malayi Melatonin receptor type 1A 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Treponema pallidum fructose-bisphosphate aldolase 0.0335 1 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1188 0.1965
Schistosoma mansoni neuropeptide receptor 0.0194 0.5581 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1188 0.2103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Brugia malayi neuropeptide F receptor 0.0194 0.5581 1
Echinococcus granulosus G protein coupled receptor 139 0.0194 0.5581 1
Schistosoma mansoni opsin-like receptor 0.0194 0.5581 1
Echinococcus multilocularis serotonin receptor 0.0194 0.5581 1
Echinococcus granulosus neuropeptide receptor 0.0194 0.5581 1
Brugia malayi GnHR receptor homolog 0.0194 0.5581 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1188 0.2103
Onchocerca volvulus 0.0194 0.5581 1
Schistosoma mansoni neuropeptide F-like receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0107 0.2886 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0194 0.5581 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0107 0.2886 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Echinococcus granulosus sex peptide receptor 0.0194 0.5581 1
Onchocerca volvulus 0.0031 0.0516 0.0225
Onchocerca volvulus 0.0194 0.5581 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Brugia malayi Dopamine receptor 0.0194 0.5581 1
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0113 0.0172
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0037 0.0709 0.1238
Echinococcus granulosus 7tm_1 domain containing protein 0.0194 0.5581 1
Echinococcus multilocularis neuropeptide s receptor 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0107 0.2886 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni amine GPCR 0.0194 0.5581 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.382 0.6845
Loa Loa (eye worm) hypothetical protein 0.0027 0.04 0.0717
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0194 0.5581 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.1655 0.2943
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi glucose-6-phosphate dehydrogenase 0.0107 0.2886 0.5111
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0113 0.0172
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.5581 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.1188 0.203
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0194 0.5581 1
Echinococcus granulosus fmrfamide receptor 0.0194 0.5581 1
Brugia malayi hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0113 0.0172
Schistosoma mansoni biogenic amine receptor 0.0194 0.5581 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0194 0.5581 1
Echinococcus multilocularis neuropeptide Y receptor 0.0194 0.5581 1
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0516 0.0812
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0194 0.5581 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0194 0.5581 1
Echinococcus granulosus orexin receptor type 2 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0032
Brugia malayi neuropeptide F receptor 0.0194 0.5581 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0194 0.5581 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0194 0.5581 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.04 0.0717
Brugia malayi hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) neuropeptide F receptor 0.0194 0.5581 1
Brugia malayi Muscleblind-like protein 0.0171 0.4892 0.8751
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.04 0.0479
Brugia malayi G protein-coupled receptor F59B2.13 0.0194 0.5581 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0194 0.5581 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.04 0.0479
Loa Loa (eye worm) hypothetical protein 0.0027 0.04 0.0717
Echinococcus granulosus g protein coupled receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Brugia malayi putative neuropeptide receptor NPR1 0.0194 0.5581 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0113 0.0172
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0194 0.5581 1
Echinococcus granulosus g-protein coupled receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0113 0.0203
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Echinococcus multilocularis neuropeptide receptor 0.0194 0.5581 1
Brugia malayi G-protein coupled receptor 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0194 0.5581 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0194 0.5581 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0164 0.4656 1
Echinococcus multilocularis muscleblind protein 0.0171 0.4892 0.8762
Echinococcus granulosus allatostatin A receptor 0.0194 0.5581 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0194 0.5581 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0069 0.0123
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0516 0.0925
Brugia malayi Dopamine receptor protein 2 0.0194 0.5581 1
Echinococcus granulosus tm gpcr rhodopsin 0.0194 0.5581 1
Echinococcus multilocularis neuropeptides capa receptor 0.0194 0.5581 1
Schistosoma mansoni hypothetical protein 0.0194 0.5581 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0117 0.3183 1
Schistosoma mansoni amine GPCR 0.0194 0.5581 1
Echinococcus multilocularis G protein coupled receptor 139 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0113 0.0203
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0194 0.5581 1
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0107 0.2886 0.5071
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0194 0.5581 1
Echinococcus multilocularis neuropeptide Y receptor 0.0194 0.5581 1
Schistosoma mansoni lamin 0.0031 0.0516 0.0738
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0194 0.5581 1
Onchocerca volvulus 0.0194 0.5581 1
Brugia malayi G protein-coupled receptor 0.0194 0.5581 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0194 0.5581 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0194 0.5581 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0113 0.0203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Echinococcus granulosus neuropeptide receptor A26 0.0194 0.5581 1
Schistosoma mansoni amine GPCR 0.0194 0.5581 1
Brugia malayi jmjC domain containing protein 0.0018 0.0113 0.008
Loa Loa (eye worm) hypothetical protein 0.0141 0.3932 0.7045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0194 0.5581 1
Echinococcus multilocularis lamin 0.0031 0.0516 0.0897
Echinococcus granulosus hypothetical protein 0.0194 0.5581 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0186 0.0333
Onchocerca volvulus 0.0031 0.0516 0.0225
Echinococcus multilocularis G-protein coupled receptor, putative 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.382 0.6845
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0035 0.0657 0.1962
Echinococcus granulosus neuropeptides capa receptor 0.0194 0.5581 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0194 0.5581 1
Schistosoma mansoni opsin-like receptor 0.0194 0.5581 1
Echinococcus multilocularis orexin receptor type 2 0.0194 0.5581 1
Echinococcus multilocularis g protein coupled receptor 0.0194 0.5581 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0194 0.5581 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.5581 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0113 0.0203
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0194 0.5581 1
Brugia malayi RE15519p 0.0194 0.5581 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 1 1
Schistosoma mansoni opsin-like receptor 0.0194 0.5581 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0113 0.0172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0194 0.5581 1
Brugia malayi jmjC domain containing protein 0.0067 0.1655 0.2877

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.137 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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