Detailed information for compound 1589817

Basic information

Technical information
  • TDR Targets ID: 1589817
  • Name: N-[(5-nitro-2-piperidin-1-ylphenyl)methyliden eamino]-2-(9-oxoacridin-10-yl)acetamide
  • MW: 483.519 | Formula: C27H25N5O4
  • H donors: 1 H acceptors: 4 LogP: 4.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1c2ccccc2c(=O)c2c1cccc2)N/N=C/c1cc(ccc1N1CCCCC1)[N+](=O)[O-]
  • InChi: 1S/C27H25N5O4/c33-26(18-31-24-10-4-2-8-21(24)27(34)22-9-3-5-11-25(22)31)29-28-17-19-16-20(32(35)36)12-13-23(19)30-14-6-1-7-15-30/h2-5,8-13,16-17H,1,6-7,14-15,18H2,(H,29,33)/b28-17+
  • InChiKey: CTGBYKAHHPGOAN-OGLMXYFKSA-N  


Substructure search Similarity search

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Synonyms

  • N-[[5-nitro-2-(1-piperidyl)phenyl]methyleneamino]-2-(9-oxoacridin-10-yl)acetamide
  • N-[[5-nitro-2-(1-piperidyl)phenyl]methyleneamino]-2-(9-oxo-10-acridinyl)acetamide
  • 2-(9-ketoacridin-10-yl)-N-[(5-nitro-2-piperidino-benzylidene)amino]acetamide
  • N-[(5-nitro-2-piperidin-1-yl-phenyl)methylideneamino]-2-(9-oxoacridin-10-yl)ethanamide
  • BIM-0043137.P001
  • MLS000571985
  • N'-[5-nitro-2-(1-piperidinyl)benzylidene]-2-(9-oxo-10(9H)-acridinyl)acetohydrazide
  • SMR000194004
  • CBMicro_042982

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldo keto reductase 0.0393 0.524 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0648 0.1169
Echinococcus multilocularis aldo keto reductase 0.0393 0.524 0.524
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0202 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0202 0.031
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0081 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Trichomonas vaginalis aldo/keto reductase, putative 0.0393 0.524 1
Leishmania major cathepsin L-like protease 0.0077 0.0876 0.1607
Mycobacterium tuberculosis Probable reductase 0.0109 0.1318 0.2458
Echinococcus multilocularis aldo keto reductase 0.0393 0.524 0.524
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0091 0.0097
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.0472 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Schistosoma mansoni potassium channel beta 0.0114 0.1384 0.2641
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Leishmania major cysteine peptidase A (CPA) 0.002 0.0091 0.0097
Loa Loa (eye worm) oxidoreductase 0.0393 0.524 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0393 0.524 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0202 0.1201
Echinococcus granulosus voltage gated potassium channel subunit 0.0114 0.1384 0.2641
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0081 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0081 0.0154
Echinococcus multilocularis muscleblind protein 1 0.0319 0.4226 0.4226
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0091 0.0091
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0081 0.0078
Onchocerca volvulus 0.0393 0.524 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0081 0.0078
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0472 0.0758
Schistosoma mansoni DNA polymerase eta 0.002 0.0081 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.003 0.0232 0.0293
Leishmania major hypothetical protein, conserved 0.003 0.0232 0.0369
Echinococcus granulosus hypothetical protein 0.0393 0.524 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0091 0.0097
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0386 0.0737
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.004 0.0077
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0091 0.0019
Brugia malayi NADH-dependent xylose reductase 0.0114 0.1384 0.2584
Trichomonas vaginalis aldo-keto reductase, putative 0.0114 0.1384 0.2584
Onchocerca volvulus 0.0114 0.1384 0.2511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Brugia malayi Cathepsin L-like precursor 0.002 0.0091 0.0097
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Trypanosoma brucei unspecified product 0.002 0.0081 0.0078
Loa Loa (eye worm) oxidoreductase 0.0393 0.524 1
Echinococcus multilocularis muscleblind protein 0.0319 0.4226 0.4226
Plasmodium vivax aldehyde reductase, putative 0.0114 0.1384 1
Echinococcus granulosus dna polymerase eta 0.002 0.0081 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.004 0.0077
Brugia malayi hypothetical protein 0.002 0.0083 0.0082
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0202 0.031
Entamoeba histolytica alcohol dehydrogenase, putative 0.0114 0.1384 0.2525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1199 0.2228
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0078
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1318 0.2216
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0081 0.0078
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0091 0.0019
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0393 0.524 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0081 0.0078
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0091 0.0173
Leishmania major cathepsin L-like protease 0.002 0.0091 0.0097
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0091 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0393 0.524 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0114 0.1384 0.2584
Loa Loa (eye worm) cysteine protease 0.002 0.0091 0.0019
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0114 0.1384 0.2584
Trichomonas vaginalis aldo/keto reductase, putative 0.0393 0.524 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0202 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1199 0.2288
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Loa Loa (eye worm) hypothetical protein 0.0393 0.524 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0081 0.0078
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0091 0.0173
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0081 0.0078
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Mycobacterium leprae Conserved hypothetical protein 0.0279 0.3667 0.6879
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0202 0.031
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Onchocerca volvulus 0.0393 0.524 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0232 0.0369
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0876 0.1607
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0202 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0078
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Plasmodium falciparum aldo-keto reductase, putative 0.0114 0.1384 1
Echinococcus multilocularis cysteine protease 0.002 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1384 0.2584
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1199 0.2288
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0114 0.1384 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0081 0.0081
Trichomonas vaginalis aldo-keto reductase, putative 0.0114 0.1384 0.2584
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Brugia malayi Muscleblind-like protein 0.0319 0.4226 0.8051
Echinococcus multilocularis voltage gated potassium channel subunit 0.0114 0.1384 0.1384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Trypanosoma cruzi aldo-keto reductase 0.0393 0.524 1
Onchocerca volvulus 0.0393 0.524 1
Echinococcus multilocularis aldo keto reductase 0.0393 0.524 0.524
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0472 0.3213
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1486 0.2781
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0393 0.524 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Loa Loa (eye worm) oxidoreductase 0.0393 0.524 1
Leishmania major cathepsin L-like protease 0.002 0.0091 0.0097
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0081 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Giardia lamblia Aldose reductase 0.0393 0.524 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Onchocerca volvulus 0.0182 0.2333 0.4355
Entamoeba histolytica aldose reductase, putative 0.0393 0.524 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0202 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Toxoplasma gondii cathepsin CPL 0.002 0.0091 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0386 0.0737
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0091 0.0019
Leishmania major cathepsin L-like protease 0.0077 0.0876 0.1607
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0232 0.1427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0114 0.1384 0.2584
Entamoeba histolytica alcohol dehydrogenase, putative 0.0114 0.1384 0.2525
Loa Loa (eye worm) ctsf protein 0.002 0.0091 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0091 0.0097
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0393 0.524 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1318 0.2458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Trichomonas vaginalis aldo/keto reductase, putative 0.0393 0.524 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Leishmania major aldo-keto reductase-like protein 0.0393 0.524 1
Trypanosoma brucei prostaglandin f synthase 0.0393 0.524 1
Schistosoma mansoni pol-related 0.0393 0.524 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1318 0.2458
Plasmodium falciparum aldehyde reductase, putative 0.0114 0.1384 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0232 0.1427
Toxoplasma gondii thioredoxin reductase 0.0048 0.0472 0.083
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0091 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0386 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0386 0.0737
Loa Loa (eye worm) hypothetical protein 0.0182 0.2333 0.4366
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0386 0.0665
Loa Loa (eye worm) oxidoreductase 0.0393 0.524 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0472 0.3213
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1318 0.2458
Echinococcus granulosus aldo keto reductase 0.0393 0.524 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0472 0.0901
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0078
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0393 0.524 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0784 0.143
Plasmodium falciparum thioredoxin reductase 0.0048 0.0472 0.3213
Trypanosoma cruzi aldo/keto reductase, putative 0.0393 0.524 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0202 0.031
Schistosoma mansoni aldo-keto reductase 0.0393 0.524 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0393 0.524 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0232 0.0369
Plasmodium vivax vivapain-2 0.002 0.0091 0.0376
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0081 0.0078
Entamoeba histolytica aldose reductase, putative 0.0393 0.524 1
Mycobacterium ulcerans oxidoreductase 0.0393 0.524 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0232 0.0369
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0876 0.1607
Onchocerca volvulus 0.0393 0.524 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0202 0.031
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1486 0.2781
Brugia malayi hypothetical protein 0.0182 0.2333 0.441
Trichomonas vaginalis aldo-keto reductase, putative 0.0114 0.1384 0.2584
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0081 0.0078
Brugia malayi glutathione reductase 0.0048 0.0472 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Mycobacterium leprae Possible oxidoreductase 0.0114 0.1384 0.2346
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0114 0.1384 0.2584
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1318 0.2458
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0091 0.0019
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0232 0.1427
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0091 0.0376
Echinococcus granulosus dna polymerase kappa 0.002 0.0081 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0114 0.1384 0.2641
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0081 0.0154
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0232 0.0369
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1318 0.2458
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1199 0.1199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Brugia malayi Cathepsin L-like precursor 0.002 0.0091 0.0097
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0091 0.0376
Brugia malayi Cathepsin L-like precursor 0.002 0.0091 0.0097
Trypanosoma brucei aldo-keto reductase, putative 0.0393 0.524 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0202 0.1201
Mycobacterium tuberculosis Conserved protein 0.0114 0.1384 0.2584
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Echinococcus granulosus cathepsin l1 0.002 0.0091 0.0173
Leishmania major cathepsin L-like protease 0.002 0.0091 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0081 0.0078
Leishmania major DNA polymerase kappa, putative 0.002 0.0081 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0386 0.0386
Toxoplasma gondii aldose reductase, putative 0.0393 0.524 1
Brugia malayi hypothetical protein 0.003 0.0232 0.0369
Leishmania major cathepsin L-like protease 0.002 0.0091 0.0097
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0114 0.1384 0.2584
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Trypanosoma brucei trypanothione reductase 0.0048 0.0472 0.083
Trypanosoma brucei aldo/keto reductase, putative 0.0114 0.1384 0.2584
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0081 0.0078
Plasmodium falciparum glutathione reductase 0.0048 0.0472 0.3213
Plasmodium vivax vivapain-2 0.002 0.0091 0.0376
Loa Loa (eye worm) hypothetical protein 0.01 0.1199 0.2167
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0091 0.0173
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0393 0.524 1
Loa Loa (eye worm) oxidoreductase 0.0393 0.524 1
Leishmania major trypanothione reductase 0.0048 0.0472 0.083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Echinococcus multilocularis dna polymerase eta 0.002 0.0081 0.0081
Onchocerca volvulus 0.0393 0.524 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Trypanosoma cruzi aldo/keto reductase, putative 0.0114 0.1384 0.2584
Loa Loa (eye worm) fibroinase 0.002 0.0091 0.0019
Loa Loa (eye worm) hypothetical protein 0.0319 0.4226 0.8035
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0081 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0091 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0386 0.0386
Onchocerca volvulus 0.0393 0.524 1
Giardia lamblia Aldose reductase 0.0393 0.524 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0081 0.0154
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0393 0.524 1
Entamoeba histolytica aldose reductase, putative 0.0393 0.524 1
Entamoeba histolytica hypothetical protein 0.0028 0.0202 0.0234
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Brugia malayi Thioredoxin reductase 0.0048 0.0472 0.083
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0091 0.0097
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0876 0.1607
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0091 0.0376
Toxoplasma gondii aldo-keto reductase 0.0114 0.1384 0.2584
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0393 0.524 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0386 0.0737
Onchocerca volvulus 0.01 0.1199 0.2152
Entamoeba histolytica cysteine protease, putative 0.002 0.0091 0.0019
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0472 0.083
Echinococcus granulosus aldehyde reductase 0.0279 0.3667 0.6999
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0081 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0386 0.0737
Leishmania major cathepsin L-like protease 0.0077 0.0876 0.1607
Leishmania major prostaglandin f synthase, putative 0.0393 0.524 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0472 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0081 0.0078
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0472 0.083
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0876 0.1607
Echinococcus multilocularis cysteine protease 0.002 0.0091 0.0091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0393 0.524 0.524
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1486 0.2781
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0393 0.524 1
Leishmania major cathepsin L-like protease 0.002 0.0091 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0876 0.1607
Loa Loa (eye worm) hypothetical protein 0.0319 0.4226 0.8035
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0114 0.1384 0.2525
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0202 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0091 0.0173
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0081 0.0078
Echinococcus granulosus muscleblind protein 0.0319 0.4226 0.8066
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1486 0.255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0091 0.0097
Echinococcus multilocularis aldo keto reductase 0.0393 0.524 0.524
Trichomonas vaginalis aldo-keto reductase, putative 0.0393 0.524 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0091 0.0097
Echinococcus granulosus aldo keto reductase 0.0393 0.524 1
Leishmania major DNA polymerase eta, putative 0.002 0.0081 0.0078
Echinococcus multilocularis aldehyde reductase 0.0279 0.3667 0.3667
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0081 0.0078
Mycobacterium ulcerans hypothetical protein 0.0114 0.1384 0.2584
Schistosoma mansoni aldo-keto reductase 0.0393 0.524 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0091 0.0097
Mycobacterium tuberculosis Probable oxidoreductase 0.0393 0.524 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0091 0.0097

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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