TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 413.425 | Formula: C24H19N3O4
H donors: 4 H acceptors: 4 LogP: 4.34 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(c1ccccc1)NC(=O)c1ccccc1NC(=O)c1cc2c([nH]1)cccc2
InChi: 1S/C24H19N3O4/c28-22(27-21(24(30)31)15-8-2-1-3-9-15)17-11-5-7-13-19(17)26-23(29)20-14-16-10-4-6-12-18(16)25-20/h1-14,21,25H,(H,26,29)(H,27,28)(H,30,31)
InChiKey: DPICGIFVBZZLMH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Cholecystokinin A receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132882	All targets in OG5_132882
Brugia malayi	sulfakinin receptor protein	Get druggable targets OG5_132882	All targets in OG5_132882
Brugia malayi	hypothetical protein	Get druggable targets OG5_132882	All targets in OG5_132882

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	rhodopsin orphan GPCR	Cholecystokinin A receptor	444 aa	363 aa	19.6 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Cholecystokinin A receptor	444 aa	383 aa	21.7 %
Echinococcus multilocularis	neuropeptides capa receptor	Cholecystokinin A receptor	444 aa	400 aa	21.0 %
Echinococcus multilocularis	g protein coupled receptor	Cholecystokinin A receptor	444 aa	396 aa	23.2 %
Echinococcus granulosus	g protein coupled receptor	Cholecystokinin A receptor	444 aa	396 aa	23.5 %
Echinococcus multilocularis	orexin receptor type 2	Cholecystokinin A receptor	444 aa	362 aa	22.4 %
Onchocerca volvulus		Cholecystokinin A receptor	444 aa	385 aa	28.6 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Cholecystokinin A receptor	444 aa	379 aa	24.8 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Cholecystokinin A receptor	444 aa	374 aa	24.6 %
Echinococcus granulosus	orexin receptor type 2	Cholecystokinin A receptor	444 aa	366 aa	23.5 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Cholecystokinin A receptor	444 aa	364 aa	28.6 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Cholecystokinin A receptor	444 aa	395 aa	24.6 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Cholecystokinin A receptor	444 aa	362 aa	28.2 %
Echinococcus multilocularis	g protein coupled receptor	Cholecystokinin A receptor	444 aa	403 aa	24.1 %
Echinococcus multilocularis	serotonin receptor	Cholecystokinin A receptor	444 aa	468 aa	22.4 %
Echinococcus granulosus	g protein coupled receptor	Cholecystokinin A receptor	444 aa	399 aa	23.3 %
Schistosoma mansoni	amine GPCR	Cholecystokinin A receptor	444 aa	412 aa	26.2 %
Schistosoma japonicum	FMRFamide receptor, putative	Cholecystokinin A receptor	444 aa	363 aa	21.2 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Cholecystokinin A receptor	444 aa	380 aa	24.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0105	0.3925	0.4478
Schistosoma mansoni	ATP-binding cassette transporter	0.0017	0.0436	0.1088
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0017	0.0436	0.1088
Schistosoma mansoni	Smad4	0.0007	0.0035	0.0063
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0007	0.0035	0.0063
Brugia malayi	Glutamate receptor 2 precursor	0.0017	0.0436	0.0402
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.1306	0.331
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.003	0.0966	0.0935
Echinococcus multilocularis	cpg binding protein	0.0028	0.088	0.2222
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0052	0.1804	0.3232
Trichomonas vaginalis	aldo-keto reductase, putative	0.003	0.0966	0.1241
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.003	0.0966	0.0557
Onchocerca volvulus		0.0027	0.0819	0.0039
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0058	0.2044	0.5197
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.006	0.0128
Loa Loa (eye worm)	oxidoreductase	0.0105	0.3925	0.3904
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.1306	0.331
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.002	0.0564	0.1415
Plasmodium falciparum	aldehyde reductase, putative	0.003	0.0966	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.006	0.0128
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0105	0.3925	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0105	0.3925	1
Echinococcus multilocularis	smad	0.0007	0.0035	0.0063
Onchocerca volvulus		0.0105	0.3925	0.4478
Schistosoma mansoni	potassium channel beta	0.003	0.0966	0.2443
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Schistosoma mansoni	glutamate receptor kainate	0.0017	0.0436	0.1088
Echinococcus granulosus	histone lysine methyltransferase setb	0.0026	0.0792	0.1997
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0125	0.009
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Echinococcus multilocularis	glutamate receptor 2	0.0017	0.0436	0.1088
Toxoplasma gondii	aldose reductase, putative	0.0105	0.3925	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Loa Loa (eye worm)	oxidoreductase	0.0105	0.3925	0.3904
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0007	0.0035	0.0063
Schistosoma mansoni	glutamate receptor NMDA	0.0087	0.322	0.82
Echinococcus multilocularis	voltage gated potassium channel subunit	0.003	0.0966	0.2443
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.003	0.0966	0.0935
Schistosoma mansoni	smad1 5 8 and	0.0007	0.0035	0.0063
Echinococcus multilocularis	glutamate receptor NMDA	0.0067	0.2416	0.6146
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Giardia lamblia	Aldose reductase	0.0105	0.3925	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.003	0.0966	0.1241
Trichomonas vaginalis	aldo/keto reductase, putative	0.0105	0.3925	0.504
Echinococcus multilocularis	aldo keto reductase	0.0105	0.3925	1
Loa Loa (eye worm)	hypothetical protein	0.0258	1	1
Onchocerca volvulus		0.0105	0.3925	0.4478
Plasmodium falciparum	aldo-keto reductase, putative	0.003	0.0966	0.5
Echinococcus granulosus	aldo keto reductase	0.0105	0.3925	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0105	0.3925	0.3904
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Onchocerca volvulus		0.0105	0.3925	0.4478
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0105	0.3925	0.3904
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Loa Loa (eye worm)	glutamate receptor 1	0.0017	0.0436	0.0402
Brugia malayi	Glutamate receptor 1 precursor	0.0017	0.0436	0.0402
Echinococcus granulosus	glutamate receptor 2	0.002	0.0564	0.1415
Leishmania major	aldo-keto reductase-like protein	0.0105	0.3925	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.002	0.0564	0.1415
Trichomonas vaginalis	aldo-keto reductase, putative	0.003	0.0966	0.1241
Echinococcus granulosus	nmda type glutamate receptor	0.0073	0.2666	0.6785
Echinococcus multilocularis	nmda type glutamate receptor	0.0073	0.2666	0.6785
Schistosoma mansoni	smad1 5 8 and	0.0007	0.0035	0.0063
Trypanosoma brucei	prostaglandin f synthase	0.0105	0.3925	1
Echinococcus multilocularis	nmda type glutamate receptor	0.007	0.2544	0.6474
Leishmania major	prostaglandin f synthase, putative	0.0105	0.3925	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0026	0.0792	0.1997
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0105	0.3925	0.3904
Echinococcus granulosus	hypothetical protein	0.0105	0.3925	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.1306	0.331
Loa Loa (eye worm)	MH2 domain-containing protein	0.0102	0.3794	0.3773
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0792	0.1997
Loa Loa (eye worm)	transcription factor SMAD2	0.0102	0.3794	0.3773
Brugia malayi	NADH-dependent xylose reductase	0.003	0.0966	0.0935
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0017	0.0436	0.1088
Onchocerca volvulus		0.0203	0.7788	1
Entamoeba histolytica	aldose reductase, putative	0.0105	0.3925	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Schistosoma mansoni	pol-related	0.0105	0.3925	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0792	0.1997
Echinococcus granulosus	aldo keto reductase	0.0105	0.3925	1
Onchocerca volvulus		0.0105	0.3925	0.4478
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0125	0.0293
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0966	0.1241
Brugia malayi	Pre-SET motif family protein	0.0178	0.6816	0.6805
Mycobacterium ulcerans	oxidoreductase	0.0105	0.3925	1
Brugia malayi	MH2 domain containing protein	0.0102	0.3794	0.3773
Echinococcus multilocularis	Smad4	0.0007	0.0035	0.0063
Schistosoma mansoni	glutamate receptor kainate	0.0017	0.0436	0.1088
Schistosoma mansoni	glutamate receptor kainate	0.0017	0.0436	0.1088
Mycobacterium leprae	Conserved hypothetical protein	0.0075	0.2718	0.5922
Entamoeba histolytica	aldose reductase, putative	0.0105	0.3925	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0105	0.3925	0.504
Schistosoma mansoni	cpg binding protein	0.0028	0.088	0.2222
Loa Loa (eye worm)	oxidoreductase	0.0105	0.3925	0.3904
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0125	0.0293
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0105	0.3925	0.504
Loa Loa (eye worm)	oxidoreductase	0.0105	0.3925	0.3904
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.002	0.0564	0.1415
Trichomonas vaginalis	aldo/keto reductase, putative	0.0105	0.3925	0.504
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0039	0.1306	0.1275
Loa Loa (eye worm)	glutamate receptor 2	0.0017	0.0436	0.0402
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.0819	0.0787
Echinococcus granulosus	mothers against decapentaplegic 5	0.0007	0.0035	0.0063
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0039	0.1306	0.1275
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.1306	0.331
Echinococcus granulosus	Smad4	0.0007	0.0035	0.0063
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Trypanosoma cruzi	aldo-keto reductase	0.0105	0.3925	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Echinococcus granulosus	glutamate receptor NMDA	0.0067	0.2416	0.6146
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0105	0.3925	0.3904
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.003	0.0966	0.2443
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.002	0.0564	0.1415
Schistosoma mansoni	cpg binding protein	0.0027	0.0819	0.2068
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.003	0.0966	0.0557
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0026	0.0792	0.1997
Loa Loa (eye worm)	oxidoreductase	0.0105	0.3925	0.3904
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.003	0.0966	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.1306	0.331
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.1306	0.331
Entamoeba histolytica	aldose reductase, putative	0.0105	0.3925	1
Trichomonas vaginalis	set domain proteins, putative	0.0203	0.7788	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0178	0.6816	0.6805
Giardia lamblia	Aldose reductase	0.0105	0.3925	0.5
Echinococcus granulosus	voltage gated potassium channel subunit	0.003	0.0966	0.2443
Echinococcus granulosus	cpg binding protein	0.0028	0.088	0.2222
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0007	0.0035	0.0063
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.006	0.0128
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Onchocerca volvulus		0.003	0.0966	0.0249
Toxoplasma gondii	aldo-keto reductase	0.003	0.0966	0.0557
Schistosoma mansoni	aldo-keto reductase	0.0105	0.3925	1
Brugia malayi	sulfakinin receptor protein	0.0258	1	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.002	0.0564	0.1415
Echinococcus granulosus	aldo keto reductase	0.0105	0.3925	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.002	0.0564	0.1415
Echinococcus multilocularis	aldo keto reductase	0.0105	0.3925	1
Schistosoma mansoni	cpg binding protein	0.0028	0.088	0.2222
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0105	0.3925	0.504
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0792	0.076
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.1306	0.331
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.006	0.0128
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0026	0.0792	0.1997
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Schistosoma mansoni	smad	0.0007	0.0035	0.0063
Trypanosoma cruzi	aldo/keto reductase, putative	0.0105	0.3925	1
Plasmodium vivax	aldehyde reductase, putative	0.003	0.0966	1
Schistosoma mansoni	smad1 5 8 and	0.0007	0.0035	0.0063
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.006	0.0128
Schistosoma mansoni	glutamate receptor NMDA	0.0017	0.0436	0.1088
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Echinococcus multilocularis	aldo keto reductase	0.0105	0.3925	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.3925	0.3904
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Onchocerca volvulus		0.0105	0.3925	0.4478
Echinococcus granulosus	aldehyde reductase	0.0075	0.2718	0.6918
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.002	0.0564	0.1415
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0105	0.3925	1
Brugia malayi	Pre-SET motif family protein	0.0026	0.0792	0.076
Echinococcus granulosus	glutamate receptor 2	0.0014	0.0314	0.0776
Echinococcus granulosus	nmda type glutamate receptor	0.007	0.2544	0.6474
Echinococcus granulosus	smad	0.0007	0.0035	0.0063
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0007	0.0035	0.0063
Brugia malayi	CXXC zinc finger family protein	0.0027	0.0819	0.0787
Schistosoma mansoni	aldo-keto reductase	0.0105	0.3925	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0105	0.3925	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0025	0.0732	0.1843
Schistosoma mansoni	glutamate receptor AMPA	0.0017	0.0436	0.1088
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.002	0.0564	0.1415
Echinococcus multilocularis	aldehyde reductase	0.0075	0.2718	0.6918
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0105	0.3925	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0792	0.1997
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0105	0.3925	0.504
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Trypanosoma brucei	aldo-keto reductase, putative	0.0105	0.3925	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0105	0.3925	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0105	0.3925	0.504
Echinococcus multilocularis	glutamate receptor 2	0.002	0.0564	0.1415
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0121	0.0086
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.003	0.0966	0.1241
Echinococcus multilocularis	glutamate receptor 2	0.0014	0.0314	0.0776
Echinococcus multilocularis	aldo keto reductase	0.0105	0.3925	1
Schistosoma mansoni	glutamate receptor AMPA	0.0017	0.0436	0.1088

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.317 uM	Displacement of [125I]-BH-CCK8 from CCK1 receptor in Sprague-Dawley rat pancreatic acini after 120 hrs by gamma-counting	ChEMBL.	21728335

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1933099

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1589845