TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 434.523 | Formula: C24H34O7
H donors: 1 H acceptors: 4 LogP: 2.76 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)OC[C@]1(C)[C@@H](CC[C@@]2([C@@H]1CCC(=C)[C@H]2C/C=C/1\[C@H](O)COC1=O)C)OC(=O)C
InChi: 1S/C24H34O7/c1-14-6-9-20-23(4,18(14)8-7-17-19(27)12-29-22(17)28)11-10-21(31-16(3)26)24(20,5)13-30-15(2)25/h7,18-21,27H,1,6,8-13H2,2-5H3/b17-7+/t18-,19-,20+,21-,23+,24+/m1/s1
InChiKey: UWKRNYBRHWJSBJ-IZQYNGGQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0249	0.0954	0.0954
Leishmania major	mitotic cyclin, putative	0.006	0.0133	0.0133
Trypanosoma cruzi	cdc2-related kinase 1	0.0829	0.3473	0.3473
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.003	0	0.5
Brugia malayi	Cytochrome P450 family protein	0.0059	0.013	0.013
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.003	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0829	0.3473	0.3473
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.0133	0.0133
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.0133	0.0133
Giardia lamblia	Cyclin fold protein 1, putative	0.006	0.0133	0.0133
Leishmania major	cyclin	0.0598	0.2469	0.2469
Trichomonas vaginalis	cyclins, putative	0.0598	0.2469	0.2469
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.003	0	0.5
Echinococcus multilocularis	cyclin B3 1	0.0249	0.0954	0.0954
Schistosoma mansoni	g1/s-specific cyclin C	0.006	0.0133	0.0133
Entamoeba histolytica	cyclin, domain containing protein	0.006	0.0133	0.0382
Brugia malayi	Egg laying defective protein 4	0.0035	0.0023	0.0023
Onchocerca volvulus	Protein CNPPD1 homolog	0.006	0.0133	0.0537
Trypanosoma cruzi	cdc2-related kinase 3	0.0829	0.3473	0.3473
Echinococcus multilocularis	cyclins	0.0249	0.0954	0.0954
Trichomonas vaginalis	cyclin B3, putative	0.006	0.0133	0.0133
Trypanosoma brucei	cyclin 9	0.006	0.0133	0.0133
Echinococcus multilocularis	mitogen activated protein kinase	0.2332	1	1
Echinococcus multilocularis	cyclins	0.0249	0.0954	0.0954
Echinococcus multilocularis	calcium activated potassium channel	0.0032	0.0011	0.0011
Plasmodium falciparum	cyclin 1	0.006	0.0133	0.0382
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2332	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0023	0.0023
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0035	0.0023	0.0023
Trichomonas vaginalis	CMGC family protein kinase	0.2332	1	1
Onchocerca volvulus	Cyclin L homolog	0.006	0.0133	0.0537
Brugia malayi	cyclin fold protein 1 variant b	0.006	0.0133	0.0133
Echinococcus multilocularis	cyclin b3	0.0249	0.0954	0.0954
Plasmodium falciparum	cGMP-dependent protein kinase	0.0035	0.0023	0.0065
Trichomonas vaginalis	cyclin D, putative	0.006	0.0133	0.0133
Trypanosoma cruzi	cyclin 9, putative	0.006	0.0133	0.0133
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.2332	1	1
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.006	0.0133	0.0382
Plasmodium vivax	protein kinase Crk2	0.0829	0.3473	1
Schistosoma mansoni	cyclin d	0.006	0.0133	0.0133
Echinococcus multilocularis	Cyclin L1	0.006	0.0133	0.0133
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.013	0.013
Trypanosoma brucei	protein kinase, putative	0.2332	1	1
Loa Loa (eye worm)	hypothetical protein	0.0598	0.2469	0.2469
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0058	0.0058
Loa Loa (eye worm)	cyclin C	0.006	0.0133	0.0133
Echinococcus granulosus	cyclin dependent kinase	0.0829	0.3473	0.3473
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.2332	1	1
Echinococcus granulosus	cyclin dependent kinase 1	0.0829	0.3473	0.3473
Echinococcus granulosus	cyclin y	0.006	0.0133	0.0133
Trypanosoma cruzi	cyclin 6, putative	0.0598	0.2469	0.2469
Brugia malayi	Cyclin C	0.006	0.0133	0.0133
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.003	0	0.5
Echinococcus multilocularis	cyclin t1	0.006	0.0133	0.0133
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.006	0.0133	0.0133
Echinococcus granulosus	cyclins	0.0249	0.0954	0.0954
Echinococcus multilocularis	cyclins	0.0249	0.0954	0.0954
Echinococcus granulosus	cyclins	0.0249	0.0954	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1386	0.1386
Trichomonas vaginalis	cyclins, putative	0.0409	0.1648	0.1648
Trichomonas vaginalis	cyclins, putative	0.0598	0.2469	0.2469
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.003	0	0.5
Echinococcus multilocularis	cyclin y	0.006	0.0133	0.0133
Chlamydia trachomatis	serine/threonine-protein kinase	0.003	0	0.5
Trichomonas vaginalis	cyclin A, putative	0.006	0.0133	0.0133
Onchocerca volvulus	Cyclin L homolog	0.006	0.0133	0.0537
Brugia malayi	Protein kinase domain containing protein	0.0829	0.3473	0.3473
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0023	0.0023
Echinococcus multilocularis	cyclins	0.0249	0.0954	0.0954
Echinococcus granulosus	cyclin y	0.006	0.0133	0.0133
Echinococcus granulosus	cyclin dependent kinase 5	0.0829	0.3473	0.3473
Loa Loa (eye worm)	hypothetical protein	0.006	0.0133	0.0133
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0829	0.3473	0.3473
Chlamydia trachomatis	serine/threonine protein kinase	0.003	0	0.5
Giardia lamblia	G2/mitotic-specific cyclin B	0.0598	0.2469	0.2469
Echinococcus granulosus	cyclin B3 1	0.0249	0.0954	0.0954
Trichomonas vaginalis	cyclin B3, putative	0.006	0.0133	0.0133
Trichomonas vaginalis	CMGC family protein kinase	0.2332	1	1
Schistosoma mansoni	Cyclin fold protein	0.006	0.0133	0.0133
Leishmania major	cyclin 9, putative	0.006	0.0133	0.0133
Toxoplasma gondii	hypothetical protein	0.006	0.0133	0.0133
Trypanosoma cruzi	cyclin, putative	0.0598	0.2469	0.2469
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.0133	0.0133
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.0133	0.0133
Brugia malayi	hypothetical protein	0.006	0.0133	0.0133
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.006	0.0133	0.0382
Schistosoma mansoni	cyclin B3	0.0249	0.0954	0.0954
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0035	0.0023	0.0023
Echinococcus multilocularis	mitogen activated protein kinase 3	0.2332	1	1
Schistosoma mansoni	cyclin k	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclin B3, putative	0.0249	0.0954	0.0954
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.003	0	0.5
Echinococcus granulosus	cyclin B	0.0598	0.2469	0.2469
Giardia lamblia	Kinase, CMGC CDK	0.0829	0.3473	0.3473
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.003	0	0.5
Trichomonas vaginalis	cyclin D, putative	0.0249	0.0954	0.0954
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.003	0	0.5
Brugia malayi	cell division control protein 2 homolog	0.0829	0.3473	0.3473
Echinococcus multilocularis	cyclin G2	0.006	0.0133	0.0133
Entamoeba histolytica	cell division protein kinase 2, putative	0.0829	0.3473	1
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.003	0	0.5
Plasmodium vivax	cyclin 4, putative	0.006	0.0133	0.0382
Schistosoma mansoni	hypothetical protein	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclins, putative	0.0598	0.2469	0.2469
Toxoplasma gondii	cyclin dependent kinase binding protein	0.006	0.0133	0.0133
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0598	0.2469	0.2469
Loa Loa (eye worm)	cyclin domain-containing protein	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclins, putative	0.0249	0.0954	0.0954
Trichomonas vaginalis	cyclin D, putative	0.0249	0.0954	0.0954
Echinococcus multilocularis	cyclin k	0.006	0.0133	0.0133
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.003	0	0.5
Echinococcus granulosus	cyclin G2	0.006	0.0133	0.0133
Loa Loa (eye worm)	cyclin domain-containing protein	0.006	0.0133	0.0133
Trichomonas vaginalis	CMGC family protein kinase	0.0829	0.3473	0.3473
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0019	0.0019
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.006	0.0133	0.0133
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0829	0.3473	0.3473
Trichomonas vaginalis	conserved hypothetical protein	0.0249	0.0954	0.0954
Entamoeba histolytica	cyclin, domain containing protein	0.006	0.0133	0.0382
Plasmodium vivax	cyclin homologue, putative	0.006	0.0133	0.0382
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.006	0.0133	0.0133
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0829	0.3473	0.3473
Trichomonas vaginalis	cyclin B, putative	0.0598	0.2469	0.2469
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.003	0	0.5
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.2332	1	1
Echinococcus multilocularis	cyclin dependent kinase	0.0829	0.3473	0.3473
Schistosoma mansoni	cyclin G2	0.006	0.0133	0.0133
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.006	0.0133	0.0133
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.003	0	0.5
Echinococcus granulosus	cyclins	0.0249	0.0954	0.0954
Leishmania major	protein kinase, putative	0.0035	0.0023	0.0023
Loa Loa (eye worm)	cyclin domain-containing protein	0.006	0.0133	0.0133
Echinococcus multilocularis	cyclin y	0.006	0.0133	0.0133
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.0133	0.0133
Schistosoma mansoni	serine/threonine protein kinase	0.2332	1	1
Echinococcus granulosus	cyclins	0.0249	0.0954	0.0954
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0829	0.3473	0.3473
Echinococcus granulosus	cyclin t1	0.006	0.0133	0.0133
Trypanosoma brucei	cyclin 3	0.006	0.0133	0.0133
Schistosoma mansoni	serine/threonine protein kinase	0.0829	0.3473	0.3473
Toxoplasma gondii	hypothetical protein	0.0189	0.0693	0.0693
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.003	0	0.5
Plasmodium vivax	hypothetical protein, conserved	0.006	0.0133	0.0382
Mycobacterium ulcerans	Ser/Thr protein kinase	0.003	0	0.5
Trypanosoma cruzi	cdc2-related kinase 1	0.0829	0.3473	0.3473
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclin A, putative	0.0598	0.2469	0.2469
Trichomonas vaginalis	CMGC family protein kinase	0.2332	1	1
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0598	0.2469	0.2469
Brugia malayi	hypothetical protein	0.006	0.0133	0.0133
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0035	0.0023	0.0023
Giardia lamblia	Cyclin A	0.0249	0.0954	0.0954
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.006	0.0133	0.0133
Schistosoma mansoni	cyclins	0.0249	0.0954	0.0954
Trypanosoma cruzi	cyclin, putative	0.0598	0.2469	0.2469
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0035	0.0023	0.0023
Entamoeba histolytica	cyclin, putative	0.0249	0.0954	0.2747
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0035	0.0023	0.0023
Onchocerca volvulus		0.006	0.0133	0.0537
Giardia lamblia	Hypothetical protein	0.006	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0598	0.2469	0.2469
Echinococcus granulosus	Cyclin L1	0.006	0.0133	0.0133
Echinococcus multilocularis	expressed conserved protein	0.0035	0.0023	0.0023
Loa Loa (eye worm)	cyclin domain-containing protein	0.006	0.0133	0.0133
Plasmodium falciparum	cyclin	0.0249	0.0954	0.2747
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.006	0.0133	0.0382
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.003	0	0.5
Plasmodium falciparum	protein kinase 5	0.0829	0.3473	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.0133	0.0133
Echinococcus multilocularis	cyclin G2	0.006	0.0133	0.0133
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.0042	0.0042
Echinococcus multilocularis	G1:S specific cyclin D1	0.006	0.0133	0.0133
Echinococcus multilocularis	cyclin dependent kinase 5	0.0829	0.3473	0.3473
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0031	0.0031
Trichomonas vaginalis	cyclins, putative	0.006	0.0133	0.0133
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.0042	0.0042
Trichomonas vaginalis	CMGC family protein kinase	0.0829	0.3473	0.3473
Echinococcus multilocularis	cyclins	0.0249	0.0954	0.0954
Echinococcus multilocularis	cyclin A3 4	0.006	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0799	0.3344	0.3344
Echinococcus granulosus	cyclins	0.006	0.0133	0.0133
Entamoeba histolytica	cyclin family protein	0.0249	0.0954	0.2747
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0033	0.0016	0.0016
Trypanosoma cruzi	cdc2-related kinase 3	0.0829	0.3473	0.3473
Giardia lamblia	Hypothetical protein	0.006	0.0133	0.0133
Loa Loa (eye worm)	cyclin domain-containing protein	0.0249	0.0954	0.0954
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0035	0.0023	0.0023
Toxoplasma gondii	cyclin 4, putative	0.006	0.0133	0.0133
Schistosoma mansoni	cyclin G	0.006	0.0133	0.0133
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0829	0.3473	0.3473
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.003	0	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.003	0	0.5
Mycobacterium ulcerans	Ser/Thr protein kinase	0.003	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.006	0.0133	0.0133
Schistosoma mansoni	cyclin B	0.0598	0.2469	0.2469
Mycobacterium ulcerans	Ser/Thr protein kinase	0.003	0	0.5
Trichomonas vaginalis	cyclins, putative	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclin B, putative	0.006	0.0133	0.0133
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.006	0.0133	0.0133
Entamoeba histolytica	cell division protein kinase 2, putative	0.0829	0.3473	1
Entamoeba histolytica	cyclin C, putative	0.006	0.0133	0.0382
Giardia lamblia	Cyclin B-like protein	0.006	0.0133	0.0133
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.2332	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.2332	1	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.2332	1	1
Echinococcus granulosus	cyclin k	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclins, putative	0.0598	0.2469	0.2469
Echinococcus multilocularis	cyclins	0.0249	0.0954	0.0954
Trichomonas vaginalis	cyclin B, putative	0.0598	0.2469	0.2469
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0023	0.0023
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.006	0.0133	0.0133
Echinococcus multilocularis	cyclin dependent kinase 1	0.0829	0.3473	0.3473
Chlamydia trachomatis	serine/threonine protein kinase	0.003	0	0.5
Trypanosoma cruzi	mitotic cyclin, putative	0.006	0.0133	0.0133
Echinococcus granulosus	mitogen activated protein kinase 3	0.2332	1	1
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.003	0	0.5
Mycobacterium ulcerans	Ser/Thr protein kinase	0.003	0	0.5
Giardia lamblia	Kinase, CMGC CDK	0.0829	0.3473	0.3473
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.2332	1	1
Trypanosoma brucei	mitotic cyclin 6	0.0598	0.2469	0.2469
Schistosoma mansoni	serine/threonine protein kinase	0.0829	0.3473	0.3473
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0058	0.0058
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0598	0.2469	0.2469
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0249	0.0954	0.0954
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.0042	0.0042
Echinococcus granulosus	cGMP dependent protein kinase	0.0035	0.0023	0.0023
Brugia malayi	Cyclin, N-terminal domain containing protein	0.006	0.0133	0.0133
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.006	0.0133	0.0133
Loa Loa (eye worm)	cyclin domain-containing protein	0.006	0.0133	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclin B, putative	0.006	0.0133	0.0133
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2332	1	1
Echinococcus granulosus	cyclin b3	0.0249	0.0954	0.0954
Echinococcus granulosus	cyclin G2	0.006	0.0133	0.0133
Echinococcus granulosus	calcium activated potassium channel	0.0032	0.0011	0.0011
Echinococcus multilocularis	cyclins	0.0249	0.0954	0.0954
Entamoeba histolytica	cyclin family protein	0.0249	0.0954	0.2747
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.003	0	0.5
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0249	0.0954	0.0954
Schistosoma mansoni	cyclin l	0.006	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.006	0.0133	0.0133
Echinococcus granulosus	G1:S specific cyclin D1	0.006	0.0133	0.0133
Giardia lamblia	Hypothetical protein	0.0249	0.0954	0.0954
Echinococcus multilocularis	cyclin	0.006	0.0133	0.0133
Schistosoma mansoni	hypothetical protein	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclin B, putative	0.0598	0.2469	0.2469
Echinococcus multilocularis	cyclin dependent kinase 1	0.0829	0.3473	0.3473
Echinococcus multilocularis	cyclin B	0.0598	0.2469	0.2469
Loa Loa (eye worm)	cyclin domain-containing protein	0.006	0.0133	0.0133
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.2332	1	1
Echinococcus granulosus	cyclin A3 4	0.006	0.0133	0.0133
Trichomonas vaginalis	cyclin B, putative	0.0598	0.2469	0.2469
Echinococcus granulosus	cyclins	0.0249	0.0954	0.0954
Entamoeba histolytica	hypothetical protein	0.006	0.0133	0.0382
Giardia lamblia	Kinase, CMGC MAPK	0.2332	1	1
Leishmania major	protein kinase, putative	0.0035	0.0023	0.0023
Onchocerca volvulus		0.0598	0.2469	1
Leishmania major	mitotic cyclin, putative	0.006	0.0133	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0133	0.0133
Trypanosoma cruzi	mitotic cyclin, putative	0.006	0.0133	0.0133
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0598	0.2469	0.2469
Trypanosoma brucei	cdc2-related kinase 1	0.0829	0.3473	0.3473
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.0042	0.0042
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.003	0	0.5
Loa Loa (eye worm)	CYL-1 protein	0.006	0.0133	0.0133
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.003	0	0.5
Trypanosoma brucei	mitotic cyclin	0.006	0.0133	0.0133
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0829	0.3473	0.3473
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0031	0.0031
Entamoeba histolytica	cyclin, putative	0.0598	0.2469	0.711
Trypanosoma brucei	cdc2-related kinase 3	0.0829	0.3473	0.3473
Trichomonas vaginalis	cyclin B, putative	0.0249	0.0954	0.0954
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0133	0.0133
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0829	0.3473	0.3473
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0133	0.0133
Echinococcus granulosus	cyclin	0.006	0.0133	0.0133
Echinococcus granulosus	mitogen activated protein kinase	0.2332	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 2.65 uM	Cytotoxicity against mouse P388 cells by SRB assay	ChEMBL.	22154665
ED50 (functional)	= 15.26 uM	Cytotoxicity against human Col2 cells by SRB assay	ChEMBL.	22154665
ED50 (functional)	= 19.69 uM	Cytotoxicity against human MCF7 cells by SRB assay	ChEMBL.	22154665
ED50 (functional)	= 34.72 uM	Cytotoxicity against human Lu1 cells by SRB assay	ChEMBL.	22154665
ED50 (functional)	= 35.22 uM	Cytotoxicity against human KB cells by SRB assay	ChEMBL.	22154665

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1933970

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1589877