TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.461 | Formula: C20H22F4N2S
H donors: 0 H acceptors: 0 LogP: 5.4 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)SCCCN1CCN(CC1)c1ccc(cc1)C(F)(F)F
InChi: 1S/C20H22F4N2S/c21-17-4-8-19(9-5-17)27-15-1-10-25-11-13-26(14-12-25)18-6-2-16(3-7-18)20(22,23)24/h2-9H,1,10-15H2
InChiKey: QLMIVFXMQPUHKG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D3	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Starlite/ChEMBL	References
Rattus norvegicus	Dopamine D4 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	Octopamine receptor, putative	Get druggable targets OG5_133249	All targets in OG5_133249

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	dopamine receptor D3	400 aa	392 aa	19.9 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Dopamine D4 receptor	387 aa	347 aa	23.3 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Dopamine D4 receptor	387 aa	350 aa	31.4 %
Brugia malayi	Serotonin/octopamine receptor family protein 7	Dopamine D4 receptor	387 aa	373 aa	29.0 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Dopamine D4 receptor	387 aa	378 aa	26.5 %
Loa Loa (eye worm)	hypothetical protein	Dopamine D4 receptor	387 aa	355 aa	22.3 %
Onchocerca volvulus		Dopamine D4 receptor	387 aa	315 aa	22.5 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Dopamine D4 receptor	387 aa	356 aa	23.6 %
Brugia malayi	sulfakinin receptor protein	Dopamine D4 receptor	387 aa	316 aa	22.8 %
Onchocerca volvulus		Dopamine D4 receptor	387 aa	346 aa	34.1 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Dopamine D4 receptor	387 aa	349 aa	31.2 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Dopamine D4 receptor	387 aa	373 aa	28.7 %
Onchocerca volvulus		Dopamine D4 receptor	387 aa	391 aa	30.7 %
Loa Loa (eye worm)	hypothetical protein	Dopamine D4 receptor	387 aa	368 aa	26.9 %
Echinococcus granulosus	g protein coupled receptor	Dopamine D4 receptor	387 aa	342 aa	21.3 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Dopamine D4 receptor	387 aa	356 aa	26.4 %
Schistosoma mansoni	amine GPCR	Dopamine D4 receptor	387 aa	394 aa	26.6 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Dopamine D4 receptor	387 aa	371 aa	27.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0037	0.0008	0.5
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cGMP dependent protein kinase	0.0042	0.0026	0.0018
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0037	0.0008	0.0008
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0304	0.0921	0.0914
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0018	0.001
Echinococcus granulosus	cyclin G2	0.0073	0.0132	0.0124
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2953	1	1
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0037	0.0008	0.5
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0042	0.0026	0.0018
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.2953	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0132	0.0132
Loa Loa (eye worm)	STE/STE11/MEKK4 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0037	0.0008	0.0008
Giardia lamblia	Hypothetical protein	0.0304	0.0921	0.0914
Loa Loa (eye worm)	AUR protein kinase	0.0037	0.0008	0.0008
Entamoeba histolytica	hypothetical protein	0.0073	0.0132	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/CAMKL/NUAK protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0042	0.0026	0.0018
Loa Loa (eye worm)	CK1 protein kinase	0.0037	0.0008	0.0008
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0073	0.0132	0.0124
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0042	0.0026	0.0018
Echinococcus multilocularis	cyclin y	0.0073	0.0132	0.0124
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0037	0.0008	0.0008
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.0037	0.0008	0.5
Echinococcus multilocularis	cyclin y	0.0073	0.0132	0.0124
Entamoeba histolytica	cell division protein kinase 2, putative	0.1011	0.3345	1
Loa Loa (eye worm)	WNK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	serotonin receptor	0.0161	0.0434	0.0426
Loa Loa (eye worm)	NEK/NEK8 protein kinase	0.0037	0.0008	0.0008
Entamoeba histolytica	cyclin family protein	0.0304	0.0921	0.2737
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0073	0.0132	0.0124
Trypanosoma brucei	protein kinase, putative	0.2953	1	1
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0009	0.0001
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDK10 protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclins, putative	0.0073	0.0132	0.0124
Chlamydia trachomatis	serine/threonine protein kinase	0.0037	0.0008	0.5
Trichomonas vaginalis	cyclin B, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclins, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	calcium activated potassium channel	0.004	0.0017	0.0009
Echinococcus multilocularis	cyclins	0.0304	0.0921	0.0914
Echinococcus multilocularis	cyclin k	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CAMK/CAMKL/AMPK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	NRBP protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/CAMKL/LKB protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0304	0.0921	0.0914
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	CMGC family protein kinase	0.1011	0.3345	0.334
Trypanosoma brucei	cyclin 3	0.0073	0.0132	0.0124
Plasmodium vivax	cyclin homologue, putative	0.0073	0.0132	0.0371
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	SCY1 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0037	0.0008	0.0008
Schistosoma mansoni	cyclin G2	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0037	0.0008	0.0008
Giardia lamblia	Kinase, CMGC CDK	0.1011	0.3345	0.334
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0037	0.0008	0.0008
Schistosoma mansoni	cyclin l	0.0073	0.0132	0.0124
Loa Loa (eye worm)	TLK protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclins	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CAMK/CASK protein kinase	0.0037	0.0008	0.0008
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.0037	0.0008	0.5
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0037	0.0008	0.0008
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.2953	1	1
Trypanosoma brucei	mitotic cyclin	0.0073	0.0132	0.0124
Leishmania major	cyclin 9, putative	0.0073	0.0132	0.0124
Echinococcus multilocularis	cyclin t1	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CK1 protein kinase	0.0037	0.0008	0.0008
Leishmania major	cyclin	0.0728	0.2377	0.2371
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclin A3 4	0.0073	0.0132	0.0124
Echinococcus granulosus	cyclin y	0.0073	0.0132	0.0124
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0073	0.0132	0.0124
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0037	0.0008	0.5
Loa Loa (eye worm)	cyclin domain-containing protein	0.0073	0.0132	0.0132
Echinococcus multilocularis	Cyclin L1	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0037	0.0008	0.0008
Onchocerca volvulus		0.0728	0.2377	1
Trichomonas vaginalis	cyclins, putative	0.0498	0.1588	0.1581
Loa Loa (eye worm)	hypothetical protein	0.0425	0.1337	0.1337
Trichomonas vaginalis	cyclin A, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0037	0.0008	0.0008
Leishmania major	mitotic cyclin, putative	0.0073	0.0132	0.0124
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0161	0.0434	0.0426
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	CMGC family protein kinase	0.1011	0.3345	0.334
Loa Loa (eye worm)	ULK protein kinase	0.0037	0.0008	0.0008
Giardia lamblia	Hypothetical protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	cyclin domain-containing protein	0.0304	0.0921	0.0921
Leishmania major	protein kinase, putative	0.0042	0.0026	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Entamoeba histolytica	cell division protein kinase 2, putative	0.1011	0.3345	1
Schistosoma mansoni	serine/threonine protein kinase	0.1011	0.3345	0.334
Trypanosoma cruzi	cyclin 9, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDK8 protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin B, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0037	0.0008	0.0008
Leishmania major	mitotic cyclin, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/MAPK protein kinase	0.0037	0.0008	0.0008
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0073	0.0132	0.0371
Loa Loa (eye worm)	CAMK/PHK protein kinase	0.0037	0.0008	0.0008
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.0037	0.0008	0.5
Echinococcus multilocularis	cyclins	0.0304	0.0921	0.0914
Entamoeba histolytica	cyclin family protein	0.0304	0.0921	0.2737
Echinococcus granulosus	cyclins	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CMGC/MAPK/NMO protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0037	0.0008	0.0008
Entamoeba histolytica	cyclin, domain containing protein	0.0073	0.0132	0.0371
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0037	0.0008	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0037	0.0009	0.0001
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.2953	1	1
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.0037	0.0008	0.5
Plasmodium falciparum	protein kinase 5	0.1011	0.3345	1
Schistosoma mansoni	cyclin G	0.0073	0.0132	0.0124
Echinococcus granulosus	mitogen activated protein kinase 3	0.2953	1	1
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0073	0.0132	0.0124
Trypanosoma cruzi	cyclin 6, putative	0.0728	0.2377	0.2371
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0132	0.0124
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0073	0.0132	0.0124
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0037	0.0008	0.5
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0037	0.0008	0.0008
Trypanosoma cruzi	cdc2-related kinase 1	0.1011	0.3345	0.334
Loa Loa (eye worm)	STE/STE20/YSK protein kinase	0.0037	0.0008	0.0008
Onchocerca volvulus	Cyclin L homolog	0.0073	0.0132	0.0523
Giardia lamblia	Cyclin B-like protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CK1 protein kinase	0.0037	0.0008	0.0008
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.1011	0.3345	0.334
Trichomonas vaginalis	CMGC family protein kinase	0.2953	1	1
Loa Loa (eye worm)	NEK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	cyclin domain-containing protein	0.0073	0.0132	0.0132
Trichomonas vaginalis	cyclin B, putative	0.0728	0.2377	0.2371
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0073	0.0132	0.0124
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0304	0.0921	0.0914
Echinococcus granulosus	cyclin B3 1	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Onchocerca volvulus	Cyclin L homolog	0.0073	0.0132	0.0523
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cyclin y	0.0073	0.0132	0.0124
Echinococcus multilocularis	calcium activated potassium channel	0.004	0.0017	0.0009
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0037	0.0008	0.0008
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0041	0.0021	0.0013
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.1011	0.3345	0.334
Brugia malayi	Cyclin C	0.0073	0.0132	0.0124
Brugia malayi	cell division control protein 2 homolog	0.1011	0.3345	0.334
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclin b3	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0037	0.0008	0.0008
Onchocerca volvulus		0.0073	0.0132	0.0523
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE11/MEKK2 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	cyclin domain-containing protein	0.0073	0.0132	0.0132
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0037	0.0008	0.5
Giardia lamblia	G2/mitotic-specific cyclin B	0.0728	0.2377	0.2371
Echinococcus multilocularis	cyclin G2	0.0073	0.0132	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0728	0.2377	0.2377
Loa Loa (eye worm)	NAK/MPSK protein kinase	0.0037	0.0008	0.0008
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/CAMKL/SNRK protein kinase	0.0037	0.0008	0.0008
Chlamydia trachomatis	serine/threonine-protein kinase	0.0037	0.0008	0.5
Trypanosoma cruzi	mitotic cyclin, putative	0.0073	0.0132	0.0124
Trichomonas vaginalis	CMGC family protein kinase	0.1011	0.3345	0.334
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE11/ASK protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cyclin dependent kinase 5	0.1011	0.3345	0.334
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.0037	0.0008	0.5
Loa Loa (eye worm)	camk/dcamkl protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	serine/threonine protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0042	0.0026	0.0026
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	serine/threonine protein kinase	0.0037	0.0008	0.0008
Brugia malayi	hypothetical protein	0.0073	0.0132	0.0124
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2953	1	1
Loa Loa (eye worm)	NAK/BIKE protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cyclins	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.1011	0.3345	0.334
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0728	0.2377	0.2371
Echinococcus multilocularis	cyclin B3 1	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin D, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	AGC protein kinase	0.0037	0.0008	0.0008
Schistosoma mansoni	cyclin B	0.0728	0.2377	0.2371
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0728	0.2377	0.2371
Trichomonas vaginalis	CMGC family protein kinase	0.2953	1	1
Echinococcus granulosus	cyclin t1	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0037	0.0008	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0026	0.0018
Echinococcus granulosus	cyclins	0.0304	0.0921	0.0914
Loa Loa (eye worm)	BUB protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0073	0.0132	0.0132
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.0037	0.0008	0.5
Loa Loa (eye worm)	TKL/LISK/TESK protein kinase	0.0037	0.0008	0.0008
Giardia lamblia	Hypothetical protein	0.0073	0.0132	0.0124
Trypanosoma brucei	cdc2-related kinase 1	0.1011	0.3345	0.334
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CK1 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0037	0.0008	0.0008
Toxoplasma gondii	hypothetical protein	0.023	0.067	0.0663
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.1011	0.3345	0.3345
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0132	0.0132
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0037	0.0008	0.0008
Plasmodium vivax	protein kinase Crk2	0.1011	0.3345	1
Loa Loa (eye worm)	CMGC/RCK/MAK protein kinase	0.0037	0.0008	0.0008
Chlamydia trachomatis	serine/threonine protein kinase	0.0037	0.0008	0.5
Trypanosoma brucei	cyclin 9	0.0073	0.0132	0.0124
Trichomonas vaginalis	cyclins, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0037	0.0008	0.0008
Entamoeba histolytica	cyclin, putative	0.0304	0.0921	0.2737
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0037	0.0008	0.0008
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0042	0.0026	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	TKL/MLK/MLK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK protein kinase	0.0037	0.0008	0.0008
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0073	0.0132	0.0124
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0073	0.0132	0.0124
Echinococcus granulosus	cyclin G2	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.2953	1	1
Loa Loa (eye worm)	TTK protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclins	0.0304	0.0921	0.0914
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0073	0.0132	0.0371
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	cyclin domain-containing protein	0.0073	0.0132	0.0132
Loa Loa (eye worm)	AUR protein kinase	0.0037	0.0008	0.0008
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.1011	0.3345	0.334
Echinococcus multilocularis	cyclin G2	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/DYRK/PRP4 protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin B, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0037	0.0008	0.0008
Giardia lamblia	Kinase, CMGC CDK	0.1011	0.3345	0.334
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	mitogen activated protein kinase 3	0.2953	1	1
Loa Loa (eye worm)	CK1 protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	serotonin receptor	0.0161	0.0434	0.0426
Trypanosoma cruzi	cdc2-related kinase 1	0.1011	0.3345	0.334
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0031	0.0023
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	cmgc/cdk/pitslre protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0434	0.0434
Trypanosoma brucei	cdc2-related kinase 3	0.1011	0.3345	0.334
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.0089	0.0089
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0037	0.0008	0.0008
Plasmodium falciparum	cyclin	0.0304	0.0921	0.2737
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/MAST/MAST protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0037	0.0008	0.0008
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.0037	0.0008	0.5
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	TBCK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	cyclin domain-containing protein	0.0073	0.0132	0.0132
Echinococcus granulosus	cyclin dependent kinase 1	0.1011	0.3345	0.334
Schistosoma mansoni	hypothetical protein	0.0073	0.0132	0.0124
Toxoplasma gondii	cyclin 4, putative	0.0073	0.0132	0.0124
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.0037	0.0008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0073	0.0132	0.0124
Leishmania major	protein kinase, putative	0.0042	0.0026	0.0018
Loa Loa (eye worm)	plk/plk-unclassified protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	G1:S specific cyclin D1	0.0073	0.0132	0.0124
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0037	0.0008	0.0008
Trypanosoma brucei	mitotic cyclin 6	0.0728	0.2377	0.2371
Plasmodium vivax	cyclin 4, putative	0.0073	0.0132	0.0371
Loa Loa (eye worm)	TKL/IRAK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE20/STLK protein kinase	0.0037	0.0008	0.0008
Plasmodium falciparum	cGMP-dependent protein kinase	0.0042	0.0026	0.0054
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0037	0.0008	0.5
Schistosoma mansoni	cyclin B3	0.0304	0.0921	0.0914
Trichomonas vaginalis	cyclin B3, putative	0.0073	0.0132	0.0124
Echinococcus granulosus	cyclins	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0037	0.0008	0.0008
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.0037	0.0008	0.5
Trypanosoma cruzi	cyclin, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	CDC7 protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cyclin b3	0.0304	0.0921	0.0914
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclins	0.0304	0.0921	0.0914
Brugia malayi	Egg laying defective protein 4	0.0042	0.0026	0.0018
Trichomonas vaginalis	cyclin D, putative	0.0304	0.0921	0.0914
Entamoeba histolytica	cyclin, putative	0.0728	0.2377	0.7099
Loa Loa (eye worm)	serine/threonine protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	NEK/NEK6 protein kinase	0.0037	0.0008	0.0008
Trypanosoma cruzi	cyclin, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	cyclin domain-containing protein	0.0073	0.0132	0.0132
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0026	0.0018
Loa Loa (eye worm)	serine/threonine protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.1011	0.3345	0.3345
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.0037	0.0008	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.2953	1	1
Loa Loa (eye worm)	CAMK protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclin	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclins, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0037	0.0008	0.0008
Brugia malayi	hypothetical protein	0.0073	0.0132	0.0124
Trypanosoma cruzi	mitotic cyclin, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CK1/DUAL protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	Cyclin L1	0.0073	0.0132	0.0124
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.2953	1	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.2953	1	1
Echinococcus multilocularis	cyclin dependent kinase	0.1011	0.3345	0.334
Trichomonas vaginalis	CMGC family protein kinase	0.2953	1	1
Schistosoma mansoni	cyclin d	0.0073	0.0132	0.0124
Loa Loa (eye worm)	cyclin C	0.0073	0.0132	0.0132
Loa Loa (eye worm)	CAMK/CAMKL/BRSK protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin B, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	serine/threonine protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Echinococcus granulosus	G1:S specific cyclin D1	0.0073	0.0132	0.0124
Schistosoma mansoni	Cyclin fold protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0037	0.0008	0.0008
Brugia malayi	Protein kinase domain containing protein	0.1011	0.3345	0.334
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.004	0.0018	0.001
Loa Loa (eye worm)	STE/STE20/FRAY protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMKK/META protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE7 protein kinase	0.0037	0.0008	0.0008
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDK4 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CYL-1 protein	0.0073	0.0132	0.0132
Loa Loa (eye worm)	CAMK/CAMKL/NIM1 protein kinase	0.0037	0.0008	0.0008
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0974	0.3218	0.3218
Giardia lamblia	Cyclin A	0.0304	0.0921	0.0914
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.0037	0.0008	0.5
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0018	0.0018
Echinococcus granulosus	cyclin	0.0073	0.0132	0.0124
Echinococcus multilocularis	cyclin dependent kinase 1	0.1011	0.3345	0.334
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	PEK/PEK protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclins, putative	0.0304	0.0921	0.0914
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0042	0.0026	0.0018
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/SRPK protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cyclin B	0.0728	0.2377	0.2371
Loa Loa (eye worm)	serine/threonine protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0073	0.0132	0.0124
Echinococcus multilocularis	cyclin dependent kinase 1	0.1011	0.3345	0.334
Trichomonas vaginalis	cyclin A, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0037	0.0008	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0132	0.0124
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0037	0.0008	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0018	0.001
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Schistosoma mansoni	cyclins	0.0304	0.0921	0.0914
Echinococcus granulosus	cyclins	0.0304	0.0921	0.0914
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin B, putative	0.0304	0.0921	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0434	0.0434
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0037	0.0008	0.5
Giardia lamblia	Cyclin fold protein 1, putative	0.0073	0.0132	0.0124
Trichomonas vaginalis	cyclin D, putative	0.0304	0.0921	0.0914
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Schistosoma mansoni	g1/s-specific cyclin C	0.0073	0.0132	0.0124
Loa Loa (eye worm)	IKK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin B3, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	VPS15 protein kinase	0.0037	0.0008	0.0008
Entamoeba histolytica	cyclin, domain containing protein	0.0073	0.0132	0.0371
Plasmodium falciparum	cyclin 1	0.0073	0.0132	0.0371
Onchocerca volvulus	Protein CNPPD1 homolog	0.0073	0.0132	0.0523
Loa Loa (eye worm)	WEE protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclins	0.0304	0.0921	0.0914
Loa Loa (eye worm)	SCY1 protein kinase	0.0037	0.0008	0.0008
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.2953	1	1
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.0037	0.0008	0.5
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1 protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	cyclin A3 4	0.0073	0.0132	0.0124
Loa Loa (eye worm)	STE/STE7/MEK3 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	IRE protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	CMGC family protein kinase	0.2953	1	1
Echinococcus granulosus	cyclin dependent kinase	0.1011	0.3345	0.334
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0073	0.0132	0.0124
Trichomonas vaginalis	cyclins, putative	0.0728	0.2377	0.2371
Echinococcus multilocularis	cyclin dependent kinase 5	0.1011	0.3345	0.334
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	ULK/ULK protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclins	0.0304	0.0921	0.0914
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0728	0.2377	0.2371
Brugia malayi	Cytochrome P450 family protein	0.0061	0.0089	0.0081
Loa Loa (eye worm)	haspin protein kinase	0.0037	0.0008	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0026	0.0018
Trichomonas vaginalis	cyclins, putative	0.0728	0.2377	0.2371
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0037	0.0008	0.0008
Trypanosoma cruzi	cdc2-related kinase 3	0.1011	0.3345	0.334
Loa Loa (eye worm)	CK1/VRK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AUR protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin B3, putative	0.0304	0.0921	0.0914
Trypanosoma cruzi	cdc2-related kinase 3	0.1011	0.3345	0.334
Loa Loa (eye worm)	PEK/HRI protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/DYRK/HIPK protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	biogenic amine 5HT receptor	0.0161	0.0434	0.0426
Echinococcus granulosus	mitogen activated protein kinase	0.2953	1	1
Echinococcus granulosus	cyclin k	0.0073	0.0132	0.0124
Brugia malayi	cyclin fold protein 1 variant b	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0037	0.0008	0.0008
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.0037	0.0008	0.5
Loa Loa (eye worm)	CAMK/PSK protein kinase	0.0037	0.0008	0.0008
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0073	0.0132	0.0371
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/MAPK protein kinase	0.0037	0.0008	0.0008
Toxoplasma gondii	hypothetical protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0037	0.0008	0.0008
Trichomonas vaginalis	cyclin B, putative	0.0073	0.0132	0.0124
Loa Loa (eye worm)	CAMK/TRBL protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0037	0.0008	0.0008
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.1011	0.3345	0.334
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0037	0.0008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0031	0.0023
Giardia lamblia	Kinase, CMGC MAPK	0.2953	1	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	expressed conserved protein	0.0042	0.0026	0.0018
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0037	0.0008	0.0008
Echinococcus multilocularis	cyclin B	0.0728	0.2377	0.2371
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0132	0.0371
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	STE/STE20/SLK protein kinase	0.0037	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0073	0.0132	0.0124
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.1011	0.3345	0.3345
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.0037	0.0008	0.0008
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0728	0.2377	0.2371
Echinococcus multilocularis	mitogen activated protein kinase	0.2953	1	1
Schistosoma mansoni	cyclin k	0.0073	0.0132	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0728	0.2377	0.2377
Entamoeba histolytica	cyclin C, putative	0.0073	0.0132	0.0371
Echinococcus granulosus	cyclins	0.0304	0.0921	0.0914
Loa Loa (eye worm)	NAK/GAK protein kinase	0.0037	0.0008	0.0008
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.0037	0.0008	0.5
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0037	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0008	0.0008
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	STE/STE20/MST protein kinase	0.0037	0.0008	0.0008
Loa Loa (eye worm)	AGC/YANK protein kinase	0.0037	0.0008	0.0008

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 89 nM	Displacement of [3H]N-methylspiperone from rat dopamine D4 receptor by liquid scintillation counting	ChEMBL.	22245230
Ki (binding)	= 544 nM	Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting	ChEMBL.	22245230
Ki (binding)	= 1080 nM	Displacement of [3H]8-OH-DPAT from human 5HT1A receptor by liquid scintillation counting	ChEMBL.	22245230
Ki (binding)	= 1129 nM	Displacement of [3H]DOI from human 5HT2A receptor after 1 hr by liquid scintillation counting	ChEMBL.	22245230
Ki (binding)	= 4753 nM	Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting	ChEMBL.	22245230

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1940410

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1589882