Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1204 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.01 | 0.0654 | 0.0575 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.01 | 0.0654 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.01 | 0.0654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 0.6776 | 0.6698 |
Schistosoma mansoni | tar DNA-binding protein | 0.0413 | 0.3311 | 0.4886 |
Schistosoma mansoni | tar DNA-binding protein | 0.0413 | 0.3311 | 0.4886 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.01 | 0.0654 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0823 | 0.6776 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.01 | 0.0654 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0413 | 0.3311 | 0.4886 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.01 | 0.0654 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0381 | 0.3034 | 0.4477 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.01 | 0.0654 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0654 | 0.1975 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0823 | 0.6776 | 0.6748 |
Echinococcus multilocularis | tar DNA binding protein | 0.0413 | 0.3311 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.01 | 0.0654 | 0.043 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0654 | 0.1975 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0654 | 0.1975 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.01 | 0.0654 | 0.0965 |
Schistosoma mansoni | hypothetical protein | 0.0381 | 0.3034 | 0.4477 |
Brugia malayi | TAR-binding protein | 0.0413 | 0.3311 | 0.3254 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.3034 | 0.2866 |
Loa Loa (eye worm) | hypothetical protein | 0.1204 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0413 | 0.3311 | 0.4886 |
Loa Loa (eye worm) | TAR-binding protein | 0.0413 | 0.3311 | 0.315 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0381 | 0.3034 | 0.9164 |
Schistosoma mansoni | hypothetical protein | 0.0381 | 0.3034 | 0.4477 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0413 | 0.3311 | 0.315 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.01 | 0.0654 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0381 | 0.3034 | 0.9164 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.01 | 0.0654 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.01 | 0.0654 | 0.1975 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0381 | 0.3034 | 0.2866 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1369 | 0.1162 |
Brugia malayi | RNA binding protein | 0.0413 | 0.3311 | 0.3254 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1204 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.01 | 0.0654 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0381 | 0.3034 | 0.9164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0413 | 0.3311 | 0.4886 |
Schistosoma mansoni | hypothetical protein | 0.0381 | 0.3034 | 0.4477 |
Brugia malayi | hypothetical protein | 0.005 | 0.0234 | 0.0152 |
Echinococcus granulosus | tar DNA binding protein | 0.0413 | 0.3311 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0381 | 0.3034 | 0.9164 |
Brugia malayi | N-terminal motif family protein | 0.0184 | 0.1369 | 0.1297 |
Brugia malayi | Isocitrate dehydrogenase | 0.01 | 0.0654 | 0.0575 |
Loa Loa (eye worm) | RNA binding protein | 0.0413 | 0.3311 | 0.315 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.01 | 0.0654 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0381 | 0.3034 | 0.9164 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0381 | 0.3034 | 0.2975 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0381 | 0.3034 | 0.2975 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0413 | 0.3311 | 0.3254 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0184 | 0.1369 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0381 | 0.3034 | 0.9164 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.01 | 0.0654 | 0.1975 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.01 | 0.0654 | 0.1975 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
TC50 (ADMET) | = 3.38 mM | Neurotoxicity against human neuroblastoma SH-SY5Y cells using MTT dye conversion assay | ChEMBL. | 14611843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.