Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.019 | 0.0021 | 0.0022 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2005 | 0.1261 | 0.1137 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Chlamydia trachomatis | acetyl-CoA carboxylase biotin carboxyl carrier protein | 0.0518 | 0.0245 | 0.0172 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.019 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.0287 | 0.0087 | 0.4595 | |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0518 | 0.0245 | 0.0245 |
Leishmania major | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0518 | 0.0245 | 0.0107 |
Toxoplasma gondii | pyruvate carboxylase | 0.5635 | 0.3742 | 0.362 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.019 | 0.0021 | 0.0021 |
Echinococcus granulosus | serotonin transporter | 0.0438 | 0.019 | 0.019 |
Leishmania major | dihydrolipoamide acetyltransferase precursorlike protein | 0.0518 | 0.0245 | 0.0107 |
Onchocerca volvulus | 0.0287 | 0.0087 | 0.4595 | |
Echinococcus multilocularis | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Echinococcus multilocularis | tumor protein p63 | 0.0357 | 0.0135 | 0.0135 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0226 | 0.0045 | 0.0047 |
Echinococcus granulosus | tumor protein p63 | 0.0357 | 0.0135 | 0.0135 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0287 | 0.0087 | 0.0087 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0518 | 0.0245 | 0.0176 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0287 | 0.0087 | 0.0087 |
Echinococcus multilocularis | dihydrolipoyllysine residue acetyltransferase | 0.0518 | 0.0245 | 0.0245 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0427 | 0.0183 | 0.019 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0287 | 0.0087 | 0.0087 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0438 | 0.019 | 0.019 |
Chlamydia trachomatis | dihydrolipoamide succinyltransferase | 0.0518 | 0.0245 | 0.0172 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.2249 | 0.1428 | 0.1428 |
Brugia malayi | SH2 domain containing protein | 0.0287 | 0.0087 | 0.0091 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0518 | 0.0245 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.2523 | 0.1615 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0343 | 0.0126 | 0.0126 |
Wolbachia endosymbiont of Brugia malayi | carbamoyl phosphate synthase large subunit | 0.1274 | 0.0761 | 0.1476 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0518 | 0.0245 | 0.0176 |
Trypanosoma brucei | acetyl-CoA carboxylase | 1.4794 | 1 | 1 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.2005 | 0.1261 | 0.2905 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0427 | 0.0183 | 0.019 |
Chlamydia trachomatis | acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | 0.2005 | 0.1261 | 0.3349 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0226 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.2249 | 0.1428 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0518 | 0.0245 | 0.0254 |
Echinococcus multilocularis | Immunoglobulin | 0.0226 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Schistosoma mansoni | dihydrolipoamide S-acetyltransferase | 0.0518 | 0.0245 | 0.0245 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.5635 | 0.3742 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0287 | 0.0087 | 0.0087 |
Echinococcus granulosus | dihydrolipoyllysine residue succinyltransferase | 0.0518 | 0.0245 | 0.0245 |
Schistosoma mansoni | dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase | 0.0518 | 0.0245 | 0.0245 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.2005 | 0.1261 | 0.2905 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0287 | 0.0087 | 0.0087 |
Brugia malayi | MH2 domain containing protein | 0.0392 | 0.0159 | 0.0165 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0287 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | TK protein kinase | 0.0287 | 0.0087 | 0.0091 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0364 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.5635 | 0.3742 | 0.3653 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0287 | 0.0087 | 0.0087 |
Onchocerca volvulus | 0.0287 | 0.0087 | 0.4595 | |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.0087 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Trypanosoma brucei | unspecified product | 0.3705 | 0.2423 | 0.2315 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0438 | 0.019 | 0.019 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0287 | 0.0087 | 0.0087 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.2005 | 0.1261 | 0.2905 |
Echinococcus multilocularis | roundabout 2 | 0.0299 | 0.0096 | 0.0096 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0518 | 0.0245 | 0.0245 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0518 | 0.0245 | 0.0176 |
Trypanosoma brucei | 2-oxoglutarate dehydrogenase E2 component, putative | 0.0518 | 0.0245 | 0.0107 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0438 | 0.019 | 0.0197 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.2005 | 0.1261 | 0.2905 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.5635 | 0.3742 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0299 | 0.0096 | 0.0096 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | SRC-1 | 0.0287 | 0.0087 | 0.0091 |
Echinococcus multilocularis | Immunoglobulin | 0.0226 | 0.0045 | 0.0045 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0287 | 0.0087 | 0.0087 |
Treponema pallidum | pyruvate carboxylase subunit B | 0.0518 | 0.0245 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0287 | 0.0087 | 0.0087 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.5635 | 0.3742 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.2005 | 0.1261 | 0.1261 |
Mycobacterium leprae | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) | 0.2005 | 0.1261 | 0.2905 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0287 | 0.0087 | 0.0087 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0287 | 0.0087 | 0.0087 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.2005 | 0.1261 | 0.1866 |
Echinococcus granulosus | c src tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Trypanosoma brucei | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative | 0.1274 | 0.0761 | 0.0631 |
Echinococcus granulosus | Immunoglobulin | 0.0226 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.0087 | 0.0091 |
Onchocerca volvulus | 0.0438 | 0.019 | 1 | |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0287 | 0.0087 | 0.0087 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 1.4794 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 1.4794 | 1 | 1 |
Plasmodium vivax | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative | 0.0518 | 0.0245 | 0.0078 |
Brugia malayi | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta | 0.0518 | 0.0245 | 0.0254 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0299 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0518 | 0.0245 | 0.0254 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0287 | 0.0087 | 0.0087 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0364 | 0.014 | 0.014 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0287 | 0.0087 | 0.0087 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0438 | 0.019 | 0.019 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0287 | 0.0087 | 0.0087 |
Trypanosoma brucei | pyruvate dehydrogenase complex E3 binding protein, putative | 0.0518 | 0.0245 | 0.0107 |
Schistosoma mansoni | vesicular amine transporter | 0.0265 | 0.0072 | 0.0072 |
Toxoplasma gondii | 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein | 0.0518 | 0.0245 | 0.0056 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0287 | 0.0087 | 0.0091 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0438 | 0.019 | 0.0197 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0438 | 0.019 | 0.0197 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Brugia malayi | dihydrolipoamide S-acetyltransferase precursor, putative | 0.0518 | 0.0245 | 0.0254 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.2005 | 0.1261 | 0.2905 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.0087 | 0.0091 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.5635 | 0.3742 | 1 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.2005 | 0.1261 | 0.2905 |
Chlamydia trachomatis | biotin carboxylase | 0.5117 | 0.3388 | 1 |
Brugia malayi | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Leishmania major | dihydrolipoamide branched chain transacylase, putative | 0.0518 | 0.0245 | 0.0107 |
Trypanosoma brucei | dihydrolipoamide branched chain transacylase, putative | 0.0518 | 0.0245 | 0.0107 |
Onchocerca volvulus | 0.0287 | 0.0087 | 0.4595 | |
Echinococcus granulosus | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Echinococcus multilocularis | serotonin transporter | 0.0438 | 0.019 | 0.019 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0438 | 0.019 | 0.019 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.2005 | 0.1261 | 0.1092 |
Brugia malayi | hypothetical protein | 0.0226 | 0.0045 | 0.0047 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0226 | 0.0045 | 0.0047 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.2249 | 0.1428 | 0.1428 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2005 | 0.1261 | 0.1137 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0287 | 0.0087 | 0.0091 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0343 | 0.0126 | 0.0126 |
Mycobacterium leprae | Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) | 0.2005 | 0.1261 | 0.2905 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0438 | 0.019 | 0.0197 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0518 | 0.0245 | 0.0176 |
Echinococcus granulosus | dihydrolipoyllysine residue acetyltransferase | 0.0518 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.5635 | 0.3742 | 0.3742 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0287 | 0.0087 | 0.0087 |
Onchocerca volvulus | 0.0438 | 0.019 | 1 | |
Toxoplasma gondii | carbamoylphosphate synthetase | 0.1274 | 0.0761 | 0.0582 |
Brugia malayi | kinase, mitochondrial precursor | 0.0364 | 0.014 | 0.0145 |
Mycobacterium ulcerans | carbamoyl phosphate synthase large subunit | 0.1274 | 0.0761 | 0.1476 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.2005 | 0.1261 | 0.1137 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.5635 | 0.3742 | 0.5994 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0392 | 0.0159 | 0.0165 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0045 | 0.0047 |
Mycobacterium leprae | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 | 0.2005 | 0.1261 | 0.2905 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0438 | 0.019 | 0.0197 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.057 | 0.028 | 0.028 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Toxoplasma gondii | dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase | 0.0518 | 0.0245 | 0.0056 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Schistosoma mansoni | nephrin | 0.0226 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | serotonin transporter b | 0.0438 | 0.019 | 0.0197 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0438 | 0.019 | 0.019 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.2005 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0045 | 0.0047 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 1.4275 | 0.9646 | 1 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase, putative | 0.0518 | 0.0245 | 0.0176 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.2249 | 0.1428 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Echinococcus granulosus | roundabout 2 | 0.0299 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0045 | 0.0047 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0226 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0045 | 0.0047 |
Toxoplasma gondii | dihydrolipoamide acyltransferase, putative | 0.0518 | 0.0245 | 0.0056 |
Echinococcus multilocularis | sodium channel protein | 0.057 | 0.028 | 0.028 |
Chlamydia trachomatis | dihydrolipoamide succinyltransferase | 0.0518 | 0.0245 | 0.0172 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0045 | 0.0047 |
Schistosoma mansoni | tyrosine kinase | 0.0202 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0518 | 0.0245 | 0.0254 |
Echinococcus multilocularis | dihydrolipoyllysine residue succinyltransferase | 0.0518 | 0.0245 | 0.0245 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0287 | 0.0087 | 0.0541 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0769 | 0.0417 | 0.0417 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.5635 | 0.3742 | 0.3653 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Brugia malayi | SH2 domain containing protein | 0.0287 | 0.0087 | 0.0091 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.5635 | 0.3742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2249 | 0.1428 | 0.1481 |
Brugia malayi | hypothetical protein | 0.0287 | 0.0087 | 0.0091 |
Chlamydia trachomatis | dihydrolipoamide acetyltransferase | 0.0518 | 0.0245 | 0.0172 |
Trypanosoma cruzi | glutamine dependent carbamoyl-phosphate synthase, putative | 0.1274 | 0.0761 | 0.1035 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0438 | 0.019 | 0.019 |
Plasmodium falciparum | carbamoyl phosphate synthetase | 0.1274 | 0.0761 | 0.0814 |
Leishmania major | acetyl-CoA carboxylase, putative | 1.4794 | 1 | 1 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0364 | 0.014 | 0.014 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0518 | 0.0245 | 0.0176 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.2249 | 0.1428 | 0.1428 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.0087 | 0.0091 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0364 | 0.014 | 0.014 |
Plasmodium falciparum | dihydrolipoamide acyltransferase component E2 | 0.0518 | 0.0245 | 0.0078 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2005 | 0.1261 | 0.1866 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0769 | 0.0417 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0045 | 0.0047 |
Plasmodium falciparum | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex | 0.0518 | 0.0245 | 0.0078 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0438 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.019 | 0.0197 |
Leishmania major | carboxylase, putative | 0.5635 | 0.3742 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0096 | 0.0099 |
Echinococcus granulosus | neuroglian | 0.0226 | 0.0045 | 0.0045 |
Onchocerca volvulus | 0.0438 | 0.019 | 1 | |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0438 | 0.019 | 0.019 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0287 | 0.0087 | 0.0087 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E2 | 0.0518 | 0.0245 | 0.0056 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.2523 | 0.1615 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.9159 | 0.615 | 1 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.019 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0438 | 0.019 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.014 | 0.0145 |
Echinococcus granulosus | Biotin lipoyl attachment | 0.0518 | 0.0245 | 0.0245 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0287 | 0.0087 | 0.0087 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.1274 | 0.0761 | 0.0761 |
Leishmania major | carbamoyl-phosphate synthase, putative | 0.1274 | 0.0761 | 0.0631 |
Echinococcus multilocularis | Biotin lipoyl attachment | 0.0518 | 0.0245 | 0.0245 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0287 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0096 | 0.0099 |
Brugia malayi | protein-tyrosine kinase | 0.0287 | 0.0087 | 0.0091 |
Brugia malayi | Carboxyl transferase domain containing protein | 1.4275 | 0.9646 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 1.0706 | 0.7207 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.5635 | 0.3742 | 0.5994 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0392 | 0.0159 | 0.0165 |
Plasmodium falciparum | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex | 0.0518 | 0.0245 | 0.0078 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Trypanosoma cruzi | glutamine-dependent carbamoyl-phosphate synthetase, putative | 0.1274 | 0.0761 | 0.1035 |
Brugia malayi | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor | 0.0518 | 0.0245 | 0.0254 |
Brugia malayi | SRC-1 | 0.0287 | 0.0087 | 0.0091 |
Plasmodium vivax | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative | 0.0518 | 0.0245 | 0.0078 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0438 | 0.019 | 0.019 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.1274 | 0.0761 | 0.0761 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.5635 | 0.3742 | 0.3653 |
Schistosoma mansoni | pyruvate carboxylase | 0.5635 | 0.3742 | 0.3742 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0438 | 0.019 | 0.0197 |
Onchocerca volvulus | 0.0438 | 0.019 | 1 | |
Onchocerca volvulus | 0.0287 | 0.0087 | 0.4595 | |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.2005 | 0.1261 | 0.2905 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.5635 | 0.3742 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.2249 | 0.1428 | 0.1481 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0287 | 0.0087 | 0.0091 |
Schistosoma mansoni | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Echinococcus granulosus | tyrosine kinase | 0.0287 | 0.0087 | 0.0087 |
Echinococcus granulosus | sodium channel protein | 0.057 | 0.028 | 0.028 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0287 | 0.0087 | 0.0087 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 1.0706 | 0.7207 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.057 | 0.028 | 0.0143 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.5635 | 0.3742 | 0.3742 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 1.4794 | 1 | 1 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.816 | 0.5467 | 0.5467 |
Echinococcus granulosus | twitchin | 0.0226 | 0.0045 | 0.0045 |
Echinococcus granulosus | defective proboscis extension response | 0.0226 | 0.0045 | 0.0045 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.5635 | 0.3742 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.2005 | 0.1261 | 0.2905 |
Toxoplasma gondii | biotin-requiring enzyme domain-containing protein | 0.0518 | 0.0245 | 0.0056 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.5635 | 0.3742 | 0.3742 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.0087 | 0.0091 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.2005 | 0.1261 | 0.1261 |
Trypanosoma brucei | dihydrolipoamide acetyltransferase E2 subunit, putative | 0.0518 | 0.0245 | 0.0107 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.2249 | 0.1428 | 0.1428 |
Schistosoma mansoni | acetyl-CoA carboxylase | 1.4794 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0226 | 0.0045 | 0.0045 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0287 | 0.0087 | 0.0087 |
Onchocerca volvulus | 0.0287 | 0.0087 | 0.4595 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0287 | 0.0087 | 0.0087 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0287 | 0.0087 | 0.0087 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.5635 | 0.3742 | 1 |
Plasmodium vivax | carbamoyl phosphate synthetase, putative | 0.1274 | 0.0761 | 0.0814 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0438 | 0.019 | 0.019 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0438 | 0.019 | 0.019 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.2249 | 0.1428 | 0.1481 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.0087 | 0.0091 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.2249 | 0.1428 | 0.1428 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0226 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0096 | 0.0099 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.2005 | 0.1261 | 0.2905 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.2005 | 0.1261 | 0.1866 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0287 | 0.0087 | 0.0087 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.1274 | 0.0761 | 0.0761 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0769 | 0.0417 | 0.0417 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.5635 | 0.3742 | 0.3742 |
Leishmania major | dihydrolipoamide acetyltransferase precursor, putative | 0.0518 | 0.0245 | 0.0107 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.624 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.338 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.275 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.187 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.137 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.049 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.029 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.973 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.952 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.935 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.921 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.861 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.86 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.856 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.847 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.827 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.815 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.775 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.724 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.