Detailed information for compound 1590134

Basic information

Technical information
  • TDR Targets ID: 1590134
  • Name: N-(2-phenylethyl)-4-[[3-(2-phenyl-1,3-thiazol -4-yl)prop-2-enoylamino]methyl]benzamide
  • MW: 467.582 | Formula: C28H25N3O2S
  • H donors: 2 H acceptors: 3 LogP: 5.08 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C/c1csc(n1)c1ccccc1)NCc1ccc(cc1)C(=O)NCCc1ccccc1
  • InChi: 1S/C28H25N3O2S/c32-26(16-15-25-20-34-28(31-25)24-9-5-2-6-10-24)30-19-22-11-13-23(14-12-22)27(33)29-18-17-21-7-3-1-4-8-21/h1-16,20H,17-19H2,(H,29,33)(H,30,32)/b16-15+
  • InChiKey: YQJPNSCXSQHZSY-FOCLMDBBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-phenylethyl)-4-[[[(E)-3-(2-phenyl-1,3-thiazol-4-yl)prop-2-enoyl]amino]methyl]benzamide
  • N-(2-phenylethyl)-4-[[[(E)-3-(2-phenylthiazol-4-yl)prop-2-enoyl]amino]methyl]benzamide
  • N-(2-phenylethyl)-4-[[3-(2-phenylthiazol-4-yl)prop-2-enoylamino]methyl]benzamide
  • 4-[[[(E)-1-oxo-3-(2-phenyl-4-thiazolyl)prop-2-enyl]amino]methyl]-N-(2-phenylethyl)benzamide
  • 4-[[[1-oxo-3-(2-phenyl-4-thiazolyl)prop-2-enyl]amino]methyl]-N-(2-phenylethyl)benzamide
  • N-(2-phenylethyl)-4-[[[(E)-3-(2-phenylthiazol-4-yl)acryloyl]amino]methyl]benzamide
  • N-(2-phenylethyl)-4-[[[3-(2-phenylthiazol-4-yl)acryloyl]amino]methyl]benzamide
  • NCI60_036601
  • NSC702131

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0075 0.557 1
Echinococcus multilocularis somatostatin receptor 0.0075 0.557 1
Echinococcus granulosus hypothetical protein 0.0075 0.557 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0075 0.557 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.557 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.557 0.557
Schistosoma mansoni growth hormone secretagogue receptor 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.3951 0.3951
Schistosoma mansoni hypothetical protein 0.0074 0.5371 0.9643
Brugia malayi Dopamine receptor 0.0075 0.557 0.557
Schistosoma mansoni neuropeptide receptor 0.0075 0.557 1
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.557 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0075 0.557 0.557
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.557 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis neuropeptide s receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Brugia malayi Serotonin receptor 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Brugia malayi Dopamine receptor protein 2 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0075 0.557 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0075 0.557 0.557
Schistosoma mansoni alpha-1 adrenergic receptor 0.0075 0.557 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0075 0.557 0.557
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.557 1
Echinococcus multilocularis sex peptide receptor 0.0075 0.557 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Schistosoma mansoni adenoreceptor 0.0075 0.557 1
Schistosoma mansoni amine GPCR 0.0075 0.557 1
Schistosoma mansoni hypothetical protein 0.0075 0.557 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0075 0.557 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis neuropeptide receptor 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni amine GPCR 0.0075 0.557 1
Schistosoma mansoni histamine h1 receptor 0.0075 0.557 1
Echinococcus granulosus somatostatin receptor 0.0075 0.557 1
Echinococcus granulosus neuropeptide receptor 0.0075 0.557 1
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus multilocularis serotonin receptor 0.0075 0.557 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0075 0.557 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0075 0.557 1
Echinococcus granulosus g-protein coupled receptor 0.0075 0.557 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.557 1
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.557 1
Schistosoma mansoni hypothetical protein 0.0075 0.557 1
Brugia malayi Melatonin receptor type 1A 0.0075 0.557 0.557
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0075 0.557 0.557
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.557 1
Brugia malayi follicle stimulating hormone receptor 0.0075 0.557 0.557
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.557 0.557
Echinococcus granulosus tar DNA binding protein 0.0063 0.3951 0.7092
Echinococcus granulosus neuropeptide receptor A26 0.0075 0.557 1
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0075 0.557 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0075 0.557 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Brugia malayi ORL1-like opioid receptor 0.0075 0.557 0.557
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3951 0.7092
Schistosoma mansoni hypothetical protein 0.0075 0.557 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.557 1
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.557 1
Schistosoma mansoni biogenic amine receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0075 0.557 0.5
Schistosoma mansoni amine GPCR 0.0075 0.557 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0075 0.557 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis fmrfamide receptor 0.0075 0.557 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.557 1
Schistosoma mansoni biogenic amine receptor 0.0075 0.557 1
Brugia malayi GnHR receptor homolog 0.0075 0.557 0.557
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Echinococcus multilocularis allatostatin A receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Brugia malayi G protein-coupled receptor 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus granulosus neuropeptide receptor 0.0075 0.557 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0075 0.557 1
Schistosoma mansoni opsin-like receptor 0.0075 0.557 1
Echinococcus granulosus sex peptide receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0075 0.557 1
Echinococcus granulosus g protein coupled receptor 0.0075 0.557 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.557 1
Brugia malayi putative neuropeptide receptor NPR1 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.557 0.557
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.557 1
Brugia malayi neuropeptide F receptor 0.0075 0.557 0.557
Loa Loa (eye worm) TAR-binding protein 0.0063 0.3951 0.3951
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.557 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 1 1
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0075 0.557 1
Schistosoma mansoni neuropeptide receptor 0.0075 0.557 1
Echinococcus granulosus g protein coupled receptor 0.0075 0.557 1
Schistosoma mansoni opsin-like receptor 0.0075 0.557 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.557 1
Brugia malayi putative neuropeptide receptor 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.557 1
Brugia malayi G-protein coupled receptor 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0075 0.557 1
Echinococcus multilocularis g protein coupled receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3951 0.7092
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis fmrfamide receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0075 0.557 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3951 0.7092
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus multilocularis g protein coupled receptor 0.0075 0.557 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0075 0.557 0.557
Brugia malayi sulfakinin receptor protein 0.0075 0.557 0.557
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.557 1
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.5371 0.5371
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.557 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3951 0.7092
Brugia malayi Serotonin receptor 0.0075 0.557 0.557
Echinococcus granulosus g protein coupled receptor 0.0075 0.557 1
Brugia malayi RNA binding protein 0.0063 0.3951 0.3951
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Brugia malayi Dopamine receptor protein 1 0.0075 0.557 0.557
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Brugia malayi RE15519p 0.0075 0.557 0.557
Echinococcus multilocularis neuropeptide FF receptor 2 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis neuropeptide receptor A26 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.557 1
Schistosoma mansoni amine GPCR 0.0075 0.557 1
Onchocerca volvulus 0.0075 0.557 0.5
Schistosoma mansoni opsin-like receptor 0.0075 0.557 1
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.557 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0075 0.557 1
Brugia malayi TAR-binding protein 0.0063 0.3951 0.3951
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis g-protein coupled receptor 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0075 0.557 1
Loa Loa (eye worm) TYRA-2 protein 0.0075 0.557 0.557
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0074 0.5371 0.5371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.557 1
Echinococcus granulosus neuropeptide s receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.557 1
Schistosoma mansoni amine GPCR 0.0075 0.557 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.3951 0.3951
Schistosoma mansoni hypothetical protein 0.0075 0.557 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0075 0.557 1
Onchocerca volvulus 0.0075 0.557 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.557 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0075 0.557 0.557
Echinococcus multilocularis g protein coupled receptor 0.0075 0.557 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0075 0.557 1
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.557 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.557 1
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.557 0.557
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.557 1
Echinococcus granulosus allatostatin A receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0075 0.557 0.557
Brugia malayi AKH receptor 0.0075 0.557 0.557
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0075 0.557 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.557 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0075 0.557 0.557
Brugia malayi larval opioid receptor 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Brugia malayi G-protein coupled receptor 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis orexin receptor type 2 0.0075 0.557 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0075 0.557 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.3951 0.7092
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0075 0.557 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0075 0.557 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0075 0.557 0.5
Onchocerca volvulus 0.0075 0.557 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3951 0.7092
Schistosoma mansoni neuropeptide receptor 0.0075 0.557 1
Echinococcus granulosus orexin receptor type 2 0.0075 0.557 1
Echinococcus granulosus serotonin receptor 0.0075 0.557 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis serotonin receptor 0.0075 0.557 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0075 0.557 1
Echinococcus granulosus G protein coupled receptor 139 0.0075 0.557 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.557 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0075 0.557 1
Onchocerca volvulus 0.0075 0.557 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Brugia malayi neuropeptide F receptor 0.0075 0.557 0.557
Loa Loa (eye worm) melatonin receptor type 1A 0.0075 0.557 0.557
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.557 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0108 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.3951 0.3951
Schistosoma mansoni biogenic amine receptor 0.0075 0.557 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Echinococcus multilocularis neuropeptide receptor 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.557 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Echinococcus granulosus dro:myosuppressin receptor 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Onchocerca volvulus 0.0075 0.557 0.5
Schistosoma mansoni myosin xvIII 0.0075 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Loa Loa (eye worm) hypothetical protein 0.0075 0.557 0.557
Echinococcus granulosus fmrfamide receptor 0.0075 0.557 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.557 1
Brugia malayi hypothetical protein 0.0075 0.557 0.557
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.557 1
Schistosoma mansoni neuropeptide receptor 0.0075 0.557 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.164 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.714 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.614 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.527 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.348 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.318 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.158 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.053 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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