Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0788 | 0.0357 | 0.0356 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0788 | 0.0357 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0797 | 0.0361 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0788 | 0.0357 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0788 | 0.0357 | 0.0356 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 0.0088 | 0.0187 |
Brugia malayi | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Onchocerca volvulus | Bile acid receptor homolog | 2.084 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0882 | 0.0403 | 0.1421 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 0.0403 | 0.0401 |
Brugia malayi | nuclear receptor NHR-67 | 0.0788 | 0.0357 | 0.0356 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.167 | 0.0781 | 0.259 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | steroid hormone receptor | 0.167 | 0.0781 | 0.0781 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.167 | 0.0781 | 0.2593 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.167 | 0.0781 | 0.0781 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.167 | 0.0781 | 0.2593 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0057 | 0.0065 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.167 | 0.0781 | 0.0781 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0797 | 0.0361 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | nuclear receptor NHR-88 | 0.167 | 0.0781 | 0.0781 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0788 | 0.0357 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.167 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.167 | 0.0781 | 0.078 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0788 | 0.0357 | 0.1243 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0797 | 0.0361 | 0.1195 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0788 | 0.0357 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0049 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | nuclear receptor NHR-88 | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | tailless protein | 0.0788 | 0.0357 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0057 | 0.0187 |
Schistosoma mansoni | thyroid hormone receptor | 0.1799 | 0.0844 | 0.28 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.167 | 0.0781 | 0.0781 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0049 | 0.0002 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0284 | 0.0115 | 0.0113 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0049 | 0.0002 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.167 | 0.0781 | 0.259 |
Loa Loa (eye worm) | acetyltransferase | 0.0167 | 0.0059 | 0.0057 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.167 | 0.0781 | 0.0781 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0788 | 0.0357 | 0.118 |
Echinococcus multilocularis | FTZ F1 alpha | 0.167 | 0.0781 | 0.2909 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.013 | 0.0041 | 0.0129 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.167 | 0.0781 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0788 | 0.0357 | 0.118 |
Loa Loa (eye worm) | steroid hormone receptor | 0.167 | 0.0781 | 0.078 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.167 | 0.0781 | 0.2593 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.167 | 0.0781 | 0.0781 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0788 | 0.0357 | 0.118 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0788 | 0.0357 | 0.1184 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0788 | 0.0357 | 0.0356 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 0.0088 | 0.0287 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0797 | 0.0361 | 0.0361 |
Brugia malayi | conserved hypotetical protein | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | nuclear hormone receptor | 0.167 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.167 | 0.0781 | 0.078 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.167 | 0.0781 | 0.0781 |
Onchocerca volvulus | 0.0788 | 0.0357 | 0.0356 | |
Schistosoma mansoni | coup transcription factor | 0.167 | 0.0781 | 0.2593 |
Schistosoma mansoni | nuclear receptor | 0.0788 | 0.0357 | 0.1184 |
Onchocerca volvulus | 0.0788 | 0.0357 | 0.0356 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0788 | 0.0357 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.167 | 0.0781 | 0.078 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.167 | 0.0781 | 0.2909 |
Brugia malayi | hypothetical protein | 0.0882 | 0.0403 | 0.0402 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0002 | 0.0001 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.167 | 0.0781 | 0.259 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0882 | 0.0403 | 0.0401 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0045 | 0 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0049 | 0.0002 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.167 | 0.0781 | 0.0781 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.167 | 0.0781 | 0.2593 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 2.084 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0882 | 0.0403 | 0.1335 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.167 | 0.0781 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 0.0403 | 0.0401 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0284 | 0.0115 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.167 | 0.0781 | 0.0781 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0162 | 0.0056 | 0.0181 |
Schistosoma mansoni | zinc finger protein | 0.0788 | 0.0357 | 0.1184 |
Echinococcus granulosus | geminin | 0.0164 | 0.0057 | 0.0184 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.167 | 0.0781 | 0.2593 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.167 | 0.0781 | 0.078 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0788 | 0.0357 | 0.1184 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.167 | 0.0781 | 0.2593 |
Echinococcus granulosus | FTZ F1 alpha | 0.167 | 0.0781 | 0.259 |
Schistosoma mansoni | nuclear hormone receptor | 0.0788 | 0.0357 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.167 | 0.0781 | 0.078 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.167 | 0.0781 | 0.2909 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0788 | 0.0357 | 0.0356 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0788 | 0.0357 | 0.118 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0284 | 0.0115 | 0.0378 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0882 | 0.0403 | 0.0402 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0882 | 0.0403 | 0.0402 |
Loa Loa (eye worm) | DR-78 | 0.0788 | 0.0357 | 0.0356 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.167 | 0.0781 | 0.2909 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0284 | 0.0115 | 0.0114 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.167 | 0.0781 | 0.078 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0797 | 0.0361 | 0.126 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0167 | 0.0059 | 0.0058 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0002 | 0.0001 |
Brugia malayi | hypothetical protein | 0.0882 | 0.0403 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.167 | 0.0781 | 0.078 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.6306 | 0.3011 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1799 | 0.0844 | 0.28 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1799 | 0.0844 | 0.3154 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0788 | 0.0357 | 0.0356 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0882 | 0.0403 | 0.1331 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0788 | 0.0357 | 0.1243 |
Brugia malayi | nuclear hormone receptor | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | nuclear receptor RXR | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.167 | 0.0781 | 0.2593 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.167 | 0.0781 | 0.2909 |
Schistosoma mansoni | hypothetical protein | 0.013 | 0.0041 | 0.0133 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.167 | 0.0781 | 0.259 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0167 | 0.0059 | 0.0192 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0284 | 0.0115 | 0.0291 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0057 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 0.0403 | 0.0401 |
Brugia malayi | ecdysone receptor | 0.0788 | 0.0357 | 0.0356 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.167 | 0.0781 | 0.2909 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.0088 | 0.0087 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0049 | 0.0002 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.167 | 0.0781 | 0.0781 |
Brugia malayi | hypothetical protein | 0.0229 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.167 | 0.0781 | 0.078 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.167 | 0.0781 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 0.0403 | 0.0401 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0788 | 0.0357 | 0.0356 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.167 | 0.0781 | 0.0781 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.167 | 0.0781 | 0.2593 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.167 | 0.0781 | 0.078 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0882 | 0.0403 | 0.1335 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.167 | 0.0781 | 0.0781 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.167 | 0.0781 | 0.0781 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.167 | 0.0781 | 0.0781 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.6306 | 0.3011 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0284 | 0.0115 | 0.0291 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.167 | 0.0781 | 0.078 |
Brugia malayi | nuclear receptor RXR | 0.0882 | 0.0403 | 0.0402 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.167 | 0.0781 | 0.2593 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.167 | 0.0781 | 0.078 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.167 | 0.0781 | 0.2909 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 0.0403 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.167 | 0.0781 | 0.078 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0284 | 0.0115 | 0.0375 |
Onchocerca volvulus | 0.167 | 0.0781 | 0.0781 | |
Brugia malayi | hypothetical protein | 0.0788 | 0.0357 | 0.0356 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.167 | 0.0781 | 0.2909 |
Schistosoma mansoni | nuclear hormone receptor | 0.0788 | 0.0357 | 0.1184 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0788 | 0.0357 | 0.1184 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.167 | 0.0781 | 0.259 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.167 | 0.0781 | 0.0781 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.167 | 0.0781 | 0.259 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.167 | 0.0781 | 0.0781 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0167 | 0.0059 | 0.007 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.5424 | 0.2587 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.167 | 0.0781 | 0.259 |
Schistosoma mansoni | nuclear receptor | 0.0788 | 0.0357 | 0.1184 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.167 | 0.0781 | 0.0781 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 59 uM | Inhibition of Clostridium botulinum BoNT/A light chain-mediated SNAP-25 substrate cleavage after 40 mins by FRET assay | ChEMBL. | 22082667 |
IC50 (binding) | > 100 uM | Inhibition of Bacillus anthracis lethal factor using MCA-KKVYPYPME[dnp]Kamide peptide substrate after 30 mins by FRET assay | ChEMBL. | 22082667 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.