Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D4 receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0164 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.3427 | 0.3427 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.3427 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.007 | 0.3427 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3427 | 0.3427 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0164 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.3427 | 0.3427 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0164 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3427 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3427 | 0.3427 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3427 | 0.3427 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3427 | 0.3427 |
Brugia malayi | RNA binding protein | 0.007 | 0.3427 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Displacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation counting | ChEMBL. | 22245230 | |
Ki (binding) | Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting | ChEMBL. | 22245230 | |
Ki (binding) | = 4.5 nM | Displacement of [3H]N-methylspiperone from rat dopamine D4 receptor by liquid scintillation counting | ChEMBL. | 22245230 |
Ki (binding) | = 25 nM | Displacement of [3H]8-OH-DPAT from human 5HT1A receptor by liquid scintillation counting | ChEMBL. | 22245230 |
Ki (binding) | = 46 nM | Displacement of [3H]DOI from human 5HT2A receptor after 1 hr by liquid scintillation counting | ChEMBL. | 22245230 |
Ki (binding) | = 67.9 nM | Displacement of [3H]pyrilamine from human H1 receptor by liquid scintillation counting | ChEMBL. | 22245230 |
Ki (binding) | = 79.3 nM | Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by liquid scintillation counting | ChEMBL. | 22245230 |
Ki (binding) | = 119 nM | Displacement of [3H]N-methylspiperone from human dopamine D2 receptor by liquid scintillation counting | ChEMBL. | 22245230 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.