Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glutathione reductase | 0.0095 | 0.2535 | 0.4968 |
Plasmodium falciparum | glutathione reductase | 0.0095 | 0.2535 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0572 | 0.0541 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.3905 | 0.5333 |
Treponema pallidum | NADH oxidase | 0.0033 | 0.0313 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.3905 | 0.7651 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0033 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0095 | 0.2535 | 0.2985 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.3905 | 0.5333 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0167 | 0.5103 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0241 | 0.7757 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0.0313 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0572 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0096 | 0.2555 | 0.4681 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0572 | 0.0541 |
Leishmania major | trypanothione reductase | 0.0095 | 0.2535 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0572 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0033 | 0.0313 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0033 | 0.0313 | 0.0613 |
Brugia malayi | Thioredoxin reductase | 0.0095 | 0.2535 | 0.4968 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0095 | 0.2535 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0167 | 0.5103 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0095 | 0.2535 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0572 | 0.0267 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0033 | 0.0313 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0095 | 0.2535 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0217 | 0.6892 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0033 | 0.0313 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0096 | 0.2555 | 0.4681 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0572 | 0.0267 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0572 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0217 | 0.6892 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0217 | 0.6892 | 0.8837 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0217 | 0.6892 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0241 | 0.7757 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0572 | 0.1121 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0217 | 0.6892 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0241 | 0.7757 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0033 | 0.0313 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0095 | 0.2535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5103 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0167 | 0.5103 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0095 | 0.2535 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0167 | 0.5103 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0217 | 0.6892 | 0.8837 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0095 | 0.2535 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0241 | 0.7757 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0033 | 0.0313 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0.0313 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5103 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0033 | 0.0313 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0572 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.852 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.708 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.691 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.505 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.483 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.