Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0171 | 0.0809 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.018 | 0.0867 | 0.068 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1627 | 1 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.018 | 0.0867 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0171 | 0.0809 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0398 | 0.02 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1627 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.0106 | 0.0398 | 0.02 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1627 | 1 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0108 | 0.0411 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1627 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0106 | 0.0398 | 0.02 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1627 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1627 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1627 | 1 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0106 | 0.0398 | 0.02 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1627 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1627 | 1 | 1 |
Mycobacterium ulcerans | ATPase | 0.0108 | 0.0411 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1627 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0911 | 0.5483 | 0.5054 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0108 | 0.0411 | 0.00000046583 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1627 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1627 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1627 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1627 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1627 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0171 | 0.0809 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.018 | 0.0867 | 0.068 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1627 | 1 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0911 | 0.5483 | 0.539 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1627 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.018 | 0.0867 | 0.0476 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.018 | 0.0867 | 0.0867 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0171 | 0.0809 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1627 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1627 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0171 | 0.0809 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1627 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.572 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.