Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-Raf proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.0187 | 0.0194 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0187 | 0.0194 |
Brugia malayi | ecdysteroid receptor | 0.0167 | 0.6207 | 0.6443 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0187 | 0.0187 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.0187 | 0.0194 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0187 | 0.0187 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0187 | 0.0194 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0187 | 0.0194 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.0187 | 0.0187 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.0187 | 0.0194 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0187 | 0.0188 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.0187 | 0.0187 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0.0187 | 0.0187 |
Brugia malayi | Raf kinase | 0.0253 | 0.9633 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0148 | 0.5443 | 0.5471 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0187 | 0.0188 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0187 | 0.0187 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0187 | 0.0194 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0187 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0187 | 0.0188 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.0187 | 0.0188 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0187 | 0.0188 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0187 | 0.0194 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.0187 | 0.0187 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.0187 | 0.0187 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.0187 | 0.0194 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0187 | 0.0188 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.0187 | 0.0194 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.0187 | 0.0187 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0187 | 0.0188 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0187 | 0.0194 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0187 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0187 | 0.0188 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0187 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0187 | 0.0188 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.0187 | 0.0194 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0187 | 0.0188 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.0187 | 0.0187 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.0187 | 0.0187 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0262 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.0187 | 0.0187 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0167 | 0.6207 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0187 | 0.0194 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.0187 | 0.0194 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0187 | 0.0188 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.0187 | 0.0188 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.6207 | 0.6239 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0187 | 0.0194 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.9949 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0187 | 0.0188 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0187 | 0.0188 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0187 | 0.0194 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.0187 | 0.0187 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0187 | 0.0187 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0187 | 0.0187 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0187 | 0.0194 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0187 | 0.0187 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0187 | 0.0187 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.