Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.9011 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.2696 | 0.2696 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.9011 | 0.9002 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2696 | 0.2696 |
Echinococcus multilocularis | musashi | 0.0027 | 0.2696 | 0.2629 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.2696 | 0.2424 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.9011 | 0.9002 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.2696 | 0.2424 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 1 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.2696 | 0.2629 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.9011 | 0.8646 |
Onchocerca volvulus | 0.0027 | 0.2696 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.2696 | 0.2629 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.9011 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.2696 | 0.2629 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.2696 | 0.2629 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2604 | 0.2604 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.9011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0092 | 0.0092 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.9011 | 0.8646 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.4804 | 0.4756 |
Onchocerca volvulus | 0.0027 | 0.2696 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.2696 | 0.2696 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0067 | 1 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 1 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.4804 | 0.4756 |
Echinococcus multilocularis | lamin | 0.0027 | 0.2696 | 0.2629 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0359 | 0.0359 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.9011 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.9011 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 10.3 uM | Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (functional) | = 49 uM | Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against human MT4 cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (functional) | > 100 uM | Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (functional) | > 100 uM | Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (functional) | > 100 uM | Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (functional) | > 100 uM | Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (functional) | > 100 uM | Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (functional) | > 100 uM | Cytotoxicity against human DU145 cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay | ChEMBL. | 22047799 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against mock-infected human MT4 cells assessed as reduction in proliferation after 96 hrs by MTT method | ChEMBL. | 25014745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.