Detailed information for compound 1591681

Basic information

Technical information
  • TDR Targets ID: 1591681
  • Name: (1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl)sul fanylmethanimidamide
  • MW: 212.355 | Formula: C11H20N2S
  • H donors: 1 H acceptors: 0 LogP: 3.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)SC1CC2C(C1(C)CC2)(C)C
  • InChi: 1S/C11H20N2S/c1-10(2)7-4-5-11(10,3)8(6-7)14-9(12)13/h7-8H,4-6H2,1-3H3,(H3,12,13)
  • InChiKey: FZEFQGSAQNAPBA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1,7,7-trimethylnorbornan-2-yl)sulfanylformamidine
  • [(1,7,7-trimethyl-2-norbornanyl)thio]formamidine
  • (2-bornylthio)formamidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0233 0.1509 0.1509
Leishmania major proteasome beta 3 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma brucei proteasome subunit beta type-2, putative 0.057 0.4519 0.4519
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0233 0.1509 0.1509
Giardia lamblia Proteasome subunit beta type 1 0.092 0.7643 0.7224
Echinococcus multilocularis proteasome subunit alpha type 6 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit alpha type, putative 0.0233 0.1509 0.1509
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0233 0.1509 0.0463
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0233 0.1509 0.1509
Echinococcus granulosus proteasome subunit beta t family 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0233 0.1509 0.0463
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0233 0.1509 0.0463
Loa Loa (eye worm) proteasome subunit beta type 1 0.092 0.7643 0.7352
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0233 0.1509 0.1509
Giardia lamblia Proteasome subunit beta type 2 0.057 0.4519 0.3546
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0233 0.1509 0.5
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0233 0.1509 0.0463
Plasmodium vivax proteasome subunit beta type-6, putative 0.0233 0.1509 0.1509
Trypanosoma brucei proteasome beta 6 subunit 0.092 0.7643 0.7643
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1184 1 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0233 0.1509 0.0463
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0233 0.1509 0.1509
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1184 1 1
Brugia malayi Proteasome A-type and B-type family protein 0.0233 0.1509 0.0463
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0233 0.1509 0.0463
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0233 0.1509 0.0463
Leishmania major proteasome alpha 1 subunit, putative 0.0233 0.1509 0.1509
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0233 0.1509 0.0463
Brugia malayi proteasome subunit alpha type 3 0.0233 0.1509 0.0463
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1184 1 1
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0233 0.1509 0.1509
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.057 0.4519 0.3546
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0233 0.1509 0.0463
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.092 0.7643 0.7224
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0186 0.1096 0.1096
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0233 0.1509 0.1509
Leishmania major proteasome beta 7 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi 20S proteasome subunit 0.057 0.4519 0.4519
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit alpha1, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0233 0.1509 0.1509
Leishmania major proteasome alpha 7 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0233 0.1509 0.0463
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0233 0.1509 0.0463
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0233 0.1509 0.1509
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0186 0.1096 0.1096
Echinococcus granulosus Proteasome subunit alpha type 7 0.0233 0.1509 0.1509
Brugia malayi proteasome subunit alpha type 1 0.0233 0.1509 0.0463
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0233 0.1509 0.1509
Echinococcus multilocularis proteasome subunit alpha type 2 0.0233 0.1509 0.1509
Echinococcus granulosus proteasome prosome macropain subunit beta 0.057 0.4519 0.4519
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0233 0.1509 0.1509
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0233 0.1509 0.1509
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0233 0.1509 0.1509
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1184 1 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0233 0.1509 0.1509
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0233 0.1509 0.1509
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0233 0.1509 0.1509
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0233 0.1509 0.1509
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0233 0.1509 0.1509
Echinococcus multilocularis proteasome (prosome, macropain) 0.1184 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0233 0.1509 0.1509
Echinococcus multilocularis proteasome subunit beta type 6 0.0233 0.1509 0.1509
Leishmania major proteasome alpha 7 subunit, putative 0.0233 0.1509 0.1509
Echinococcus granulosus proteasome subunit alpha type 2 0.0233 0.1509 0.1509
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0233 0.1509 0.0463
Echinococcus granulosus proteasome subunit beta type 7 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit beta type 1, putative 0.092 0.7643 0.7643
Echinococcus granulosus proteasome subunit beta type 6 0.0233 0.1509 0.1509
Leishmania major proteasome alpha 2 subunit, putative 0.0233 0.1509 0.1509
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0233 0.1509 0.1509
Echinococcus granulosus proteasome prosome macropain subunit beta 0.092 0.7643 0.7643
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0233 0.1509 0.1509
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0233 0.1509 0.1509
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0233 0.1509 0.1509
Leishmania major proteasome beta 2 subunit, putative 0.057 0.4519 0.4519
Plasmodium falciparum proteasome subunit beta type-1, putative 0.092 0.7643 0.7224
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0233 0.1509 0.1509
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0233 0.1509 0.0463
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1184 1 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.057 0.4519 0.3546
Loa Loa (eye worm) proteasome subunit beta type 2 0.057 0.4519 0.3845
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0233 0.1509 0.1509
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0233 0.1509 0.1509
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0233 0.1509 0.1509
Leishmania major proteasome alpha 1 subunit, putative 0.0233 0.1509 0.1509
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0233 0.1509 0.1509
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1184 1 1
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0233 0.1509 0.0463
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0233 0.1509 0.1509
Loa Loa (eye worm) PAS-3 protein 0.0233 0.1509 0.0463
Leishmania major proteasome beta 2 subunit, putative 0.0233 0.1509 0.1509
Echinococcus granulosus proteasome subunit alpha type 6 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0233 0.1509 0.1509
Plasmodium vivax proteasome subunit beta type-5, putative 0.1184 1 1
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0233 0.1509 0.0463
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1184 1 1
Mycobacterium ulcerans proteasome PrcB 0.1184 1 1
Trypanosoma brucei proteasome beta 7 subunit 0.0233 0.1509 0.1509
Brugia malayi Proteasome A-type and B-type family protein 0.0233 0.1509 0.0463
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.057 0.4519 0.3845
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.057 0.4519 0.4519
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0233 0.1509 0.0463
Loa Loa (eye worm) proteasome subunit beta type 3 0.0233 0.1509 0.0463
Echinococcus granulosus subfamily T1A non peptidase ue 0.0233 0.1509 0.1509
Echinococcus granulosus proteasome prosome macropain 0.1184 1 1
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0233 0.1509 0.0463
Plasmodium vivax proteasome subunit beta type-3, putative 0.0233 0.1509 0.1509
Brugia malayi 20S proteasome alpha5 subunit 0.0233 0.1509 0.0463
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0233 0.1509 0.0463
Brugia malayi Proteasome subunit alpha type 7-1 0.0233 0.1509 0.0463
Leishmania major proteasome alpha 3 subunit, putative 0.0233 0.1509 0.1509
Toxoplasma gondii peptidase, T1 family protein 0.0233 0.1509 0.1509
Brugia malayi proteasome subunit alpha type 4 0.0233 0.1509 0.0463
Plasmodium vivax proteasome subunit beta type-1, putative 0.092 0.7643 0.7643
Toxoplasma gondii heat shock protein hslv, putative 0.0233 0.1509 0.1509
Leishmania major proteasome beta-1 subunit, putative 0.0233 0.1509 0.1509
Leishmania major proteasome beta 5 subunit, putative 0.1184 1 1
Brugia malayi Proteasome subunit alpha type 1 0.0233 0.1509 0.0463
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0233 0.1509 0.1509
Plasmodium vivax proteasome subunit beta type-7, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.092 0.7643 0.7643
Plasmodium falciparum proteasome subunit beta type-5 0.1184 1 1
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.092 0.7643 0.7643
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0233 0.1509 0.1509
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0233 0.1509 0.1509
Plasmodium vivax proteasome subunit beta type-4, putative 0.0233 0.1509 0.1509
Brugia malayi Proteasome A-type and B-type family protein 0.0233 0.1509 0.0463
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.057 0.4519 0.3546
Toxoplasma gondii proteasome subunit beta type 2, putative 0.057 0.4519 0.4519
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0233 0.1509 0.0463
Plasmodium vivax proteasome subunit beta type-2, putative 0.057 0.4519 0.4519
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1184 1 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.092 0.7643 0.7352
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0233 0.1509 0.1509
Onchocerca volvulus Notchless protein homolog 0.0233 0.1509 0.5
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.092 0.7643 0.7643
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit beta type, putative 0.1184 1 1
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0233 0.1509 0.0463
Brugia malayi proteasome subunit alpha type 2 0.0233 0.1509 0.0463
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0233 0.1509 0.0463
Trypanosoma brucei proteasome alpha 7 subunit 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0233 0.1509 0.1509
Echinococcus granulosus Proteasome subunit alpha beta 0.0233 0.1509 0.1509
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.092 0.7643 0.7643
Brugia malayi proteasome subunit beta type 3 0.0233 0.1509 0.0463
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0233 0.1509 0.1509
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0233 0.1509 0.1509
Echinococcus multilocularis proteasome subunit beta type 7 0.0233 0.1509 0.1509
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0233 0.1509 0.1509
Plasmodium falciparum proteasome subunit beta type-2, putative 0.057 0.4519 0.3546
Entamoeba histolytica proteasome subunit beta type 1, putative 0.092 0.7643 0.7224
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0233 0.1509 0.1509
Brugia malayi proteasome subunit beta type 1 0.092 0.7643 0.7352
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0233 0.1509 0.0463
Brugia malayi proteasome subunit alpha type 6 0.0233 0.1509 0.0463
Toxoplasma gondii proteasome subunit 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.057 0.4519 0.3845
Brugia malayi proteasome subunit beta type 2 0.057 0.4519 0.3845
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1184 1 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0233 0.1509 0.1509
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0233 0.1509 0.0463
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0233 0.1509 0.1509
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0233 0.1509 0.1509
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0233 0.1509 0.1509
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0233 0.1509 0.1509
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0233 0.1509 0.0463
Toxoplasma gondii proteasome beta subunit 0.0233 0.1509 0.1509
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.057 0.4519 0.4519
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1184 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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