Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | In vivo effect on [3H]-GABA release from rat cortical synaptosomes at 100 microM (No effect) | ChEMBL. | 6276545 |
Effect (functional) | = 30 % | In vivo maximal effect for synaptosomal GABA uptake at 100 uM | ChEMBL. | 6276545 |
Effect (functional) | = 30 % | In vivo maximal effect for synaptosomal GABA uptake at 100 uM | ChEMBL. | 6276545 |
IC50 (binding) | > 20 uM | Inhibition of 2 nM [3H]-muscimol binding to Gamma-aminobutyric-acid (GABA-A) receptor in rat brain crude synaptic membranes | ChEMBL. | 6276545 |
IC50 (binding) | > 20 uM | Inhibition of 2 nM [3H]-muscimol binding to Gamma-aminobutyric-acid (GABA-A) receptor in rat brain crude synaptic membranes | ChEMBL. | 6276545 |
Inhibition (functional) | = 30 % | In vivo inhibition of succinate formation in the synaptosomal Gamma-amino-N-butyrate transaminase assay at 100 uM | ChEMBL. | 6276545 |
Inhibition (functional) | = 30 % | In vivo inhibition of succinate formation in the synaptosomal Gamma-amino-N-butyrate transaminase assay at 100 uM | ChEMBL. | 6276545 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.