Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0017 | 0.0376 | 0.0371 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.001 | 0.0055 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0017 | 0.0376 | 0.1391 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0893 | 0.0889 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.2488 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0012 | 0.011 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0012 | 0.011 | 0.1425 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.044 | 0.0436 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.2488 | 0.2485 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0064 | 0.2488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Mycobacterium leprae | putative cytochrome p450 | 0.001 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | nuclear hormone receptor | 0.0017 | 0.0376 | 0.1391 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0376 | 0.1391 |
Brugia malayi | steroid hormone receptor | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.2673 | 0.267 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0017 | 0.0376 | 0.0371 |
Echinococcus multilocularis | 0.001 | 0.0055 | 0.019 | |
Brugia malayi | nuclear hormone receptor | 0.0017 | 0.0376 | 0.0371 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0009 | 0.0002 | 0.0178 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.4888 | 0.4886 |
Loa Loa (eye worm) | carboxylesterase | 0.0068 | 0.2673 | 0.267 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0068 | 0.2673 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2673 | 0.267 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0376 | 0.0371 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0017 | 0.0376 | 0.1391 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Carboxylesterase family protein | 0.0012 | 0.011 | 0.0105 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0012 | 0.011 | 0.0395 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.2488 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0017 | 0.0376 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0012 | 0.011 | 0.0395 |
Giardia lamblia | Myb 1-like protein | 0.0009 | 0.0002 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.001 | 0.0055 | 0.019 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0017 | 0.0376 | 0.1391 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0376 | 0.0371 |
Loa Loa (eye worm) | cytochrome P450 | 0.001 | 0.0055 | 0.0051 |
Echinococcus granulosus | carboxylesterase 5A | 0.0068 | 0.2673 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.0055 | 0.019 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.2488 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.044 | 0.0436 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.1267 | 0.4731 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.2488 | 0.9307 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0017 | 0.0376 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0376 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | ecdysteroid receptor | 0.0017 | 0.0376 | 0.0371 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0017 | 0.0376 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.2673 | 0.267 |
Brugia malayi | cytochrome P450 | 0.001 | 0.0055 | 0.0051 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.4888 | 0.4886 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0376 | 0.0371 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.1267 | 0.4731 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0017 | 0.0376 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.044 | 0.1582 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0376 | 0.0371 |
Echinococcus granulosus | neuroligin | 0.0012 | 0.011 | 0.0395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0376 | 0.0371 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0012 | 0.011 | 0.0395 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.2673 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0068 | 0.2673 | 0.267 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.2673 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0012 | 0.011 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0.044 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0376 | 0.1391 |
Trichomonas vaginalis | MYB, putative | 0.0009 | 0.0002 | 0.0178 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0017 | 0.0376 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2673 | 0.267 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0012 | 0.011 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0017 | 0.0376 | 0.1391 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.044 | 0.0436 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0376 | 0.1391 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0017 | 0.0376 | 0.1391 |
Echinococcus multilocularis | neuroligin | 0.0012 | 0.011 | 0.0395 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0376 | 0.1391 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0376 | 0.1391 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0017 | 0.0376 | 0.1391 |
Schistosoma mansoni | cytochrome P450 | 0.001 | 0.0055 | 0.019 |
Schistosoma mansoni | acetylcholinesterase | 0.0012 | 0.011 | 0.0395 |
Brugia malayi | nuclear receptor NHR-88 | 0.0017 | 0.0376 | 0.0371 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | gliotactin | 0.0012 | 0.011 | 0.0395 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0231 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0012 | 0.011 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0376 | 0.0371 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.044 | 0.0436 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0012 | 0.011 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0376 | 0.1391 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.2488 | 0.9307 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0376 | 0.1391 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.2673 | 1 |
Onchocerca volvulus | 0.0017 | 0.0376 | 1 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0017 | 0.0376 | 0.1391 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0017 | 0.0376 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0012 | 0.011 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0376 | 0.1391 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.044 | 0.1582 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0012 | 0.011 | 0.0395 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0017 | 0.0376 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0012 | 0.011 | 0.0395 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0012 | 0.011 | 0.0395 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.2673 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.044 | 0.0436 |
Mycobacterium leprae | Conserved hypothetical protein | 0.001 | 0.0055 | 0.5 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0009 | 0.0002 | 0.0178 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0012 | 0.011 | 0.0395 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0012 | 0.011 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.2488 | 0.2485 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0376 | 0.1391 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0893 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.044 | 0.1582 |
Loa Loa (eye worm) | carboxylesterase | 0.0012 | 0.011 | 0.0105 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0068 | 0.2673 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0012 | 0.011 | 0.0105 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0012 | 0.011 | 0.0395 |
Brugia malayi | Cytochrome P450 family protein | 0.001 | 0.0055 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0012 | 0.011 | 0.0395 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0012 | 0.011 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0376 | 0.0371 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0376 | 0.1391 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.044 | 0.1582 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.2488 | 0.9307 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0017 | 0.0376 | 0.1391 |
Brugia malayi | Carboxylesterase family protein | 0.0012 | 0.011 | 0.0105 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0376 | 0.0371 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0017 | 0.0376 | 0.1391 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0017 | 0.0376 | 0.1391 |
Echinococcus granulosus | FTZ F1 alpha | 0.0017 | 0.0376 | 0.1391 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0376 | 0.1391 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.2488 | 1 |
Brugia malayi | hypothetical protein | 0.0012 | 0.011 | 0.0105 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0017 | 0.0376 | 0.1391 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.4888 | 0.4886 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0376 | 0.1391 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0017 | 0.0376 | 0.0371 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0376 | 0.1391 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0012 | 0.011 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0376 | 0.0371 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0017 | 0.0376 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0017 | 0.0376 | 0.1391 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.619 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.403 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.364 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.287 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.277 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.