Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.8709 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1419 | 0.1629 |
Schistosoma mansoni | alpha-glucosidase | 0.0164 | 0.5976 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0042 | 0.1069 | 0.1228 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0705 | 0.0793 |
Schistosoma mansoni | alpha glucosidase | 0.0042 | 0.1069 | 0.1428 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0147 | 0.53 | 0.743 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0252 | 0.2354 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1419 | 0.2039 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.53 | 0.8819 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0252 | 0.0289 |
Schistosoma mansoni | thyroid hormone receptor | 0.0159 | 0.5776 | 0.9651 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0705 | 0.081 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1069 | 0.1069 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.1069 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0705 | 0.0793 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0705 | 0.0668 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.8709 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0252 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.019 | 0.7046 | 0.809 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0042 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0705 | 0.081 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1419 | 0.1718 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0042 | 0.1069 | 0.1204 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0042 | 0.1069 | 0.1228 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0042 | 0.1069 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0252 | 0.0289 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1069 | 0.1069 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0159 | 0.5776 | 0.8132 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0042 | 0.1069 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0252 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0147 | 0.53 | 0.743 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1419 | 0.2039 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0042 | 0.1069 | 0.1069 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0705 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0705 | 0.0793 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0705 | 0.5548 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.4725 | 0.5426 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0252 | 0.0252 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1069 | 0.1069 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1419 | 0.1629 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0705 | 0.0668 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0252 | 0.2354 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1419 | 0.1718 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0252 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0042 | 0.1069 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0252 | 0.2354 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0252 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0705 | 0.0705 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0705 | 0.0793 |
Schistosoma mansoni | thyroid hormone receptor | 0.0159 | 0.5776 | 0.9651 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0042 | 0.1069 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0042 | 0.1069 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0164 | 0.5976 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.019 | 0.7046 | 0.809 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 0.7046 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 0.7046 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.019 | 0.7046 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0705 | 0.0668 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0252 | 0.0252 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0042 | 0.1069 | 0.1204 |
Onchocerca volvulus | 0.011 | 0.3807 | 0.3807 | |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0252 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1419 | 0.1718 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1069 | 0.1069 |
Trichomonas vaginalis | set domain proteins, putative | 0.0263 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0252 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.1069 | 0.1069 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.1069 | 0.1069 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.1069 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1419 | 0.1718 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1419 | 0.2039 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.4725 | 0.5426 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0252 | 0.2354 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0656 | 0.0595 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.4725 | 0.5426 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0252 | 0.2354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.495 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.757 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.742 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.734 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.619 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.611 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.512 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.436 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.