Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0732 | 0.7114 | 0.7049 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0876 | 1 | 1 |
Onchocerca volvulus | 0.0732 | 0.7114 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0732 | 0.7114 | 0.7049 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Plasmodium vivax | vivapain-2 | 0.0732 | 0.7114 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0732 | 0.7114 | 0.7114 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Onchocerca volvulus | 0.0732 | 0.7114 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0732 | 0.7114 | 0.7049 |
Loa Loa (eye worm) | hypothetical protein | 0.0876 | 1 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0388 | 0.0222 | 0.0222 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0876 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0876 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0388 | 0.0222 | 0.0312 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0388 | 0.0222 | 0.0222 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0497 | 0.2415 | 0.2243 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0732 | 0.7114 | 1 |
Onchocerca volvulus | 0.0732 | 0.7114 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0732 | 0.7114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.2415 | 0.2415 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0732 | 0.7114 | 0.7114 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0732 | 0.7114 | 0.7114 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0876 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0732 | 0.7114 | 0.7114 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0497 | 0.2415 | 0.3394 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0732 | 0.7114 | 0.7114 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0732 | 0.7114 | 0.7114 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.2415 | 0.2415 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0497 | 0.2415 | 0.2243 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0388 | 0.0222 | 0.0312 |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Echinococcus granulosus | cathepsin b | 0.0876 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 0.7114 | 0.7114 |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0732 | 0.7114 | 0.7114 |
Brugia malayi | Cathepsin L-like precursor | 0.0732 | 0.7114 | 0.7049 |
Echinococcus multilocularis | cathepsin b | 0.0876 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0732 | 0.7114 | 0.7049 |
Toxoplasma gondii | cathepsin CPL | 0.0732 | 0.7114 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0732 | 0.7114 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0732 | 0.7114 | 0.7114 |
Leishmania major | cysteine peptidase A (CPA) | 0.0732 | 0.7114 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0732 | 0.7114 | 0.7049 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0732 | 0.7114 | 0.7049 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0732 | 0.7114 | 0.7114 |
Brugia malayi | Cathepsin L-like precursor | 0.0732 | 0.7114 | 0.7049 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0732 | 0.7114 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0388 | 0.0222 | 0.0222 |
Echinococcus granulosus | cathepsin l1 | 0.0497 | 0.2415 | 0.2243 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0388 | 0.0222 | 0.0222 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.2415 | 0.2415 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0388 | 0.0222 | 0.0222 |
Brugia malayi | Cathepsin L-like precursor | 0.0497 | 0.2415 | 0.2243 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0732 | 0.7114 | 0.7114 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0388 | 0.0222 | 0.0222 |
Onchocerca volvulus | 0.0732 | 0.7114 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Onchocerca volvulus | 0.0732 | 0.7114 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0732 | 0.7114 | 0.7049 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0732 | 0.7114 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0732 | 0.7114 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0497 | 0.2415 | 0.2243 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0497 | 0.2415 | 0.2415 |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Echinococcus granulosus | cathepsin b | 0.0876 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0732 | 0.7114 | 0.7049 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0732 | 0.7114 | 0.7114 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0377 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0732 | 0.7114 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0732 | 0.7114 | 0.7114 |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0388 | 0.0222 | 0.0312 |
Plasmodium vivax | vivapain-2 | 0.0732 | 0.7114 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0876 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0732 | 0.7114 | 0.7049 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0497 | 0.2415 | 0.3394 |
Brugia malayi | Cathepsin L-like precursor | 0.0732 | 0.7114 | 0.7049 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0876 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Onchocerca volvulus | 0.0732 | 0.7114 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0497 | 0.2415 | 0.2415 |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0388 | 0.0222 | 0.0312 |
Leishmania major | cathepsin L-like protease | 0.0732 | 0.7114 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0377 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0732 | 0.7114 | 0.7049 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0732 | 0.7114 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0732 | 0.7114 | 0.7049 |
Giardia lamblia | Cathepsin B precursor | 0.0377 | 0 | 0.5 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0388 | 0.0222 | 0.0222 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0388 | 0.0222 | 0.0222 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0732 | 0.7114 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0732 | 0.7114 | 0.7049 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0497 | 0.2415 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0732 | 0.7114 | 0.7049 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0732 | 0.7114 | 1 |
Onchocerca volvulus | 0.0732 | 0.7114 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 27 % | Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-6 M | ChEMBL. | 2170647 |
Inhibition (functional) | = 27 % | Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-6 M | ChEMBL. | 2170647 |
Inhibition (functional) | = 73 % | Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-5 M | ChEMBL. | 2170647 |
Inhibition (functional) | = 73 % | Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-5 M | ChEMBL. | 2170647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.