Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0482 | 0.6669 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0254 | 0.2536 | 0.2393 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0352 | 0.4313 | 0.4204 |
Entamoeba histolytica | protein kinase, putative | 0.0124 | 0.0188 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0412 | 0.5408 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0993 | 0.0891 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0993 | 0.0891 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0254 | 0.2536 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0254 | 0.2536 | 0.5 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0114 | 0 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0482 | 0.6669 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0124 | 0.0188 | 1 |
Trypanosoma brucei | unspecified product | 0.0167 | 0.0963 | 0.079 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0643 | 0.9578 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0666 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0666 | 1 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0254 | 0.2536 | 0.2393 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0666 | 1 | 1 |
Schistosoma mansoni | pyruvate carboxylase | 0.0254 | 0.2536 | 0.2393 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0254 | 0.2536 | 0.5 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0666 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0168 | 0.0993 | 0.0857 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0643 | 0.9578 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0124 | 0.0188 | 0.0037 |
Chlamydia trachomatis | biotin carboxylase | 0.023 | 0.2114 | 0.5 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0254 | 0.2536 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0254 | 0.2536 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0254 | 0.2536 | 0.2393 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0666 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0352 | 0.4313 | 0.4414 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0254 | 0.2536 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0254 | 0.2536 | 0.4498 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0254 | 0.2536 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0254 | 0.2536 | 0.4498 |
Entamoeba histolytica | protein kinase, putative | 0.0124 | 0.0188 | 1 |
Leishmania major | carboxylase, putative | 0.0254 | 0.2536 | 0.2393 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0666 | 1 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0254 | 0.2536 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0254 | 0.2536 | 0.2393 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0254 | 0.2536 | 0.2393 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0254 | 0.2536 | 0.2393 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0352 | 0.4313 | 0.4204 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0352 | 0.4313 | 0.4204 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0124 | 0.0188 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0254 | 0.2536 | 0.2393 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.