Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1036 | 0.4388 | 0.4388 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | ecdysteroid receptor | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0547 | 0.2248 | 0.2248 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1036 | 0.4388 | 1 |
Brugia malayi | plexin A | 0.004 | 0.0027 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Echinococcus granulosus | FTZ F1 alpha | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0489 | 0.1992 | 0.1992 |
Brugia malayi | nuclear receptor RXR | 0.0489 | 0.1992 | 0.4538 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0489 | 0.1992 | 0.4538 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1036 | 0.4388 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0489 | 0.1992 | 0.4504 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Onchocerca volvulus | 0.0489 | 0.1992 | 0.4538 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1036 | 0.4388 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | nuclear receptor NHR-88 | 0.1036 | 0.4388 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1036 | 0.4388 | 0.4388 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Schistosoma mansoni | nuclear receptor | 0.0489 | 0.1992 | 0.1992 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1036 | 0.4388 | 1 |
Brugia malayi | hypothetical protein | 0.0547 | 0.2248 | 0.5123 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | plexin A | 0.004 | 0.0027 | 0.0062 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0489 | 0.1992 | 0.4504 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1036 | 0.4388 | 1 |
Onchocerca volvulus | 0.0489 | 0.1992 | 0.4538 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0489 | 0.1992 | 0.1992 |
Schistosoma mansoni | nuclear hormone receptor | 0.1036 | 0.4388 | 0.4388 |
Brugia malayi | steroid hormone receptor | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1036 | 0.4388 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0489 | 0.1992 | 0.4504 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1036 | 0.4388 | 1 |
Brugia malayi | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1036 | 0.4388 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1036 | 0.4388 | 0.4388 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1036 | 0.4388 | 0.4388 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1036 | 0.4388 | 1 |
Brugia malayi | hypothetical protein | 0.0547 | 0.2248 | 0.5123 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1036 | 0.4388 | 0.4388 |
Schistosoma mansoni | zinc finger protein | 0.0489 | 0.1992 | 0.1992 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0547 | 0.2248 | 0.5123 |
Brugia malayi | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0547 | 0.2248 | 0.5123 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1036 | 0.4388 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0489 | 0.1992 | 0.1992 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.2248 | 0.5123 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0489 | 0.1992 | 0.4504 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1036 | 0.4388 | 0.4388 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0489 | 0.1992 | 0.4538 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1036 | 0.4388 | 0.4388 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0547 | 0.2248 | 0.5093 |
Brugia malayi | nuclear hormone receptor | 0.1036 | 0.4388 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1036 | 0.4388 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | nuclear hormone receptor | 0.0489 | 0.1992 | 0.4538 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0489 | 0.1992 | 0.4504 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0489 | 0.1992 | 0.4504 |
Brugia malayi | ecdysone receptor | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | tailless protein | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | nuclear receptor NHR-88 | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0489 | 0.1992 | 0.4538 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1036 | 0.4388 | 0.4388 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0489 | 0.1992 | 0.4538 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0489 | 0.1992 | 0.4504 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1036 | 0.4388 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1036 | 0.4388 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1036 | 0.4388 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | coup transcription factor | 0.1036 | 0.4388 | 0.4388 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1036 | 0.4388 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0489 | 0.1992 | 0.4504 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1036 | 0.4388 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Schistosoma mansoni | thyroid hormone receptor | 0.1036 | 0.4388 | 0.4388 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0489 | 0.1992 | 0.4504 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0547 | 0.2248 | 0.5093 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.2248 | 0.5123 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1036 | 0.4388 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1036 | 0.4388 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1036 | 0.4388 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1036 | 0.4388 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1036 | 0.4388 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1036 | 0.4388 | 1 |
Onchocerca volvulus | 0.1036 | 0.4388 | 1 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1036 | 0.4388 | 0.4388 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.2248 | 0.5123 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.2248 | 0.5123 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1036 | 0.4388 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1036 | 0.4388 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0547 | 0.2248 | 0.5123 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.2248 | 0.5123 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0489 | 0.1992 | 0.4538 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1036 | 0.4388 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0489 | 0.1992 | 0.4504 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1036 | 0.4388 | 0.4388 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0489 | 0.1992 | 0.1992 |
Brugia malayi | nuclear receptor RXR | 0.0547 | 0.2248 | 0.5123 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0489 | 0.1992 | 0.4504 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0489 | 0.1992 | 0.4504 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0489 | 0.1992 | 0.1992 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0547 | 0.2248 | 0.2248 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1036 | 0.4388 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0489 | 0.1992 | 0.4538 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 0.4388 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1036 | 0.4388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.1992 | 0.4538 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1036 | 0.4388 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.