Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0881 | 0.9849 | 1 |
Brugia malayi | Tnks protein | 0.0111 | 0.0906 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0731 | 0.811 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0062 | 0.0339 | 0.0212 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0731 | 0.811 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0177 | 0.0218 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0177 | 0.0218 |
Onchocerca volvulus | Tankyrase homolog | 0.0111 | 0.0906 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0133 | 0.0135 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0881 | 0.9849 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0621 | 0.6822 | 0.6927 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0731 | 0.811 | 0.8234 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.0253 | 0.2554 | 0.2492 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0731 | 0.811 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Echinococcus granulosus | tankyrase | 0.0111 | 0.0906 | 0.0795 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0142 | 0.1266 | 0.1166 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.1266 | 0.0975 |
Schistosoma mansoni | tankyrase | 0.0111 | 0.0906 | 0.0919 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0133 | 0.0164 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.5702 | 0.7031 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0542 | 0.5906 | 0.5 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0062 | 0.0339 | 0.0345 |
Brugia malayi | WGR domain containing protein | 0.0731 | 0.811 | 0.8234 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0062 | 0.0339 | 0.0345 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0062 | 0.0339 | 0.0418 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0177 | 0.018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0133 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0122 | 0.015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0374 | 0.3963 | 0.3942 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0142 | 0.1266 | 0.1166 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0906 | 0.0595 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0731 | 0.811 | 0.821 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0499 | 0.5413 | 0.6674 |
Brugia malayi | WGR domain containing protein | 0.0881 | 0.9849 | 1 |
Echinococcus multilocularis | tankyrase | 0.0111 | 0.0906 | 0.0795 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0906 | 0.0595 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0177 | 0.018 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0374 | 0.3963 | 0.3942 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0881 | 0.9849 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0731 | 0.811 | 0.821 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0133 | 0.0135 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.0906 | 1 |
Leishmania major | DNA repair protein, putative | 0.0043 | 0.0122 | 0.5 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0881 | 0.9849 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0906 | 0.0595 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0133 | 0.0135 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0731 | 0.811 | 1 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0542 | 0.5906 | 0.5 |
Loa Loa (eye worm) | tnks protein | 0.0111 | 0.0906 | 0.1117 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0232 | 0.2315 | 0.2246 |
Entamoeba histolytica | zinc finger protein, putative | 0.0111 | 0.0906 | 0.0595 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0062 | 0.0339 | 0.0212 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0906 | 0.0595 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 16.21 % | Inhibition of human recombinant CAMK2delta using tetramethylbenzidine as substrate at 10 uM by spectrophotometry analysis | ChEMBL. | 22112539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.