Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0074 | 0.1045 | 0.1045 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0851 | 0.0851 |
Brugia malayi | Pre-SET motif family protein | 0.0227 | 0.4839 | 0.4823 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0074 | 0.1045 | 0.1045 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0524 | 0.0496 |
Onchocerca volvulus | 0.0074 | 0.1045 | 0.1818 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0074 | 0.1045 | 0.1018 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0851 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Brugia malayi | Carboxylesterase family protein | 0.0436 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0524 | 0.0496 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.1045 | 0.1018 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0227 | 0.4839 | 0.4823 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.1045 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.1045 | 0.1018 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0524 | 0.0524 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0851 | 0.0824 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.1045 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Echinococcus multilocularis | GPCR, family 2 | 0.0066 | 0.0851 | 0.0824 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0524 | 0.0496 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0074 | 0.1045 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.3375 | 0.5098 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.1045 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Onchocerca volvulus | 0.0074 | 0.1045 | 0.1818 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0524 | 0.0496 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.003 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0436 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0142 | 0.2738 | 0.2717 |
Echinococcus multilocularis | neuroligin | 0.0074 | 0.1045 | 0.1018 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.1045 | 0.1018 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.1045 | 0.1018 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0066 | 0.0851 | 0.0824 |
Trichomonas vaginalis | set domain proteins, putative | 0.0259 | 0.5614 | 1 |
Onchocerca volvulus | 0.0074 | 0.1045 | 0.1818 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Onchocerca volvulus | 0.0074 | 0.1045 | 0.1818 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3491 | 0.3472 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0851 | 0.0824 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0208 | 0.4364 | 0.4348 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0074 | 0.1045 | 0.1018 |
Echinococcus granulosus | neuroligin | 0.0074 | 0.1045 | 0.1045 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0851 | 0.0824 |
Brugia malayi | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0066 | 0.0851 | 0.0824 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.1045 | 0.1018 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.2738 | 0.2717 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0208 | 0.4364 | 0.4348 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0524 | 0.0524 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0074 | 0.1045 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0318 | 0.7067 | 0.7058 |
Echinococcus granulosus | geminin | 0.0318 | 0.7067 | 0.7067 |
Onchocerca volvulus | 0.0074 | 0.1045 | 0.1818 | |
Schistosoma mansoni | gliotactin | 0.0074 | 0.1045 | 0.1018 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0066 | 0.0851 | 0.0824 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.003 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0074 | 0.1045 | 0.1018 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0074 | 0.1045 | 0.1045 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0851 | 0.0824 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0851 | 0.0824 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0436 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.4364 | 0.4348 |
Schistosoma mansoni | acetylcholinesterase | 0.0074 | 0.1045 | 0.1018 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0173 | 0.3491 | 0.3472 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0208 | 0.4364 | 0.4348 |
Echinococcus granulosus | carboxylesterase 5A | 0.0436 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0851 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2738 | 0.2717 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0318 | 0.7067 | 0.7058 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.1045 | 0.1018 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0066 | 0.0851 | 0.0851 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0524 | 0.0496 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0524 | 0.0496 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0074 | 0.1045 | 0.1018 |
Loa Loa (eye worm) | carboxylesterase | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.1045 | 0.1018 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0074 | 0.1045 | 0.1018 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.1045 | 0.1018 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.003 | 0.003 |
Echinococcus multilocularis | geminin | 0.0318 | 0.7067 | 0.7058 |
Onchocerca volvulus | 0.0259 | 0.5614 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0524 | 0.0496 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0851 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1045 | 0.1018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 280.87 uM | Cytotoxicity against human C8166 cells by MTT assay | ChEMBL. | 18278869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.