TDR Targets

Basic information

Technical information

TDR Targets ID: 1592179
Name: (2E)-2-[2-(3-bromophenyl)propylidene]-5-(dime thylaminomethyl)cyclopentan-1-one hydrochlori de
MW: 372.728 | Formula: C17H23BrClNO
H donors: 0 H acceptors: 1 LogP: 4.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN(CC1CC/C(=C\C(c2cccc(c2)Br)C)/C1=O)C.Cl
InChi: 1S/C17H22BrNO.ClH/c1-12(13-5-4-6-16(18)10-13)9-14-7-8-15(17(14)20)11-19(2)3;/h4-6,9-10,12,15H,7-8,11H2,1-3H3;1H/b14-9+;
InChiKey: QQQULCYJFLOBTO-KYIGKLDSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2E)-2-[2-(3-bromophenyl)propylidene]-5-(dimethylaminomethyl)-1-cyclopentanone hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ATP binding cassette sub family B	0.0034	0.061	0.0608
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0034	0.0622	0.0912
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0231	0.0229
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0223	0.6805	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0231	1
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0059	0.0257
Schistosoma mansoni	ran	0.0022	0.0231	0.0229
Echinococcus granulosus	GPCR family 2	0.0017	0.0059	0.0057
Schistosoma mansoni	hypothetical protein	0.0017	0.0059	0.0057
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0223	0.6805	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0034	0.0622	0.062
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0059	0.0059
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0034	0.0622	0.0711
Schistosoma mansoni	hypothetical protein	0.0037	0.0699	0.0698
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0367	0.0537
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0034	0.0622	0.062
Trichomonas vaginalis	ABC transporter, putative	0.0034	0.0622	0.0711
Schistosoma mansoni	ap endonuclease	0.002	0.0149	0.0147
Trichomonas vaginalis	abcb9, putative	0.0034	0.0622	0.0711
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0223	0.6805	1
Leishmania major	GTP-binding protein, putative	0.0022	0.0231	0.3695
Schistosoma mansoni	hypothetical protein	0.0017	0.0059	0.0057
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.049	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0367	0.0367
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0149	0.0216
Trichomonas vaginalis	taga, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0622	0.0622
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0231	0.6279
Echinococcus granulosus	multidrug resistance protein 1	0.0034	0.0622	0.062
Entamoeba histolytica	P-glycoprotein-2	0.0034	0.0622	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0015	0.0002	0.0002
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0149	0.0147
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0034	0.0622	0.062
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0367	1
Entamoeba histolytica	P-glyco protein 6, putative	0.0034	0.0622	1
Echinococcus granulosus	multidrug resistance protein 1	0.0034	0.0622	0.062
Schistosoma mansoni	lamin	0.0028	0.0427	0.0425
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0034	0.0622	0.0912
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.049	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0034	0.0622	0.0711
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0427	0.1854
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0034	0.0622	0.062
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0231	0.0337
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0059	0.0057
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0699	0.3038
Echinococcus granulosus	importin subunit beta 1	0.003	0.049	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0034	0.061	0.061
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0149	0.0149
Echinococcus multilocularis	importin subunit beta 1	0.003	0.049	0.0489
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0231	0.1003
Echinococcus multilocularis	lamin dm0	0.0028	0.0427	0.0425
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0034	0.0622	0.062
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0015	0.0002	0.0002
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0305	0.8296
Schistosoma mansoni	hypothetical protein	0.0177	0.5283	0.5283
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0223	0.6805	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0305	0.4882
Plasmodium vivax	multidrug resistance protein 1, putative	0.0034	0.0622	0.0912
Trichomonas vaginalis	ran, putative	0.0022	0.0231	0.0124
Echinococcus multilocularis	lamin	0.0028	0.0427	0.0425
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0034	0.0622	0.062
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0024	0.0285	0.0206
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0034	0.0622	0.0711
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0427	0.0425
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0367	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0149	0.2368
Echinococcus granulosus	lamin	0.0028	0.0427	0.0425
Schistosoma mansoni	multidrug resistance protein	0.0034	0.0622	0.062
Entamoeba histolytica	P-glycoprotein-1	0.0034	0.0622	1
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0059	0.0057
Brugia malayi	multidrug resistance protein 3	0.0034	0.0622	0.2701
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.049	0.0718
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1251	0.5434
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0149	0.4024
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0034	0.061	0.0608
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0034	0.0622	0.0912
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0034	0.0622	0.0912
Echinococcus granulosus	multidrug resistance protein 1	0.0024	0.0285	0.0284
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0149	0.0216
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0059	0.0057
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0149	0.3005
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0231	0.0231
Schistosoma mansoni	hypothetical protein	0.0177	0.5283	0.5283
Brugia malayi	intermediate filament protein	0.0028	0.0427	0.1854
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0149	0.2368
Onchocerca volvulus		0.0028	0.0427	0.6853
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0034	0.0622	0.062
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0034	0.0622	0.0711
Leishmania major	hypothetical protein, conserved	0.0026	0.0367	0.5885
Entamoeba histolytica	P-glycoprotein-2, putative	0.0034	0.0622	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0223	0.6805	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0034	0.0622	0.0711
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0034	0.0622	0.0622
Plasmodium falciparum	importin beta, putative	0.003	0.049	0.0718
Entamoeba histolytica	Ran family GTPase	0.0022	0.0231	0.3695
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0367	0.0537
Entamoeba histolytica	P-glycoprotein 5, putative	0.0034	0.0622	1
Plasmodium falciparum	multidrug resistance protein 1	0.0034	0.0622	0.0912
Brugia malayi	hypothetical protein	0.0017	0.0062	0.027
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0231	0.0337
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1251	0.5434
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0002	0.0002
Echinococcus multilocularis	musashi	0.0028	0.0427	0.0425
Echinococcus multilocularis	multidrug resistance protein 1	0.0034	0.0622	0.062
Trichomonas vaginalis	ABC transporter, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0427	0.0427
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0028	0.041	0.041
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0034	0.0622	0.062
Trichomonas vaginalis	ABC transporter, putative	0.0034	0.0622	0.0711
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0059	0.0257
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0367	0.0537
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0231	0.0337
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0034	0.0622	1
Entamoeba histolytica	P-glycoprotein-5	0.0034	0.0622	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0223	0.6805	1
Brugia malayi	RNA, U transporter 1	0.0086	0.2303	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0059	0.0057
Leishmania major	p-glycoprotein	0.0034	0.0622	1
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0223	0.6805	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0149	0.0147
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0427	0.0427
Toxoplasma gondii	exonuclease III APE	0.002	0.0149	0.0216
Echinococcus granulosus	geminin	0.0177	0.5283	0.5283
Entamoeba histolytica	P-glycoprotein-2	0.0034	0.0622	1
Trichomonas vaginalis	ABC transporter, putative	0.0034	0.0622	0.0711
Onchocerca volvulus		0.0028	0.0427	0.6853
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0034	0.0622	0.062
Schistosoma mansoni	lamin	0.0028	0.0427	0.0425
Schistosoma mansoni	hypothetical protein	0.0017	0.0059	0.0057
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0231	0.0229
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0305	0.4882
Loa Loa (eye worm)	multidrug resistance protein 3	0.0034	0.0622	0.0622
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0149	0.4024
Schistosoma mansoni	smdr2	0.0034	0.0622	0.062
Onchocerca volvulus		0.0034	0.0622	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0059	0.0057
Schistosoma mansoni	multidrug resistance protein	0.0034	0.0622	0.062
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0034	0.0622	0.0711
Schistosoma mansoni	ran	0.0022	0.0231	0.0229
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0034	0.0622	0.0711
Echinococcus granulosus	intermediate filament protein	0.0028	0.0427	0.0425
Schistosoma mansoni	hypothetical protein	0.0321	1	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0149	0.5
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0367	0.7469
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0305	0.0234
Echinococcus granulosus	lamin dm0	0.0028	0.0427	0.0425
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0321	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0002	0.0008
Brugia malayi	ABC transporter family protein	0.0034	0.0622	0.2701
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0034	0.0622	0.0711
Schistosoma mansoni	multidrug resistance protein	0.0034	0.0622	0.062
Echinococcus multilocularis	geminin	0.0177	0.5283	0.5283
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0223	0.6805	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0059	0.0057
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0367	0.0537
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0034	0.0622	0.0711
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0149	0.0216
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0034	0.0622	0.0711
Brugia malayi	hypothetical protein	0.0026	0.0367	0.1593
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0002	0.0008
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0034	0.0622	0.062
Echinococcus multilocularis	multidrug resistance protein 1	0.0024	0.0285	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0427	0.0427
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1251	0.1251
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0231	0.6279
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0149	0.0645
Trichomonas vaginalis	abcb9, putative	0.0034	0.0622	0.0711
Echinococcus granulosus	multidrug resistance protein 1	0.0034	0.0622	0.062
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0231	0.469
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0059	0.0059
Schistosoma mansoni	importin beta-1	0.003	0.049	0.0489
Trichomonas vaginalis	hypothetical protein	0.0223	0.6805	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0034	0.0622	0.0711
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0622	0.0622
Echinococcus multilocularis	snurportin 1	0.0321	1	1
Brugia malayi	Importin beta-1 subunit	0.003	0.049	0.213
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0002	0.0002
Trichomonas vaginalis	abcb9, putative	0.0034	0.0622	0.0711
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0305	0.0234
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0034	0.0622	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0699	0.0699
Schistosoma mansoni	ap endonuclease	0.002	0.0149	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1251	0.1251
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0305	0.0234
Echinococcus granulosus	multidrug resistance protein 1	0.0024	0.0285	0.0284
Plasmodium vivax	importin-beta 2, putative	0.003	0.049	0.0718
Loa Loa (eye worm)	hypothetical protein	0.003	0.049	0.049
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0149	0.0216
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0149	0.0216

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.514	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.874	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.861	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.749	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.745	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.74	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.718	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.71	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.658	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1979783

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1592179