Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0006 | 0.0006 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0363 | 0.0588 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0139 | 0.6167 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.213 | 0.3447 |
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0006 | 0.0006 |
Echinococcus multilocularis | protein patched | 0.0057 | 0.213 | 0.213 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0139 | 0.6167 | 0.6167 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0006 | 0.001 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0363 | 0.0363 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0363 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0065 | 0.2524 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0363 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0139 | 0.6167 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0363 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.6167 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0057 | 0.213 | 0.213 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0363 | 0.0363 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0139 | 0.6167 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0139 | 0.6167 | 0.6167 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0057 | 0.213 | 0.213 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0216 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0139 | 0.6167 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0057 | 0.213 | 0.3447 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0065 | 0.2524 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0057 | 0.213 | 0.213 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0363 | 0.0588 |
Brugia malayi | CHE-14 protein | 0.0057 | 0.213 | 0.3453 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0139 | 0.6167 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0363 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0363 | 0.0588 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0139 | 0.6167 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0057 | 0.213 | 0.213 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0363 | 0.0579 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0065 | 0.2524 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0057 | 0.213 | 0.3453 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0015 | 0.0024 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0065 | 0.2524 | 1 |
Schistosoma mansoni | patched 1 | 0.0057 | 0.213 | 0.3453 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0363 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0363 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.213 | 0.8176 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0139 | 0.6167 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0057 | 0.213 | 0.213 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0363 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0057 | 0.213 | 0.213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.72 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.682 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.666 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.604 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.571 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.368 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.321 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.073 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.