TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.323 | Formula: C16H15N5O2
H donors: 3 H acceptors: 3 LogP: 0.8 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc2c(c1)n1CCCNC(=O)c1c2)Nc1c[nH]nc1
InChi: 1S/C16H15N5O2/c22-15(20-12-8-18-19-9-12)11-3-2-10-6-14-16(23)17-4-1-5-21(14)13(10)7-11/h2-3,6-9H,1,4-5H2,(H,17,23)(H,18,19)(H,20,22)
InChiKey: ULNZFQKAFXCYBO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ribosomal protein S6 kinase, 90kDa, polypeptide 2		No references
Homo sapiens	ribosomal protein S6 kinase, 90kDa, polypeptide 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_128147	All targets in OG5_128147
Schistosoma japonicum	IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing	Get druggable targets OG5_128147	All targets in OG5_128147
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	Get druggable targets OG5_128147	All targets in OG5_128147
Giardia lamblia	Kinase, AGC AKT	Get druggable targets OG5_128147	All targets in OG5_128147
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_128147	All targets in OG5_128147
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	Get druggable targets OG5_128147	All targets in OG5_128147
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	Get druggable targets OG5_128147	All targets in OG5_128147
Leishmania mexicana	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_128147	All targets in OG5_128147
Leishmania braziliensis	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_128147	All targets in OG5_128147
Brugia malayi	ribosomal protein S6 kinase alpha 3	Get druggable targets OG5_128147	All targets in OG5_128147
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_128147	All targets in OG5_128147
Leishmania infantum	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_128147	All targets in OG5_128147
Leishmania donovani	rac serine-threonine kinase, putative	Get druggable targets OG5_128147	All targets in OG5_128147
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128147	All targets in OG5_128147
Schistosoma japonicum	IPR000719,Protein kinase,domain-containing	Get druggable targets OG5_128147	All targets in OG5_128147
Schistosoma japonicum	Ribosomal protein S6 kinase alpha-2, putative	Get druggable targets OG5_128147	All targets in OG5_128147

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.0216	0.0253
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0783	0.2962
Brugia malayi	Proteasome A-type and B-type family protein	0.0069	0.2644	0.3103
Trypanosoma cruzi	cysteine proteinase, putative	0.0014	0.0216	0.0817
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0783	0.0919
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0034	0.1125	0.0929
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0034	0.1125	0.1125
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0783	0.2336
Schistosoma mansoni	serine/threonine kinase	0.0034	0.1125	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0783	0.0783
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0396	0.0396
Leishmania major	proteasome beta 5 subunit, putative	0.0069	0.2644	0.2405
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0069	0.2644	0.5
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0069	0.2644	0.2644
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0034	0.1125	0.1125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Echinococcus multilocularis	protein kinase c epsilon type	0.0034	0.1125	0.0929
Echinococcus granulosus	cathepsin l1	0.0027	0.0783	0.058
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Schistosoma mansoni	serine/threonine protein kinase	0.0236	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0783	0.0783
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0069	0.2644	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0783	0.0919
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.0783	0.2336
Plasmodium falciparum	proteasome subunit beta type-5	0.0069	0.2644	1
Echinococcus multilocularis	cysteine protease	0.0027	0.0783	0.058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0034	0.1125	0.3744
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0069	0.2644	1
Plasmodium vivax	vivapain-3	0.0014	0.0216	0.0817
Brugia malayi	p70 ribosomal S6 kinase beta	0.0034	0.1125	0.132
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.1125	0.1125
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Entamoeba histolytica	protein kinase, putative	0.0034	0.1125	0.3744
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.1125	0.1125
Echinococcus granulosus	cathepsin l1	0.0018	0.0396	0.0185
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1125	0.1125
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0034	0.1125	0.0929
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0034	0.1125	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0783	0.2336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Echinococcus multilocularis	cysteine protease	0.0027	0.0783	0.058
Entamoeba histolytica	protein kinase, putative	0.0034	0.1125	0.3744
Loa Loa (eye worm)	cysteine protease	0.0027	0.0783	0.0783
Toxoplasma gondii	proteasome subunit beta type, putative	0.0069	0.2644	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0216	0.0216
Trypanosoma cruzi	cysteine protease, putative	0.0014	0.0216	0.0817
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0034	0.1125	0.1125
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0783	0.2962
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0034	0.1125	0.1125
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0034	0.1125	0.1125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Brugia malayi	protein kinase C II.	0.0034	0.1125	0.132
Loa Loa (eye worm)	ctsf protein	0.0027	0.0783	0.0783
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0069	0.2644	1
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.0203	0.8521	1
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0034	0.1125	0.1125
Echinococcus granulosus	Protein kinase C brain isozyme	0.0034	0.1125	0.0929
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0783	0.2962
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.1125	0.1125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Echinococcus granulosus	serine:threonine protein kinase N2	0.0034	0.1125	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0396	0.0396
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0034	0.1125	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0783	0.0919
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Brugia malayi	Protein kinase domain containing protein	0.0034	0.1125	0.132
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0783	0.0783
Plasmodium vivax	vivapain-2	0.0027	0.0783	0.2962
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0783	0.2962
Brugia malayi	cathepsin L-like precursor	0.0018	0.0396	0.0465
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0396	0.0743
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Onchocerca volvulus		0.0027	0.0783	1
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0396	0.0743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0783	0.0783
Onchocerca volvulus		0.0027	0.0783	1
Entamoeba histolytica	protein kinase, putative	0.0034	0.1125	0.3744
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0783	0.0783
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Echinococcus granulosus	NDR protein kinase	0.0034	0.1125	0.0929
Echinococcus granulosus	proteasome prosome macropain	0.0069	0.2644	0.2482
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.0783	0.2336
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0783	0.0919
Toxoplasma gondii	AGC kinase	0.0034	0.1125	0.1836
Entamoeba histolytica	protein kinase, putative	0.0034	0.1125	0.3744
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0069	0.2644	0.2482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0783	0.2336
Echinococcus multilocularis	serine threonine protein kinase	0.0034	0.1125	0.0929
Echinococcus multilocularis	protein kinase c iota type	0.0034	0.1125	0.0929
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0203	0.8521	1
Onchocerca volvulus		0.0027	0.0783	1
Brugia malayi	Protein kinase domain containing protein	0.0034	0.1125	0.132
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0783	0.2336
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0014	0.0216	0.0817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0069	0.2644	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0069	0.2644	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0396	0.0396
Brugia malayi	Papain family cysteine protease containing protein	0.0014	0.0216	0.0253
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0216	0.0216
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0396	0.0465
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0034	0.1125	0.0929
Trypanosoma cruzi	cysteine proteinase, putative	0.0014	0.0216	0.0817
Schistosoma mansoni	atypical protein kinase C	0.0034	0.1125	0.1125
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0783	0.0919
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0018	0.0396	0.1499
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0236	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0018	0.0396	0.0465
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0034	0.1125	0.0929
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0396	0.0465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0034	0.1125	0.1125
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.1125	0.1125
Onchocerca volvulus		0.0027	0.0783	1
Giardia lamblia	Kinase, AGC AKT	0.0203	0.8521	1
Echinococcus granulosus	protein kinase c iota type	0.0034	0.1125	0.0929
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0069	0.2644	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0034	0.1125	0.0929
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0069	0.2644	0.2644
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0783	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0783	0.058
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0783	0.0919
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0034	0.1092	0.3609
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0783	0.0919
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Loa Loa (eye worm)	fibroinase	0.0027	0.0783	0.0783
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0783	0.058
Onchocerca volvulus		0.0027	0.0783	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0396	0.0396
Plasmodium vivax	vivapain-2	0.0027	0.0783	0.2962
Onchocerca volvulus		0.0027	0.0783	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Brugia malayi	Hr1 repeat family protein	0.0034	0.1125	0.132
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0783	0.058
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0783	0.2336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.1125	0.3744
Plasmodium vivax	vivapain-1	0.0014	0.0216	0.0817
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0783	0.2962
Plasmodium vivax	unspecified product	0.0014	0.0216	0.0817
Brugia malayi	Protein kinase domain containing protein	0.0034	0.1125	0.132
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Echinococcus granulosus	protein kinase C gamma type	0.0034	0.1125	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0396	0.0743
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0783	1
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0783	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0783	0.058
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0783	0.058
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0034	0.1125	0.0929
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.0783	0.2336
Trypanosoma cruzi	cysteine peptidase, putative	0.0014	0.0216	0.0817
Echinococcus granulosus	protein kinase c epsilon type	0.0034	0.1125	0.0929
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0069	0.2644	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0783	0.2336
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0236	1	1
Mycobacterium ulcerans	proteasome PrcB	0.0069	0.2644	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.1125	0.1125
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0783	0.2336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0783	0.2336
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.1125	0.1125
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0216	0.0216
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0783	0.058
Onchocerca volvulus		0.0027	0.0783	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 43 nM	Inhibition of RSK2 phosphorylation by luminescence assay	ChEMBL.	22100312
IC50 (binding)	= 43 nM	Kinase Glo Plus Assay	BINDINGDB.	No reference
IC50 (binding)	> 10000 nM	Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter gene	ChEMBL.	22100312

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1938794

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1592492