TDR Targets

Basic information

Technical information

TDR Targets ID: 1592555
Name: phenylmethyl 3-methyl-2-[methyl-[2-[methyl-[3 -methyl-2-[(2-methylpropan-2-yl)oxycarbonylam ino]butanoyl]amino]-3-phenylpropanoyl]amino]b utanoate
MW: 581.743 | Formula: C33H47N3O6
H donors: 1 H acceptors: 4 LogP: 6.12 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: O=C(OC(C)(C)C)NC(C(=O)N(C(C(=O)N(C(C(=O)OCc1ccccc1)C(C)C)C)Cc1ccccc1)C)C(C)C
InChi: 1S/C33H47N3O6/c1-22(2)27(34-32(40)42-33(5,6)7)30(38)35(8)26(20-24-16-12-10-13-17-24)29(37)36(9)28(23(3)4)31(39)41-21-25-18-14-11-15-19-25/h10-19,22-23,26-28H,20-21H2,1-9H3,(H,34,40)
InChiKey: GVJPJTSQBZTISS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

phenylmethyl 2-[[2-[[2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]-methyl-amino]-3-phenyl-propanoyl]-methyl-amino]-3-methyl-butanoate
2-[[2-[[2-[(tert-butoxy-oxomethyl)amino]-3-methyl-1-oxobutyl]-methylamino]-1-oxo-3-phenylpropyl]-methylamino]-3-methylbutanoic acid phenylmethyl ester
2-[[2-[[2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]-methyl-amino]-3-phenyl-propanoyl]-methyl-amino]-3-methyl-butyric acid benzyl ester
phenylmethyl 3-methyl-2-[methyl-[2-[methyl-[3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]-3-phenyl-propanoyl]amino]butanoate
NSC655092
AIDS-160866
AIDS160866
Benzyl 9-benzyl-6,12-diisopropyl-2,2,8,11-tetramethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate
NCI60_019055
NCI60_019060
NSC655097

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0789	0.1445	1
Brugia malayi	Variant SH3 domain containing protein	0.0116	0.0107	0.0126
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0092	0.0059	0.0059
Trypanosoma cruzi	synaptotagmin, putative	0.0116	0.0107	0.5465
Trichomonas vaginalis	Proline-rich protein, putative	0.0116	0.0107	0.0737
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Echinococcus granulosus	neural cell expressed developmentally	0.0116	0.0107	0.0107
Onchocerca volvulus		0.0557	0.0983	0.7923
Schistosoma mansoni	copine	0.0116	0.0107	0.0107
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0116	0.0107	0.0107
Trypanosoma brucei	C2 domain containing protein, putative	0.0116	0.0107	0.0346
Entamoeba histolytica	calcium-binding protein, putative	0.0116	0.0107	0.0737
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0789	0.1445	0.1762
Toxoplasma gondii	AGC kinase	0.0789	0.1445	1
Schistosoma mansoni	synaptotagmin	0.0116	0.0107	0.0107
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0116	0.0107	0.0107
Echinococcus granulosus	protein kinase c eta type	0.0557	0.0983	0.0983
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0576	0.102	0.1205
Echinococcus multilocularis	synaptotagmin	0.0116	0.0107	0.0107
Schistosoma mansoni	mctp-related	0.0116	0.0107	0.0107
Leishmania major	c2 domain protein, putative	0.0116	0.0107	0.5465
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0576	0.102	0.1244
Trichomonas vaginalis	copine, putative	0.0116	0.0107	0.0737
Echinococcus multilocularis	serine threonine protein kinase	0.4538	0.8893	0.8893
Trichomonas vaginalis	copine, putative	0.0116	0.0107	0.0737
Trichomonas vaginalis	synaptotagmin, putative	0.0116	0.0107	0.0737
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0116	0.0107	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0116	0.0107	0.0737
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Echinococcus granulosus	Rac GTPase activating protein 1	0.0557	0.0983	0.0983
Entamoeba histolytica	protein kinase, putative	0.0081	0.0037	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Schistosoma mansoni	unc-13 (munc13)	0.0116	0.0107	0.0107
Loa Loa (eye worm)	raf kinase	0.0557	0.0983	0.1199
Echinococcus multilocularis	synaptotagmin	0.0116	0.0107	0.0107
Echinococcus granulosus	serine:threonine protein kinase N2	0.0789	0.1445	0.1445
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0081	0.0037	0.0037
Echinococcus multilocularis	synaptotagmin	0.0116	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Brugia malayi	C1-like domain containing protein	0.0576	0.102	0.1205
Echinococcus multilocularis	N chimaerin	0.0557	0.0983	0.0983
Echinococcus granulosus	synaptotagmin protein 4	0.0116	0.0107	0.0107
Trichomonas vaginalis	cyclins, putative	0.0136	0.0146	0.1013
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0673	0.1213	0.1213
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0143	0.0161	0.0161
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0116	0.0107	0.0107
Entamoeba histolytica	protein kinase, putative	0.0134	0.0144	0.0994
Trichomonas vaginalis	cyclins, putative	0.0136	0.0146	0.1013
Brugia malayi	neuroendocrine convertase 1 precursor	0.009	0.0055	0.0065
Trichomonas vaginalis	ion channel nompc, putative	0.0116	0.0107	0.0737
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0789	0.1445	0.1762
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0116	0.0107	0.0107
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0087	0.0049	0.0342
Trypanosoma cruzi	cyclin 6, putative	0.0136	0.0146	1
Trichomonas vaginalis	synaptotagmin, putative	0.0116	0.0107	0.0737
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0116	0.0107	0.5465
Echinococcus multilocularis	myotubularin protein 13	0.0557	0.0983	0.0983
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0557	0.0983	0.0983
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.1462	0.2781	0.3391
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0092	0.0059	0.0405
Trypanosoma brucei	C2 domain containing protein, putative	0.0116	0.0107	0.0346
Schistosoma mansoni	rabphilin-3a	0.0116	0.0107	0.0107
Schistosoma mansoni	protein kinase	0.0081	0.0037	0.0037
Echinococcus granulosus	furin	0.0143	0.0161	0.0161
Schistosoma mansoni	synaptotagmin	0.0116	0.0107	0.0107
Entamoeba histolytica	DENN domain protein	0.0116	0.0107	0.0737
Trypanosoma brucei	synaptotagmin, putative	0.0116	0.0107	0.0346
Trichomonas vaginalis	synaptotagmin, putative	0.0116	0.0107	0.0737
Schistosoma mansoni	protein kinase C mu	0.0576	0.102	0.102
Trichomonas vaginalis	copine, putative	0.0116	0.0107	0.0737
Trypanosoma brucei	mitotic cyclin 6	0.0136	0.0146	0.0634
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0116	0.0107	0.0107
Echinococcus granulosus	synaptotagmin	0.0116	0.0107	0.0107
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0081	0.0037	0.0037
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Loa Loa (eye worm)	hypothetical protein	0.419	0.8202	1
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0087	0.0049	0.0049
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0789	0.1445	0.1762
Trichomonas vaginalis	STE family protein kinase	0.0081	0.0037	0.0257
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0116	0.0107	0.0346
Trypanosoma cruzi	C2 domain containing protein, putative	0.0116	0.0107	0.5465
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0146	0.0179
Brugia malayi	endoprotease bli-4 precursor	0.0143	0.0161	0.019
Brugia malayi	Protein kinase domain containing protein	0.0789	0.1445	0.1706
Trichomonas vaginalis	synaptotagmin, putative	0.0116	0.0107	0.0737
Echinococcus granulosus	synaptotagmin 2	0.0116	0.0107	0.0107
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0136	0.0146	1
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0081	0.0037	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Leishmania major	phospholipase c-like protein	0.0116	0.0107	0.5465
Echinococcus granulosus	copine 9	0.0116	0.0107	0.0107
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0576	0.102	0.102
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.3633	0.7095	0.7095
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0673	0.1213	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Echinococcus granulosus	myoferlin	0.0116	0.0107	0.0107
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0789	0.1445	1
Plasmodium vivax	ferlin, putative	0.0116	0.0107	0.5
Echinococcus multilocularis	neural cell expressed, developmentally	0.0116	0.0107	0.0107
Brugia malayi	Protein kinase domain containing protein	0.0789	0.1445	0.1706
Echinococcus multilocularis	cyclin B	0.0136	0.0146	0.0146
Entamoeba histolytica	hypothetical protein	0.0116	0.0107	0.0737
Giardia lamblia	Hypothetical protein	0.0092	0.0059	0.1959
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Entamoeba histolytica	protein kinase, putative	0.0789	0.1445	1
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Plasmodium falciparum	ferlin, putative	0.0116	0.0107	0.5
Echinococcus granulosus	protein piccolo	0.0116	0.0107	0.0107
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0116	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Schistosoma mansoni	serine/threonine protein kinase	0.0789	0.1445	0.1445
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0116	0.0107	0.0107
Trichomonas vaginalis	cyclin A, putative	0.0136	0.0146	0.1013
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0116	0.0107	0.0737
Entamoeba histolytica	hypothetical protein, conserved	0.0116	0.0107	0.0737
Entamoeba histolytica	hypothetical protein	0.0116	0.0107	0.0737
Echinococcus multilocularis	protein piccolo	0.0116	0.0107	0.0107
Entamoeba histolytica	diacylglycerol kinase, putative	0.0557	0.0983	0.6804
Echinococcus multilocularis	unc 13 (munc13)	0.0673	0.1213	0.1213
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0116	0.0107	0.0107
Schistosoma mansoni	synaptotagmin 12	0.0116	0.0107	0.0107
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0789	0.1445	0.1762
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.0107	0.5465
Echinococcus granulosus	Diacylglycerol kinase theta	0.0557	0.0983	0.0983
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0116	0.0107	0.0107
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Loa Loa (eye worm)	synaptotagmin-1	0.0116	0.0107	0.013
Echinococcus multilocularis	synaptotagmin	0.0116	0.0107	0.0107
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0081	0.0037	0.0037
Schistosoma mansoni	protein kinase	0.0081	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0116	0.0107	0.0107
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Trichomonas vaginalis	cyclins, putative	0.0136	0.0146	0.1013
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0059	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Trypanosoma brucei	hypothetical protein, conserved	0.0116	0.0107	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0116	0.0107	0.013
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Schistosoma mansoni	protein kinase	0.0081	0.0037	0.0037
Loa Loa (eye worm)	C2 domain-containing protein	0.0116	0.0107	0.013
Echinococcus multilocularis		0.0115	0.0106	0.0106
Toxoplasma gondii	diacylglycerol kinase, putative	0.0557	0.0983	0.655
Loa Loa (eye worm)	C2 domain-containing protein	0.0116	0.0107	0.013
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Schistosoma mansoni	diacylglycerol kinase theta	0.0557	0.0983	0.0983
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0116	0.0107	0.0346
Echinococcus multilocularis	protein kinase c iota type	0.1346	0.2552	0.2552
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0116	0.0107	0.0107
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0116	0.0107	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0116	0.0107	0.0107
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0557	0.0983	0.1199
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.5095	1	1
Schistosoma mansoni	fer-1-related	0.0116	0.0107	0.0107
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0116	0.0107	0.0346
Echinococcus granulosus	protein kinase c iota type	0.1346	0.2552	0.2552
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Echinococcus multilocularis	neuroendocrine convertase 2	0.009	0.0055	0.0055
Trypanosoma brucei	predicted C2 domain protein	0.0116	0.0107	0.0346
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Entamoeba histolytica	hypothetical protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0116	0.0107	0.0737
Echinococcus granulosus	neuroendocrine convertase 2	0.009	0.0055	0.0055
Brugia malayi	Hr1 repeat family protein	0.0789	0.1445	0.1706
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0557	0.0983	0.0983
Entamoeba histolytica	protein kinase, putative	0.0081	0.0037	0.0257
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0557	0.0983	0.0983
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0557	0.0983	0.1199
Echinococcus granulosus	intersectin 2	0.0116	0.0107	0.0107
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.0107	0.5465
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0116	0.0107	0.0107
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.0107	0.5465
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Entamoeba histolytica	hypothetical protein, conserved	0.0116	0.0107	0.0737
Echinococcus granulosus	synaptotagmin 15	0.0116	0.0107	0.0107
Schistosoma mansoni	rac gtpase activating protein	0.0557	0.0983	0.0983
Echinococcus granulosus	raf serine:threonine protein kinase	0.0557	0.0983	0.0983
Schistosoma mansoni	hypothetical protein	0.0557	0.0983	0.0983
Plasmodium falciparum	double C2-like domain-containing protein	0.0116	0.0107	0.5
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Giardia lamblia	G2/mitotic-specific cyclin B	0.0136	0.0146	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0136	0.0146	0.0173
Echinococcus multilocularis	RNA directed DNA polymerase	0.3633	0.7095	0.7095
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Trypanosoma cruzi	synaptotagmin, putative	0.0116	0.0107	0.5465
Onchocerca volvulus		0.0673	0.1213	1
Trichomonas vaginalis	cyclin B, putative	0.0136	0.0146	0.1013
Entamoeba histolytica	p21-activated kinase	0.0081	0.0037	0.0257
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0116	0.0107	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0146	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Entamoeba histolytica	protein kinase, putative	0.0081	0.0037	0.0257
Brugia malayi	phospholipase C homolog	0.0116	0.0107	0.0126
Brugia malayi	p70 ribosomal S6 kinase beta	0.0789	0.1445	0.1706
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0116	0.0107	0.5465
Schistosoma mansoni	protein kinase C	0.0673	0.1213	0.1213
Brugia malayi	Protein kinase c protein 2	0.4324	0.8469	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Trypanosoma brucei	predicted C2 domain protein	0.0116	0.0107	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Brugia malayi	protein kinase C II.	0.1462	0.2781	0.3284
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Schistosoma mansoni	synaptotagmin	0.0116	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0116	0.0107	0.5465
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0136	0.0146	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Loa Loa (eye worm)	C2 domain-containing protein	0.0116	0.0107	0.013
Schistosoma mansoni	serine/threonine protein kinase	0.5095	1	1
Echinococcus multilocularis	protein kinase c eta type	0.0557	0.0983	0.0983
Leishmania major	cyclin	0.0136	0.0146	1
Schistosoma mansoni	hypothetical protein	0.0116	0.0107	0.0107
Trichomonas vaginalis	STE family protein kinase	0.0081	0.0037	0.0257
Trichomonas vaginalis	cyclins, putative	0.0136	0.0146	0.1013
Schistosoma mansoni	synaptotagmin 12	0.0116	0.0107	0.0107
Trichomonas vaginalis	STE family protein kinase	0.0081	0.0037	0.0257
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0081	0.0037	0.0037
Entamoeba histolytica	protein kinase, putative	0.0134	0.0144	0.0994
Brugia malayi	serine/threonine-protein kinase PAK 7	0.0744	0.1356	0.1601
Brugia malayi	LD23056p	0.0116	0.0107	0.0126
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0557	0.0983	0.0983
Trichomonas vaginalis	copine, putative	0.0116	0.0107	0.0737
Brugia malayi	celfurPC protein	0.0115	0.0106	0.0125
Echinococcus granulosus	synaptotagmin	0.0116	0.0107	0.0107
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0116	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0673	0.1213	0.1479
Schistosoma mansoni	otoferlin	0.0116	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	synaptotagmin, putative	0.0116	0.0107	0.0737
Schistosoma mansoni	protein kinase C mu	0.0557	0.0983	0.0983
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0789	0.1445	0.1762
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0557	0.0983	0.1199
Schistosoma mansoni	serine/threonine protein kinase	0.0789	0.1445	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Brugia malayi	RhoGEF domain containing protein	0.0557	0.0983	0.1161
Leishmania major	copine i-like protein	0.0116	0.0107	0.5465
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Echinococcus granulosus	synaptotagmin	0.0116	0.0107	0.0107
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0576	0.102	0.102
Trypanosoma brucei	cAMP binding protein, putative	0.0116	0.0107	0.0346
Brugia malayi	protein kinase C3,putative	0.0576	0.102	0.1205
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0789	0.1445	0.1445
Brugia malayi	diacylglycerol kinase	0.0557	0.0983	0.1161
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0116	0.0107	0.0107
Entamoeba histolytica	hypothetical protein	0.0116	0.0107	0.0737
Brugia malayi	proprotein convertase 2	0.009	0.0055	0.0065
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0116	0.0107	0.5465
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0116	0.0107	0.0107
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0136	0.0146	0.0173
Trypanosoma cruzi	cyclin, putative	0.0136	0.0146	1
Echinococcus granulosus	active breakpoint cluster region	0.0116	0.0107	0.0107
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.3768	0.7362	0.8976
Schistosoma mansoni	vav2	0.0557	0.0983	0.0983
Trypanosoma cruzi	cAMP binding protein, putative	0.0116	0.0107	0.5465
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Brugia malayi	diacylglycerol kinase	0.0557	0.0983	0.1161
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.0107	0.5465
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Entamoeba histolytica	C2 domain protein, putative	0.0116	0.0107	0.0737
Echinococcus multilocularis	copine 9	0.0116	0.0107	0.0107
Brugia malayi	Copine family protein	0.0116	0.0107	0.0126
Echinococcus granulosus	copine 9	0.0116	0.0107	0.0107
Trichomonas vaginalis	synaptotagmin, putative	0.0116	0.0107	0.0737
Trypanosoma brucei	C2 domain containing protein, putative	0.0116	0.0107	0.0346
Schistosoma mansoni	synaptotagmin	0.0116	0.0107	0.0107
Schistosoma mansoni	synaptotagmin	0.0116	0.0107	0.0107
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0789	0.1445	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0771	0.1408	0.9743
Schistosoma mansoni	unc-13 (munc13)	0.0673	0.1213	0.1213
Schistosoma mansoni	diacylglycerol kinase theta	0.0557	0.0983	0.0983
Echinococcus granulosus	NDR protein kinase	0.0789	0.1445	0.1445
Echinococcus granulosus	RNA directed DNA polymerase	0.3633	0.7095	0.7095
Echinococcus multilocularis	active breakpoint cluster region	0.0116	0.0107	0.0107
Echinococcus multilocularis	synaptotagmin 15	0.0116	0.0107	0.0107
Entamoeba histolytica	hypothetical protein	0.0116	0.0107	0.0737
Brugia malayi	Synapse defective protein 1	0.0116	0.0107	0.0126
Schistosoma mansoni	unc-13 (munc13)	0.0673	0.1213	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Brugia malayi	Ras association domain family 1 isoform A	0.0557	0.0983	0.1161
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Schistosoma mansoni	cyclin B	0.0136	0.0146	0.0146
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0116	0.0107	0.0737
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0789	0.1445	0.1445
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0789	0.1445	0.1762
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0087	0.0049	0.0342
Echinococcus granulosus	myotubularin protein 13	0.0557	0.0983	0.0983
Brugia malayi	Synapse defective protein 1	0.0116	0.0107	0.0126
Echinococcus granulosus	synaptotagmin	0.0116	0.0107	0.0107
Entamoeba histolytica	diacylglycerol kinase, putative	0.0557	0.0983	0.6804
Schistosoma mansoni	synaptotagmin-like protein	0.0116	0.0107	0.0107
Onchocerca volvulus		0.0557	0.0983	0.7923
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0557	0.0983	0.1199
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Brugia malayi	Protein kinase domain containing protein	0.0576	0.102	0.1205
Echinococcus multilocularis	calpain 5	0.0116	0.0107	0.0107
Entamoeba histolytica	hypothetical protein	0.0116	0.0107	0.0737
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0081	0.0037	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Entamoeba histolytica	hypothetical protein	0.0557	0.0983	0.6804
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.0107	0.5465
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0789	0.1445	0.1762
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0116	0.0107	0.0107
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Entamoeba histolytica	protein kinase, putative	0.0789	0.1445	1
Echinococcus granulosus	unc 13 munc13	0.0673	0.1213	0.1213
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0116	0.0107	0.0107
Echinococcus multilocularis	synaptotagmin protein 4	0.0116	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0116	0.0107	0.0107
Echinococcus granulosus	protein kinase c epsilon type	0.1462	0.2781	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Brugia malayi	NEDD4.2	0.0116	0.0107	0.0126
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Schistosoma mansoni	glut4 vesicle protein-related	0.0116	0.0107	0.0107
Echinococcus multilocularis	CAAX prenyl protease 2	0.0092	0.0059	0.0059
Trichomonas vaginalis	cyclins, putative	0.0093	0.0061	0.0423
Schistosoma mansoni	hypothetical protein	0.0116	0.0107	0.0107
Trichomonas vaginalis	STE family protein kinase	0.0081	0.0037	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0576	0.102	0.1244
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0116	0.0107	0.0126
Schistosoma mansoni	serine/threonine protein kinase	0.5095	1	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0789	0.1445	0.1445
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0557	0.0983	0.0983
Brugia malayi	Copine VIII	0.0116	0.0107	0.0126
Schistosoma mansoni	serine/threonine protein kinase	0.1462	0.2781	0.2781
Schistosoma mansoni	serine/threonine protein kinase	0.0557	0.0983	0.0983
Loa Loa (eye worm)	Nedd4-PD	0.0116	0.0107	0.013
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Brugia malayi	Protein kinase domain	0.0081	0.0037	0.0044
Entamoeba histolytica	C2 domain containing protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0116	0.0107	0.5465
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.0107	0.5465
Trichomonas vaginalis	copine, putative	0.0116	0.0107	0.0737
Echinococcus granulosus	UNCoordinated family member unc 13	0.0116	0.0107	0.0107
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0682	0.1233	0.1233
Entamoeba histolytica	CAAX prenyl protease family	0.0092	0.0059	0.0405
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0789	0.1445	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0034	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0116	0.0107	0.0107
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0116	0.0107	0.0737
Echinococcus granulosus	otoferlin	0.0116	0.0107	0.0107
Echinococcus granulosus	extended synaptotagmin 2	0.0116	0.0107	0.0107
Plasmodium vivax	ferlin, putative	0.0116	0.0107	0.5
Echinococcus multilocularis	extended synaptotagmin 2	0.0116	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Trypanosoma brucei	hypothetical protein, conserved	0.0116	0.0107	0.0346
Schistosoma mansoni	hypothetical protein	0.0116	0.0107	0.0107
Echinococcus multilocularis	copine 9	0.0116	0.0107	0.0107
Leishmania major	c2 domain protein, putative	0.0116	0.0107	0.5465
Echinococcus granulosus	cyclin B	0.0136	0.0146	0.0146
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0116	0.0107	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0161	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Loa Loa (eye worm)	C2 domain-containing protein	0.0116	0.0107	0.013
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0116	0.0107	0.0107
Trichomonas vaginalis	annexin VII, putative	0.0116	0.0107	0.0737
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0116	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0789	0.1445	0.1445
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Echinococcus granulosus	CAAX prenyl protease 2	0.0092	0.0059	0.0059
Brugia malayi	Variant SH3 domain containing protein	0.0557	0.0983	0.1161
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0116	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Echinococcus multilocularis	myoferlin	0.0116	0.0107	0.0107
Brugia malayi	Pleckstrin Homology Domain	0.0557	0.0983	0.1161
Loa Loa (eye worm)	C2 domain-containing protein	0.0116	0.0107	0.013
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Echinococcus granulosus	N chimaerin	0.0557	0.0983	0.0983
Schistosoma mansoni	serine/threonine protein kinase	0.0576	0.102	0.102
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0682	0.1233	0.1233
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Echinococcus granulosus	calpain 5	0.0116	0.0107	0.0107
Brugia malayi	CAAX amino terminal protease family protein	0.0092	0.0059	0.0069
Echinococcus granulosus	synaptotagmin	0.0116	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0116	0.0107	0.0107
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0116	0.0107	0.013
Brugia malayi	RhoGAP domain containing protein	0.0557	0.0983	0.1161
Schistosoma mansoni	synaptotagmin	0.0116	0.0107	0.0107
Plasmodium falciparum	ferlin, putative	0.0116	0.0107	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Entamoeba histolytica	protein kinase, putative	0.0789	0.1445	1
Schistosoma mansoni	serine/threonine protein kinase	0.0789	0.1445	0.1445
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Echinococcus multilocularis	PAK box P21 Rho binding	0.0081	0.0037	0.0037
Schistosoma mansoni	rho gtpase activating protein	0.0116	0.0107	0.0107
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0116	0.0107	0.0737
Echinococcus multilocularis	synaptotagmin	0.0116	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0557	0.0983	0.1199
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0789	0.1445	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Entamoeba histolytica	cyclin, putative	0.0136	0.0146	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Trypanosoma brucei	C2 domain containing protein, putative	0.0116	0.0107	0.0346
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0087	0.0049	0.0049
Entamoeba histolytica	protein kinase, putative	0.0081	0.0037	0.0257
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0116	0.0107	0.013
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0116	0.0107	0.0107
Echinococcus multilocularis		0.0116	0.0107	0.0107
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0116	0.0107	0.0107
Onchocerca volvulus		0.0136	0.0146	0.036
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0092	0.0059	0.0059
Brugia malayi	Synaptotagmin protein 3	0.0116	0.0107	0.0126
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0116	0.0107	0.0107
Trichomonas vaginalis	AGC family protein kinase	0.0789	0.1445	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0107	0.013
Loa Loa (eye worm)	C2 domain-containing protein	0.0116	0.0107	0.013
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0116	0.0107	0.0107
Plasmodium vivax	hypothetical protein, conserved	0.0116	0.0107	0.5
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0116	0.0107	0.0107
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0116	0.0107	0.0737
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0557	0.0983	0.0983
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Brugia malayi	Protein kinase domain containing protein	0.0789	0.1445	0.1706
Brugia malayi	calpain 5	0.0116	0.0107	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0789	0.1445	0.1762
Trichomonas vaginalis	synaptotagmin, putative	0.0116	0.0107	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Schistosoma mansoni	serine/threonine protein kinase	0.0576	0.102	0.102
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Plasmodium vivax	double C2-like domain-containing protein, putative	0.0116	0.0107	0.5
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Brugia malayi	Synaptotagmin I	0.0116	0.0107	0.0126
Trypanosoma cruzi	cyclin, putative	0.0136	0.0146	1
Trichomonas vaginalis	cyclin B, putative	0.0136	0.0146	0.1013
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Echinococcus multilocularis	protein kinase c epsilon type	0.1462	0.2781	0.2781
Leishmania major	hypothetical protein, conserved	0.0116	0.0107	0.5465
Schistosoma mansoni	serine/threonine kinase	0.0789	0.1445	0.1445
Brugia malayi	WW domain containing protein	0.0116	0.0107	0.0126
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0744	0.1356	0.1653
Trypanosoma cruzi	hypothetical protein, conserved	0.0116	0.0107	0.5465
Echinococcus multilocularis	intersectin 2	0.0116	0.0107	0.0107
Trichomonas vaginalis	cyclin B, putative	0.0136	0.0146	0.1013
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0116	0.0107	0.0107
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0789	0.1445	0.1445
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0116	0.0107	0.0737
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0557	0.0983	0.0983
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0116	0.0107	0.0737
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Echinococcus granulosus	Immunoglobulin E set	0.0116	0.0107	0.0107
Brugia malayi	C2 domain containing protein	0.0116	0.0107	0.0126
Echinococcus multilocularis	synaptotagmin 2	0.0116	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Loa Loa (eye worm)	copine family protein	0.0116	0.0107	0.013
Schistosoma mansoni	serine/threonine protein kinase	0.0789	0.1445	0.1445
Trichomonas vaginalis	cyclin B, putative	0.0136	0.0146	0.1013
Loa Loa (eye worm)	hypothetical protein	0.3633	0.7095	0.8651
Schistosoma mansoni	atypical protein kinase C	0.1346	0.2552	0.2552
Echinococcus granulosus	protein kinase C gamma type	0.4538	0.8893	0.8893
Brugia malayi	RhoGAP domain containing protein	0.0557	0.0983	0.1161
Loa Loa (eye worm)	endoprotease bli-4	0.0143	0.0161	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0107	0.0737
Trichomonas vaginalis	STE family protein kinase	0.0081	0.0037	0.0257
Trypanosoma brucei	predicted C2 domain protein	0.0116	0.0107	0.0346
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0789	0.1445	0.1445

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.812	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.786	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.71	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.476	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.431	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.388	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.353	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.275	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.164	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.106	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.069	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1982426

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1592555