Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0182 | 0.0362 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0182 | 0.0491 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0182 | 0.0362 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1276 | 0.344 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0319 | 1 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.371 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.371 | 0.7381 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.077 | 0.1532 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1276 | 0.344 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1276 | 0.344 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.371 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0182 | 0.0362 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0182 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.077 | 0.2075 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.077 | 0.2075 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0182 | 0.0362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.371 | 0.7381 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0182 | 0.0362 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0182 | 0.0362 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0165 | 0.5027 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.371 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0182 | 0.0491 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5027 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.371 | 0.7381 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.371 | 0.7381 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.371 | 0.7381 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0182 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1276 | 0.344 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5027 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0182 | 0.0362 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.371 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0182 | 0.0491 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.371 | 0.7381 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0182 | 0.0362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.371 | 0.7381 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.371 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0182 | 0.0491 |
Brugia malayi | RNA binding protein | 0.0125 | 0.371 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 43 % | Evaluated for binding affinity of the compound towards human Cannabinoid receptor 1 at a concentration of 20 microM | ChEMBL. | 14980654 |
Inhibition (binding) | = 43 % | Evaluated for binding affinity of the compound towards human Cannabinoid receptor 1 at a concentration of 20 microM | ChEMBL. | 14980654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.