Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.7802 | 0.7802 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.7802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.7802 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.7802 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.1907 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.7802 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.7802 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.7802 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.1907 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.297 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.297 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.7802 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.1907 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.7802 | 0.7802 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.7802 | 0.7802 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.7802 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.7802 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.7802 | 0.7802 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.1907 | 0.6421 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 0.3807 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.297 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.297 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.297 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 0.3807 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.1907 | 0.6421 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.297 | 0.297 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.297 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.7802 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.7802 | 0.7802 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.297 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.7802 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.7802 | 0.7802 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.297 | 1 |
Onchocerca volvulus | 0.0023 | 0.297 | 1 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.297 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.7802 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.297 | 0.3807 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.297 | 0.297 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.7802 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1736 | 0.5844 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.7802 | 0.7802 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1907 | 0.1907 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.7802 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.297 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.