Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0727 | 0.6632 | 0.6591 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0283 | 0.1477 | 0.1374 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0283 | 0.1477 | 0.1852 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0843 | 0.7979 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 0.7643 | 0.8702 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0779 | 0.7238 | 0.9056 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0779 | 0.7238 | 0.9071 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.0321 | 0.0255 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0436 | 0.3251 | 0.3983 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0474 | 0.3698 | 0.4553 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0223 | 0.0781 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.2648 | 0.3011 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0843 | 0.7979 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0283 | 0.1477 | 0.1727 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0471 | 0.3659 | 0.4504 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0219 | 0.073 | 0.0775 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0223 | 0.0781 | 0.0841 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0779 | 0.7238 | 0.9056 |
Loa Loa (eye worm) | hypothetical protein | 0.0836 | 0.79 | 0.8994 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0166 | 0.012 | 0.0143 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0565 | 0.4749 | 0.589 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0588 | 0.5017 | 0.6231 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0279 | 0.1431 | 0.1668 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1017 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0588 | 0.5017 | 0.6231 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0843 | 0.7979 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0626 | 0.5464 | 0.68 |
Schistosoma mansoni | immunophilin | 0.0843 | 0.7979 | 0.7955 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0283 | 0.1477 | 0.1374 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0436 | 0.3251 | 0.3983 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0474 | 0.3698 | 0.4553 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | 0.0319 | 0.1888 | 0.1789 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.046 | 0.3531 | 0.434 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0435 | 0.3244 | 0.3974 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0404 | 0.2882 | 0.3514 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0384 | 0.2648 | 0.3217 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0288 | 0.0322 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0436 | 0.3251 | 0.3983 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1017 | 1 | 1 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0627 | 0.5471 | 0.6809 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0779 | 0.7238 | 0.7204 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0384 | 0.2648 | 0.2559 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0283 | 0.1477 | 0.1846 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0384 | 0.2648 | 0.2559 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0626 | 0.5464 | 0.68 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0565 | 0.4749 | 0.589 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0779 | 0.7238 | 0.9056 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0404 | 0.2882 | 0.3514 |
Giardia lamblia | GTOR | 0.0779 | 0.7238 | 0.9049 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0435 | 0.3244 | 0.3974 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0843 | 0.7979 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0223 | 0.0781 | 0.0972 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0588 | 0.5017 | 0.6231 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0565 | 0.4749 | 0.5949 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0283 | 0.1477 | 0.1727 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0223 | 0.0781 | 0.0841 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0223 | 0.0781 | 0.0841 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0471 | 0.3659 | 0.4504 |
Loa Loa (eye worm) | hypothetical protein | 0.0727 | 0.6632 | 0.755 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0223 | 0.0781 | 0.0841 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0843 | 0.7979 | 1 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0283 | 0.1477 | 0.1374 |
Loa Loa (eye worm) | FKBP5 protein | 0.0843 | 0.7979 | 0.9085 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0436 | 0.3251 | 0.3983 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0727 | 0.6632 | 0.6591 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0779 | 0.7238 | 0.907 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0836 | 0.79 | 0.9899 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0166 | 0.012 | 0.0143 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0843 | 0.7979 | 0.9085 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0283 | 0.1477 | 0.1727 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0843 | 0.7979 | 0.5 |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.0184 | 0.0321 | 0.041 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0843 | 0.7979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.012 | 0.013 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0779 | 0.7238 | 0.9056 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0843 | 0.7979 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0843 | 0.7979 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0843 | 0.7979 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0843 | 0.7979 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0223 | 0.0781 | 0.0841 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0283 | 0.1477 | 0.1727 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0336 | 0.2094 | 0.2512 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0843 | 0.7979 | 0.7955 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0452 | 0.3439 | 0.4223 |
Echinococcus granulosus | DNA dependent protein kinase catalytic subunit | 0.0319 | 0.1888 | 0.1789 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0588 | 0.5017 | 0.6231 |
Schistosoma mansoni | immunophilin | 0.0843 | 0.7979 | 0.7955 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0627 | 0.5471 | 0.6857 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0435 | 0.3244 | 0.3974 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0565 | 0.4749 | 0.589 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0588 | 0.5017 | 0.6231 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0565 | 0.4749 | 0.589 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0471 | 0.3659 | 0.4504 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0283 | 0.1477 | 0.1727 |
Trichomonas vaginalis | immunophilin, putative | 0.0843 | 0.7979 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0779 | 0.7238 | 0.824 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0283 | 0.1477 | 0.1846 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0321 | 0.0359 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0627 | 0.5471 | 0.6855 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0299 | 0.1664 | 0.1902 |
Leishmania major | fk506-binding protein 1-like protein | 0.0843 | 0.7979 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0372 | 0.2503 | 0.3032 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0565 | 0.4749 | 0.589 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0843 | 0.7979 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0843 | 0.7979 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0223 | 0.0781 | 0.0669 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0626 | 0.5464 | 0.68 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0779 | 0.7238 | 0.9056 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0812 | 0.7614 | 0.7585 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0779 | 0.7238 | 0.7204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0283 | 0.1477 | 0.1727 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0779 | 0.7238 | 0.907 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0779 | 0.7238 | 0.9056 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0843 | 0.7979 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.051 | 0.4107 | 0.5073 |
Echinococcus multilocularis | fk506 binding protein | 0.0843 | 0.7979 | 0.7955 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0662 | 0.588 | 0.7329 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0843 | 0.7979 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0912 | 0.8782 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0843 | 0.7979 | 0.7955 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0498 | 0.3973 | 0.4903 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0843 | 0.7979 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0843 | 0.7979 | 0.5 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.0283 | 0.1477 | 0.1852 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0283 | 0.1477 | 0.1727 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0626 | 0.5464 | 0.68 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0283 | 0.1477 | 0.1727 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0843 | 0.7979 | 0.7955 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0843 | 0.7979 | 1 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0779 | 0.7238 | 0.7204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0626 | 0.5464 | 0.68 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0588 | 0.5017 | 0.6231 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0779 | 0.7238 | 0.9056 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0527 | 0.4308 | 0.5328 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0588 | 0.5017 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0843 | 0.7979 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0565 | 0.4749 | 0.5949 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0283 | 0.1477 | 0.1677 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0843 | 0.7979 | 0.7955 |
Schistosoma mansoni | immunophilin | 0.0727 | 0.6632 | 0.6591 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0779 | 0.7238 | 0.9071 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0843 | 0.7979 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0588 | 0.5017 | 0.6231 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0223 | 0.0781 | 0.0841 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0779 | 0.7238 | 0.9056 |
Entamoeba histolytica | hypothetical protein | 0.046 | 0.3531 | 0.434 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.272 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.772 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.693 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.587 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.556 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.446 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.363 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.064 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.