Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0073 | 0.6498 | 0.6498 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0063 | 0.518 | 0.4693 |
Schistosoma mansoni | immunophilin | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.3713 | 0.3713 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0063 | 0.518 | 0.518 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0064 | 0.5205 | 0.5205 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0078 | 0.7204 | 0.7204 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3962 | 0.3353 |
Trichomonas vaginalis | immunophilin, putative | 0.0063 | 0.518 | 0.518 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0916 | 0.0916 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.3962 | 0.3353 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0078 | 0.7204 | 0.7204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0059 | 0.4499 | 0.4499 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0098 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0073 | 0.6498 | 0.6498 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0063 | 0.518 | 0.4693 |
Loa Loa (eye worm) | FKBP5 protein | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.3713 | 0.3713 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0063 | 0.518 | 0.4693 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0073 | 0.6498 | 0.6498 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.5501 | 0.5501 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0098 | 1 | 1 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0078 | 0.7215 | 0.6934 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0063 | 0.518 | 0.4693 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0098 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0058 | 0.4418 | 0.4418 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0916 | 0.0916 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0063 | 0.518 | 0.4693 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0063 | 0.518 | 0.4693 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0063 | 0.518 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0098 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0063 | 0.518 | 0.4693 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0063 | 0.518 | 0.4693 |
Schistosoma mansoni | immunophilin | 0.0063 | 0.518 | 0.4693 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0046 | 0.2796 | 0.207 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0058 | 0.4418 | 0.4418 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0098 | 1 | 1 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0098 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0073 | 0.6498 | 0.6498 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0098 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.3713 | 0.3713 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0098 | 1 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0098 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0073 | 0.6498 | 0.6498 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0916 | 0.0916 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0073 | 0.6498 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0063 | 0.518 | 0.518 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0059 | 0.4499 | 0.4499 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0078 | 0.7204 | 0.7204 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0078 | 0.7215 | 0.6934 |
Schistosoma mansoni | immunophilin | 0.0055 | 0.3962 | 0.3353 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0059 | 0.4499 | 0.4499 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0084 | 0.8002 | 0.8002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0916 | 0.0916 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.3713 | 0.3713 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0098 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0063 | 0.518 | 0.518 |
Echinococcus multilocularis | fk506 binding protein | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0078 | 0.7204 | 0.7204 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0063 | 0.518 | 0.4693 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.3962 | 0.3353 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0073 | 0.6498 | 0.6498 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0078 | 0.7215 | 0.6934 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0916 | 0.0916 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.3702 | 0.3702 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0063 | 0.518 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0078 | 0.7204 | 0.7204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0098 | 1 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0098 | 1 | 1 |
Giardia lamblia | GTOR | 0.0098 | 1 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0098 | 1 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0098 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0063 | 0.518 | 0.4693 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0073 | 0.6498 | 0.6498 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0041 | 0.201 | 0.1204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.3702 | 0.3702 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.3702 | 0.3702 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0063 | 0.518 | 0.4693 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0098 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0063 | 0.518 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0063 | 0.518 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.765 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.737 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.731 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.613 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.509 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.505 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.49 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.445 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.41 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.384 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.