Detailed information for compound 1593089

Basic information

Technical information
  • TDR Targets ID: 1593089
  • Name: 3-[(3,4-dimethoxyphenyl)amino]-6-(trifluorome thyl)quinoxaline-2-carboxylic acid
  • MW: 393.317 | Formula: C18H14F3N3O4
  • H donors: 2 H acceptors: 4 LogP: 4.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)Nc1nc2cc(ccc2nc1C(=O)O)C(F)(F)F
  • InChi: 1S/C18H14F3N3O4/c1-27-13-6-4-10(8-14(13)28-2)22-16-15(17(25)26)23-11-5-3-9(18(19,20)21)7-12(11)24-16/h3-8H,1-2H3,(H,22,24)(H,25,26)
  • InChiKey: UBDOSWJUPUOBME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3,4-dimethoxyphenyl)amino]-6-(trifluoromethyl)-2-quinoxalinecarboxylic acid
  • NSC680552
  • NCI60_028733

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.003 0.4507 1
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.3264 0.2908
Echinococcus granulosus tyrosine protein kinase Fps85D 0.003 0.4507 0.4436
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.4507 0.4436
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus tyrosine protein kinase ABL1 0.003 0.4507 0.4436
Echinococcus granulosus epidermal growth factor receptor 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0025 0.3264 0.3176
Loa Loa (eye worm) hypothetical protein 0.0016 0.0846 0.0846
Echinococcus multilocularis tyrosine protein kinase Src42A 0.003 0.4507 0.4436
Plasmodium falciparum protein kinase, putative 0.0026 0.3384 1
Brugia malayi hypothetical protein 0.0025 0.3264 0.2908
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0025 0.3264 0.3176
Echinococcus multilocularis tyrosine protein kinase ABL1 0.003 0.4507 0.4436
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.3264 0.3176
Echinococcus multilocularis integrin linked protein kinase 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Echinococcus multilocularis tyrosine kinase 0.0025 0.3264 0.3176
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0025 0.3264 0.2908
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0025 0.3264 0.3176
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Loa Loa (eye worm) TK/Met protein kinase 0.0025 0.3264 0.3264
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0846 0.0727
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.003 0.4507 0.4436
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.003 0.4507 0.4218
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Entamoeba histolytica SH2-protein kinase domain containing protein 0.003 0.4507 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0025 0.3264 0.3176
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.3264 0.3264
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.9713 0.9713
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/RYK protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) TK/INSR protein kinase 0.0025 0.3264 0.3264
Schistosoma mansoni tyrosine kinase 0.003 0.4507 0.3999
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis insulin receptor 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0128
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 1 1
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus c src tyrosine kinase 0.003 0.4507 0.4436
Echinococcus multilocularis protein kinase 0.0025 0.3264 0.3176
Echinococcus multilocularis raf serine:threonine protein kinase 0.0025 0.3264 0.3176
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.4507 0.4436
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0025 0.3264 0.2641
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.3264 0.3176
Echinococcus granulosus fibroblast growth factor receptor 4 0.0025 0.3264 0.3176
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.5609 0.5377
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis transfer RNA-Thr 0.0025 0.3264 0.3176
Loa Loa (eye worm) SRC-1 0.003 0.4507 0.4507
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Echinococcus multilocularis musashi 0.0027 0.3759 0.3678
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Onchocerca volvulus 0.003 0.4507 1
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0025 0.3264 0.3176
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Echinococcus multilocularis ephrin type A receptor 4 A 0.0025 0.3264 0.3176
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus mitogen activated protein kinase 0.0052 1 1
Brugia malayi protein-tyrosine kinase 0.003 0.4507 0.4218
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.3264 0.3176
Brugia malayi Raf kinase 0.0025 0.3264 0.2908
Loa Loa (eye worm) TK/ALK protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.3264 0.3264
Schistosoma mansoni hypothetical protein 0.0035 0.5609 0.5203
Onchocerca volvulus 0.0027 0.3759 0.3982
Loa Loa (eye worm) TK/DDR protein kinase 0.0025 0.3264 0.3264
Echinococcus multilocularis tyrosine kinase 0.003 0.4507 0.4436
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.3759 0.3759
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus granulosus natriuretic peptide receptor 1 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.3264 0.3264
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.3384 0.0178
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0846 0.0363
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.003 0.4507 0.4436
Echinococcus granulosus intermediate filament protein 0.0027 0.3759 0.3678
Echinococcus multilocularis lamin 0.0027 0.3759 0.3678
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0026 0.3384 0.0178
Echinococcus granulosus tyrosine kinase 0.003 0.4507 0.4436
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.3264 0.3264
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0025 0.3264 0.2641
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.3264 0.2908
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus protein kinase 0.0025 0.3264 0.3176
Echinococcus granulosus lamin 0.0027 0.3759 0.3678
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.3384 0.0178
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0025 0.3264 0.2908
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.3264 0.3176
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.3264 0.2641
Brugia malayi Tyrosine-protein kinase PR2 0.0025 0.3264 0.2908
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 1 1
Echinococcus multilocularis lamin dm0 0.0027 0.3759 0.3678
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.3264 0.3176
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.3264 0.3176
Brugia malayi Furin-like cysteine rich region family protein 0.0025 0.3264 0.2908
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0846 0.0727
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 1 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0025 0.3264 0.3176
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0025 0.3264 0.2641
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.9713 0.9698
Echinococcus multilocularis activated cdc42 kinase 1 0.0025 0.3264 0.3176
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Onchocerca volvulus 0.003 0.4507 1
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0031 0.4627 0.4557
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 1 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0025 0.3264 0.3176
Echinococcus granulosus kinase suppressor of Ras 1 0.0025 0.3264 0.3176
Loa Loa (eye worm) serine/threonine protein kinase 0.0025 0.3264 0.3264
Echinococcus multilocularis epidermal growth factor receptor 0.0025 0.3264 0.3176
Echinococcus multilocularis protein kinase 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Brugia malayi Protein kinase domain containing protein 0.003 0.4507 0.4218
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Loa Loa (eye worm) TK/ABL protein kinase 0.003 0.4507 0.4507
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Schistosoma mansoni lamin 0.0027 0.3759 0.3182
Loa Loa (eye worm) TK protein kinase 0.003 0.4507 0.4507
Echinococcus granulosus tyrosine kinase 0.0025 0.3264 0.3176
Brugia malayi integrin-linked kinase 0.0025 0.3264 0.2908
Brugia malayi bone morphogenetic protein type 1 receptor 0.0025 0.3264 0.2908
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0025 0.3264 0.3176
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.003 0.4507 0.4436
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0026 0.3384 0.3298
Brugia malayi Protein kinase domain containing protein 0.003 0.4507 0.4218
Brugia malayi ephrin receptor 1 precursor 0.0025 0.3264 0.2908
Echinococcus granulosus lamin dm0 0.0027 0.3759 0.3678
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0025 0.3264 0.3264
Onchocerca volvulus 0.003 0.4507 1
Schistosoma mansoni tyrosine protein kinase 0.0025 0.3264 0.2641
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.3264 0.2641
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus granulosus activin receptor type 0.0026 0.3384 0.3298
Brugia malayi hypothetical protein 0.0025 0.3264 0.2908
Brugia malayi Protein kinase domain containing protein 0.003 0.4507 0.4218
Echinococcus multilocularis c src tyrosine kinase 0.003 0.4507 0.4436
Brugia malayi Protein kinase domain containing protein 0.003 0.4507 0.4218
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0025 0.3264 0.2908
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.3264 0.3176
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.003 0.4507 0.4436
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Schistosoma mansoni protein kinase 0.0026 0.3384 0.2772
Schistosoma mansoni protein kinase 0.0026 0.3384 0.2772
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.3264 0.3264
Echinococcus multilocularis FL cytokine receptor 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0025 0.3264 0.3176
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.4507 0.4218
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0846 0.0363
Echinococcus multilocularis epidermal growth factor receptor 0.0025 0.3264 0.3176
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Echinococcus multilocularis heat shock protein 70 0.0025 0.3264 0.3176
Trypanosoma brucei protein kinase, putative 0.0026 0.3384 0.0178
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0025 0.3264 0.3176
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.003 0.4507 0.4436
Echinococcus multilocularis GPCR, family 2 0.0016 0.0846 0.0727
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0846 0.0727
Echinococcus granulosus tyrosine kinase 0.003 0.4507 0.4436
Echinococcus granulosus tyrosine protein kinase Src42A 0.003 0.4507 0.4436
Echinococcus multilocularis tyrosine protein kinase pr2 0.0025 0.3264 0.3176
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.3264 0.2908
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Schistosoma mansoni tyrosine kinase 0.003 0.4507 0.3999
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0052 1 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0025 0.3264 0.2641
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Echinococcus granulosus integrin linked protein kinase 0.0025 0.3264 0.3176
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus epidermal growth factor receptor 0.0025 0.3264 0.3176
Echinococcus granulosus tyrosine protein kinase HCK 0.0025 0.3264 0.3176
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis protein tyrosine kinase 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0026 0.3384 0.3298
Loa Loa (eye worm) hypothetical protein 0.003 0.4507 0.4507
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Echinococcus multilocularis tyrosine protein kinase Src64B 0.003 0.4507 0.4436
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.3264 0.3176
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0025 0.3264 0.3176
Schistosoma mansoni intermediate filament proteins 0.0027 0.3759 0.3182
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0025 0.3264 0.2641
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0025 0.3264 0.2908
Schistosoma mansoni ephrin receptor 0.0025 0.3264 0.2641
Echinococcus granulosus tyrosine protein kinase Blk 0.003 0.4507 0.4436
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.3384 0.0178
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Onchocerca volvulus 0.003 0.4507 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.003 0.4507 0.4436
Loa Loa (eye worm) TK/EGFR protein kinase 0.0025 0.3264 0.3264
Schistosoma mansoni tyrosine kinase 0.003 0.4507 0.3999
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0846 0.0846
Echinococcus granulosus GPCR family 2 0.0016 0.0846 0.0727
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0025 0.3264 0.3264
Schistosoma mansoni serine/threonine protein kinase 0.0052 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Echinococcus multilocularis tyrosine protein kinase shark 0.003 0.4507 0.4436
Schistosoma mansoni tyrosine kinase 0.003 0.4507 0.3999
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0025 0.3264 0.3264
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0025 0.3264 0.2908
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0846 0.0727
Trypanosoma brucei protein kinase, putative 0.0052 1 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0025 0.3264 0.3176
Onchocerca volvulus 0.003 0.4507 1
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Plasmodium vivax protein kinase, putative 0.0025 0.3264 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0025 0.3264 0.3176
Loa Loa (eye worm) hypothetical protein 0.0051 0.9713 0.9713
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus granulosus protein tyrosine kinase 0.0025 0.3264 0.3176
Schistosoma mansoni serine/threonine RGC 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/FAK protein kinase 0.0025 0.3264 0.3264
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0025 0.3264 0.3176
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.3264 0.3176
Onchocerca volvulus 0.0027 0.3759 0.3982
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.9713 0.9698
Loa Loa (eye worm) intermediate filament protein 0.0027 0.3759 0.3759
Leishmania major protein kinase, putative 0.0026 0.3384 0.0178
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0025 0.3264 0.3264
Schistosoma mansoni tyrosine kinase 0.003 0.4507 0.3999
Echinococcus granulosus activated cdc42 kinase 1 0.0025 0.3264 0.3176
Brugia malayi hypothetical protein 0.003 0.4507 0.4218
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Echinococcus granulosus raf serine:threonine protein kinase 0.0025 0.3264 0.3176
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Schistosoma mansoni tyrosine kinase 0.003 0.4507 0.3999
Echinococcus multilocularis tyrosine protein kinase Blk 0.003 0.4507 0.4436
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Brugia malayi SH2 domain containing protein 0.003 0.4507 0.4218
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus granulosus tyrosine protein kinase 0.0025 0.3264 0.3176
Echinococcus granulosus ephrin type A receptor 4 A 0.0025 0.3264 0.3176
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0025 0.3264 0.3264
Plasmodium vivax tyrosine kinase-like protein, putative 0.0025 0.3264 0.5
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis natriuretic peptide receptor 1 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK/ACK protein kinase 0.0025 0.3264 0.3264
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.3759 0.343
Schistosoma mansoni protein kinase 0.0026 0.3384 0.2772
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Echinococcus granulosus tyrosine protein kinase shark 0.003 0.4507 0.4436
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.3264 0.3176
Schistosoma mansoni protein tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0025 0.3264 0.3176
Echinococcus multilocularis tyrosine protein kinase Fgr 0.003 0.4507 0.4436
Echinococcus multilocularis protein KINase family member (kin 25) 0.0025 0.3264 0.3176
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.3264 0.3264
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.4507 0.4507
Schistosoma mansoni lamin 0.0027 0.3759 0.3182
Schistosoma mansoni ephrin receptor 0.0025 0.3264 0.2641
Loa Loa (eye worm) hypothetical protein 0.0027 0.3759 0.3759
Echinococcus multilocularis activin receptor type 0.0026 0.3384 0.3298
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.3264 0.3176
Schistosoma mansoni hypothetical protein 0.0025 0.3264 0.2641
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Plasmodium vivax tyrosine kinase-like protein, putative 0.0025 0.3264 0.5
Brugia malayi SH2 domain containing protein 0.003 0.4507 0.4218
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Loa Loa (eye worm) hypothetical protein 0.0035 0.5609 0.5609
Echinococcus granulosus activated cdc42 kinase 1 0.0025 0.3264 0.3176
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Loa Loa (eye worm) hypothetical protein 0.0027 0.363 0.363
Echinococcus granulosus insulin receptor 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.3264 0.3264
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.3264 0.3176
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.3264 0.3176
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.4507 0.3999
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Loa Loa (eye worm) TK/CSK protein kinase 0.0025 0.3264 0.3264
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Brugia malayi C-terminal src kinase protein 1 0.0025 0.3264 0.2908
Loa Loa (eye worm) protein kinase domain-containing protein 0.0025 0.3264 0.3264
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.3264 0.3176
Echinococcus granulosus tyrosine protein kinase Src64B 0.003 0.4507 0.4436
Echinococcus multilocularis tyrosine protein kinase 0.0025 0.3264 0.3176
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 1 1
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.003 0.4507 0.4436
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0052 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0025 0.3264 0.3176
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0025 0.3264 0.3176
Loa Loa (eye worm) TK protein kinase 0.0025 0.3264 0.3264
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.003 0.4507 0.4436
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Echinococcus multilocularis kinase suppressor of Ras 1 0.0025 0.3264 0.3176
Entamoeba histolytica protein kinase domain containing protein 0.0026 0.3384 0.0965
Brugia malayi SRC-1 0.003 0.4507 0.4218
Brugia malayi Protein kinase domain containing protein 0.0025 0.3264 0.2908
Loa Loa (eye worm) hypothetical protein 0.0025 0.3264 0.3264
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0025 0.3264 0.2908
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 1 1
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Echinococcus granulosus tyrosine protein kinase Srms 0.003 0.4507 0.4436
Brugia malayi intermediate filament protein 0.0027 0.3759 0.343
Schistosoma mansoni protein kinase 0.0025 0.3264 0.2641
Schistosoma mansoni tyrosine kinase 0.0025 0.3264 0.2641
Echinococcus multilocularis tyrosine protein kinase HCK 0.0025 0.3264 0.3176
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.003 0.4507 0.4436

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.812 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.721 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.667 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.649 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.632 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.579 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.574 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.55 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.547 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.368 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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