Detailed information for compound 1593096

Basic information

Technical information
  • TDR Targets ID: 1593096
  • Name: 1,3-di(phenyl)-3-(2-phenylethynyl)-2-benzofur an-1-ol
  • MW: 388.457 | Formula: C28H20O2
  • H donors: 1 H acceptors: 1 LogP: 5.65 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1(OC(c2c1cccc2)(C#Cc1ccccc1)c1ccccc1)c1ccccc1
  • InChi: 1S/C28H20O2/c29-28(24-16-8-3-9-17-24)26-19-11-10-18-25(26)27(30-28,23-14-6-2-7-15-23)21-20-22-12-4-1-5-13-22/h1-19,29H
  • InChiKey: CQTISHGZIRFFLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-di(phenyl)-3-(2-phenylethynyl)isobenzofuran-1-ol
  • 1,3-di(phenyl)-3-(2-phenylethynyl)-1-isobenzofuranol
  • NCI60_008865
  • 1,3-Diphenyl-3-(phenylethynyl)-1,3-dihydro-2-benzofuran-1-ol
  • AIDS-132906
  • AIDS132906
  • NSC627693

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei protein kinase, putative 0.005 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/DDR protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0016 0.0727 0.0727
Echinococcus multilocularis raf serine:threonine protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.6544 0.034
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.6422 0.6422
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0034 0.5552 0.5552
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus multilocularis insulin receptor 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Echinococcus multilocularis mitogen activated protein kinase 0.005 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus granulosus integrin linked protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Plasmodium vivax protein kinase, putative 0.0037 0.6422 0.5
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Loa Loa (eye worm) serine/threonine protein kinase 0.0037 0.6422 0.6422
Brugia malayi Receptor family ligand binding region containing protein 0.0037 0.6422 0.6282
Echinococcus granulosus insulin receptor 0.0037 0.6422 0.6422
Brugia malayi hypothetical protein 0.0037 0.6422 0.6282
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.6544 0.034
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0037 0.6422 0.6282
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine protein kinase 0.0037 0.6422 0.6141
Onchocerca volvulus 0.0037 0.6422 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0037 0.6422 1
Schistosoma mansoni hypothetical protein 0.0037 0.6422 0.6141
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Echinococcus multilocularis receptor type guanylyl cyclase 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Brugia malayi Tyrosine-protein kinase abl-1 0.0037 0.6422 0.6282
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0037 0.6544 0.6544
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase shark 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0037 0.6422 0.6422
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.6422 0.6422
Echinococcus multilocularis lamin dm0 0.0027 0.3678 0.3678
Echinococcus multilocularis musashi 0.0027 0.3678 0.3678
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Onchocerca volvulus 0.0037 0.6422 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 1 1
Brugia malayi intermediate filament protein 0.0027 0.3678 0.343
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0037 0.6422 0.6422
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.6422 0.6141
Loa Loa (eye worm) TK/ROR protein kinase 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.6422 0.6422
Echinococcus multilocularis c src tyrosine kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis ephrin type A receptor 4 A 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/RYK protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0037 0.6422 0.6422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.9709 0.9698
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.6422 0.6422
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0037 0.6544 0.6544
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0037 0.6422 0.6141
Echinococcus granulosus tyrosine kinase 0.0037 0.6422 0.6422
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis lamin 0.0027 0.3678 0.3678
Brugia malayi Guanylyl cyclase protein 23 0.0037 0.6422 0.6282
Echinococcus multilocularis natriuretic peptide receptor 1 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Lyn 0.0037 0.6544 0.6544
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.6422 0.6422
Echinococcus multilocularis GPCR, family 2 0.0016 0.0727 0.0727
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) SRC-1 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6422 0.6422
Echinococcus granulosus receptor type guanylyl cyclase 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Schistosoma mansoni ephrin receptor 0.0037 0.6422 0.6141
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.6422 0.6422
Brugia malayi bone morphogenetic protein type 1 receptor 0.0037 0.6422 0.6282
Echinococcus multilocularis activated cdc42 kinase 1 0.0037 0.6422 0.6422
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.6422 0.6422
Schistosoma mansoni protein kinase 0.0037 0.6544 0.6272
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.6422 0.6282
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis FL cytokine receptor 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.6422 0.6422
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.9709 0.9709
Brugia malayi integrin-linked kinase 0.0037 0.6422 0.6282
Onchocerca volvulus 0.0037 0.6422 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Leishmania major protein kinase, putative 0.0037 0.6544 0.034
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0037 0.6544 0.034
Loa Loa (eye worm) TK/ALK protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/EPH protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus granulosus protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis tyrosine protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.6422 0.6141
Echinococcus granulosus mitogen activated protein kinase 3 0.005 1 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.6422 0.6282
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus granulosus raf serine:threonine protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.6422 0.6141
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0037 0.6422 1
Brugia malayi Furin-like cysteine rich region family protein 0.0037 0.6422 0.6282
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.6422 0.6422
Onchocerca volvulus 0.0037 0.6422 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0037 0.6422 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Schistosoma mansoni intermediate filament proteins 0.0027 0.3678 0.3182
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.6422 0.6422
Echinococcus granulosus protein tyrosine kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.6422 0.6422
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0727 0.0727
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Schistosoma mansoni protein tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus granulosus lamin 0.0027 0.3678 0.3678
Schistosoma mansoni protein kinase 0.0037 0.6544 0.6272
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0037 0.6422 0.6422
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0727 0.0363
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.6422 0.6422
Plasmodium falciparum protein kinase, putative 0.0037 0.6544 1
Schistosoma mansoni lamin 0.0027 0.3678 0.3182
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.6422 0.6422
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0026 0.3548 0.3548
Echinococcus multilocularis tyrosine protein kinase shark 0.0037 0.6422 0.6422
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.6544 1
Brugia malayi hypothetical protein 0.0037 0.6422 0.6282
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.5552 0.5377
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Plasmodium vivax tyrosine kinase-like protein, putative 0.0037 0.6422 0.5
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0037 0.6422 0.6422
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0037 0.6422 0.6422
Onchocerca volvulus 0.0037 0.6422 1
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6422 0.6141
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0377 0.0377
Echinococcus granulosus tyrosine protein kinase Srms 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Brugia malayi C-terminal src kinase protein 1 0.0037 0.6422 0.6282
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0037 0.6422 0.6422
Schistosoma mansoni lamin 0.0027 0.3678 0.3182
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Echinococcus granulosus c src tyrosine kinase 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Echinococcus granulosus intermediate filament protein 0.0027 0.3678 0.3678
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/ABL protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.3678 0.3678
Brugia malayi SH2 domain containing protein 0.0037 0.6422 0.6282
Loa Loa (eye worm) protein kinase domain-containing protein 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Onchocerca volvulus 0.0037 0.6422 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0037 0.6422 0.6422
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 1 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0037 0.6422 0.6422
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Onchocerca volvulus 0.0037 0.6422 1
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine kinase 0.0037 0.6422 0.6422
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.6422 0.6141
Schistosoma mansoni serine/threonine RGC 0.0037 0.6422 0.6141
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis heat shock protein 70 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Onchocerca volvulus 0.0037 0.6422 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0727 0.0727
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase pr2 0.0037 0.6422 0.6422
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.9709 0.9698
Echinococcus multilocularis tyrosine kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase Abl 0.0037 0.6422 0.6422
Echinococcus multilocularis protein KINase family member (kin 25) 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/ACK protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Trypanosoma brucei protein kinase, putative 0.0037 0.6544 0.034
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus granulosus GPCR family 2 0.0016 0.0727 0.0727
Echinococcus granulosus activin receptor type 0.0037 0.6544 0.6544
Onchocerca volvulus 0.0037 0.6422 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus granulosus lamin dm0 0.0027 0.3678 0.3678
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0727 0.0727
Echinococcus granulosus fibroblast growth factor receptor 4 0.0037 0.6422 0.6422
Onchocerca volvulus 0.0037 0.6422 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/Met protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis transfer RNA-Thr 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0727 0.0727
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Brugia malayi ephrin receptor 1 precursor 0.0037 0.6422 0.6282
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni protein kinase 0.0037 0.6544 0.6272
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6422 0.6141
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.6422 0.6422
Onchocerca volvulus 0.0037 0.6422 1
Echinococcus multilocularis protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0037 0.6422 0.6282
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.3678 0.343
Brugia malayi SRC-1 0.0037 0.6422 0.6282
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0727 0.0363
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Onchocerca volvulus 0.0037 0.6422 1
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.6422 0.6141
Onchocerca volvulus Tyrosine kinase homolog 0.0037 0.6422 1
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.6422 0.6422
Loa Loa (eye worm) hypothetical protein 0.0049 0.9709 0.9709
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.6422 0.6282
Schistosoma mansoni hypothetical protein 0.0034 0.5552 0.5203
Echinococcus multilocularis activin receptor type 0.0037 0.6544 0.6544
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 1 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0037 0.6422 0.6422
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.6422 0.6282
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6422 0.6422
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 1 1
Onchocerca volvulus 0.0037 0.6422 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0037 0.6422 0.6422
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0727 0.0727
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.6422 0.6422
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus natriuretic peptide receptor 1 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Loa Loa (eye worm) TK/INSR protein kinase 0.0037 0.6422 0.6422
Onchocerca volvulus 0.0037 0.6422 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Schistosoma mansoni serine/threonine protein kinase 0.005 1 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni ephrin receptor 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Brugia malayi hypothetical protein 0.0037 0.6422 0.6282
Echinococcus granulosus tyrosine protein kinase ABL1 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis integrin linked protein kinase 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0037 0.6422 0.6422
Echinococcus granulosus mitogen activated protein kinase 0.005 1 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0037 0.6422 0.6422
Brugia malayi Protein kinase domain containing protein 0.0037 0.6422 0.6282
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.6544 0.034
Loa Loa (eye worm) TK/FAK protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6422 0.6422
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.6422 0.6282
Schistosoma mansoni protein kinase 0.0037 0.6422 0.6141
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.6422 0.6422
Echinococcus multilocularis protein tyrosine kinase 0.0037 0.6422 0.6422
Brugia malayi Tyrosine-protein kinase PR2 0.0037 0.6422 0.6282
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.6422 0.6422
Loa Loa (eye worm) intermediate filament protein 0.0027 0.3678 0.3678
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Brugia malayi protein-tyrosine kinase 0.0037 0.6422 0.6282
Loa Loa (eye worm) hypothetical protein 0.0037 0.6422 0.6422
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0037 0.6422 0.6422
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0037 0.6422 0.6422
Echinococcus granulosus kinase suppressor of Ras 1 0.0037 0.6422 0.6422
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Echinococcus multilocularis protein kinase 0.0037 0.6422 0.6422
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6422 0.6422
Giardia lamblia Kinase, CMGC MAPK 0.005 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.6422 0.6141
Loa Loa (eye worm) hypothetical protein 0.0027 0.3678 0.3678
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.6422 0.6422
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Schistosoma mansoni tyrosine kinase 0.0037 0.6422 0.6141
Brugia malayi Raf kinase 0.0037 0.6422 0.6282
Loa Loa (eye worm) TK protein kinase 0.0037 0.6422 0.6422
Brugia malayi SH2 domain containing protein 0.0037 0.6422 0.6282
Onchocerca volvulus 0.0037 0.6422 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0037 0.6422 0.6422

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.768 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.706 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.588 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.488 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.46 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.398 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.103 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.976 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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