Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Peroxidasin | 0.0226 | 0.8081 | 0.9687 |
Brugia malayi | hypothetical protein | 0.0167 | 0.5057 | 0.6062 |
Onchocerca volvulus | Peroxidase homolog | 0.0226 | 0.8081 | 0.6118 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Echinococcus granulosus | geminin | 0.0188 | 0.6115 | 0.7566 |
Onchocerca volvulus | 0.0226 | 0.8081 | 0.6118 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Brugia malayi | Animal haem peroxidase family protein | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Echinococcus granulosus | peroxidasin | 0.0226 | 0.8081 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0226 | 0.8081 | 0.6118 |
Brugia malayi | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Brugia malayi | Animal haem peroxidase family protein | 0.0226 | 0.8081 | 0.9687 |
Schistosoma mansoni | peroxidasin | 0.0226 | 0.8081 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.8343 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0226 | 0.8081 | 0.6118 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Brugia malayi | Animal haem peroxidase family protein | 0.0226 | 0.8081 | 0.9687 |
Onchocerca volvulus | 0.0226 | 0.8081 | 0.6118 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0226 | 0.8081 | 0.9687 |
Trichomonas vaginalis | set domain proteins, putative | 0.0262 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Onchocerca volvulus | Peroxidasin homolog | 0.0226 | 0.8081 | 0.6118 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Brugia malayi | Animal haem peroxidase family protein | 0.0226 | 0.8081 | 0.9687 |
Echinococcus multilocularis | peroxidasin | 0.0226 | 0.8081 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.8343 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0226 | 0.8081 | 0.9687 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.6115 | 0.7566 |
Brugia malayi | Blistered cuticle protein 3 | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0226 | 0.8081 | 0.9687 |
Onchocerca volvulus | Peroxidase homolog | 0.0226 | 0.8081 | 0.6118 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0226 | 0.8081 | 0.9687 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Schistosoma mansoni | peroxidasin | 0.0226 | 0.8081 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0226 | 0.8081 | 0.6118 |
Onchocerca volvulus | 0.0226 | 0.8081 | 0.6118 | |
Echinococcus multilocularis | geminin | 0.0188 | 0.6115 | 0.7566 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.6115 | 0.7566 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5057 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.8081 | 0.9687 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 58.5 nM | Antimalarial activity against chloroquine-, pyrimethamine-resistant ring stage Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay | ChEMBL. | 22111907 |
EC50 (functional) | = 475 nM | Antimalarial activity against chloroquine-, mefloquine-, pyrimethamine-,atovaquone-resistant ring stage Plasmodium falciparum TM90-C2B infected in human A positive erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay | ChEMBL. | 22111907 |
EC50 (ADMET) | = 16 uM | Antiproliferative against mouse J774 cells after 72 hrs by Cell titer assay | ChEMBL. | 22111907 |
Ratio EC50 (functional) | = 8.12 | Resistance ratio, ratio of EC50 for chloroquine-, mefloquine, pyrimethamine-,atovaquone-resistant ring stage Plasmodium falciparum TM90-C2B to EC50 for chloroquine-, pyrimethamine-resistant Plasmodium falciparum W2 | ChEMBL. | 22111907 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22111907 | |
Mus musculus | ChEMBL23 | 22111907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.