Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.2957 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.05 | 0.1183 | 0.1183 |
Onchocerca volvulus | 0.05 | 0.1183 | 0.5 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.05 | 0.1183 | 0.1183 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.05 | 0.1183 | 0.1183 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2957 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.05 | 0.1183 | 0.1183 |
Echinococcus multilocularis | acetylcholinesterase | 0.2957 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.05 | 0.1183 | 0.1183 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2957 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.05 | 0.1183 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.05 | 0.1183 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2957 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2957 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2957 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2957 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2957 | 1 | 1 |
Onchocerca volvulus | 0.05 | 0.1183 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.2957 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2957 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.05 | 0.1183 | 0.1183 |
Schistosoma mansoni | acetylcholinesterase | 0.05 | 0.1183 | 0.1183 |
Onchocerca volvulus | 0.05 | 0.1183 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.05 | 0.1183 | 0.1183 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.05 | 0.1183 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.05 | 0.1183 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.05 | 0.1183 | 0.1183 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.05 | 0.1183 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.05 | 0.1183 | 0.1183 |
Onchocerca volvulus | 0.05 | 0.1183 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.05 | 0.1183 | 0.1183 |
Echinococcus granulosus | BC026374 protein S09 family | 0.05 | 0.1183 | 0.1183 |
Onchocerca volvulus | 0.05 | 0.1183 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.05 | 0.1183 | 0.1183 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.05 | 0.1183 | 0.1183 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.05 | 0.1183 | 0.1183 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.05 | 0.1183 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2957 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.492 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.172 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.169 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.757 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.719 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.662 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.502 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.485 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.429 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.328 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.