Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0047 | 0.0047 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0077 | 0.2132 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0077 | 0.0201 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.0257 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0.0081 | 0.0081 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0036 | 0.1943 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.005 | 0.268 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0027 | 0.1058 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0075 | 0.4029 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1649 | 0.3818 | 1 |
Echinococcus granulosus | geminin | 0.0169 | 0.036 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.036 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.0257 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.005 | 0.268 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.003 | 0.0036 | 0.6897 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0077 | 0.2132 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.003 | 0.0036 | 0.1943 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.003 | 0.0036 | 0.1943 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0037 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0027 | 0.5207 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0049 | 0.0081 | 0.0081 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.0185 | 1 |
Toxoplasma gondii | ATPase, AAA family protein | 0.003 | 0.0036 | 0.0036 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.0185 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0119 | 0.4648 |
Giardia lamblia | Kinase, PLK | 0.0094 | 0.0185 | 1 |
Brugia malayi | topoisomerase | 0.003 | 0.0036 | 0.1401 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0185 | 0.5142 |
Brugia malayi | DKFZp564C0469 protein | 0.003 | 0.0036 | 0.1401 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0027 | 0.5207 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0081 | 0.4387 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.003 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.0257 | 1 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.4296 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0027 | 0.5207 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0052 | 0.2032 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.0185 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0037 | 0.0052 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0119 | 0.3314 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.0081 | 0.0081 |
Schistosoma mansoni | topbp1 | 0.003 | 0.0036 | 0.0999 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0049 | 0.0081 | 0.0081 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0185 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0036 | 0.1943 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0185 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.0185 | 0.7211 |
Echinococcus granulosus | replication factor c subunit 1 | 0.003 | 0.0036 | 0.0999 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0036 | 0.1943 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0119 | 0.3314 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0081 | 0.3164 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0049 | 0.0081 | 0.0081 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0006 | 0.0217 |
Echinococcus multilocularis | geminin | 0.0169 | 0.036 | 0.0943 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0036 | 0.1943 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0081 | 0.3164 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0119 | 0.4648 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0081 | 0.3164 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0077 | 0.2132 |
Schistosoma mansoni | topbp1 | 0.003 | 0.0036 | 0.0999 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0027 | 0.1467 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0119 | 0.4648 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.003 | 0.0036 | 0.0036 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.005 | 0.013 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0027 | 0.1467 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0185 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0081 | 0.4387 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0027 | 0.1467 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0119 | 0.4648 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.0185 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.0185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0081 | 0.3164 |
Echinococcus multilocularis | nibrin | 0.003 | 0.0036 | 0.0094 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0185 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0077 | 0.2132 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0077 | 0.2132 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.0081 | 0.4387 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0037 | 0.0052 | 0.0052 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0077 | 0.2991 |
Brugia malayi | hypothetical protein | 0.0036 | 0.005 | 0.1932 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0052 | 0.2032 |
Onchocerca volvulus | 0.0049 | 0.0081 | 0.4387 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0049 | 0.0081 | 0.4387 |
Brugia malayi | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.003 | 0.0036 | 0.1401 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.003 | 0.0036 | 0.6897 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0119 | 0.3314 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.003 | 0.0036 | 0.1943 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0052 | 0.2032 |
Schistosoma mansoni | DNA ligase IV | 0.003 | 0.0036 | 0.0999 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0036 | 0.1943 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.003 | 0.0036 | 0.1943 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.036 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0081 | 0.3164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0119 | 0.3314 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0027 | 0.1058 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.005 | 0.1378 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0047 | 0.0047 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.003 | 0.0036 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.005 | 0.1378 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.005 | 0.268 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.003 | 0.0036 | 0.1943 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0037 | 0.0052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0027 | 0.0027 |
Echinococcus granulosus | nibrin | 0.003 | 0.0036 | 0.0999 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0037 | 0.0052 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.003 | 0.0036 | 0.1943 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0077 | 0.0201 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.4296 | 1 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.003 | 0.0036 | 0.1943 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0081 | 0.0081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0119 | 0.3314 |
Treponema pallidum | DNA ligase (lig) | 0.003 | 0.0036 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0081 | 0.4387 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0185 | 1 |
Schistosoma mansoni | kinase | 0.0048 | 0.0078 | 0.2152 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0185 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0047 | 0.0047 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0119 | 0.4648 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0035 | 0.0047 | 0.0047 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.0081 | 0.4387 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0075 | 0.4029 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.0185 | 0.0485 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0077 | 0.2991 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0036 | 0.1943 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.005 | 0.268 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.4296 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0049 | 0.0081 | 0.0081 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0049 | 0.0081 | 0.0081 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.003 | 0.0036 | 0.1943 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0052 | 0.2032 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0081 | 0.3164 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.003 | 0.0036 | 0.1401 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.003 | 0.0036 | 0.1943 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.0185 | 0.5142 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0119 | 0.4648 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0036 | 0.1401 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0119 | 0.0313 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.003 | 0.0036 | 0.0999 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.0185 | 0.7211 |
Onchocerca volvulus | 0.003 | 0.0036 | 0.1943 | |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.003 | 0.0036 | 0.0036 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0027 | 0.1467 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0052 | 0.2032 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0036 | 0.1943 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0036 | 0.1943 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0081 | 0.0081 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.0081 | 0.0081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0119 | 0.3314 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0049 | 0.0081 | 0.0081 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.003 | 0.0036 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.005 | 0.1378 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.0185 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.592 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.