Detailed information for compound 1593697

Basic information

Technical information
  • TDR Targets ID: 1593697
  • Name: 6-chloro-N-(6-fluoro-1,3-benzothiazol-2-yl)-1 ,3-benzothiazol-2-amine
  • MW: 335.807 | Formula: C14H7ClFN3S2
  • H donors: 1 H acceptors: 2 LogP: 5.77 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)sc(n2)Nc1nc2c(s1)cc(cc2)Cl
  • InChi: 1S/C14H7ClFN3S2/c15-7-1-3-9-11(5-7)20-13(17-9)19-14-18-10-4-2-8(16)6-12(10)21-14/h1-6H,(H,17,18,19)
  • InChiKey: FUOWKJNMKQIWQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6-chloro-1,3-benzothiazol-2-yl)-(6-fluoro-1,3-benzothiazol-2-yl)amine
  • ZINC04137766

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) patched family protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0018 0.0017
Loa Loa (eye worm) carboxylesterase 0.0669 0.0456 0.1671
Onchocerca volvulus 0.0012 0.0002 0.0022
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0003 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0026 0.0026
Brugia malayi Carboxylesterase family protein 0.396 0.273 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0015 0.0056
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0669 0.0456 0.0489
Onchocerca volvulus Protein patched homolog 0.0012 0.0002 0.0022
Onchocerca volvulus 0.102 0.0699 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0669 0.0456 0.0489
Mycobacterium ulcerans carboxylesterase, LipT 0.0669 0.0456 0.0456
Echinococcus granulosus cpg binding protein 0.003 0.0015 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0056
Onchocerca volvulus 0.0012 0.0002 0.0022
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0222 0.0147 0.054
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.102 0.0699 0.2557
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0003 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0003 0.0041
Trypanosoma cruzi UDP-galactopyranose mutase 0.102 0.0699 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.001 0.021
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0015 0.0054
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.001 0.021
Toxoplasma gondii hypothetical protein 0.0012 0.0002 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0056 0.0205
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0083 0.0051 0.0188
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0003 0.0003
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0669 0.0456 1
Schistosoma mansoni hypothetical protein 0.008 0.0049 0.0179
Schistosoma mansoni BC026374 protein (S09 family) 0.0669 0.0456 0.167
Brugia malayi hypothetical protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0194 0.0128 0.0467
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0003 0.0003
Echinococcus multilocularis carbonic anhydrase II 0.0316 0.0212 0.0778
Loa Loa (eye worm) hypothetical protein 0.0669 0.0456 0.1671
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0098 0.0062 0.0226
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0103
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0031 0.0015 0.0054
Onchocerca volvulus 0.0012 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.102 0.0699 0.2558
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0015 0.0056
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0196 0.013 0.0473
Toxoplasma gondii histone lysine-specific demethylase 0.102 0.0699 0.9983
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0026 0.0026
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0009 0.0031
Loa Loa (eye worm) carboxylesterase 0.0669 0.0456 0.1671
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0026 0.2016
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0003 0.0003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0056 0.0205
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.001 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.102 0.0699 0.0749
Echinococcus granulosus expressed conserved protein 0.0182 0.0119 0.0438
Echinococcus multilocularis lysine specific histone demethylase 1A 0.102 0.0699 0.2558
Onchocerca volvulus 0.0029 0.0014 0.019
Onchocerca volvulus 0.0012 0.0002 0.0022
Brugia malayi SWIRM domain containing protein 0.102 0.0699 0.2557
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.396 0.273 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi CHE-14 protein 0.0083 0.0051 0.0186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0026 0.0026
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0669 0.0456 0.0489
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi CXXC zinc finger family protein 0.0029 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Toxoplasma gondii patched family protein 0.0012 0.0002 0.0022
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0018 0.0017
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.0194 0.0128 0.0467
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0222 0.0147 0.0538
Echinococcus granulosus dnaJ subfamily B 0.0409 0.0276 0.1012
Echinococcus granulosus acetylcholinesterase 0.396 0.273 1
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0036 0.0132
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0003 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0026 0.0327
Echinococcus multilocularis 0.102 0.0699 0.2558
Loa Loa (eye worm) hypothetical protein 0.0047 0.0026 0.0095
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0 0.0000029697
Echinococcus granulosus GPCR family 2 0.0031 0.0015 0.0056
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0003 0.0041
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.102 0.0699 1
Echinococcus multilocularis snurportin 1 0.0308 0.0206 0.0756
Echinococcus multilocularis protein patched 0.0083 0.0051 0.0188
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0003 0.0001
Schistosoma mansoni cpg binding protein 0.0029 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.102 0.0699 0.2558
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0003 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0026 0.0094
Onchocerca volvulus 0.0012 0.0002 0.0022
Echinococcus granulosus BC026374 protein S09 family 0.0669 0.0456 0.1671
Onchocerca volvulus 0.0669 0.0456 0.6529
Echinococcus multilocularis carboxylesterase 5A 0.396 0.273 1
Brugia malayi RNA binding protein 0.0061 0.0036 0.0131
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0669 0.0456 0.1671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0056 0.0204
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Schistosoma mansoni hypothetical protein 0.0308 0.0206 0.0755
Schistosoma mansoni Lysine-specific histone demethylase 1 0.102 0.0699 0.2557
Schistosoma mansoni hypothetical protein 0.008 0.0049 0.0179
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0026 0.0327
Echinococcus multilocularis cpg binding protein 0.003 0.0015 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0003 0.0011
Loa Loa (eye worm) patched family protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.102 0.0699 0.2558
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0015 0.0056
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0036 0.0131
Echinococcus multilocularis replication factor c subunit 1 0.001 0 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.004 0.0145
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0222 0.0147 0.0538
Onchocerca volvulus 0.0012 0.0002 0.0022
Schistosoma mansoni neuroligin 3 (S09 family) 0.0669 0.0456 0.167
Leishmania major GTP-binding protein, putative 0.0021 0.0009 0.0075
Plasmodium vivax patched family protein, putative 0.0012 0.0002 0.0022
Brugia malayi hypothetical protein 0.0669 0.0456 0.167
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0015 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Trypanosoma brucei carbonic anhydrase-like protein 0.0316 0.0212 1
Schistosoma mansoni patched 1 0.0083 0.0051 0.0186
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0116
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0066
Onchocerca volvulus 0.0047 0.0026 0.0367
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.001 0.0137
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0003 0.0012
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.102 0.0699 1
Echinococcus multilocularis carbonic anhydrase 0.0222 0.0147 0.054
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Echinococcus multilocularis Niemann Pick C1 protein 0.0277 0.0185 0.0677
Loa Loa (eye worm) carbonic anhydrase 3 0.0316 0.0212 0.0778
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0036 0.0131
Plasmodium vivax hypothetical protein, conserved 0.102 0.0699 1
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Brugia malayi Patched related family protein 4 0.0012 0.0002 0.0006
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0066
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0003 0.0003
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 1.4479 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0026 0.2016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0015 0.0056
Echinococcus granulosus snurportin 1 0.0308 0.0206 0.0756
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0017 0.0016
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.102 0.0699 0.2558
Schistosoma mansoni carbonic anhydrase-related 0.0222 0.0147 0.0538
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0 0.5
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0031
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0316 0.0212 0.0778
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0003 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0036 0.0132
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0017 0.0016
Echinococcus multilocularis nibrin 0.001 0 0.0002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0222 0.0147 0.0538
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0036 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0003 0.0136
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0003 0.0227
Loa Loa (eye worm) carboxylesterase 0.396 0.273 1
Plasmodium falciparum protoporphyrinogen oxidase 0.102 0.0699 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0026 0.0026
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0026 0.2016
Schistosoma mansoni gliotactin 0.0669 0.0456 0.167
Echinococcus granulosus acetylcholinesterase 0.396 0.273 1
Toxoplasma gondii hypothetical protein 0.0222 0.0147 0.2102
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0036 0.0131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Mycobacterium ulcerans oxidoreductase 0.102 0.0699 0.0698
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0056 0.0205
Brugia malayi hypothetical protein 0.0036 0.0019 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Plasmodium vivax protoporphyrinogen oxidase, putative 0.102 0.0699 1
Echinococcus multilocularis acetylcholinesterase 0.396 0.273 1
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0 0.00000013832
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0056 0.0204
Brugia malayi Carboxylesterase family protein 0.0669 0.0456 0.167
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0036 0.0131
Loa Loa (eye worm) hypothetical protein 0.0102 0.0064 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0056 0.0204
Schistosoma mansoni hypothetical protein 0.0031 0.0015 0.0054
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0003 0.0041
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.0276 0.1012
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0316 0.0212 0.0776
Brugia malayi Carboxylesterase family protein 0.0669 0.0456 0.167
Entamoeba histolytica hypothetical protein 0.0023 0.001 0.0753
Brugia malayi hypothetical protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Echinococcus granulosus para nitrobenzyl esterase 0.0669 0.0456 0.1671
Brugia malayi Carboxylesterase family protein 0.0669 0.0456 0.167
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0669 0.0456 0.1671
Brugia malayi Importin beta-1 subunit 0.0029 0.0014 0.0049
Schistosoma mansoni carbonic anhydrase 0.0222 0.0147 0.0538
Schistosoma mansoni carbonic anhydrase-related 0.0222 0.0147 0.0538
Echinococcus granulosus carbonic anhydrase 0.0222 0.0147 0.054
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0003 0.0001
Plasmodium vivax hypothetical protein, conserved 0.102 0.0699 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0009 0.0031
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0316 0.0212 0.0776
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0026 0.0026
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0018 0.0251
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Echinococcus granulosus lysine specific histone demethylase 1A 0.102 0.0699 0.2558
Schistosoma mansoni amine oxidase 0.102 0.0699 0.2557
Loa Loa (eye worm) hypothetical protein 0.0222 0.0147 0.054
Echinococcus granulosus importin subunit beta 1 0.0029 0.0014 0.005
Loa Loa (eye worm) oxidoreductase 0.0014 0.0003 0.0012
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0003 0.0041
Echinococcus multilocularis BC026374 protein (S09 family) 0.0669 0.0456 0.1671
Loa Loa (eye worm) hypothetical protein 0.0669 0.0456 0.1671
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Loa Loa (eye worm) patched family protein 0.0012 0.0002 0.0007
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0003 0.0011
Echinococcus multilocularis carbonic anhydrase 0.0222 0.0147 0.054
Loa Loa (eye worm) hypothetical protein 0.396 0.273 1
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0051 0.0188
Schistosoma mansoni hypothetical protein 0.008 0.0049 0.0179
Onchocerca volvulus 0.0669 0.0456 0.6529
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0051 0.1115
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0002 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0036 0.0131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Schistosoma mansoni hypothetical protein 0.008 0.0049 0.0179
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0051 0.0188
Schistosoma mansoni hypothetical protein 0.0067 0.004 0.0145
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.003
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0014 0.0191
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Plasmodium falciparum importin beta, putative 0.0029 0.0014 0.0191
Brugia malayi Carboxylesterase family protein 0.396 0.273 1
Mycobacterium tuberculosis Possible oxidoreductase 0.102 0.0699 0.0749
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0669 0.0456 0.167
Echinococcus granulosus lysine specific histone demethylase 1A 0.102 0.0699 0.2558
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0019 0.0067
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0003 0.0041
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0409 0.0276 0.1011
Onchocerca volvulus 0.0669 0.0456 0.6529
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.1437
Toxoplasma gondii patched family protein 0.0012 0.0002 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0017 0.0016
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0009 0.0116
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0036 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0003 0.0011
Loa Loa (eye worm) patched family protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0194 0.0128 0.0467
Leishmania major importin beta-1 subunit, putative 0.0023 0.001 0.0096
Brugia malayi TAR-binding protein 0.0061 0.0036 0.0131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0062 0.0226
Echinococcus multilocularis protein dispatched 1 0.0095 0.0059 0.0217
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0669 0.0456 0.1671
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0003 0.0063
Echinococcus multilocularis acetylcholinesterase 0.396 0.273 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0003 0.0011
Treponema pallidum DNA ligase (lig) 0.001 0 0.5
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0026 0.0367
Schistosoma mansoni hypothetical protein 0.0031 0.0015 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Echinococcus granulosus carbonic anhydrase II 0.0316 0.0212 0.0778
Loa Loa (eye worm) hypothetical protein 0.0669 0.0456 0.1671
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0014 0.005
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0026 0.0327
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0316 0.0212 0.3036
Echinococcus multilocularis carbonic anhydrase 0.0222 0.0147 0.054
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0026 0.0095
Echinococcus multilocularis tumor protein p63 0.0338 0.0227 0.0832
Plasmodium falciparum carbonic anhydrase 0.0222 0.0147 0.2105
Echinococcus multilocularis neuroligin 0.0669 0.0456 0.1671
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi RNA, U transporter 1 0.0082 0.005 0.0183
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.102 0.0699 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0381
Schistosoma mansoni acetylcholinesterase 0.0669 0.0456 0.167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Echinococcus granulosus carbonic anhydrase 0.0222 0.0147 0.054
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0026 0.0367
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 1.3459 0.9295 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0669 0.0456 0.1671
Echinococcus multilocularis para nitrobenzyl esterase 0.0669 0.0456 0.1671
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0026 0.0026
Toxoplasma gondii patched family protein 0.0012 0.0002 0.0022
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0003 0.0041
Echinococcus granulosus replication factor c subunit 1 0.001 0 0.0002
Brugia malayi protein C24B5.3 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0003 0.0011
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.1021 0.07 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0066
Onchocerca volvulus 0.0014 0.0003 0.0041
Trichomonas vaginalis spcc417.12 protein, putative 0.0669 0.0456 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0003 0.0001
Loa Loa (eye worm) RNA binding protein 0.0061 0.0036 0.0132
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0194 0.0128 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0026 0.0026
Brugia malayi hypothetical protein 0.0012 0.0002 0.0006
Echinococcus multilocularis protoporphyrinogen oxidase 0.102 0.0699 0.2558
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0669 0.0456 0.167
Brugia malayi Patched related family protein 12 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0062 0.0224
Schistosoma mansoni hypothetical protein 0.0031 0.0015 0.0054
Schistosoma mansoni importin beta-1 0.0029 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.1437
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0003 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0026 0.0094
Onchocerca volvulus 0.0014 0.0003 0.0041
Toxoplasma gondii patched family protein 0.0012 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Mycobacterium ulcerans monoamine oxidase 0.102 0.0699 0.0698
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0003 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0019 0.0069
Onchocerca volvulus 0.0669 0.0456 0.6529
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0003 0.0003
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0 0.00000082843
Schistosoma mansoni amine oxidase 0.102 0.0699 0.2557
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0009 0.0116
Brugia malayi Myosin head containing protein 0.0012 0.0002 0.0006
Trichomonas vaginalis ran, putative 0.0021 0.0009 0.0177
Leishmania major carbonic anhydrase-like protein 0.0316 0.0212 0.3007
Toxoplasma gondii ATPase, AAA family protein 0.001 0 0.00000053997
Loa Loa (eye worm) hypothetical protein 0.102 0.0699 0.2558
Entamoeba histolytica Ran family GTPase 0.0021 0.0009 0.0636
Echinococcus granulosus carbonic anhydrase 0.0222 0.0147 0.054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.396 0.273 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0222 0.0147 0.0538
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0003 0.0041
Echinococcus granulosus nibrin 0.001 0 0.0002
Schistosoma mansoni ran 0.0021 0.0009 0.003
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0003 0.0012
Onchocerca volvulus 0.0669 0.0456 0.6529
Loa Loa (eye worm) hypothetical protein 0.0669 0.0456 0.1671
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0116
Echinococcus granulosus tumor protein p63 0.0338 0.0227 0.0832
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0066
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0 0.00000082843
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0222 0.0147 0.0538
Schistosoma mansoni hypothetical protein 0.0222 0.0147 0.0538
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0018 0.0251
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Brugia malayi hypothetical protein 0.0012 0.0002 0.0006
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0669 0.0456 0.1671
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0026 0.0026
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0036 0.0019 0.0067
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0206 0.0756
Echinococcus multilocularis expressed conserved protein 0.0182 0.0119 0.0438
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0031 0.0443
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0003 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0014 0.0629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0056 0.0205
Loa Loa (eye worm) hypothetical protein 0.0067 0.004 0.0147
Loa Loa (eye worm) hypothetical protein 0.102 0.0699 0.2558
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.1437
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0222 0.0147 0.054
Chlamydia trachomatis protoporphyrinogen oxidase 0.102 0.0699 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0019 0.0069
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0003 0.0001
Onchocerca volvulus 0.0014 0.0003 0.0041
Echinococcus granulosus Niemann Pick C1 protein 0.0277 0.0185 0.0677
Leishmania major UDP-galactopyranose mutase 0.102 0.0699 1
Entamoeba histolytica hypothetical protein 0.0036 0.0019 0.1437
Onchocerca volvulus Protein patched homolog 0.0012 0.0002 0.0022
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0316 0.0212 0.0776
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0003 0.0003
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0003 0.0136
Onchocerca volvulus 0.0014 0.0003 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0062 0.0224
Loa Loa (eye worm) hypothetical protein 0.0047 0.0026 0.0095
Mycobacterium ulcerans protoporphyrinogen oxidase 0.102 0.0699 0.0698
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0015 0.0056
Brugia malayi Carboxylesterase family protein 0.0669 0.0456 0.167
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0003 0.0063
Loa Loa (eye worm) patched family protein 0.0012 0.0002 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0028 0.0101
Mycobacterium ulcerans dehydrogenase 0.102 0.0699 0.0698
Brugia malayi Patched related family protein 10 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0012
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0018 0.0251
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0316 0.0212 0.0776
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0036 0.0131
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0003 0.0011
Echinococcus granulosus tar DNA binding protein 0.0061 0.0036 0.0132
Brugia malayi hypothetical protein 0.102 0.0699 0.2557
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0003 0.0001
Echinococcus multilocularis GPCR, family 2 0.0031 0.0015 0.0056
Schistosoma mansoni cpg binding protein 0.003 0.0015 0.0053
Plasmodium vivax importin-beta 2, putative 0.0029 0.0014 0.0191
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0 0.00000082843
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0051 0.0188
Echinococcus granulosus neuroligin 0.0669 0.0456 0.1671
Schistosoma mansoni cpg binding protein 0.003 0.0015 0.0053
Schistosoma mansoni carbonic anhydrase-related 0.0222 0.0147 0.0538
Brugia malayi Niemann-Pick C1 protein precursor 0.0194 0.0128 0.0466
Brugia malayi Patched family protein 0.0012 0.0002 0.0006
Mycobacterium ulcerans hypothetical protein 0.0047 0.0026 0.0026
Echinococcus granulosus carboxylesterase 5A 0.396 0.273 1
Brugia malayi amine oxidase, flavin-containing family protein 0.102 0.0699 0.2557
Loa Loa (eye worm) acetylcholinesterase 1 0.396 0.273 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0056 0.0204
Trypanosoma cruzi UDP-galactopyranose mutase 0.102 0.0699 1
Onchocerca volvulus 0.0049 0.0028 0.0395
Onchocerca volvulus 0.0012 0.0002 0.0022
Brugia malayi protein C24B5.3 0.0012 0.0002 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0026 0.0094
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0003 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0003 0.0011
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0316 0.0212 0.3036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0813 0.0556 0.2036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0669 0.0456 0.167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0056 0.0205
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0066
Schistosoma mansoni ran 0.0021 0.0009 0.003
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.102 0.0699 1
Brugia malayi Patched protein homolog 1 0.0012 0.0002 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1594 0.1095 0.4012
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0051 0.0188
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0014 0.0629
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.005

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 41.01 uM Cytotoxicity against human THP1 cells after 48 hrs by MTT assay ChEMBL. 22115593
IC50 (functional) = 41.94 uM Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay ChEMBL. 22115593
IC50 (functional) > 50 uM Cytotoxicity against human U937 cells after 48 hrs by MTT assay ChEMBL. 22115593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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