Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 12 (macrophage elastase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 12 (macrophage elastase) | 470 aa | 467 aa | 32.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0686 | 0.0643 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0686 | 0.0643 | 0.1989 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.054 | 0.0492 | 0.1433 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3194 | 0.3233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3194 | 0.3233 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.3194 | 0.3233 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3194 | 0.3233 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3194 | 0.3233 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0686 | 0.0643 | 0.0159 |
Plasmodium vivax | hypothetical protein, conserved | 0.0686 | 0.0643 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3194 | 0.3233 | 1 |
Echinococcus granulosus | neuroligin | 0.054 | 0.0492 | 0.1433 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0686 | 0.0643 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Brugia malayi | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.0643 | 0.1989 |
Echinococcus granulosus | BC026374 protein S09 family | 0.054 | 0.0492 | 0.1433 |
Brugia malayi | Carboxylesterase family protein | 0.054 | 0.0492 | 0.1521 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0686 | 0.0643 | 0.0172 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0686 | 0.0643 | 0.5 |
Brugia malayi | hypothetical protein | 0.0686 | 0.0643 | 0.1989 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0686 | 0.0643 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0686 | 0.0643 | 0.1906 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0686 | 0.0643 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.054 | 0.0492 | 0.1521 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.9746 | 1 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0686 | 0.0643 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.0643 | 0.1989 |
Loa Loa (eye worm) | carboxylesterase | 0.054 | 0.0492 | 0.1521 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0686 | 0.0643 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0686 | 0.0643 | 0.1989 |
Loa Loa (eye worm) | hypothetical protein | 0.3194 | 0.3233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.906 | 0.9291 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0686 | 0.0643 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.054 | 0.0492 | 0.1433 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0686 | 0.0643 | 0.0172 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0686 | 0.0643 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.054 | 0.0492 | 0.1521 |
Brugia malayi | Carboxylesterase family protein | 0.3194 | 0.3233 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.054 | 0.0492 | 0.1521 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3194 | 0.3233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.0643 | 0.1989 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Mycobacterium ulcerans | dehydrogenase | 0.0686 | 0.0643 | 0.0159 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0686 | 0.0643 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0686 | 0.0643 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.054 | 0.0492 | 0.1433 |
Onchocerca volvulus | 0.0686 | 0.0643 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.3194 | 0.3233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.0643 | 0.1989 |
Echinococcus granulosus | carboxylesterase 5A | 0.3194 | 0.3233 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0686 | 0.0643 | 0.0552 |
Brugia malayi | Carboxylesterase family protein | 0.054 | 0.0492 | 0.1521 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0686 | 0.0643 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.054 | 0.0492 | 0.1433 |
Echinococcus multilocularis | 0.0686 | 0.0643 | 0.1906 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.054 | 0.0492 | 0.1433 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.054 | 0.0492 | 0.1433 |
Schistosoma mansoni | amine oxidase | 0.0686 | 0.0643 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.0643 | 0.1989 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0686 | 0.0643 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.054 | 0.0492 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0686 | 0.0643 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0686 | 0.0643 | 0.1906 |
Echinococcus multilocularis | acetylcholinesterase | 0.3194 | 0.3233 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.054 | 0.0492 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0686 | 0.0643 | 0.0159 |
Brugia malayi | Carboxylesterase family protein | 0.3194 | 0.3233 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0686 | 0.0643 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.0492 | 0.1521 |
Schistosoma mansoni | amine oxidase | 0.0686 | 0.0643 | 0.0552 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0686 | 0.0643 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0686 | 0.0643 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.0643 | 0.1989 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 nM | Inhibition of human MMP-12 | ChEMBL. | 22153340 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.