Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0468 | 0.0446 | 0.1054 |
Mycobacterium ulcerans | oxidoreductase | 0.053 | 0.053 | 0.0088 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.053 | 0.053 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0468 | 0.0446 | 0.1054 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.7532 | 1 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.053 | 0.053 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.053 | 0.053 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.053 | 0.053 | 0.1294 |
Plasmodium vivax | hypothetical protein, conserved | 0.053 | 0.053 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0468 | 0.0446 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.053 | 0.1487 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.053 | 0.053 | 0.1294 |
Brugia malayi | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0468 | 0.0446 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.053 | 0.1487 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0468 | 0.0446 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0468 | 0.0446 | 0.1054 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.053 | 0.053 | 0.0095 |
Echinococcus granulosus | acetylcholinesterase | 0.2773 | 0.3563 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0468 | 0.0446 | 0.1054 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.053 | 0.053 | 0.1294 |
Onchocerca volvulus | 0.053 | 0.053 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0468 | 0.0446 | 0.1252 |
Loa Loa (eye worm) | carboxylesterase | 0.2773 | 0.3563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2773 | 0.3563 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2773 | 0.3563 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2773 | 0.3563 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2773 | 0.3563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Loa Loa (eye worm) | carboxylesterase | 0.0468 | 0.0446 | 0.1252 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.053 | 0.053 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.053 | 0.053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.053 | 0.1487 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.053 | 0.053 | 0.1294 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0468 | 0.0446 | 0.1054 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.053 | 0.053 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.053 | 0.053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.053 | 0.1487 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.053 | 0.053 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2773 | 0.3563 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0468 | 0.0446 | 0.1054 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2773 | 0.3563 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.053 | 0.053 | 0.0088 |
Brugia malayi | hypothetical protein | 0.053 | 0.053 | 0.1487 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0468 | 0.0446 | 0.1054 |
Brugia malayi | Carboxylesterase family protein | 0.0468 | 0.0446 | 0.1252 |
Mycobacterium ulcerans | monoamine oxidase | 0.053 | 0.053 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.053 | 0.053 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0468 | 0.0446 | 0.1252 |
Schistosoma mansoni | amine oxidase | 0.053 | 0.053 | 0.1294 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.053 | 0.053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.053 | 0.053 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0468 | 0.0446 | 0.1252 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.053 | 0.053 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Echinococcus multilocularis | acetylcholinesterase | 0.2773 | 0.3563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2773 | 0.3563 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.053 | 0.053 | 0.0088 |
Brugia malayi | SWIRM domain containing protein | 0.053 | 0.053 | 0.1487 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0446 | 0.1252 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.053 | 0.1487 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.053 | 0.053 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0468 | 0.0446 | 0.1054 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0468 | 0.0446 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0468 | 0.0446 | 0.1054 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.053 | 0.053 | 0.1294 |
Echinococcus granulosus | acetylcholinesterase | 0.2773 | 0.3563 | 1 |
Echinococcus multilocularis | 0.053 | 0.053 | 0.1294 | |
Echinococcus granulosus | carboxylesterase 5A | 0.2773 | 0.3563 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0468 | 0.0446 | 0.1252 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.053 | 0.053 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0468 | 0.0446 | 0.1054 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.7001 | 0.9283 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.053 | 0.053 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0468 | 0.0446 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.053 | 0.1487 |
Schistosoma mansoni | gliotactin | 0.0468 | 0.0446 | 0.1054 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0468 | 0.0446 | 0.1054 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2773 | 0.3563 | 1 |
Schistosoma mansoni | amine oxidase | 0.053 | 0.053 | 0.1294 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.053 | 0.053 | 0.1487 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 56.16 % | Growth inhibition of human HCT116 cells at 1 mg/mL after 48 hrs by MTT assay | ChEMBL. | 22137847 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.