Detailed information for compound 1594158

Basic information

Technical information
  • TDR Targets ID: 1594158
  • Name: 2,5-dimethoxy-N-(3-morpholin-4-ylpropyl)benze nesulfonamide
  • MW: 344.426 | Formula: C15H24N2O5S
  • H donors: 1 H acceptors: 2 LogP: 0.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)NCCCN1CCOCC1)OC
  • InChi: 1S/C15H24N2O5S/c1-20-13-4-5-14(21-2)15(12-13)23(18,19)16-6-3-7-17-8-10-22-11-9-17/h4-5,12,16H,3,6-11H2,1-2H3
  • InChiKey: YFONESYPCBRHKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,5-dimethoxy-N-(3-morpholinopropyl)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0102 0.3937 0.3601
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0231 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0077 0.275 0.2348
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2585 0.2174
Entamoeba histolytica hypothetical protein 0.0184 0.7775 0.7652
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.275 0.2348
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.275 0.2348
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0525 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.275 0.2348
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2585 0.2174
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0224 0.9677 0.966
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.003 0.0525 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0231 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0231 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.2428 0.2659
Echinococcus multilocularis tar DNA binding protein 0.0074 0.2585 0.2174
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.003 0.0525 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.003 0.0525 0.0525
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0159 0.6588 0.6399
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0231 1 1
Brugia malayi hypothetical protein 0.0029 0.0491 0.0491
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0159 0.6588 0.6399
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0525 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.003 0.0525 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0231 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0077 0.275 0.2348
Loa Loa (eye worm) TAR-binding protein 0.0074 0.2585 0.2876
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0149 0.6162 0.5949
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.275 0.2348
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0077 0.275 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0111 0.4363 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0231 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0149 0.6162 0.6162
Loa Loa (eye worm) RNA binding protein 0.0074 0.2585 0.2876
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2585 0.2174
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0184 0.7775 0.7652
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2585 0.2174
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.275 0.275
Brugia malayi RNA binding protein 0.0074 0.2585 0.2585
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.2428 0.2037
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0077 0.275 0.2376
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.003 0.0525 0.0037
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.7775 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.6162 0.7786
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.2585 0.2876
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.003 0.0525 0.0154
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.2585 0.2585
Loa Loa (eye worm) hypothetical protein 0.0081 0.2944 0.3368
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2585 0.2174
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.003 0.0525 0.0037
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0149 0.6162 0.5949
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.003 0.0525 0.0048
Echinococcus granulosus tar DNA binding protein 0.0074 0.2585 0.2174
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0231 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0231 1 1
Brugia malayi TAR-binding protein 0.0074 0.2585 0.2585
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0231 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0525 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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